52 completed, 6 terminated, 3 active not recruiting, 3 recruiting. 19 Phase 2, 18 Phase 1, 14 Phase 3, 6 Early Phase 1, 6 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 18F-LY3950321-01 Biodistribution and Safety Study 18F-LY3950321, PET Scan - Diagnostic Agent Adverse Reaction, Radiation Exposure | Early Phase 1 | Completed | Avid Radiopharmaceuticals | 6 | 2023-02-28 | 2023-04-28 |
| Early Clinical Evaluation of 18F-LY3546117 in Tumor Imaging 18F-LY3546117 Injection, PET Scan - Neoplasms, Neoplasms Malignant | Early Phase 1 | Unknown | Avid Radiopharmaceuticals | 30 | 2022-04-12 | 2022-04-25 |
| University of Pittsburgh Brain Health Initiative Cognitive/Neuropsychological Testing, Vestibular/Ocular-Motor Testing, Sleep Evaluation - Traumatic Brain Injury | Recruiting | David Okonkwo, MD, PhD | 300 | 2019-11-18 | 2026-06-22 | |
| Evaluation of Flortaucipir PET Signal and Cognitive Change in Early Alzheimer's Disease flortaucipir F18, Brain PET Scan - Alzheimer Disease | Phase 3 | Completed | Avid Radiopharmaceuticals | 205 | 2019-03-28 | 2020-08-28 |
| A Reader Study to Assess Accuracy and Reliability of Flortaucipir F 18 Positron Emission Tomography (PET) Scan Interpretation flortaucipir F 18 - Alzheimer Disease | Phase 3 | Completed | Avid Radiopharmaceuticals | 242 | 2019-03-26 | 2020-09-09 |
| Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease DaTscan, F18-AV-45, FDG-PET - Alzheimer's Disease, Lewy Body Dementia | Recruiting | Douglas Scharre | 76 | 2018-08-30 | 2026-10-15 | |
| Tau Screening Study in Subjects With Early Symptomatic AD Flortaucipir F18, Brain PET Scan - Alzheimer Disease | Phase 2 | Completed | Avid Radiopharmaceuticals | 161 | 2018-03-08 | 2020-08-24 |
| Tau Screening Study in Patients With Early Symptomatic AD Flortaucipir F18, Brain PET Scan - Alzheimer Disease | Phase 2 | Completed | Avid Radiopharmaceuticals | 155 | 2017-11-21 | 2020-08-24 |
| Flortaucipir PET Imaging in Subjects With FTD Flortaucipir F18, Brain PET scan - Frontotemporal Dementia | Phase 1 | Completed | Avid Radiopharmaceuticals | 16 | 2017-04-11 | 2020-09-25 |
| Flortaucipir 18F PET Imaging in BIOCARD Study Flortaucipir F18, Brain PET scan - Cognitive Decline | Phase 1 | Terminated | Avid Radiopharmaceuticals | 23 | 2017-03-23 | 2020-09-25 |
| The Role of F-18 Florbetapir in the Early Detection of Cardiac Amyloidosis F-18 florbetapir - Cardiac Amyloidosis | Phase 4 | Terminated | The Cleveland Clinic | 12 | 2017-01-01 | 2021-07-27 |
| 18F-AV-1451 High Resolution Autopsy Study Flortaucipir F18 - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 3 | 2016-11-26 | 2025-06-10 |
| Imaging Tau Deposition in the Brain of Elderly Subjects 18F-AV-1451 (Tau-PET tracer) - Mild Cognitive Impairment, Healthy | Not applicable | Active not recruiting | University of Zurich | 141 | 2016-11-01 | 2023-11-09 |
| Registry of Amyloid Positive Patients for Alzheimer's Disease Drug Research Trials florbetapir F 18 PET scan - Alzheimer Disease, Cognition Disorders | Completed | Avid Radiopharmaceuticals | 317 | 2016-10-01 | 2018-10-24 | |
| PET Tau - Neurodegenerative Disease Imaging 18F-AV-1451 - Neurodegenerative Disease | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 300 | 2016-08-23 | 2026-10-16 |
| Follow up 18F-AV-1451 Scan in Confirmatory Cohort Subjects From Study 18F-AV-1451-A05 Flortaucipir F18, PET Scan - Alzheimer's Disease | Phase 2 | Completed | Avid Radiopharmaceuticals | 79 | 2016-08-01 | 2020-08-24 |
| 18F-AV-1451 PET Imaging in Participants Enrolled in the LEARN Study 18F-AV-1451 - Cognition Disorders | Phase 1 | Completed | University of Southern California | 55 | 2016-08-01 | 2023-11-18 |
| 18F-AV-1451 PET Imaging in TBI 18F-AV-1451 - Traumatic Brain Injury | Phase 1 | Withdrawn | Avid Radiopharmaceuticals | 2015-10-01 | 2016-02-05 | |
| 18F-AV-1451 Autopsy Study Flortaucipir F18, PET Scan - Alzheimer's Disease | Phase 3 | Completed | Avid Radiopharmaceuticals | 156 | 2015-09-01 | 2020-09-07 |
| Tau Imaging in Professional Fighters Flortaucipir F18, Brain PET scan - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 35 | 2015-02-18 | 2020-09-10 |
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Alzheimer Disease (48) · Cognitive Dysfunction (11) · Parkinson Disease (4) · Brain Injuries, Traumatic (3) · Neurodegenerative Diseases (3) · Cognition Disorders (2) · Dementia (2) · Diabetes Mellitus, Type 1 (2) · Diabetes Mellitus, Type 2 (2) · Frontotemporal Dementia (2) · Lewy Body Disease (2) · Amyloid Neuropathies, Familial (1) · Brain Concussion (1) · Cerebral Amyloid Angiopathy (1) · Cerebral Hemorrhage (1)
florbetapir (36) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (25) · florbenazine F 18 (5) · Magnetic Resonance Spectroscopy (4) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (3) · gantenerumab (2) · solanezumab (2) · tau Proteins (2) · (N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole (1) · Arginine (1) · Fluorodeoxyglucose F18 (1) · Hematologic Tests (1) · Magnetic Resonance Imaging (1) · Physical Examination (1) · flutemetamol (1)
United States (53) · Australia (6) · France (5) · Japan (4) · Canada (3) · United Kingdom (3) · Ireland (2) · Italy (2) · Netherlands (2) · Puerto Rico (2) · Spain (2) · Argentina (1) · Brazil (1) · Colombia (1) · Germany (1)
Randall J Bateman, MD (2) · Christoph Hock, Prof.Dr. med (1) · David Irwin, MD (1) · David O Okonkwo, MD, PhD (1) · Douglas W Scharre, MD (1) · Gary W Cline, Ph.D. (1) · Kitt F Petersen, M.D. (1)
PMID 22749065, PMID 33587110, PMID 42467182, PMID 20501908, PMID 21245183, PMID 24716655, PMID 28570698, PMID 29284675, PMID 30969506, PMID 31958082, PMID 32338734, PMID 32394598, PMID 32542468, PMID 33141172, PMID 36110925, PMID 37017737, PMID 38412412, PMID 38683602, PMID 39254220, PMID 39974075, PMID 40120616, PMID 40985290
R01AG046179 (2), U01AG042791 (2), R01AG053267 (1), R43NS063607 (1), R56AG053267 (1), U01AG059798 (1)