196 terminated. 196 Phase 2, 18 Phase 3, 13 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 196 | Terminated 196 |
| Phase 3 | 18 | Terminated 18 |
| Phase 1 | 13 | Terminated 13 |
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Study Assessing the Safety and Efficacy of OK-101 Treatment in Subjects With Neuropathic Corneal Pain OK-101 0.05%, OK-101 0.1%, Placebo - Neuropathic Pain | Phase 2 | Terminated | Okyo Pharma Ltd | 18 | 2024-10-15 | 2025-08-15 |
| Methotrexate for Immune Related Arthritis or Arthralgias (IMPACT 2.1) Methotrexate - Arthritis, Arthralgia | Phase 2 | Terminated | AHS Cancer Control Alberta | 27 | 2024-08-12 | 2026-01-06 |
| Lavender Aromatherapy to Decrease Anxiety/Pain Perception During Office Hysteroscopy Lavandula angustifolia, Aura Cacia, Placebo - Anxiety, Pain, Procedural | Phase 2 | Terminated | University of Florida | 22 | 2024-06-01 | 2026-06-10 |
| Safety and Effect on Pain and Function According to RAPID-3 of IHL-675A in Patients With Rheumatoid Arthritis IHL-675A, Cannabidiol, Hydroxychloroquine - Rheumatoid Arthritis | Phase 2 | Terminated | Incannex Healthcare Ltd | 20 | 2023-11-22 | 2026-03-27 |
| A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain GSK3858279, Placebo - Pain | Phase 2 | Terminated | GlaxoSmithKline | 147 | 2023-09-20 | 2025-11-21 |
| A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain GSK3858279, Placebo - Pain, Osteoarthritis, Knee | Phase 2 | Terminated | GlaxoSmithKline | 314 | 2023-09-13 | 2025-11-10 |
| Duloxetine Impact on Postoperative Pain Control and Outcomes Duloxetine 60 MG, Placebo - Acute Post-operative Pain, Chronic Post Operative Pain | Phase 2 | Terminated | Scripps Health | 17 | 2023-05-30 | 2025-05-04 |
| Cannabidiol for the Treatment of Pelvic Pain in Endometriosis (DREAMLAND) Cannabis Derivatives, Placebo, Hormonal Contraceptive Agents - Endometriosis, Pelvic Pain | Phase 2 / Phase 3 | Terminated | University of Sao Paulo | 50 | 2023-01-03 | 2025-04-02 |
| Cannabidiol 133mg + Cannabigerol 66mg + Tetrahydrocannabinol 4mg Vs Placebo As Adjuvant Treatment in Chronic Migraine - Placebo oral drops, Cannabidiol + Cannabigerol + Tetrahydrocannabinol 133/66/4mg - Chronic Migraine, Headache, Overuse Headache Medication | Phase 2 / Phase 3 | Terminated | Hospital Israelita Albert Einstein | 110 | 2022-10-18 | 2025-02-24 |
| A Study to Evaluate the Efficacy and Safety of HR18042 Tablets for Postoperative Analgesia After Impacted Teeth Removal Surgery. HR18042 tablets, Tramadol hydrochloride SR Tablets, Placebos - Pain | Phase 2 | Terminated | Jiangsu HengRui Medicine Co., Ltd. | 110 | 2022-08-11 | 2025-06-26 |
| A Trial of SHR0410 Injection in Postsurgical Pain Management SHR0410 Injection, Placebo for SHR0410 Injection - Postsurgical Pain | Phase 2 | Terminated | Jiangsu HengRui Medicine Co., Ltd. | 31 | 2022-08-09 | 2025-06-22 |
| Evaluation of the Dexmedetomidine Transdermal Systems for Postoperative Analgesia Following Abdominoplasty DMTS Patch, Placebo Patch - Pain, Postoperative | Phase 2 | Terminated | Teikoku Pharma USA, Inc. | 179 | 2022-07-07 | 2025-12-24 |
| Study Assessing Pain Relief After Replacement of the Knee ATX-101, bupivacaine hydrochloride without epinephrine - Acute Postoperative Pain | Phase 2 | Terminated | Allay Therapeutics, Inc. | 112 | 2022-06-07 | 2025-08-14 |
| Erenumab-aooe for the Management of Trigeminal Neuropathic Pain. Erenumab-Aooe, Placebo - Trigeminal Neuropathy | Phase 2 | Terminated | University of Maryland, Baltimore | 5 | 2022-05-31 | 2024-03-22 |
