296 completed, 73 unknown, 63 recruiting, 41 terminated. 298 Not applicable, 82 Phase 4, 38 Phase 3, 30 Phase 2, 13 Phase 1.
Follow this condition Literature Review of Opioid Use trials Research Report on Opioid Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement Computerized brief intervention, Psychological sessions, Opioid taper recommendations - Pain, Opioid Use | Not applicable | Not yet recruiting | Henry Ford Health System | 80 | 2027-03-01 | 2026-08-10 |
| Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment Mild Cognitive Impairment (MCI), Opioid Use | Not yet recruiting | Miklos Kertai | 552 | 2027-01-01 | 2026-10-21 | |
| Quadro-Iliac Plane Block for Postoperative Analgesia in Laparoscopic Inguinal Hernia Repair Quadro-iliac plane block - Inguinal Hernia Unilateral, Postoperative Pain | Not applicable | Not yet recruiting | Marmara University Pendik Training and Research Hospital | 64 | 2026-10-15 | 2026-10-16 |
| Opioid Dispenser for Microdiscectomy/Laminectomy Opioid-Dispensing Device, App, Standard Opioid Pill Bottle - Opioid Use, Pain, Postoperative | Not applicable | Recruiting | Hospital for Special Surgery, New York | 30 | 2026-10-01 | 2025-12-08 |
| Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use Placebo, Oxycodone HCl, Kratom 8g - Opioid Use, Substance Use Disorders | Phase 1 | Recruiting | Christopher D. Verrico | 72 | 2026-09-01 | 2026-09-28 |
| Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement - Open Trial Psychological Intervention - Pain, Opioid Use | Not applicable | Not yet recruiting | Henry Ford Health System | 10 | 2026-09-01 | 2026-09-23 |
| Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery Mindfulness Based Intervention, Educational Recording - Orthopaedic Fractures, Orthopaedic Trauma Fractures and Non-unions | Not applicable | Recruiting | McMaster University | 50 | 2026-08-27 | 2026-10-07 |
| SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery Serratus Posterior Superior Intercostal Plane Block, Ultrasound-guided Erector Spinae Plane Block - Postoperative Pain, Opioid Use | Not applicable | Recruiting | Engin Çetin | 90 | 2026-07-01 | 2026-09-30 |
| OpioidRedoxStudyII Oxidative Stress, Opioid Use | Not yet recruiting | EPC Education s.r.o. | 120 | 2026-06-30 | 2026-01-13 | |
| Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention mHealth Intervention - Alcohol Drinking, Opioid Use | Not applicable | Recruiting | Brown University | 30 | 2026-06-08 | 2026-06-23 |
| VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs - ACL, Opioid Use | Not applicable | Recruiting | Columbia University | 130 | 2026-06-01 | 2026-01-07 |
| Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy Paravertebral block, Erector Spinae block - Mastectomy; Lymphedema, Chronic Pain | Not applicable | Recruiting | American University of Beirut Medical Center | 132 | 2026-05-19 | 2026-06-02 |
| Serratus vs ESP Block for Postoperative Pain in Unilateral Breast Surgery Serratus Posterior Superior Intercostal Plane Block - Post Operative Pain, Opioid Use | Not applicable | Recruiting | Engin Çetin | 54 | 2026-05-01 | 2026-09-30 |
| Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment Brief opioid-informed alcohol treatment - Alcohol Use Disorder, Opioid Use Disorder | Not applicable | Recruiting | University of Notre Dame | 60 | 2026-03-24 | 2026-06-09 |
| Autonomic Neural Blockade in Bariatric Surgery Intraoperative autonomic neural blockade (ANB), Laparoscopic Standard of Care Abdominal Wall Block - Bariatric Surgery Candidate, Pain, Postoperative | Not applicable | Recruiting | Endeavor Health | 200 | 2026-02-05 | 2026-07-29 |
| Autonomic Neural Field Block for Visceral Pain in Minimally Invasive Left-Sided Colectomy Autonomic Neural Field Block - Postoperative Pain, Postoperative Nausea | Not yet recruiting | Antonio Caycedo, MD | 400 | 2026-01-20 | 2026-01-20 | |
| Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage Lidocaine, Lidocaine and Dexamethasone - Subarachnoid Hemorrhage, Aneurysmal, Headache | Phase 2 | Recruiting | The University of Texas Medical Branch, Galveston | 15 | 2026-01-02 | 2026-01-09 |
| Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients Ketamine, standard general anesthesia - Orthopedic Trauma Surgery Patients, Postoperative Pain | Phase 4 | Recruiting | Texas Tech University Health Sciences Center | 90 | 2025-11-06 | 2026-03-24 |
| Effect of Bilateral Rectointercostal Fascial Plane Block on Postoperative Pain After Laparoscopic Sleeve Gastrectomy Bilateral Rectointercostal Fascial Plane Block, Intravenous Patient-Controlled Analgesia (IV PCA) with Morphine - Pain, Postoperative, Obesity, Morbid | Not applicable | Completed | Samsun University | 56 | 2025-11-01 | 2025-12-29 |
| The Impact of Intraoperative Methadone on Postoperative Opioid Use Methadon - Breast Cancer, Opioid Use | Phase 3 | Withdrawn | University of Utah | 2025-11-01 | 2025-11-26 |
Showing 20 of 531. Sign in to see all of them.
