80 completed, 20 unknown, 10 terminated, 9 recruiting. 43 Not applicable, 40 Phase 4, 21 Phase 3, 16 Phase 2, 9 Phase 1.
Follow Analgesics, Opioid: new trials by email Literature Review of Analgesics, Opioid trials Research Report on Analgesics, Opioid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabis Effects on Opioid Self-Administration Cannabis, Placebo Cannabis, Intranasal Opioid Agonist - Opioid Use Disorder, Cannabis Use | Phase 1 | Not yet recruiting | Shanna Babalonis, PhD | 30 | 2026-11-30 | 2026-10-14 |
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery Quality Opioids - Emergence Delirium, Emergence Agitation | Phase 4 | Not yet recruiting | Konya City Hospital | 88 | 2026-09-05 | 2026-10-06 |
| Opioid-free Anesthesia as an Alternative to General Anesthesia in Patients Undergoing Laparoscopic Peripheral Pancreatic Resection Opioid Free Anesthesia (OFA), Balanced anesthesia with opioids - Pain Management | Not applicable | Recruiting | Jagiellonian University | 200 | 2026-09-02 | 2026-09-04 |
| Opioid-free Anesthesia as an Alternative to General Anesthesia in Patients Undergoing Duodenopancreatic Surgery by Laparotomy. Opioid, OFA - Pain Management | Not applicable | Recruiting | Jagiellonian University | 200 | 2026-09-02 | 2026-09-04 |
| Psychoactive Drug Use and Acute Care Use After Trauma and Out-of-Hospital Cardiac Arrest Opioids (ATC N02A), Antiepileptics (ATC N03A), Antipsychotics (ATC N05A) - Wounds and Injuries, Out-of-Hospital Cardiac Arrest | Active not recruiting | Azienda Usl di Bologna | 52720 | 2026-06-10 | 2026-10-20 | |
| Cannabis Vs Opioids Pain Management Objective Testing Comparisons Monochromatic Infrared Photo Energy (MIRE), Transcutaneous Electrical Nerve Stimulation, Opioids - Chronic Pain, Circulatory Disorders | Not applicable | Not yet recruiting | American Association of Sensory Electrodiagnostic Medicine | 1000 | 2026-06-03 | 2025-12-29 |
| Evaluating the Efficacy and Utility of the Automated Pupillometer in Pain Assessment and Opioid Administration Guidance During the Perioperative Period: A Randomized Controlled Trial Opioid Analgesic, automated pupillometry - Postoperative Pain, Postoperative Pain Management | Not applicable | Active not recruiting | University of Malaya | 68 | 2026-05-01 | 2026-05-29 |
| Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty PNEG block, Spinal anesthesia with opioid, Spinal anesthesia without opioid - Perioperative Analgesia, Hip Replacement, Total | Not applicable | Not yet recruiting | Medical University of Gdansk | 180 | 2026-03-01 | 2026-03-04 |
| Opioid Consumption After Thoracotomy and Factors Affecting Postoperative Acute Pain Opioid Analgesic, Pain Medicine - Thoracic Anesthesia, Thoracotomy | Not yet recruiting | Ankara Ataturk Sanatorium Training and Research Hospital | 35 | 2026-01-05 | 2026-01-12 | |
| Measuring Acute Drug Demand in Humans II Blinded Study Medication - Condition 1, Blinded Study Medication - Condition 2, Blinded Study Medication - Condition 3 - Healthy Volunteers | Early Phase 1 | Withdrawn | Johns Hopkins University | 2025-11-15 | 2025-11-12 | |
| Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial Intrathecal morphine with bupivacaine, Hyperbaric Bupivicaine - Postoperative Pain, Cesarean Delivery | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 92 | 2025-10-15 | 2025-07-30 |
| INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures Ropivacaine, Non steroidal anti-inflammatory drug and opioids - Rib Fractures | Phase 4 | Recruiting | Zachary Warriner | 180 | 2025-09-23 | 2025-10-07 |
| Sacral Erector Spinae Plane Block in Transurethral Prostate Resection Surgery sacral erector spinae plane block group, Opioid Analgesics - TURP(Transurethral Resection of Prostate) | Not applicable | Completed | Adiyaman University | 60 | 2025-09-05 | 2026-03-03 |
