280 completed, 63 unknown, 41 terminated, 23 recruiting. 165 Phase 4, 83 Phase 3, 78 Not applicable, 55 Phase 2, 35 Phase 1.
Follow this drug Literature Review of Escitalopram trials Research Report on Escitalopram
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acupuncture and Escitalopram for Treating Major Depression Clinical Study acupuncture, escitalopram, sham-acupuncure - Depressive Disorder, Major | Not applicable | Not yet recruiting | Shanghai 7th People's Hospital | 216 | 2026-11-01 | 2026-03-11 |
| Efficacy and Safety of Probiotics for Anxiety Depression Probiotic, Placebo, Escitalopram - Anxiety Depression | Not applicable | Recruiting | Moon (Guangzhou) Biotechnology Co., Ltd. | 60 | 2026-06-15 | 2026-06-29 |
| Study to Evaluate the Adjunctive Effect of CreNeuroS™ CNS Fish Oil Plus Softgels in Patients With Major Depressive Disorder Receiving Escitalopram. 1. Escitalopram (as escitalopram oxalate) tablet 2. CreNeuroSTM CNS Fish Oil Plus Softgels, 1. Escitalopram (as escitalopram oxalate) tablet 2. Placebo softgels - Adjunct in the Treatment of Depressive Disorder | Not applicable | Not yet recruiting | Sichuan Credit Pharmaceutical Co., Ltd. | 80 | 2026-06-11 | 2026-06-16 |
| Deprescription of Antidepressants in Primary Care (DAPriCare) Deprescription of Antidepressants (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram) - Deprescription, Antidepressants | Early Phase 1 | Not yet recruiting | University of Huelva | 325 | 2026-06-01 | 2026-05-04 |
| Pattern Separation in Major Depressive Disorder SSRI (escitalopram or sertraline), Extended-Release Memantine, Placebo - Major Depressive Disorder (MDD) | Phase 1 | Recruiting | Jeffrey Miller | 30 | 2026-06-01 | 2026-09-15 |
| Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV Pramipexole ER, Escitalopram - Major Depressive Disorder, Mild Neurocognitive Disorder | Phase 2 | Suspended | National Institute of Allergy and Infectious Diseases (NIAID) | 186 | 2026-05-17 | 2026-07-14 |
| Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder Escitalopram (Oral antidepressant) - Depression - Major Depressive Disorder | Not applicable | Recruiting | Peking University | 200 | 2026-03-20 | 2026-08-20 |
| Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant Combination of methotrexate and escitalopram in treatment of psoriasis patients with depression and/or anxiety, Methotrexate - Depression, Anxiety | Phase 4 | Completed | Cairo University | 40 | 2026-02-01 | 2026-10-05 |
| Atorvastatin Plus Escitalopram for Depression With Dyslipidemia Escitalopram plus atorvastatin - Depressive Episode, Dyslipidemia | Completed | Hengshui City Seventh People's Hospital | 60 | 2025-09-01 | 2026-07-21 | |
| Escitalopram in Asthma Patients With Frequent Exacerbation Escitalopram, Placebo - Asthma | Phase 2 | Recruiting | University of Texas Southwestern Medical Center | 105 | 2025-05-19 | 2026-01-26 |
| Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole Escitalopram, Aripiprazole 5mg - Major Depressive Disorder (MDD), Rumination | Not applicable | Active not recruiting | Central South University | 108 | 2025-05-08 | 2026-06-12 |
| Neuroimaging of Escitalopram in Autism Spectrum Disorder Escitalopram 10mg, Placebo - Autism Spectrum Disorder | Phase 2 | Enrolling by invitation | Kathryn Unruh | 5 | 2025-04-28 | 2026-02-18 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure Clozapine, Esketamine Nasal Product, Escitalopram - Schizophrenia and Related Disorders, Major Depressive Disorder | Phase 3 | Recruiting | Dr. Inge Winter | 1254 | 2025-04-27 | 2026-01-22 |
| Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study) Moderate-intensity continuous movement and Antipsychotics intervention, Antipsychotics intervention(sertraline, escitalopram, fluoxetine, duloxetine, paroxetine, venlafaxine, and fluvoxamine) - Cardiovascular Diseases (CVD), Depression Anxiety Disorder | Not applicable | Recruiting | Guangdong Provincial People's Hospital | 106 | 2025-04-22 | 2025-06-17 |
