57 completed, 11 terminated, 9 withdrawn, 8 unknown. 41 Phase 4, 26 Phase 3, 13 Phase 2, 10 Not applicable, 7 Phase 1.
Follow oxycodone-acetaminophen: new trials by email Literature Review of oxycodone-acetaminophen trials Research Report on oxycodone-acetaminophen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-op Analgesia of Nail Unit Procedures Suzetrigine, Oxycodone/Acetaminophen, Acetaminophen - Nail Diseases | Phase 4 | Not yet recruiting | University of Miami | 45 | 2026-10-01 | 2026-10-01 |
| Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Abdominal Surgery HL-1186, HL-1186 placebo, Oxycodone-Acetaminophen - Postoperative Pain | Phase 2 / Phase 3 | Recruiting | Shanghai Huilun Pharmaceutical Co., Ltd. | 330 | 2026-05-11 | 2026-07-16 |
| Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Orthopedic Surgery HL-1186, HL-1186 placebo, Oxycodone-Acetaminophen - Postoperative Pain | Phase 2 / Phase 3 | Recruiting | Shanghai Huilun Pharmaceutical Co., Ltd. | 330 | 2026-05-09 | 2026-07-13 |
| Suzetrigine vs Norco-postoperative Mohs Pain Norco 5Mg-325Mg Tablet, Suzetrigine - Cutaneous Tumors, Mohs Micrographic Surgery | Phase 4 | Enrolling by invitation | Baylor Research Institute | 75 | 2025-11-03 | 2026-05-11 |
| RCT: Suzetrigine vs Norco for Post-op Pain Suzetrigine (SUZ), Norco - Pain Control | Phase 4 | Not yet recruiting | Jacob Lensing | 76 | 2025-10-01 | 2025-09-29 |
| Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia Methoxyflurane - Penthrox, Control, Percocet Pill - Benign Prostate Hypertrophy(BPH) | Phase 3 | Not yet recruiting | University of Manitoba | 48 | 2025-08-01 | 2025-06-12 |
| Opioid Drug Interaction Study Alprazolam, Oxycodone, Placebo - Drug Interactions, Drug Kinetics | Phase 1 / Phase 2 | Recruiting | Shanna Babalonis, PhD | 25 | 2025-04-01 | 2026-05-14 |
| Randomized Trial of Two Analgesics in Elderly ED Patients Oxycodone/acetaminophen, Ibuprofen/acetaminophen - Pain | Phase 4 | Withdrawn | Albany Medical College | 2024-07-01 | 2023-09-21 | |
| Post Operative Pain Management for ACL Reconstruction Bupivacaine HCl 0.5% Injectable Solution, Dexamethasone, Infiltration between Popliteal Artery and Capsule of the knee (iPACK) - Pain, Postoperative | Phase 3 | Unknown | Rothman Institute Orthopaedics | 154 | 2023-09-30 | 2023-09-21 |
| Post-operative Pain Management in Children With Supracondylar Humerus Fractures Ibuprofen, Hydrocodone/acetaminophen, Acetaminophen - Supracondylar Humerus Fracture | Phase 4 | Terminated | Baylor College of Medicine | 29 | 2023-09-12 | 2026-02-10 |
| Effects of Perioperative Intravenous Dexamethasone in Clinical Outcomes After Total Knee Arthroplasty in a Hispanic Population Dexamethasone, Morphine, Oxycodone and acetaminophen - Osteoarthritis, Knee | Phase 4 | Unknown | University of Puerto Rico | 100 | 2023-09-01 | 2023-09-18 |
| Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Acetaminophen 1000mg, Ibuprofen 400 mg - Nail Diseases, Nail Abnormality | Phase 4 | Completed | Weill Medical College of Cornell University | 20 | 2022-11-10 | 2023-09-28 |
| Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy Tramadol, Gabapentin, Hydrocodone-Acetaminophen - Radical Prostatectomies | Phase 2 / Phase 3 | Withdrawn | Wake Forest University Health Sciences | 2022-08-01 | 2022-09-06 | |
| NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures Acetaminophen-Hydrocodone, Acetaminophen and Ibuprofen - Supracondylar Humerus Fracture | Phase 4 | Terminated | Le Bonheur Children's Hospital | 30 | 2021-06-07 | 2024-03-08 |
| Pain Management After Shoulder Arthroplasty Total Shoulder Arthroplasty, Caffeine Pill, Percocet 10Mg-325Mg Tablet - Caffeine, Pain, Joint | Phase 3 | Unknown | Rothman Institute Orthopaedics | 160 | 2021-04-15 | 2021-05-04 |
| Multimodal Analgesia Effect on Post Surgical Patient Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product - Obesity, Morbid, Surgery | Phase 4 | Completed | University of California, Davis | 60 | 2021-01-20 | 2026-09-14 |
| Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids - Opioid Use, Opioid Dependence | Phase 2 | Active not recruiting | Northwestern University | 60 | 2021-01-01 | 2024-11-27 |
| Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed Naproxen Sodium (Aleve, BAY117031), Hydrocodone/Acetaminophen, Placebo - Pain | Phase 4 | Completed | Bayer | 221 | 2020-03-12 | 2022-07-14 |
| Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions Methadone Hydrochloride, Oxycodone-Acetaminophen - Degenerative Disc Disease, Spondylolisthesis, Lumbar Region | Phase 1 | Unknown | The Methodist Hospital Research Institute | 150 | 2020-02-11 | 2020-01-29 |
| Postoperative Pain Control in Septum and Sinus Surgery Acetaminophen 325 mg Oral Tablet, Acetaminophen 650 mg Oral Tablet, OxyCODONE 5 mg Oral Tablet - Post-operative Pain, Sinus Surgery | Phase 4 | Completed | Corewell Health East | 65 | 2019-11-27 | 2023-08-31 |
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Pain, Postoperative (25) · Pain (23) · Agnosia (10) · Acute Pain (5) · Nausea (4) · Opioid-Related Disorders (4) · Emergencies (3) · Low Back Pain (3) · Vomiting (3) · Anterior Cruciate Ligament Injuries (2) · Back Pain (2) · Constipation (2) · Fractures, Bone (2) · Head and Neck Neoplasms (2) · Median Neuropathy (2)
Henry Ford Health System (4) · Montefiore Medical Center (4) · NYU Langone Health (4) · Rothman Institute Orthopaedics (4) · Loma Linda University (3) · Mallinckrodt (3) · Albany Medical College (2) · Baylor College of Medicine (2) · Charleston Laboratories, Inc (2) · Emory University (2) · Grünenthal GmbH (2) · Shanghai Huilun Pharmaceutical Co., Ltd. (2) · The University of Texas Health Science Center, Houston (2) · University Hospitals Cleveland Medical Center (2) · University of California, Davis (2)
United States (83) · Canada (4) · China (3) · Puerto Rico (2)
Toufic R Jildeh, MD (4) · Michael Karns, MD (2) · Adam J Singer, MD (1) · Alexander Payatakes, M.D. (1) · Andrea Snow, PhD MS BS (1) · Andrew Chang, MD (1) · Annette O Arthur, PharmD (1) · Antonio Otero-Lopez, MD (1) · Apkar V Apkarian, PhD (1) · Barbara Jachniewicz, MSN, CRNFA, (1) · Benjamin Friedman, MD (1) · Bernard Schachtel, MD (1) · Brian Morrison, MD (1)
PMID 12351295, PMID 15151094, PMID 15791113, PMID 19135997, PMID 19209273, PMID 19331993, PMID 19338859, PMID 19535182, PMID 20173643, PMID 20890791, PMID 22008309, PMID 2221417, PMID 22524979, PMID 23090523, PMID 23221859, PMID 23379573, PMID 23545428, PMID 24351079, PMID 25157951, PMID 26501533, PMID 29054476, PMID 29114833, PMID 30138687, PMID 31961377, PMID 33306558, PMID 33358232, PMID 34878953, PMID 36332661, PMID 36476466, PMID 36518729, PMID 37619705, PMID 6650889, PMID 9204163
P30CA068485 (1), R01DA016718 (1)