399 completed, 63 terminated, 24 active not recruiting, 16 withdrawn. 207 Phase 2, 175 Phase 1, 108 Phase 3, 41 Phase 4, 7 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Postmarketing Study of LEQEMBI in Participants With Alzheimer's Disease No Intervention - Alzheimers Disease | Not yet recruiting | Eisai Inc. | 270 | 2026-10-30 | 2026-10-08 | |
| How Well and Safely Does Lemborexant Work for People Who Wake up at Night to Urinate (LENS) Lemborexant tablets, Placebo - Nocturia | Phase 4 | Not yet recruiting | University of Alberta | 35 | 2026-10-15 | 2026-09-25 |
| A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2511 in Participants With Early Alzheimer's Disease (AD) E2511, Donepezil - Alzheimers Disease | Phase 1 | Not yet recruiting | Eisai Inc. | 32 | 2026-10-15 | 2026-08-17 |
| A Study to Assess Potential Drug-Drug Interactions of E2086 in Healthy Participants E2086 - Healthy Volunteers | Phase 1 | Recruiting | Eisai Inc. | 93 | 2026-08-12 | 2026-10-06 |
| A Retrospective Database Study for the Development and Validation of Algorithms for Intracerebral Hemorrhage and Seizures in Alzheimer's Disease No intervention - Alzheimer's Disease | Active not recruiting | Eisai Inc. | 600 | 2026-05-11 | 2026-10-20 | |
| A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy E2086, Placebo - Narcolepsy | Phase 2 | Recruiting | Eisai Inc. | 64 | 2026-03-26 | 2026-05-14 |
| A Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Participants E2086 - Healthy Volunteers | Phase 1 | Completed | Eisai Inc. | 10 | 2025-12-31 | 2026-08-21 |
| Real-World Lenvatinib Sequencing in Unresectable Hepatocellular Carcinoma (uHCC) Lenvatinib - Carcinoma, Hepatocellular | Active not recruiting | Eisai Inc. | 170 | 2025-11-17 | 2026-09-30 | |
| Merck IIT: RRP Pembro and Lenvatinib Lenvatinib, Pembrolizumab - Human Papilloma Virus, Recurrent Respiratory Papillomatosis | Phase 2 | Recruiting | Yale University | 20 | 2025-07-18 | 2026-07-02 |
| A Postmarketing Study of Lecanemab for the Treatment of Participants With Alzheimer's Disease No Intervention - Alzheimer's Disease | Recruiting | Eisai Inc. | 6700 | 2025-05-23 | 2026-09-16 | |
| Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients Lemborexant 5 mg, Control (placebo) group - Delirium - Postoperative, Cardiac Surgery | Phase 2 | Not yet recruiting | University of British Columbia | 60 | 2025-05-01 | 2025-04-23 |
| AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLC Sotorasib, Lenvatinib - Metastatic Non Small Cell Lung Cancer, KRAS G12C | Phase 2 | Withdrawn | ETOP IBCSG Partners Foundation | 2025-03-01 | 2024-11-20 | |
| A Study of Oral E1018 in Healthy Adult Participants E1018, Placebo - Malaria, Healthy Participants | Phase 1 | Active not recruiting | Eisai Inc. | 32 | 2025-02-26 | 2026-08-07 |
| A Study to Assess the Pregnancy Outcome in Women Exposed to Dayvigo® During Pregnancy Compared to an Unexposed Control Population No Intervention - Sleep Initiation and Maintenance Disorders, Pregnancy | Active not recruiting | Eisai Inc. | 861 | 2025-01-03 | 2025-06-19 | |
| A Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's Disease E2814, Lecanemab, Placebo - Alzheimer's Disease | Phase 2 | Active not recruiting | Eisai Inc. | 105 | 2024-09-30 | 2026-02-11 |
