317 completed, 74 recruiting, 65 unknown, 31 not yet recruiting. 161 Phase 2, 149 Not applicable, 129 Phase 1, 47 Phase 3, 30 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis Cannabidiol (CBD), Placebo - Schizophrenia Spectrum Disorders, Cannabis Use | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2050-01-01 | 2021-04-19 | |
| A Hybrid Type 1 Randomized Controlled Trial of an Online and Text-Messaging Intervention to Prevent Alcohol and Cannabis Initiation, Escalation, and Consequences Among First-Year College Students Online and Text Message Intervention - Alcohol, Cannabis | Not applicable | Not yet recruiting | The University of Texas at Arlington | 800 | 2028-09-01 | 2026-10-30 |
| Efficacy and Safety of NTI164 in Children and Young Adults With Rett Syndrome NTI164, Placebo - RETT Syndrome With Proven MECP2 Mutation, Rett Syndrome | Phase 2 / Phase 3 | Not yet recruiting | Fenix Innovation Group | 40 | 2027-07-01 | 2026-09-09 |
| Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC) 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie - Cannabis Intoxication | Phase 1 | Not yet recruiting | Johns Hopkins University | 70 | 2027-02-01 | 2026-10-15 |
| Inhaled Cannabis for Treatment of PTSD High THC Cannabis, Placebo cannabis - Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | Multidisciplinary Association for Psychedelic Studies | 320 | 2027-02-01 | 2026-08-11 |
| Clinician Practice Companion to Address Youth Substance Use Practice Companion - Substance Use, Substance-Related Disorders | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2027-01-01 | 2026-10-07 |
| Applying Mixed Methods to Identify Links Between PTSD Symptoms, Cannabis Use, and Functional Behaviors With Personalized Feedback Intervention Development Personalized Feedback Session (PFS) - Stress Disorders, Post-Traumatic, Marijuana Abuse | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2027-01-01 | 2026-07-27 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance Cannabis - Cannabis Use, Impaired Driving | Phase 1 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-16 |
| Varenicline as a Treatment for Cannabis Use Disorder Varenicline (Chantix), Placebo - Cannabis Abuse | Phase 2 | Not yet recruiting | Medical University of South Carolina | 224 | 2026-12-01 | 2026-08-25 |
| Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis Cannabis (THC), Tobacco Cigarette - Cannabis Use, Tobacco | Early Phase 1 | Not yet recruiting | Hannah Harris | 12 | 2026-12-01 | 2026-11-04 |
| Cannabis and Opioid Use Disorder, Study 2 Inhaled Cannabis, Intranasal Opioid - Opioid Use Disorders, Cannabis Use | Phase 1 | Not yet recruiting | University of Kentucky | 100 | 2026-11-30 | 2026-10-09 |
| Cannabis Effects on Opioid Self-Administration Cannabis, Placebo Cannabis, Intranasal Opioid Agonist - Opioid Use Disorder, Cannabis Use | Phase 1 | Not yet recruiting | Shanna Babalonis, PhD | 30 | 2026-11-30 | 2026-10-14 |
| Trial of Tirzepatide for the Treatment of Cannabis Use Disorder Tirzepatide, Placebo - Cannabis Use Disorder | Phase 2 | Not yet recruiting | National Institute on Drug Abuse (NIDA) | 100 | 2026-11-15 | 2026-09-21 |
| Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder Delayed-release, extended-release methylphenidate, Placebo - ADHD, Cannabis Use Disorder | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 66 | 2026-11-01 | 2026-09-28 |
| An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms. Low-dose THC administration via IV, High-Dose THC administration via IV, Saline administration via IV - None Volunteer | Phase 2 | Not yet recruiting | King's College London | 100 | 2026-11-01 | 2026-10-16 |
| Lemborexant for Cannabis Use Disorder Lemborexant 10mg, Placebo, Brief Behavioural Intervention - Cannabis Use Disorder | Phase 1 / Phase 2 | Not yet recruiting | University of Calgary | 28 | 2026-11-01 | 2026-09-22 |
| Tolerability and Efficacy of CBD Extract for RLS Treatment BRC-002, Placecbo - Restless Leg Syndrome | Phase 2 | Not yet recruiting | University of Colorado, Denver | 60 | 2026-11-01 | 2026-10-08 |
