Arthritis: Clinical Trials

6405 completed, 1674 unknown, 974 recruiting, 678 terminated. 3982 Not applicable, 1463 Phase 2, 1304 Phase 3, 983 Phase 4, 844 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	3982	Completed 2197, Unknown 696, Recruiting 389, Not yet recruiting 212, Active not recruiting 182, Terminated 167, Withdrawn 93, Enrolling by invitation 32, Suspended 14
Phase 2	1463	Completed 903, Unknown 162, Terminated 157, Recruiting 98, Withdrawn 62, Not yet recruiting 44, Active not recruiting 27, Enrolling by invitation 6, Suspended 4
Phase 3	1304	Completed 939, Unknown 115, Terminated 89, Recruiting 59, Active not recruiting 46, Withdrawn 27, Not yet recruiting 22, Enrolling by invitation 6, Suspended 1
Phase 4	983	Completed 577, Unknown 169, Terminated 89, Recruiting 64, Not yet recruiting 38, Withdrawn 31, Active not recruiting 13, Enrolling by invitation 2
Phase 1	844	Completed 534, Unknown 99, Recruiting 78, Terminated 48, Withdrawn 35, Not yet recruiting 23, Active not recruiting 22, Enrolling by invitation 4, Suspended 1
Early Phase 1	83	Completed 25, Unknown 22, Recruiting 15, Not yet recruiting 10, Withdrawn 6, Active not recruiting 2, Suspended 2, Terminated 1

Follow Arthritis: new trials by email Literature Review of Arthritis trials Research Report on Arthritis

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement Aquacel Ag dressing - Osteoarthritis	Not applicable	Withdrawn	Golden Jubilee National Hospital		2050-01-01	2019-07-31
Cannabichromene Safety in Rheumatoid Arthritis Cannabichromene - Arthritis, Rheumatoid	Phase 1 / Phase 2	Withdrawn	Crystal Lederhos Smith		2028-07-15	2026-09-23
Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL) Exercise Therapy, Extracorporeal Shockwave Therapy, Ultrasound-Guided Percutaneous Irrigation - Rotator Cuff Tendinosis, Rotator Cuff Injuries	Not applicable	Suspended	University of Valencia	116	2028-01-01	2026-06-26
An Open-label Study of GC012F in Rheumatoid Arthritis. LD and GC012F CAR-T Cell Injection, GC012F CAR-T Cell Injection - Rheumatoid Arthritis	Early Phase 1	Withdrawn	Institute of Hematology & Blood Diseases Hospital, China		2027-12-01	2026-06-10
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis SyntrFuge System, Triamcinolone Injection - Knee Osteoarthritis	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	180	2027-12-01	2026-08-20
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study Physical Rehab, Focused Shockwave Therapy - Knee Osteoarthristis	Not applicable	Not yet recruiting	Pulse Wave USA	60	2027-09-25	2026-05-05
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis	Phase 2 / Phase 3	Not yet recruiting	Genascence Corporation	240	2027-07-01	2026-09-21
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain	Phase 2	Not yet recruiting	VA Office of Research and Development	102	2027-03-01	2026-06-16
Undenatured Type II Collagen for Knee Osteoarthritis Pain Placebo, Nuvicol II, Nuvicol SII - Osteoarthritis, Knee	Not applicable	Recruiting	Universidad Católica San Antonio de Murcia	120	2027-03-01	2026-10-22
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial Pain Science Education, Biomedical Education - Knee Arthritis Osteoarthritis	Not applicable	Not yet recruiting	McMaster University	82	2027-02-01	2026-09-16
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee Standard care, Multicomponent opioid reduction and pain management pathway - Knee Arthroplasty, Total, Partial Knee Arthroplasty	Not applicable	Not yet recruiting	McMaster University	170	2027-02-01	2026-10-26
A Study of Zasocitinib in Adults With Psoriatic Arthritis (LATITUDE PsA NeXt) Placebo, Zasocitinib - Psoriatic Arthritis	Phase 3	Not yet recruiting	Takeda	644	2027-01-11	2026-10-27
Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases	Not applicable	Not yet recruiting	Ladoke Akintola University of Technology, Ogbomoso, Nigeria	474	2027-01-05	2026-06-04
HTO and Tranexamic Acid Study Tranexamic Acid, Routine medial opening wedge high tibial osteotomy - Osteoarthritis, Knee	Phase 3	Not yet recruiting	Western University, Canada	200	2027-01-01	2026-09-17
Zynrelef Versus Adductor Canal Block ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution - Knee Osteoarthritis, Arthritis Knee	Phase 4	Not yet recruiting	University of Miami	120	2027-01-01	2026-06-12
Patient-Reported Outcomes Dashboard With Goal Setting to Support Shared Decision-Making in Inflammatory Arthritis Patient-Reported Outcomes Dashboard With Goal Setting - Arthritis, Psoriatic (PsA), Arthritis, Rheumatoid (RA)	Not applicable	Not yet recruiting	Northwestern University	160	2027-01-01	2026-10-15
Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis Atibuclimab, saline placebo - Knee Osteoarthritis (Knee OA)	Phase 1	Not yet recruiting	VA Office of Research and Development	40	2027-01-01	2026-07-15
Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome		Not yet recruiting	University of Pennsylvania	220	2027-01-01	2026-03-02
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis HRV-guided home exercise prescription, Traditional Home Exercise - Knee Osteoarthritis	Not applicable	Not yet recruiting	The Hong Kong Polytechnic University	240	2027-01-01	2026-02-12
Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty Total knee arthroplasty - Knee Osteoarthritis	Not applicable	Not yet recruiting	Loyola University	96	2027-01-01	2026-08-27