| Multiple Ascending Dose Phase 1 Study of ALA-3000 ALA-3000, Placebo, escitalopram, sertraline, duloxetine or venlafaxine XR - Treatment Resistant Depression | Phase 1 | Completed | Alar Pharmaceuticals Inc. | 37 | 2025-04-21 | 2025-12-31 |
| TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children Fluoxetine, Escitalopram, Sertralin - Depression - Major Depressive Disorder, Depressive Episodes | Phase 4 | Recruiting | Poznan University of Medical Sciences | 180 | 2025-04-03 | 2026-03-18 |
| Dose-Finding Clinical Trial to Evaluate the Efficacy and Safety of LV232 Capsules in the Treatment of MDD LV232 40mg, LV232 60mg, Escitalopram - MDD | Phase 2 | Recruiting | Vigonvita Life Sciences | 400 | 2025-04-03 | 2026-10-20 |
| The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. Escitalopram, Sertraline, Venlafaxine - Bipolar Depression | Phase 3 | Recruiting | Dr. Inge Winter | 418 | 2025-02-11 | 2025-09-26 |
| Neurobiological and Genomic Predictors of Relapse in Depression Antidepressant Medications - Healthy, Major Depressive Disorder (MDD) | Recruiting | Mehmet Kemal Arikan | 204 | 2025-01-01 | 2026-01-09 | |
| Assessment of the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Major Depressive Disorder FMT capsule, Escitalopram (Lexapro), Corn Starch capsules - Major Depressive Disorder (MDD), Depression - Major Depressive Disorder | Not applicable | Recruiting | Gang Wang | 214 | 2025-01-01 | 2025-12-02 |
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Depressive Disorder, Major (166) · Depression (159) · Anxiety Disorders (38) · Depressive Disorder (22) · Alzheimer Disease (11) · Depressive Disorder, Treatment-Resistant (11) · Mood Disorders (10) · Bipolar Disorder (9) · Generalized Anxiety Disorder (9) · Dementia (8) · Sleep Initiation and Maintenance Disorders (8) · Stress Disorders, Post-Traumatic (8) · Dysthymic Disorder (7) · Obsessive-Compulsive Disorder (7) · Schizophrenia (7)
Massachusetts General Hospital (16) · New York State Psychiatric Institute (16) · Duke University (9) · Emory University (9) · H. Lundbeck A/S (7) · Otsuka Pharmaceutical Development & Commercialization, Inc. (7) · University of Pittsburgh (7) · Weill Medical College of Cornell University (7) · Forest Laboratories (6) · Janssen Research & Development, LLC (6) · Sanofi (6) · Seoul National University Hospital (6) · University of Texas Southwestern Medical Center (6) · Eli Lilly and Company (5) · Medical University of Vienna (5)
United States (190) · China (38) · Canada (37) · South Korea (25) · France (22) · Germany (21) · Israel (20) · Denmark (18) · Spain (14) · Finland (12) · Sweden (12) · Mexico (11) · Brazil (10) · South Africa (10) · United Kingdom (10)
Bret Rutherford, MD (4) · Amit Anand, MD (2) · Andrew Miller, MD (2) · Dan Iosifescu, MD (2) · Dorian Williams, M.D. (2) · Heidi Munger Clary, MD (2) · Ian A Cook, MD (2)
PMID 32860422, PMID 34235612, PMID 36999619, PMID 33128208, PMID 35022754, PMID 38557430, PMID 38767196, PMID 21438794, PMID 24067192, PMID 24144505, PMID 24816198, PMID 26474010, PMID 30343455, PMID 32367114, PMID 34288609, PMID 34510411, PMID 34973081, PMID 35141873, PMID 35788366, PMID 36149841, PMID 36273682, PMID 36375174, PMID 37019044, PMID 37952772, PMID 39428602, PMID 41401709, PMID 10534584, PMID 10686270, PMID 11110112, PMID 11704071, PMID 1308374, PMID 15337269, PMID 15800181, PMID 15902586, PMID 16009352, PMID 16585452, PMID 17015814, PMID 17074942, PMID 17288694, PMID 17316822, PMID 17559729, PMID 17559755, PMID 17719567, PMID 18090508, PMID 18251622, PMID 18312057, PMID 18348597, PMID 18378867, PMID 18425072, PMID 18457236
2014 (6), 2008 (4), 2009 (2), 2016 (2), 2018 (2), 5UL1TR001420-03 (2), 1KL2RR025015-01 (1), 1RC1DA028387 (1), 1RC1MH088438 (1), 2004 (1), 2017 (1), 2019 (1), 2023 (1), 5UH3NS115108-04 (1), K23CA115908 (1)