Pain, Postoperative (185) · Opioid-Related Disorders (78) · Chronic Pain (77) · Pain (65) · Agnosia (39) · Acute Pain (24) · Substance-Related Disorders (23) · Postoperative Nausea and Vomiting (19) · Anxiety Disorders (12) · Breast Neoplasms (8) · Marijuana Abuse (8) · Wounds and Injuries (8) · Depression (7) · HIV Infections (7) · Postoperative Complications (7)
Pathological Conditions, Signs and Symptoms (343) · Signs and Symptoms (331) · Neurologic Manifestations (324) · Pain (249) · Pathologic Processes (206) · Postoperative Complications (183) · Mental Disorders (133) · Chemically-Induced Disorders (105) · Substance-Related Disorders (82) · Narcotic-Related Disorders (80) · Nervous System Diseases (62) · Behavior (44) · Neurobehavioral Manifestations (42) · Perceptual Disorders (39) · Musculoskeletal Diseases (30)
Acetaminophen (22) · Oxycodone (22) · Bupivacaine (19) · Sodium Chloride (14) · Fentanyl (11) · Lidocaine (11) · Morphine (11) · Ibuprofen (10) · Ketamine (10) · oxycodone-acetaminophen (10) · Dexamethasone (8) · Ketorolac (8) · Pregabalin (8) · Analgesics, Opioid (7) · Dexmedetomidine (7)
Hospital for Special Surgery, New York (13) · Stanford University (10) · Brigham and Women's Hospital (9) · Johns Hopkins University (9) · University of Utah (9) · Wake Forest University Health Sciences (9) · Rutgers, The State University of New Jersey (8) · University of Wisconsin, Madison (8) · University of Pennsylvania (7) · Yale University (7) · Marmara University (6) · University of Washington (6) · Universitätsklinikum Hamburg-Eppendorf (6) · Vanderbilt University Medical Center (6) · Columbia University (5)
United States (347) · Canada (30) · Turkey (Türkiye) (24) · Denmark (11) · Egypt (7) · Germany (6) · Greece (5) · Italy (5) · Lebanon (5) · Belgium (4) · China (4) · Colombia (4) · Netherlands (4) · Norway (4) · Sweden (4)
Rainer Nitzschke, MD (6) · Catherine J Fedorka, MD (3) · Ezra Golberstein, PhD (3) · Zarina Ali, MD (3) · Alexis M Roth, PhD, MPH (2) · Anish Agarwal, MD (2) · Beliz Bilgili (2) · Bradley H Lee, MD (2) · Chad Brummett, MD (2) · David H Chi, MD (2) · Hance Clarke, MD, PhD (2) · Jason Doctor, PhD (2) · Jean Wong, MD (2)
PMID 41085955, PMID 15273542, PMID 38091501, PMID 11034732, PMID 11171742, PMID 12623025, PMID 12693389, PMID 14612482, PMID 15041597, PMID 15082297, PMID 15866968, PMID 16079372, PMID 16181921, PMID 16856074, PMID 16880882, PMID 16914695, PMID 17129308, PMID 17435557, PMID 17588421, PMID 17678782, PMID 17894152, PMID 18945716, PMID 18983373, PMID 19402781, PMID 19488544, PMID 19638912, PMID 19843784, PMID 19919581, PMID 20003176, PMID 20308263, PMID 20334632, PMID 20619231, PMID 20626510, PMID 20889937, PMID 21401544, PMID 21418466, PMID 21519309, PMID 21620344, PMID 21697139, PMID 21698591, PMID 21970126, PMID 22049287, PMID 22219425, PMID 22219442, PMID 22290456, PMID 22512766, PMID 22588767, PMID 22679539, PMID 23044681, PMID 23411725
2019 (4), R33DA046084 (3), 2017 (2), K23DA040923 (2), K23HL151880 (2), R01DA016718 (2), R01DA044245 (2), R01DA045700 (2), R34DA060172 (2), 2014 (1), 2025 (1), 3UG1DA040316-06S3 (1), 4UH3DA044798-03 (1), 4UH3DA048502 (1), 5UG1DA050207 (1)