| A Study of E2086 in Healthy Adult Participants E2086, Placebo - Healthy Volunteers | Phase 1 | Completed | Eisai Inc. | 32 | 2024-06-25 | 2025-01-16 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1 E2086, E2086 Placebo, Active Comparator - Narcolepsy Type 1 (NT1) | Phase 1 | Completed | Eisai Inc. | 22 | 2024-06-20 | 2025-06-04 |
| DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease lecanemab - Alzheimer's Disease, Dementia | Phase 3 | Active not recruiting | Washington University School of Medicine | 40 | 2024-06-10 | 2026-07-27 |
| A Study of BB-1701 in Previously Treated Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive or HER2-low Unresectable or Metastatic Breast Cancer BB-1701 - Breast Cancer | Phase 2 | Completed | Eisai Inc. | 56 | 2024-04-10 | 2026-05-22 |
| DORA and LP in Alzheimer's Disease Biomarkers Lemborexant 10 mg, Lemborexant 20mg, Placebo - Alzheimer Disease | Phase 2 | Recruiting | University of Minnesota | 201 | 2024-03-11 | 2026-07-13 |
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Breast Neoplasms (40) · Neoplasms (39) · Alzheimer Disease (31) · Epilepsy (31) · Parkinson Disease 4, Autosomal Dominant Lewy Body (20) · Gastroesophageal Reflux (17) · Seizures (17) · Obesity (16) · Carcinoma, Non-Small-Cell Lung (15) · Myelodysplastic Syndromes (15) · Carcinoma, Hepatocellular (14) · Leukemia, Myeloid, Acute (14) · Melanoma (14) · Sleep Initiation and Maintenance Disorders (13) · Carcinoma, Renal Cell (10)
lenvatinib (84) · eribulin (55) · perampanel (45) · pembrolizumab (34) · Decitabine (29) · Donepezil (23) · Rabeprazole (23) · lemborexant (20) · lorcaserin (20) · fospropofol (18) · avatrombopag (15) · denileukin diftitox (15) · Zonisamide (14) · Paclitaxel (12) · Cyclophosphamide (10)
United States (430) · Canada (82) · United Kingdom (82) · France (74) · Spain (73) · Australia (70) · Germany (61) · Italy (61) · South Korea (51) · Poland (49) · Japan (47) · Russia (43) · Belgium (39) · Netherlands (31) · Taiwan (30)
David Squillacote, M.D. (5) · James Jones, MD, PharmD (5) · Yufang Lu (5) · Dale Shuster, Ph.D. (4) · Elyane Lombardy, M.D. (4) · Franklin Johnson (4) · Harish Dave (4) · James Jones, MD,PharmD (4) · Randall J Bateman, MD (3) · Sam Misir (3)
PMID 35305920, PMID 33300372, PMID 37059702, PMID 25823975, PMID 23661689, PMID 23663001, PMID 24682463, PMID 25878175, PMID 27206567, PMID 27659698, PMID 27888609, PMID 28365033, PMID 39120786, PMID 20299316, PMID 21114792, PMID 23689261, PMID 23770157, PMID 24802775, PMID 27116910, PMID 27391598, PMID 29778606, PMID 32047671, PMID 33337539, PMID 33825230, PMID 34077032, PMID 35254948, PMID 35642432, PMID 37796657, PMID 38159809, PMID 38940656, PMID 40042496, PMID 40848323, PMID 41938624, PMID 42167105, PMID 10078396, PMID 10475299, PMID 10485781, PMID 10624646, PMID 10730546, PMID 10910848, PMID 11454483, PMID 12818945, PMID 14504060, PMID 14620731, PMID 15064259, PMID 15120791, PMID 15139789, PMID 16528908, PMID 16766588, PMID 16882711
2018 (13), 2019 (9), 2023 (8), 2016 (7), 2005 (6), 2017 (6), 2009 (5), 2014 (5), 2015 (4), 2004 (3), 2008 (3), R01AG046179 (2), R01AG053267 (2), R56AG053267 (2), U01AG042791 (2)