Showing 20 of 11002. Sign in to see all of them.

Narrower conditions

Arthritis, Rheumatoid (3279)  ·  Osteoarthritis, Knee (3212)  ·  Osteoarthritis (2692)  ·  Osteoarthritis, Hip (634)  ·  Arthritis, Psoriatic (592)  ·  Spondylitis, Ankylosing (518)  ·  Pain (505)  ·  Arthritis, Juvenile (356)  ·  Motor Activity (325)  ·  Sjogren's Syndrome (318)  ·  Gout (307)  ·  Joint Diseases (237)  ·  Spondylarthritis (195)  ·  Lupus Erythematosus, Systemic (187)

Broader conditions

Musculoskeletal Diseases (10878)  ·  Joint Diseases (10765)  ·  Rheumatic Diseases (9485)  ·  Skin and Connective Tissue Diseases (4475)  ·  Connective Tissue Diseases (3990)  ·  Immune System Diseases (3946)  ·  Autoimmune Diseases (3807)  ·  Osteoarthritis (2934)  ·  Pathological Conditions, Signs and Symptoms (1868)  ·  Bone Diseases (1603)  ·  Spinal Diseases (1283)  ·  Spondylitis (1238)  ·  Signs and Symptoms (1215)  ·  Spondylarthropathies (1079)

Interventions

Methotrexate (350)  ·  Adalimumab (235)  ·  Etanercept (220)  ·  tocilizumab (193)  ·  Exercise (184)  ·  Sodium Chloride (132)  ·  Arthroplasty, Replacement, Knee (131)  ·  Infliximab (131)  ·  Abatacept (107)  ·  tofacitinib (100)  ·  Rituximab (97)  ·  Hyaluronic Acid (93)  ·  Celecoxib (87)  ·  Arthroplasty, Replacement, Hip (83)  ·  Certolizumab Pegol (78)

Sponsors

Pfizer (210)  ·  Hoffmann-La Roche (202)  ·  Zimmer Biomet (136)  ·  Novartis Pharmaceuticals (117)  ·  Bristol-Myers Squibb (106)  ·  Amgen (104)  ·  Assiut University (95)  ·  AbbVie (84)  ·  Assistance Publique - Hôpitaux de Paris (80)  ·  Riphah International University (78)  ·  Eli Lilly and Company (69)  ·  Istituto Ortopedico Rizzoli (63)  ·  GlaxoSmithKline (55)  ·  University Hospital, Montpellier (53)  ·  Merck Sharp & Dohme LLC (52)

Countries

United States (3138)  ·  France (910)  ·  Canada (825)  ·  Germany (780)  ·  United Kingdom (758)  ·  Turkey (Türkiye) (661)  ·  China (658)  ·  Spain (637)  ·  Poland (619)  ·  Italy (529)  ·  South Korea (432)  ·  Belgium (411)  ·  Denmark (389)  ·  Australia (378)  ·  Czechia (369)

Results publications

PMID 36931693, PMID 36526796, PMID 32816215, PMID 34870800, PMID 36600185, PMID 36601090, PMID 33127856, PMID 28143815, PMID 39192350, PMID 25047021, PMID 27338778, PMID 38958913, PMID 29244149, PMID 30649524, PMID 37453736, PMID 37982966, PMID 40194794, PMID 40875187, PMID 41807031, PMID 26275429, PMID 30936738, PMID 33263165, PMID 34706874, PMID 36754548, PMID 37460782, PMID 37945286, PMID 29463520, PMID 34041702, PMID 36814062, PMID 31203228, PMID 31610021, PMID 34921355, PMID 36205910, PMID 37316690, PMID 37747626, PMID 38446397, PMID 28941219, PMID 30177460, PMID 35577477, PMID 36715850, PMID 37308218, PMID 41965705, PMID 42386286, PMID 21055873, PMID 22491018, PMID 26554876, PMID 27803138, PMID 27889300, PMID 29949132, PMID 30219772

NIH funding

2009 (61), 2015 (59), 2016 (50), 2023 (42), 2014 (41), 2017 (41), 2018 (33), 2008 (30), 2025 (30), 2019 (26), 2005 (15), 2004 (6), P60AR047782 (3), R01AT004623 (3), K23AG029978 (2)