108 completed, 52 recruiting, 28 unknown, 14 not yet recruiting. 87 Not applicable, 37 Phase 2, 12 Phase 4, 10 Phase 1, 10 Phase 3.
Follow Lewy Body Disease: new trials by email Literature Review of Lewy Body Disease trials Research Report on Lewy Body Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB) | Not yet recruiting | BioSensics | 60 | 2027-01-15 | 2026-10-13 | |
| VOCALE LBD: Online Peer Support for Caregivers of People With Lewy Body Dementia VOCALE LBD: Virtual Online Communities for Aging Life Experiences: Lewy Body Dementia, Standard of Care Educational Materials - Lewy Bodies Disease, Depression Disorder | Not applicable | Not yet recruiting | University of Washington | 220 | 2026-12-01 | 2026-06-09 |
| Rhythmic Entrainment and Alertness in Lewy Body Dementia Rhythmic Auditory Cueing - Dementia With Lewy Bodies (DLB), Lewy Body Dementia (LBD) | Not applicable | Not yet recruiting | Johns Hopkins University | 30 | 2026-11-30 | 2026-10-09 |
| Alpha-synuclein Education and Disclosure in Individuals With Preclinical and Symptomatic Lewy Body Disease LBD Biomarker Education and Disclosure - Lewy Body Disease | Not yet recruiting | Stanford University | 40 | 2026-11-01 | 2026-06-15 | |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description - Dementia (Diagnosis), Alzheimer Dementia (AD) | Not yet recruiting | Zealand University Hospital | 440 | 2026-11-01 | 2026-09-02 | |
| Visual Hallucinations in Lewy Body Diseases Behavioral Tasks, MRI/MEG Scans - Lewy Body Disease, Lewy Body Dementia | Recruiting | NYU Langone Health | 234 | 2026-09-15 | 2026-09-30 | |
| Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes PARKINSON DISEASE (Disorder), Atypical Parkinsonism | Not yet recruiting | International Institute of Molecular and Cell Biology in Warsaw | 200 | 2026-06-04 | 2026-05-28 | |
| Evaluating How Red-light Therapy Applied to the Head Affects Symptoms, Daily Life, and Brain Activity in People With Dementia With Lewy Bodies LUCIOLE CAP, LUCIOLE CAP (sham version) - Photobiomodulation, Dementia With Lewy Bodies | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 40 | 2026-06-01 | 2026-06-23 |
| A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7) Donanemab, Placebo - Cognitive Dysfunction, Lewy Body Disease | Phase 2 | Recruiting | Eli Lilly and Company | 350 | 2026-05-20 | 2026-10-08 |
| 18F-mFBG Cardiac Uptake With Lewy Body Dementia 18F-MFBG - Parkinson Disease (PD), Lewy Body Dementia (LBD) | Phase 2 | Recruiting | Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) | 20 | 2026-04-30 | 2026-07-01 |
| Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder Alzheimer Disease, Dementia With Lewy Bodies (DLB) | Enrolling by invitation | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 1799 | 2026-02-19 | 2026-02-23 | |
| Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1 - Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 300 | 2026-02-13 | 2026-04-03 |
| Social-cognitive Functioning: Validation of a New Neuropsychological Test REALSOCOG, BCS, Hetero-questionnaires - Alzheimer's Disease (AD), Lewy Body Dementia (LBD) | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2026-02-04 | 2026-03-13 |
| Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders Major Depressive Disorder (MDD), Schizophenia Disorder | Enrolling by invitation | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 1310 | 2026-02-01 | 2026-04-24 | |
| Contribution of Pathological Alpha-synuclein as a Diagnostic Biomarker for Dementia With Lewy Bodies Biological : blood sampling, nasopharyngeal swab, Procedure : Lumbar puncture - Dementia With Lewy Bodies (DLB), Alzheimer's Disease (AD) | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 286 | 2026-01-01 | 2025-09-10 |
| Biofluid Research on Age-Related or Inherited Neurodegeneration Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis) | Recruiting | University of Pennsylvania | 1000 | 2025-12-12 | 2026-09-01 | |
| Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia Syn-One skin biopsy, Multi modal MRI, Assessment of dynamic EEG features over 48-hour periods across all study aims - Dementia With Lewy Bodies, Parkinson Disease Dementia | Phase 4 | Recruiting | Virginia Commonwealth University | 120 | 2025-12-08 | 2026-03-06 |
| Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH) We did not apply any interventions; only observational research was conducted. - Multiple System Atrophy, Dementia With Lewy Bodies (DLB) | Recruiting | Second Affiliated Hospital of Soochow University | 500 | 2025-11-12 | 2026-09-08 | |
| Non-invasive Diagnosis of Parkinson's Disease Parkinsons Disease (PD) | Not yet recruiting | Blekinge Institute of Technology | 60 | 2025-10-16 | 2025-10-01 |
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Alzheimer Disease (108) · Dementia (79) · Parkinson Disease (69) · Dementia, Vascular (54) · Cognitive Dysfunction (49) · Frontotemporal Dementia (38) · Multiple System Atrophy (32) · Supranuclear Palsy, Progressive (27) · Mixed Dementias (24) · Corticobasal Degeneration (19) · Neurodegenerative Diseases (16) · Amyotrophic Lateral Sclerosis (15) · REM Sleep Behavior Disorder (14) · Parkinsonian Disorders (12)
Basal Ganglia Diseases (236) · Central Nervous System Diseases (236) · Mental Disorders (235) · Brain Diseases (234) · Nervous System Diseases (233) · Neurocognitive Disorders (232) · Movement Disorders (230) · Synucleinopathies (230) · Parkinsonian Disorders (224) · Neurodegenerative Diseases (220) · Dementia (157) · Tauopathies (119) · Pathological Conditions, Signs and Symptoms (64) · Cardiovascular Diseases (62) · Vascular Diseases (62)
Donepezil (9) · Transcranial Direct Current Stimulation (5) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (3) · 3-benzenesulfonyl-8-piperazin-1-ylquinoline (3) · Electroencephalography (3) · Magnetic Resonance Imaging (3) · Magnetic Resonance Spectroscopy (3) · Memantine (3) · Neuropsychological Tests (3) · ioflupane (3) · nelotanserin (3) · Algorithms (2) · Ambroxol (2) · Blood Specimen Collection (2) · Galantamine (2)
Mayo Clinic (8) · University Hospital, Strasbourg, France (7) · Axovant Sciences Ltd. (6) · Skane University Hospital (6) · Eisai Co., Ltd. (5) · Georgetown University (5) · University College, London (5) · University of Pennsylvania (5) · Assistance Publique - Hôpitaux de Paris (4) · NYU Langone Health (4) · University of California, San Francisco (4) · University of Washington (4) · Danish Dementia Research Centre (3) · EIP Pharma Inc (3) · Eisai Inc. (3)
United States (108) · France (28) · Canada (14) · United Kingdom (14) · Italy (12) · Spain (10) · Sweden (9) · China (8) · Japan (8) · Denmark (7) · Germany (7) · Belgium (6) · Norway (6) · Netherlands (5) · South Korea (5)
Ilise Lombardo, MD (6) · Erik Stomrud, MD, PhD (3) · Fernando L Pagan, MD (3) · Aimee Spector, PhD, DClinPsych (2) · Bradley Boeve, MD (2) · Horacio C Kaufmann, MD (2) · Jeffrey Weiss, MD (2) · Jori E Fleisher, MD MSCE (2) · Julie Fields, PhD, LP (2) · Katherine L Possin, PhD (2) · Masaki Nakagawa (2) · Steven Levy, MD (2) · Adrian Ivanoiu, MD (1) · Aimee Spector, PhD, DClinPsy (1)
PMID 31566651, PMID 38706271, PMID 12021425, PMID 1202204, PMID 12671209, PMID 14676468, PMID 19500421, PMID 20729148, PMID 20944075, PMID 21878600, PMID 21908805, PMID 23527646, PMID 23666528, PMID 23785466, PMID 23911592, PMID 23930667, PMID 24969152, PMID 24993764, PMID 25044107, PMID 25155658, PMID 25162367, PMID 25411441, PMID 25635231, PMID 25713599, PMID 25713600, PMID 26120319, PMID 26354982, PMID 26756745, PMID 26836192, PMID 26856756, PMID 26878815, PMID 27042676, PMID 27146416, PMID 27164711, PMID 27241045, PMID 27357347, PMID 27362763, PMID 27393566, PMID 27469360, PMID 27579672, PMID 27694257, PMID 27709757, PMID 27765859, PMID 27900460, PMID 28061383, PMID 28179466, PMID 28271072, PMID 28323819, PMID 28689566, PMID 28800895
2017 (3), 2023 (2), P01AG066597 (2), P30AG064200 (2), R01AG056715 (2), R44AG065088 (2), 1UF1AG094587-01 (1), 2005 (1), I01CX000736 (1), K23AG073525 (1), K23AG073575 (1), K76AG060005 (1), P30AG072979 (1), P50AG008702 (1), P50AG016574 (1)