70 completed, 10 terminated, 5 unknown, 4 recruiting. 28 Phase 3, 22 Phase 4, 18 Phase 2, 13 Phase 1, 9 Not applicable.
Follow this drug Literature Review of Galantamine trials Research Report on Galantamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI) Galantamine Hydrobromide Extended Release - Spinal Cord Injury, Traumatic Spinal Cord Injury | Phase 2 / Phase 3 | Recruiting | Northwell Health | 60 | 2026-06-15 | 2026-06-04 |
| Exploration of the Efficacy and Mechanism of Galantamine (an Extract From Lycoris Aurea) in Treating Ischemic Stroke Galantamine, Standard treatment for acute ischemic stroke - Acute Ischemic Stroke AIS | Phase 2 / Phase 3 | Recruiting | Shanghai Yueyang Integrated Medicine Hospital | 66 | 2025-09-15 | 2025-09-16 |
| Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease Intravenous infusion of mononuclear cells from umbilical cord blood, Conventional medical treatment：donepezil, rivastigmine or galantamine - Alzheimer Disease (AD) | Early Phase 1 | Recruiting | Anhui Provincial Hospital | 30 | 2025-07-31 | 2025-10-06 |
| Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL) cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine) - Alzheimer Disease, Cholinesterase Inhibitors | Phase 4 | Not yet recruiting | University Hospital, Bordeaux | 1205 | 2024-06-01 | 2023-10-06 |
| Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans Galantamine, Placebo, TENS 7000 - Endothelial Dysfunction | Phase 1 / Phase 2 | Recruiting | Vanderbilt University Medical Center | 160 | 2021-12-20 | 2026-05-18 |
| Galantamine and CBT4CBT Pilot to Prevent Relapse. MAT taper with galantamine, MAT taper with placebo - Methadone or Buprenorphine Detoxoxification | Early Phase 1 | Completed | Yale University | 6 | 2018-05-01 | 2022-08-19 |
| Effect of Galantamine on Inflammation and Cognition Galantamine, Placebo - HIV Associated Cognitive Motor Complex | Phase 2 | Completed | University of Pennsylvania | 63 | 2017-10-30 | 2024-10-17 |
| Vagal Stimulation in POTS placebo sugar pill, Pyridostigmine Pill, Galantamine Pill - Postural Tachycardia Syndrome | Phase 1 | Active not recruiting | Vanderbilt University Medical Center | 11 | 2017-09-30 | 2026-07-13 |
| Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study Galantamine, Placebo - Insulin Sensitivity, Oxidative Stress | Phase 1 | Withdrawn | Vanderbilt University Medical Center | 2017-01-01 | 2018-08-13 | |
| Racial Differences in Vagal Control of Glucose Homeostasis Galantamine, Placebo Oral Capsule, Intralipid - Obesity | Phase 1 / Phase 2 | Completed | Vanderbilt University Medical Center | 23 | 2015-03-01 | 2019-03-19 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine Placebo patch & placebo capsule, Placebo patch & galantamine capsule, Nicotine patch & placebo capsule - Basic Science Study of the Mechanisms of Attentional Enhancement by Compounds Acting on the Nicotinic Receptor | Not applicable | Completed | University of Maryland, Baltimore | 43 | 2014-09-01 | 2019-11-04 |
| Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia Galantamine ER, Memantine XR - Schizophrenia, Schizoaffective Disorder | Phase 2 | Terminated | Sheppard Pratt Health System | 3 | 2014-09-01 | 2017-11-09 |
| Galantamine Effects in Patients With Metabolic Syndrome Galantamine, Placebo (for galantamine) - Abdominal Obesity Metabolic Syndrome | Phase 4 | Completed | University of Sao Paulo | 60 | 2014-03-01 | 2017-02-15 |
