330 completed, 162 unknown, 110 recruiting, 47 active not recruiting. 400 Not applicable, 97 Phase 2, 56 Phase 3, 49 Phase 1, 31 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perforated Appendicitis and Postoperative Antibiotics Pilot Trial Postoperative antibiotico-prophylaxis, No postoperative antibiotics - Perforated Appendicitis | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 100 | 2027-01-01 | 2026-09-17 |
| Assessing Heart and Brain Metabolism in Type II Diabetes Mellitus Patients Using Carbon-13 MRI C13 Hyperpolarized pyruvate injection - Diabete Type 2 | Early Phase 1 | Not yet recruiting | Sunnybrook Health Sciences Centre | 32 | 2026-10-01 | 2026-09-15 |
| Ketogenic Diet and Neuromodulation in Treatment Resistant Depression Accelerated Intermittent Theta Burst Stimulation (iTBS), Ketogenic Diet, Canadian Food Guide-Aligned Diet - Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD) | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 60 | 2026-10-01 | 2026-09-25 |
| Better Access to and Integration of Mental Health and Addiction Services Through Navigation: A Mixed-Methods Adaptive Pragmatic Clinical Trial Family Navigation Project - Mental Health, Addictions | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 480 | 2026-10-01 | 2026-07-16 |
| Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT) Eptinezumab, Placebo - Post Traumatic Headache | Phase 3 | Not yet recruiting | Sunnybrook Health Sciences Centre | 80 | 2026-09-30 | 2026-08-13 |
| Sparrow App Guided Evaluation (SAGE) Vanguard Trial for Aortic Stenosis in Adults Aged Seventy and Older Stethophone - Moderate or Severe Aortic Stenosis | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 1000 | 2026-09-01 | 2026-09-18 |
| CEST for Prostate Biopsy Biopsy-Guided Therapy Selection - Prostate Cancer Detection | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 20 | 2026-09-01 | 2026-08-25 |
| Goal-Directed Therapy to Reduce Kidney and Cardiovascular Risk in Diabetic Kidney Disease (GOLD-STANDARD) Early goal-directed Cardio-Kidney-Metabolic (CKM) care, Standard care (Comparison arm) - Diabetic Kidney Disease (DKD), Type 2 Diabetes Mellitus (T2DM) | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 100 | 2026-08-26 | 2026-09-04 |
| Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures Erector spinae plane catheter, Serratus plane catheter - Traumatic Rib Fracture(s), Traumatic Rib Fracture | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 66 | 2026-08-01 | 2026-08-10 |
| Safety and Feasibility of Next-Generation Dome Helmet (NGDH) for Focused Ultrasound Neuromodulation in Substance Use Disorder (SUD) Next Generation Dome Helmet (NGDH) - Substance Use Disorder (SUD) | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 20 | 2026-07-01 | 2026-07-06 |
| Neuromodulation and fMRI in Neurodegenerative Diseases Study Transcranial Alternating Current Stimulation - Mild Cognitive Impairment, Traumatic Brain Injury | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 30 | 2026-06-01 | 2026-05-01 |
| InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression Ketamine, Oculus VR headset - Treatment Resistant Depression | Phase 3 | Recruiting | Sunnybrook Health Sciences Centre | 31 | 2026-05-03 | 2026-08-13 |
| Early Detection of Metastatic Recurrence Among Patients With Stage II or III Triple Negative Breast Cancer Using Liquid Biopsy and Imaging ctDNA-guided imaging surveillance, Standard - Triple Negative Breast Cancer, Surveillance | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 30 | 2026-05-01 | 2026-03-17 |
| This Study Will Use Real-time Pressure Mapping Technology to Determine Which Positioning Strategies and Devices Exert the Least Amount of Pressure on Peri-operative Burn Patients Positioning and positioning devices - Hospital Acquired Pressure Injury | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 80 | 2026-05-01 | 2026-05-05 |