| Oxytocin for Hypermobile Ehlers-Danlos Syndrome Oxytocin, Placebo - Hypermobile Ehlers-Danlos Syndrome, Pain Assessment | Phase 1 / Phase 2 | Terminated | Baylor College of Medicine | 2 | 2022-05-13 | 2025-08-28 |
| A Randomized, Double-Blind, Placebo Controlled, Multicenter, Efficacy and Safety Trial of Single Cycle Tetrodotoxin in the Treatment of Chemotherapy Induced Neuropathic Pain Tetrodotoxin, Placebo - Chemotherapy-induced Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy | Phase 2 | Terminated | Wex Pharmaceuticals Inc. | 35 | 2022-04-19 | 2025-02-20 |
| A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA) canakinumab, LNA043, Placebo to canakinumab - Knee Osteoarthritis | Phase 2 | Terminated | Novartis Pharmaceuticals | 23 | 2021-08-27 | 2025-10-24 |
| Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy Oxycodone, Ibuprofen, Acetaminophen - Adenotonsillectomy, Post-operative Analgesia | Phase 1 / Phase 2 | Terminated | David Chi, MD | 73 | 2021-04-13 | 2024-08-30 |
| Sphenopalatine Ganglion Block for Headache After Concussion Lidocaine in SphenoCath device, Saline Solution in SphenoCath device - Concussion, Headache | Phase 2 | Terminated | University of Michigan | 2 | 2021-03-18 | 2022-09-14 |
| A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain BAY1817080, Placebo for BAY1817080, Placebo for Pregabalin - Neuropathic Pain Associated With Diabetic Peripheral Neuropathy | Phase 2 | Terminated | Bayer | 154 | 2021-01-22 | 2022-12-12 |
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Neuralgia (33) · Pain, Postoperative (25) · Chronic Pain (18) · Agnosia (13) · Neuralgia, Postherpetic (12) · Headache (10) · Osteoarthritis (10) · Osteoarthritis, Knee (9) · Acute Pain (8) · Arthralgia (8) · Diabetic Neuropathies (8) · Low Back Pain (8) · Migraine Disorders (7) · Angina Pectoris (6)
Neurologic Manifestations (196) · Pathological Conditions, Signs and Symptoms (196) · Signs and Symptoms (196) · Nervous System Diseases (72) · Neuromuscular Diseases (50) · Peripheral Nervous System Diseases (44) · Pathologic Processes (33) · Musculoskeletal Diseases (25) · Postoperative Complications (25) · Joint Diseases (18) · Rheumatic Diseases (16) · Neurobehavioral Manifestations (13) · Perceptual Disorders (13) · Arthritis (12)
Pregabalin (9) · Saline Solution (8) · Bupivacaine (7) · Sodium Chloride (7) · Lidocaine (5) · Morphine (5) · Ropivacaine (5) · fulranumab (5) · Acetaminophen (4) · Botulinum Toxins, Type A (3) · Duloxetine Hydrochloride (3) · Ibuprofen (3) · Ketamine (3) · Methadone (3) · Milnacipran (3)
Pfizer (10) · Wake Forest University Health Sciences (6) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (5) · Grünenthal GmbH (4) · Mayo Clinic (4) · Novartis Pharmaceuticals (4) · Allergan (3) · AstraZeneca (3) · Merck Sharp & Dohme LLC (3) · Montefiore Medical Center (3) · Pacira Pharmaceuticals, Inc (3) · Purdue Pharma LP (3) · University of Alabama at Birmingham (3) · Yale University (3) · AHS Cancer Control Alberta (2)
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PMID 26112278, PMID 33675631, PMID 11027905, PMID 11576800, PMID 1349061, PMID 17355955, PMID 20052461, PMID 20418538, PMID 21062996, PMID 21356040, PMID 22337568, PMID 22965960, PMID 23386053, PMID 23565581, PMID 24394343, PMID 24535482, PMID 24937440, PMID 25283471, PMID 26554876, PMID 27101815, PMID 27153360, PMID 27238963, PMID 27748055, PMID 28657160, PMID 31402867, PMID 31604475, PMID 34066713, PMID 34484101, PMID 34978027, PMID 35612403, PMID 36740814, PMID 37084261, PMID 37851336, PMID 38752431, PMID 40396501, PMID 8577492
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