| Haloperidol For Outpatient Symptom Management in Patients Diagnosed With Cannabinoid Hyperemesis Syndrome in the Emergrency Department Haloperidol - Cannabinoid Hyperemesis Syndrome | Early Phase 1 | Not yet recruiting | University of Illinois at Chicago | 100 | 2026-11-01 | 2026-09-01 |
| Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream Biospecimen Collection, Cannabis sativa Extract, Nicotine - Cannabis Dependence | Early Phase 1 | Not yet recruiting | Roswell Park Cancer Institute | 60 | 2026-10-15 | 2026-09-25 |
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Substance-Related Disorders (64) · Pain (35) · Psychotic Disorders (30) · Chronic Pain (24) · Schizophrenia (23) · Alcoholism (22) · Behavior, Addictive (21) · Anxiety Disorders (15) · Tobacco Use Disorder (15) · Agnosia (14) · Mental Disorders (14) · Opioid-Related Disorders (14) · Depression (13) · Marijuana Use (13)
Chemically-Induced Disorders (566) · Mental Disorders (553) · Substance-Related Disorders (503) · Pathological Conditions, Signs and Symptoms (115) · Behavior (107) · Signs and Symptoms (94) · Neurologic Manifestations (88) · Nervous System Diseases (81) · Schizophrenia Spectrum and Other Psychotic Disorders (43) · Pathologic Processes (31) · Central Nervous System Diseases (28) · Pain (27) · Neuromuscular Diseases (25) · Alcohol-Related Disorders (24) · Immune System Diseases (24)
nabiximols (109) · Dronabinol (86) · Cannabidiol (33) · Ethanol (12) · Medical Marijuana (12) · Motivational Interviewing (9) · Therapeutics (9) · Acetylcysteine (8) · Cognitive Behavioral Therapy (8) · Exercise (5) · Nicotine (5) · Sugars (5) · Transcranial Magnetic Stimulation (5) · Varenicline (5) · Atomoxetine Hydrochloride (4)
Yale University (36) · Johns Hopkins University (23) · New York State Psychiatric Institute (23) · Medical University of South Carolina (21) · University of Colorado, Denver (18) · National Institute on Drug Abuse (NIDA) (17) · University of California, San Diego (10) · University of California, Los Angeles (9) · Apurano Pharmaceuticals GmbH (8) · Centre for Addiction and Mental Health (8) · University of California, San Francisco (8) · Wayne State University (8) · Center for Medicinal Cannabis Research (7) · Massachusetts General Hospital (7) · Mclean Hospital (7)
United States (344) · Canada (60) · Germany (20) · France (18) · Israel (18) · United Kingdom (13) · Denmark (9) · Netherlands (8) · Australia (6) · Spain (6) · Hong Kong (5) · Poland (5) · Brazil (3) · Italy (3) · Puerto Rico (3)
Ziva Cooper, PhD (6) · Ryan Vandrey, PhD (5) · Kevin M Gray, MD (4) · Leslie Lundahl, PhD (4) · Shanna Babalonis, PhD (4) · Barbara J Mason, Ph.D. (3) · Deepak C D'Souza, MD (3) · Frances R Levin, M.D. (3) · Godfrey Pearlson, M.D (3) · John R Knight, MD (3) · Kevin P Hill, MD, MHS (3) · Margaret Haney, Ph.D. (3) · Margaret Haney, PhD (3) · Mohini Ranganathan, MD (3) · Ryan Vandrey, Ph.D. (3)
PMID 34532852, PMID 26144593, PMID 26257143, PMID 27436749, PMID 31527291, PMID 34173005, PMID 10259963, PMID 12648025, PMID 15094417, PMID 15695741, PMID 16223067, PMID 16317825, PMID 17063973, PMID 17355521, PMID 17429350, PMID 17566383, PMID 17916224, PMID 18182254, PMID 18620563, PMID 18728826, PMID 19099294, PMID 19587829, PMID 19883531, PMID 19896326, PMID 20076976, PMID 20347232, PMID 20576364, PMID 21049267, PMID 21176784, PMID 21185685, PMID 21296508, PMID 21359104, PMID 21397626, PMID 21408154, PMID 21671456, PMID 21865014, PMID 21869692, PMID 22076835, PMID 22373942, PMID 22578037, PMID 22795046, PMID 22879754, PMID 22921474, PMID 23052407, PMID 23141881, PMID 23146560, PMID 23171716, PMID 23179176, PMID 23188041, PMID 23327503
P50DA009236 (4), R01DA052431 (3), 2014 (2), 2019 (2), 2023 (2), 2025 (2), K12DA000357 (2), K23DA015440 (2), K23DA050808 (2), K23DA053997 (2), P60DA005186 (2), R01DA012728 (2), R01DA014296 (2), R01DA025044 (2), R01DA030988 (2)