| Efficacy of Peripheral Nerve Blocks in Total Knee Arthroplasty Opioid Analgesic (tramadol hydrochloride), Prophylactic analgesia (intravenous paracetamol), Rescue analgesia (intramuscular diclofenac sodium) - Postoperative Pain Following Knee Arthroplasty | Not applicable | Completed | Tokat Gaziosmanpasa University | 86 | 2025-06-08 | 2026-06-26 |
| Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain Opioid, Opioid Placebo - Pain, Chronic | Phase 2 | Recruiting | Mayo Clinic | 200 | 2025-04-16 | 2026-01-08 |
| Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery Inter-semispinalis Plane Block, Opioids - Pain, Postoperative | Not applicable | Recruiting | Stony Brook University | 60 | 2025-02-21 | 2026-04-29 |
| Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial NSAID, Opioid, Acetaminophen - Surgery, Pain, Post Operative | Phase 4 | Recruiting | University of Michigan | 900 | 2025-01-10 | 2026-10-20 |
| Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients Scalp nerve block, Morphine, Lidocaine - Supratentorial Tumors | Phase 4 | Completed | Aga Khan University | 62 | 2025-01-01 | 2026-02-23 |
| Perioperative Polmacoxib Reduce Opioid Consumption for Post Operative Pain After Rotator Cuff Tear. Experimental(Acelex cap m2mg), Active Comparator(NSAIDs-excluded non-opioid or opioid analgesics) - Rotator Cuff Tear | Not applicable | Unknown | Eulji University Hospital | 150 | 2024-08-23 | 2024-09-19 |
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Pain, Postoperative (31) · Pain (30) · Agnosia (27) · Chronic Pain (7) · Breast Neoplasms (5) · Opioid-Related Disorders (5) · Wounds and Injuries (5) · Rib Fractures (4) · Acute Pain (3) · Breakthrough Pain (3) · Emergencies (3) · Low Back Pain (3) · Marijuana Abuse (3) · Cancer Pain (2) · Hernia, Inguinal (2)
Ain Shams University (4) · Johns Hopkins University (4) · Jagiellonian University (3) · Mahidol University (3) · Montefiore Medical Center (3) · Seoul National University Hospital (3) · Shanna Babalonis, PhD (3) · Beth Israel Deaconess Medical Center (2) · Cali Pharmaceuticals LLC (2) · Federal University of São Paulo (2) · KK Women's and Children's Hospital (2) · Mayo Clinic (2) · McGill University Health Centre/Research Institute of the McGill University Health Centre (2) · Medical College of Wisconsin (2) · Nanjing Medical University (2)
United States (59) · Canada (11) · Turkey (Türkiye) (9) · Poland (7) · Egypt (5) · South Korea (5) · China (4) · Sweden (4) · Brazil (3) · France (3) · Germany (3) · Italy (3) · Pakistan (3) · Singapore (3) · Thailand (3)
Shanna Babalonis, PhD (3) · Erol Onel (2) · Eva-Corina Caragounis, MD (2) · Giorgio Danelli, MD (2) · Hans Granhed, MD PhD (2) · Mark Bicket, MD, PhD (2) · Sirilak Suksompong, MD (2) · Thomas W Carver, MD (2) · A Lenore Ackeman, MD, PhD (1) · Acar F Koc, Professor (1) · Adriana Cadavid, MD (1) · Alexandra Kearson, BA (1) · Amit Grover, MB BCh BAO (1) · Amy Ladd, MD (1) · Ana Abad-Torrent, M.D (1)
PMID 10776874, PMID 11877663, PMID 12620949, PMID 15714323, PMID 15905753, PMID 17464603, PMID 17822322, PMID 18582827, PMID 18622068, PMID 18843636, PMID 19411668, PMID 19470987, PMID 2024744, PMID 20974443, PMID 22079773, PMID 23406078, PMID 23701786, PMID 24682079, PMID 25009196, PMID 25009197, PMID 25077099, PMID 25480319, PMID 25751701, PMID 25901477, PMID 26135695, PMID 26497721, PMID 26512604, PMID 26588217, PMID 27187854, PMID 27866303, PMID 28179349, PMID 28623906, PMID 28866754, PMID 28922235, PMID 29374733, PMID 29672193, PMID 29927703, PMID 30074928, PMID 30202425, PMID 30229370, PMID 30252709, PMID 30278932, PMID 30376537, PMID 30424939, PMID 30935731, PMID 31045633, PMID 31298153, PMID 31387410, PMID 31645288, PMID 31653800
R01DA016718 (2), R01DA045700 (2), KL2TR000370 (1), R01DA042751 (1), U01HL150568 (1), UL1TR000371 (1)