2312 completed, 406 unknown, 277 recruiting, 245 terminated. 1336 Not applicable, 464 Phase 3, 453 Phase 4, 450 Phase 2, 368 Phase 1.
Follow Schizophrenia: new trials by email Literature Review of Schizophrenia trials Research Report on Schizophrenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis Cannabidiol (CBD), Placebo - Schizophrenia Spectrum Disorders, Cannabis Use | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2050-01-01 | 2021-04-19 | |
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2 Motion Perception Task, Sine Wave Speech Task, Volatility Task - SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder | Not applicable | Not yet recruiting | Washington University School of Medicine | 325 | 2028-04-01 | 2026-10-23 |
| Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis MANOEUVRE therapy - Psychosis, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Not yet recruiting | King's College London | 15 | 2027-09-01 | 2026-06-03 |
| Improving Quality of Informal Care for People With Schizophrenia Dyadic Multicomponent Intervention (DMI), Dyadic Benefit-Finding Intervention (DBFI) - Schizophrenia | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 228 | 2027-07-01 | 2026-08-25 |
| Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia Insightec Exablate Neuro MR-guided focused ultrasound transducer - Treatment-resistant Schizophrenia | Not applicable | Suspended | NYU Langone Health | 3 | 2027-06-01 | 2026-04-02 |
| Feasibility and Acceptability of Mobile Mental Health App for SZ and SZA Intervention via mobile application - Schizophrenia, Schizo Affective Disorder | Not applicable | Not yet recruiting | University of Pittsburgh | 44 | 2027-06-01 | 2026-09-16 |
| Prucalopride for Cognitive Functioning in Schizophrenia Prucalopride 1 MG - Schizophrenia | Not applicable | Not yet recruiting | University of Pittsburgh | 34 | 2027-05-31 | 2026-09-17 |
| Feasibility Trial of a Parent Peer-Co-Led Caregiver Group for Pediatric Early Onset Schizophrenia Spectrum Disorders Group Therapy, Treatment as Usual (TAU) - Schizophrenia; Psychosis | Not applicable | Not yet recruiting | Boston Children's Hospital | 20 | 2027-05-01 | 2026-10-09 |
| Frontal Gamma Coherence Neurofeedback for Patients With Schizophrenia Frontal gamma coherence neurofeedback, Placebo Neurofeedback - Schizophrenia, Schizoaffective | Not applicable | Not yet recruiting | BioSignal Solutions LLC | 30 | 2027-04-01 | 2026-09-24 |
| NST-SPARK Open-Label Phase 1 STTR (IGNITE) NST-SPARK - Schizophrenia / Schizoaffective Disorder | Not applicable | Not yet recruiting | North Shore Therapeutics, Inc. | 30 | 2027-03-01 | 2026-05-18 |
| LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI) LIFU - Schizophrenia, Auditory Hallucinations | Not applicable | Not yet recruiting | University of California, San Francisco | 12 | 2027-02-01 | 2026-08-05 |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| Shared Decision Making for Antipsychotic Medications The Antipsychotic Medication Decision Aid (APM-DA) - Schizophrenia, Schizoaffective Disorder | Not applicable | Not yet recruiting | New York State Psychiatric Institute | 120 | 2027-01-01 | 2026-03-30 |
| Brain Imaging of DSP-2342 DSP-2342 - SCHIZOPHRENIA 1 (Disorder) | Phase 2 | Not yet recruiting | Johns Hopkins University | 20 | 2027-01-01 | 2026-09-30 |
| A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia Xanomeline/trospium - Schizophrenia; Psychosis, Cognitive Impairment | Phase 3 | Withdrawn | European Group for Research In Schizophrenia | 2027-01-01 | 2026-10-30 | |
| Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome Semaglutide + TAU, Placebo + TAU - Schizophrenia Disorder, Metabolic Syndrome | Phase 3 | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | 600 | 2026-12-01 | 2026-08-18 |
| DecNef for Auditory Verbal Hallucinations (AVH) in Schizophrenia Decoded Neurofeedback - Schizophrenia Disorder, Schizoaffecitve Disorder | Not applicable | Not yet recruiting | Columbia University | 51 | 2026-12-01 | 2026-10-14 |
| Longitudinal PET Imaging of Antipsychotic Binding to the Dopamine-3 Receptor in Schizophrenia Brexpiprazole, Cariprazine, [11C] PHNO - Schizoaffective Disorder, Schizophreniform Disorder | Phase 1 | Not yet recruiting | New York State Psychiatric Institute | 100 | 2026-12-01 | 2026-07-20 |
| Mobile Thinking Intervention: A Inital Test Mobile Intervention for Biased Thinking - Schizophrenia, Clinical High Risk for Psychosis (CHR) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 100 | 2026-12-01 | 2026-10-13 |
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Psychotic Disorders (1057) · Bipolar Disorder (342) · Mental Disorders (214) · Depressive Disorder, Major (118) · Depression (88) · Cognitive Dysfunction (81) · Hallucinations (80) · Metabolic Syndrome (61) · Obesity (51) · Mood Disorders (50) · Schizophrenia, Treatment-Resistant (49) · Motor Activity (46) · Schizophrenia Spectrum and Other Psychotic Disorders (46) · Cognition Disorders (44)
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Risperidone (251) · Olanzapine (177) · Aripiprazole (165) · Paliperidone Palmitate (120) · Quetiapine Fumarate (101) · Therapeutics (83) · ziprasidone (73) · Transcranial Direct Current Stimulation (67) · Transcranial Magnetic Stimulation (58) · Clozapine (56) · Lurasidone Hydrochloride (45) · Haloperidol (40) · Cognitive Behavioral Therapy (39) · Cognitive Remediation (39) · Exercise (33)
Otsuka Pharmaceutical Development & Commercialization, Inc. (87) · AstraZeneca (78) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (73) · University of Maryland, Baltimore (61) · Shanghai Mental Health Center (59) · Centre for Addiction and Mental Health (57) · Yale University (53) · VA Office of Research and Development (51) · National Institute of Mental Health (NIMH) (36) · Massachusetts General Hospital (35) · Eli Lilly and Company (33) · National Taiwan University Hospital (33) · Central South University (32) · Hôpital le Vinatier (31) · University of California, San Diego (30)
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Benedicto Crespo-Facorro, Professor (13) · Hai-Gwo Hwu, Professor (12)
PMID 28433500, PMID 33539561, PMID 33854317, PMID 34091867, PMID 38958149, PMID 37142273, PMID 20537128, PMID 20537130, PMID 24423017, PMID 25890643, PMID 22198451, PMID 24955752, PMID 28350572, PMID 32476658, PMID 34689733, PMID 34751928, PMID 36369028, PMID 38085556, PMID 39144777, PMID 41130742, PMID 42393474, PMID 18466043, PMID 20840778, PMID 21155708, PMID 22935168, PMID 26493637, PMID 27188270, PMID 27743205, PMID 27816567, PMID 28117049, PMID 28318835, PMID 28640988, PMID 28692485, PMID 30420252, PMID 30470662, PMID 32336984, PMID 32606705, PMID 32840872, PMID 33861952, PMID 33914891, PMID 34004383, PMID 34901863, PMID 35235720, PMID 36418846, PMID 36711165, PMID 36772948, PMID 36883881, PMID 37230961, PMID 37756123, PMID 37777515
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