320 completed, 43 terminated, 43 unknown, 12 recruiting. 147 Phase 4, 106 Phase 3, 65 Phase 2, 55 Not applicable, 49 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Risperidone vs Cariprazine in Acute Mania Risperidone, Cariprazine - Bipolar 1 Disorder | Phase 4 | Not yet recruiting | Pakistan Institute of Medical Sciences | 50 | 2027-06-01 | 2026-06-24 |
| Shortened LSD Intervention for Major Depressive Disorder LSD, Risperidone - Major Depression Moderate, Major Depression Severe | Phase 1 | Not yet recruiting | Johns Hopkins University | 10 | 2026-10-01 | 2026-09-22 |
| Subjective Experience Following Psilocybin Psilocybin high-dose, Psilocybin low-dose, Risperidone 1 MG - Investigating the Importance of the Subjective Psychedelic Experience | Phase 2 | Recruiting | University of Calgary | 128 | 2026-05-15 | 2026-09-02 |
| Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications Roluperidone, risperidone, aripiprazole - Negative Symptoms of Schizophrenia | Phase 3 | Recruiting | Minerva Neurosciences | 380 | 2026-04-23 | 2026-07-28 |
| Effect of Cognitive Behavioral Therapy on Auditory Hallucinations and NLR in Schizophrenia Patients Cognitive Behavioral Therapy (CBT), risperidone - Schizophrenia Patients, Auditory Hallucination | Not applicable | Completed | Hasanuddin University | 50 | 2025-11-01 | 2026-04-17 |
| Effect of Curcumin Add-On Therapy on Quality of Life and IL-1β Levels in Patients With Schizophrenia Curcumin, Risperidone 4mg/day - Schizophrenia, Psychotic Disorders | Not applicable | Completed | Rinvil Renaldi | 44 | 2025-11-01 | 2026-04-14 |
| Cerebellum-based Imaging Neural Markers for Antipsychotic Response risperidone, aripiprazole - Psychosis; Acute | Phase 4 | Recruiting | Northwell Health | 120 | 2025-11-01 | 2026-05-26 |
| Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects Psilocybin (Usona Institute), Risperidone 1 MG, MRI - Depression - Major Depressive Disorder, Anhedonia | Phase 1 | Recruiting | Medical University of Vienna | 85 | 2025-11-01 | 2026-03-24 |
| Effectiveness of Ashwagandha in Schizophrenia Patients on Risperidone Risperidone 4mg/day, Ashwagandha, Placebo - Schizophrenia Patients, Neuroinflammation | Phase 2 | Completed | Hasanuddin University | 80 | 2025-10-01 | 2026-05-12 |
| Effect of Ashwagandha as Adjunct Therapy on BDNF and Cognitive Function in Schizophrenia Patients Risperidone 4mg/day, Ashwagandha, Placebo - Schizophrenia Patients | Not applicable | Completed | Hasanuddin University | 80 | 2025-09-01 | 2026-04-23 |
| the Effect of Formulation on Anxiety in Autist Childre A Randomized Controlled Trial Assesses Spirulina Syrup Plus Risperidone in Children With Non-idiopathic Autism. Anxiety is Measured Using the SCAS (Parent Version) Via Daily Online Surveys for One Week and Throughout a 3-month Follow-up Period. Spirulina Syrup, Placebo Syrup, Risperidone - Age 3 to 7 Years, Mild Autism Spectrum | Not applicable | Not yet recruiting | Shahid Sadoughi University of Medical Sciences and Health Services | 82 | 2025-07-07 | 2025-07-11 |
| Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Group A: (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol,anxiolytics: clonazepam, stedon, tavor antidepressants: seropram),, Group B (Pharmacotherapy and TAU) (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, antidepressants,, Group C (Pharmacotherapy and Psychotherapy) Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, lithium, depakine - Treatment Resistant Schizophrenia, Treatment Resistant Bipolar Disorder | Phase 4 | Active not recruiting | Dr. Stavroula Rakitzi | 84 | 2025-06-04 | 2026-05-01 |
| Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST) Psilocybin 25 mg, Risperidone 1 MG - Treatment Resistant Depression | Phase 2 | Recruiting | Centre for Addiction and Mental Health | 12 | 2025-04-21 | 2026-10-19 |
