184 completed, 44 unknown, 26 terminated, 25 recruiting. 133 Phase 4, 55 Not applicable, 55 Phase 2, 55 Phase 3, 18 Phase 1.
Follow Ketorolac: new trials by email Literature Review of Ketorolac trials Research Report on Ketorolac
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release Bupivicaine, Fentanyl, Thoracic epidural analgesia - Ventral Hernia, Ventral Hernia Repair | Phase 4 | Recruiting | Northwestern University | 40 | 2026-09-25 | 2026-10-07 |
| Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA bupivacaine-meloxicam (extended release), Bupivacaine, Ketorolac - Periarticular Block, Osteoarthritis (OA) | Phase 4 | Not yet recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 150 | 2026-07-31 | 2026-07-06 |
| Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy paracervical block, Lidocaine, ketorolac - Abnormal Uterine Bleeding, Analgesia | Phase 1 | Enrolling by invitation | Icahn School of Medicine at Mount Sinai | 60 | 2026-07-01 | 2026-10-22 |
| Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement Ketorolac, oral ibuprofen, Placebo - Pain Management, Abortion | Phase 2 | Recruiting | Rush University Medical Center | 76 | 2026-06-29 | 2026-07-06 |
| Intravenous Acetaminophen and Ketorolac for Pain Management During Extracorporeal Shockwave Lithotripsy IV midazolam, IV fentanyl, IV acetaminophen - Extracorporeal Shockwave Lithotripsy | Phase 4 | Enrolling by invitation | Horizon Health Network | 266 | 2026-04-01 | 2026-04-13 |
| Comparison of Ketorolac and Dexmedetomidine as An Adjunct to Lignocaine in Prevention of Tourniquet Induced Pain During Intravenous Regional Anesthesia Dexmedetomidine, ketorolac, Lidocaine - Tourniquet-induced Pain, Procedural Pain | Not applicable | Completed | Mayo Hospital Lahore | 70 | 2026-02-15 | 2026-10-16 |
| Midazolam Alone Versus Midazolam With Ketorolac for Sedation During Flexible Bronchoscopy. Midazolam Alone, Midazolam + ketorolac - Sedation and Analgesia Management in Patients Undergoing Flexible Bronchoscopy | Not applicable | Not yet recruiting | SYED HAIDER ALI | 50 | 2026-01-20 | 2026-01-20 |
| Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral Myringotomy Fentanyl, Ketorolac, Nerve of Arnold Block - Postoperative Pain | Phase 4 | Not yet recruiting | University of South Alabama | 300 | 2026-01-01 | 2025-12-11 |
| Optimizing Pain Treatment in Children On Mechanical Ventilation Acetaminophen, Ketorolac, Placebo - Mechanical Ventilation, Pediatric Acute Respiratory Failure | Phase 3 | Recruiting | Weill Medical College of Cornell University | 644 | 2025-12-29 | 2026-07-30 |
| Comparison of Two Dosing Regimens of Intravenous Ketorolac for Post-Cesarean Pain Control Ketorolac 30 mg, Ketorolac 15mg - Postoperative Analgesia, Cesarean Delivery | Not applicable | Completed | Cairo University | 125 | 2025-12-01 | 2026-06-17 |
| R.E.C.K vs Exparel in Robotic Nephrectomy Ropivacaine HCL, Exparel, Epinephrine - Renal Carcinoma, Nephrectomy / Methods | Phase 3 | Recruiting | Wake Forest University Health Sciences | 170 | 2025-11-14 | 2026-07-13 |
| Ketorolac Use and Fresh Embryo Transfer Outcomes Ketorolac 30 mg IV - Infertility (IVF Patients), Infertility Treatment | Phase 4 | Recruiting | Jessica D. Kresowik | 200 | 2025-11-08 | 2025-12-15 |
| Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection Ketorolac, 0.9 % saline - Aortic Dissection, Inflammation | Phase 3 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 1346 | 2025-10-27 | 2026-08-31 |
| Efficacy of Methylprednisolone for Pain Control After ACL Repair Meloxicam 15 mg, Medrol 4 MG Oral Tablet Includes Medrol Dosepak, Gabapentin 300 mg - ACL Surgery, Pain Management | Phase 4 | Recruiting | St. Louis University | 90 | 2025-10-21 | 2025-10-24 |
| Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies Acetaminophen, NSAID (Ketorolac/Ibuprofen) - Cesarean Delivery, Postpartum Comfort | Phase 4 | Active not recruiting | Thomas Jefferson University | 825 | 2025-08-26 | 2026-08-31 |
| Non-Narcotic Pain Control After ACL Reconstruction dispense of study drug, Ketorolac - ACL - Anterior Cruciate Ligament Rupture, ACL Injuries | Phase 2 | Active not recruiting | The Cleveland Clinic | 30 | 2025-07-15 | 2026-08-24 |
| Intraoperative Pectoral Block vs IV Analgesia for Pain After Modified Radical Mastectomy bupivacaine 0.5% injection, Ketorolac 30 mg IV - Mastectomy, Modified Radical | Phase 3 | Completed | Islamabad Medical and Dental College | 60 | 2025-07-01 | 2026-05-15 |
| Ketorolac at Lower Doses for Analgesic Pain Control in ICU: A Pilot Feasibility Study Ketorolac, Placebo - Pain Management | Phase 3 | Recruiting | University of Alberta | 30 | 2025-06-23 | 2026-09-28 |
| Comparing Local Anesthetic Injections to Nerve Blocks for Pain Control After Total Knee Replacement Continuous Femoral and Sciatic Nerve Block (Ropivacaine), Local Infiltration Analgesia (Ropivacaine, Ketorolac, Epinephrine) - Pain, Postoperative, Osteoarthritis, Knee | Not applicable | Completed | Christopher Male | 78 | 2025-06-01 | 2026-08-05 |
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Pain, Postoperative (73) · Pain (49) · Agnosia (26) · Cataract (12) · Migraine Disorders (12) · Acute Pain (10) · Emergencies (8) · Inflammation (8) · Renal Colic (8) · Osteoarthritis, Knee (7) · Headache (6) · Macular Edema (6) · Osteoarthritis (6) · Kidney Calculi (5) · Pancreatitis (5)
Assiut University (7) · Henry Ford Health System (7) · Montefiore Medical Center (6) · University Hospitals Cleveland Medical Center (5) · Wake Forest University Health Sciences (5) · Alberta Children's Hospital (4) · Cairo University (4) · Mayo Clinic (4) · Rothman Institute Orthopaedics (4) · University of Aarhus (4) · University of Utah (4) · Emory University (3) · IRCCS Burlo Garofolo (3) · Innovative Medical (3) · Johns Hopkins University (3)
United States (172) · Egypt (22) · Canada (18) · Italy (8) · Denmark (6) · South Korea (6) · Belgium (5) · Brazil (5) · Pakistan (5) · Iran (4) · Mexico (4) · Thailand (4) · Norway (3) · Sweden (3) · China (2)
Toufic R Jildeh, MD (4) · Stephen J Kim, MD (3) · Bryce Weber, MD FRCSC (2) · Dan Marinescu, MD (2) · Daniel S Tsze, MD, MPH (2) · Eric Donnenfeld, MD (2) · Gianluca Cappelleri, M.D. (2) · James C. Eisenach, M.D. (2) · Justin Haller, MD (2) · Michael Karns, MD (2) · Michael Khazzam, MD (2) · Mitchell R. Humphreys, M.D. (2) · Nancy Wu (2)
PMID 23058854, PMID 24976224, PMID 10100293, PMID 10422923, PMID 11133630, PMID 12298311, PMID 12411815, PMID 12934209, PMID 14508260, PMID 15513495, PMID 16196117, PMID 16452738, PMID 16651569, PMID 17403800, PMID 18165083, PMID 18484242, PMID 18599019, PMID 18779478, PMID 19135997, PMID 19209273, PMID 19214642, PMID 19520544, PMID 19535182, PMID 19535720, PMID 19668532, PMID 1977542, PMID 19935022, PMID 20216291, PMID 20557145, PMID 20736233, PMID 2082307, PMID 21091369, PMID 21145532, PMID 21187730, PMID 21236454, PMID 21248398, PMID 21294923, PMID 22227789, PMID 22285545, PMID 22871833, PMID 22892729, PMID 23121612, PMID 23177167, PMID 23567060, PMID 23669270, PMID 2367246, PMID 23702435, PMID 23937996, PMID 24264034, PMID 24336915
2008 (2), 2009 (2), 2005 (1), 2014 (1), 2019 (1), KL2TR000370 (1), P01NS041386 (1), P30CA012197 (1), R01DE005215 (1), R01EY031315 (1), R37GM048085 (1), U01HD116260 (1), U54HD071594 (1), UL1TR000135 (1), UL1TR000371 (1)