| Baseline Knowledge of Stress Urinary Incontinence Among Urogynecology Patients 15 Item Questionnaire - Stress Urinary Incontinence (SUI) | Not yet recruiting | Sunnybrook Health Sciences Centre | 90 | 2026-04-30 | 2026-04-28 | |
| Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares Glucocorticoid (GC) - Rheumatoid Arthritis (RA) | Phase 4 | Recruiting | Sunnybrook Health Sciences Centre | 220 | 2026-04-01 | 2026-04-13 |
| A Phase II Trial Evaluating Radiation Boost to Painful Spinal Metastases Radiation Boost - Spine Metastasis | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 108 | 2026-04-01 | 2026-03-17 |
| Testing a New Treatment Strategy to Improve Secondary Stroke Prevention for Older Adults: The STROKE75+ Trial Edoxaban 15 mg, Aspirin or clopidogrel - Stroke, Ischemic | Phase 3 | Not yet recruiting | Sunnybrook Health Sciences Centre | 1204 | 2026-04-01 | 2026-03-06 |
| A Dose Optimization Study of Enzalutamide in Elderly Patients With Advanced Prostate Cancer Enzalutamide Dose Escalation, Standard of Care - Prostate Cancer Patients, Elderly Patients | Phase 2 | Not yet recruiting | Sunnybrook Health Sciences Centre | 26 | 2026-04-01 | 2026-04-06 |
| Dose-dEscalated MR-Guided Radiotherapy for Localized Prostate Cancer Prostate radical radiotherapy - Intermediate Risk Prostate Cancer (Diagnosis), Prostate Cancer | Not applicable | Active not recruiting | Sunnybrook Health Sciences Centre | 24 | 2026-03-22 | 2026-09-03 |
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Breast Neoplasms (47) · Prostatic Neoplasms (44) · Depression (29) · Stroke (27) · Anxiety Disorders (22) · Depressive Disorder, Major (22) · Cognitive Dysfunction (20) · Alzheimer Disease (19) · Neoplasms (19) · Hypertension (16) · Premature Birth (16) · Arthritis (13) · Bipolar Disorder (13) · COVID-19 (13) · Cardiovascular Diseases (13)
Therapeutics (12) · Radiosurgery (11) · Exercise (9) · Standard of Care (9) · Saline Solution (8) · Sodium Chloride (8) · Transcranial Magnetic Stimulation (8) · Transcranial Direct Current Stimulation (6) · Injections (5) · Citalopram (4) · Cognitive Behavioral Therapy (4) · Deep Brain Stimulation (4) · perflutren (4) · Acetaminophen (3) · Aspirin (3)
Canada (683) · United States (28) · Australia (8) · Germany (6) · Israel (6) · United Kingdom (6) · Italy (5) · Netherlands (4) · New Zealand (4) · Spain (4) · Austria (3) · Brazil (3) · Denmark (3) · Ireland (3) · Belgium (2)
Mary J Bell, MD, FRCPC (8) · Andrew Loblaw, MD (7) · Gregory J Czarnota, PhD, MD (7) · Nathan Herrmann, MD (7) · Charles Cunningham, PhD (6) · Paul Karanicolas, MD PhD (6) · Nick Daneman, MD (5) · David M Kreindler, MD (4) · Edward LW Chow, MBBS (4) · Eric Leung, MD (4) · Krista L Lanctot, PhD (4) · Krista Lanctot, PhD (4) · Michael Dunn, MD (4) · Sandra Black, MD (4)
PMID 23457326, PMID 27622157, PMID 33067379, PMID 35504244, PMID 37419394, PMID 37619656, PMID 39901803, PMID 41506574, PMID 10194512, PMID 10355863, PMID 10396491, PMID 10718232, PMID 10866248, PMID 11112239, PMID 11510598, PMID 12634549, PMID 14625335, PMID 15327808, PMID 15564545, PMID 15729413, PMID 15941430, PMID 16182464, PMID 16527791, PMID 17156107, PMID 17257413, PMID 17540020, PMID 17635708, PMID 17635709, PMID 17877830, PMID 17915028, PMID 18285602, PMID 18465388, PMID 18591575, PMID 18664970, PMID 18759650, PMID 18784267, PMID 18840838, PMID 18930602, PMID 19068141, PMID 19078910, PMID 19426530, PMID 19718469, PMID 19817986, PMID 19923205, PMID 19930566, PMID 20006356, PMID 20082712, PMID 20110375, PMID 20124539, PMID 20146233
R01HD111018 (1), R01HL067939 (1), U54NS065705 (1)