| A Study to Evaluate the Safety and Tolerability of Long-Acting Oral Risperidone (LYN-005) in Participants With Schizophrenia or Schizoaffective Disorder LYN-005 (risperidone), Placebo for LYN-005, IR Risperidone - Schizophrenia, Schizoaffective Disorder | Phase 3 | Withdrawn | Lyndra Inc. | 2025-04-18 | 2025-04-08 | |
| A Pilot Study of Adjunctive Structured Supportive Psychotherapy in Schizophrenia Structured supportive psychotherapy, Risperidone, Unstructured Supportive Conversation - Schizophrenia, Cognitive and Executive Dysfunction | Not applicable | Completed | Hasanuddin University | 44 | 2025-03-01 | 2026-06-30 |
| Supportive Psychotherapy as Adjunct to Risperidone for Cognitive Function and Inflammation in Schizophrenia Structured Supportive Psychotherapy, Risperidone 2 mg - Schizophrenia, Cognitive Dysfunction | Phase 2 | Completed | Hasanuddin University | 46 | 2024-12-01 | 2026-03-17 |
| Biomarkers to Enhance Early Schizophrenia Treatment aripiprazole, risperidone, clozapine - Schizophenia Disorder | Phase 4 | Recruiting | Northwell Health | 180 | 2024-09-04 | 2026-07-31 |
| Magnetic Seizure Therapy for Psychotic Disorders Magnetic seizure therapy by Magnetic stimulator, Antipsychotic medications (such as olanzpine, risperidone, aripiprazole, quetiapine, amisulpride, etc) - Psychotic Disorders | Not applicable | Recruiting | Shanghai Jiao Tong University School of Medicine | 50 | 2024-09-01 | 2025-11-25 |
| Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms. Lumateperone 42 mg, Risperidone 2 mg - Apathy, Schizophrenia | Phase 3 | Recruiting | Louisiana State University Health Sciences Center Shreveport | 80 | 2024-06-01 | 2024-07-01 |
| Atypical Antipsychotic-induced Mitochondrial Dysfunction in Patients With Schizophrenia Aripiprazole, Risperidone - Schizophrenia | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2024-04-05 | 2025-11-25 |
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Schizophrenia (247) · Psychotic Disorders (106) · Bipolar Disorder (40) · Mental Disorders (18) · Dementia (16) · Autistic Disorder (14) · Alzheimer Disease (13) · Depression (12) · Cocaine-Related Disorders (10) · Mania (10) · Anxiety Disorders (9) · Aggression (8) · Attention Deficit Disorder with Hyperactivity (8) · Psychomotor Agitation (8) · Metabolic Syndrome (7)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (32) · Northwell Health (13) · Janssen, LP (11) · AstraZeneca (8) · Janssen Pharmaceutica N.V., Belgium (8) · Centre for Addiction and Mental Health (7) · University of California, Los Angeles (7) · Indivior Inc. (6) · Otsuka Pharmaceutical Development & Commercialization, Inc. (6) · Washington University School of Medicine (6) · H. Lundbeck A/S (5) · Hasanuddin University (5) · Janssen Korea, Ltd., Korea (5) · Janssen Research & Development, LLC (5) · National Institute of Mental Health (NIMH) (5)
United States (197) · China (32) · Canada (29) · Germany (16) · Spain (16) · Taiwan (16) · India (15) · Russia (14) · South Korea (13) · France (10) · Ukraine (10) · Brazil (9) · Bulgaria (9) · Israel (9) · Japan (9)
Benedicto Crespo-Facorro, Professor (3)
PMID 37811711, PMID 25978742, PMID 26107752, PMID 36883881, PMID 37756123, PMID 38958149, PMID 40730715, PMID 40779812, PMID 41272239, PMID 10084637, PMID 10496251, PMID 11559786, PMID 11765093, PMID 12091192, PMID 12153826, PMID 12218423, PMID 12399139, PMID 12509667, PMID 12562742, PMID 12633121, PMID 12777271, PMID 12823075, PMID 12823080, PMID 14661862, PMID 14735295, PMID 15000267, PMID 15005752, PMID 15056517, PMID 15110730, PMID 15115949, PMID 15169694, PMID 15289699, PMID 15323593, PMID 15330403, PMID 15349007, PMID 15367925, PMID 15465989, PMID 15492353, PMID 15541061, PMID 15569893, PMID 15572276, PMID 15677618, PMID 15723025, PMID 15898966, PMID 15950022, PMID 15960566, PMID 16023735, PMID 16086617, PMID 16135859, PMID 16168792
2018 (2), N01MH090001 (2), N01MH90001 (2), P50MH066286 (2), R01MH037705 (2), R01MH060004 (2), 2004 (1), 2005 (1), 2008 (1), 2009 (1), 2014 (1), 2015 (1), 2016 (1), 2019 (1), K23MH074540 (1)