| Symptomatic Treatment of Vascular Cognitive Impairment Galantamine, Methylphenidate, Placebo - Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular) | Phase 2 / Phase 3 | Unknown | Amsterdam UMC, location VUmc | 30 | 2014-02-01 | 2016-05-02 |
| A Study to Help People Quit Smoking. placebo, Galantamine 8mg, Galantamine 16mg - Nicotine Dependence | Not applicable | Completed | Yale University | 60 | 2013-12-01 | 2020-03-23 |
| A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy RO4602522, Placebo, Donepezil - Alzheimer's Disease | Phase 2 | Completed | Hoffmann-La Roche | 542 | 2012-10-24 | 2017-05-30 |
| Effect of Galantamine on Short-term Abstinence Galantamine, Placebo - Tobacco Use Disorder | Phase 2 | Completed | University of Pennsylvania | 98 | 2012-08-01 | 2019-02-15 |
| Effect of Galantamine on Smoking Abstinence Galantamine ER - Nicotine Addiction | Phase 2 | Completed | University of Pennsylvania | 13 | 2012-02-01 | 2017-12-26 |
| Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance Huperzine A, Donepezil, Galantamine - Biomarkers, Pharmacological | Completed | U.S. Army Medical Research and Development Command | 84 | 2012-02-01 | 2017-05-03 |
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Alzheimer Disease (38) · Dementia (25) · Memory Disorders (11) · Cognitive Dysfunction (10) · Schizophrenia (9) · Brain Diseases (6) · Psychotic Disorders (6) · Dementia, Vascular (4) · Smoking (4) · Bipolar Disorder (3) · Mental Disorders (3) · Stroke (3) · Tobacco Use Disorder (3) · Behavior, Addictive (2) · Behavioral Symptoms (2)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (14) · Yale University (8) · University of Maryland, Baltimore (5) · Vanderbilt University Medical Center (4) · Janssen Korea, Ltd., Korea (3) · Janssen Pharmaceutical K.K. (3) · University of Pennsylvania (3) · Actavis Inc. (2) · Dr. Reddy's Laboratories Limited (2) · Indiana University (2) · Massachusetts General Hospital (2) · Sunnybrook Health Sciences Centre (2) · Xian-Janssen Pharmaceutical Ltd. (2) · Amsterdam UMC, location VUmc (1) · Anhui Provincial Hospital (1)
United States (44) · Canada (5) · France (5) · Germany (4) · Australia (2) · China (2) · Czechia (2) · Japan (2) · South Korea (2) · Spain (2) · Brazil (1) · Estonia (1) · Greece (1) · Italy (1) · Latvia (1)
Mehmet Sofuoglu, M.D., Ph.D. (4) · Benoit Girard, M.D. (2) · Cyndya Shibao, MD (2) · Gaerano Morelli (2) · Rebecca Ashare, Ph.D. (2) · A Eden Evins, MD, MPH (1) · Alan Rapoport, MD (1) · Amit Anand, MD (1) · Andre Tapp, M.D. (1) · Britta Hahn, Ph.D. (1)
PMID 39498781, PMID 10881250, PMID 11110737, PMID 11606667, PMID 11965273, PMID 14676468, PMID 14967774, PMID 15525294, PMID 15990426, PMID 17388711, PMID 17620494, PMID 17621382, PMID 17986678, PMID 18667813, PMID 19042161, PMID 23782591, PMID 24591834, PMID 24964105, PMID 26040709, PMID 26482056, PMID 26796681, PMID 27846868, PMID 28295141, PMID 28550255, PMID 28705532, PMID 28724799, PMID 29286595, PMID 29559423, PMID 31910895, PMID 33189083, PMID 35659521, PMID 37267443, PMID 39359162
P50DA009241 (3), P50MH082999 (2), 2009 (1), K23DA035295 (1), K23MH064196 (1), R01DA015969 (1), R01DA029577 (1), R01DA044906 (1), R01MH079157 (1), R21DA034815 (1), R34MH077849 (1)