39 terminated. 39 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 39 | Terminated 39 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients Acetaminophen and Ibuprofen, Normal saline - Delirium, Aged | Phase 4 | Terminated | Korea University Guro Hospital | 25 | 2023-06-15 | 2025-09-05 |
| Addressing Cognitive Fog in Long-COVID-19 Patients Digital cognitive behavioral intervention-RxWell, Amphetamine-Dextroamphetamine - Cognitive Impairment, Long COVID | Phase 4 | Terminated | Eva Szigethy | 7 | 2023-04-04 | 2024-07-22 |
| Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery Dexmedetomidine, Placebo - Elderly, Hip Fracture Surgery | Phase 4 | Terminated | Peking University First Hospital | 67 | 2021-11-18 | 2025-08-05 |
| 1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study) Carbidopa/levodopa, Placebo - Depression, Cognitive Impairment | Phase 4 | Terminated | New York State Psychiatric Institute | 5 | 2021-02-10 | 2023-05-22 |
| Influence of Dexmedetomidine or Propofol on ICU Delirium Dexmedetomidine, Propofol - Delirium | Phase 4 | Terminated | University Hospital, Basel, Switzerland | 37 | 2019-03-01 | 2023-06-06 |
| Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block Dexmedetomidine, Placebo - Elderly, Knee Arthroplasty | Phase 4 | Terminated | Peking University First Hospital | 3 | 2018-12-10 | 2025-08-03 |
| Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery Dexamethasone, Normal saline, Flurbiprofen axetil - Carcinoma, Non-Small-Cell Lung, Surgery--Complications | Phase 4 | Terminated | Peking University First Hospital | 126 | 2017-08-02 | 2021-07-13 |
| Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X) emtricitabine, darunavir/cobicistat, maraviroc - Hiv, Neurocognitive Dysfunction | Phase 4 | Terminated | Giovanni Di Perri | 38 | 2017-05-15 | 2020-11-06 |
| Prazosin and Cerebrospinal Fluid (CSF) Biomarkers in Mild Traumatic Brain Injury (mTBI) prazosin hydrochloride, placebo - Dementia | Phase 4 | Terminated | VA Office of Research and Development | 9 | 2016-12-01 | 2024-02-26 |
| Flumazenil for Hypoactive Delirium Secondary to Benzodiazepine Exposure Flumazenil, Placebo - Hypoactive Delirium | Phase 4 | Terminated | University of California, Davis | 22 | 2016-03-01 | 2020-07-23 |
| Effect of Cobicistat Versus Ritonavir Boosting on the Brain Permeation of Darunavir in HIV-infected Individuals Darunavir, ritonavir, cobicistat - AIDS-related Dementia Complex | Phase 4 | Terminated | University Hospital, Basel, Switzerland | 7 | 2015-07-01 | 2017-02-02 |
| Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study Metformin, Intensive Lifestyle Intervention, Standard LIfestyle Recommendation - Mild Cognitive Impairment, Insulin Resistance | Phase 4 | Terminated | SingHealth Polyclinics | 105 | 2015-03-11 | 2023-01-11 |
| Dexamethasone and Postoperative Delirium Dexamethasone, Placebo - Delirium, Postoperative Cognitive Dysfunction | Phase 4 | Terminated | Endeavor Health | 200 | 2014-04-01 | 2021-12-21 |
| Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit Methadone, Placebo - Opioid Use, Unspecified With Withdrawal, Opioid-Induced Disorders | Phase 4 | Terminated | Henry Ford Health System | 9 | 2014-01-01 | 2025-12-05 |
| Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI Propofol, Sevoflurane, Isoflurane - Delirium on Emergence | Phase 4 | Terminated | State University of New York at Buffalo | 6 | 2014-01-01 | 2019-07-23 |
| International Substudy Enigma2 on Postoperative Cognitive Disorders Nitrous Oxide, Placebo - Anesthesia, Delirium, Dementia, Amnestic, Cognitive Disorders | Phase 4 | Terminated | University Hospital, Geneva | 140 | 2013-09-01 | 2020-12-16 |
| Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia? Acetaminophen - Emergence Agitation, Pain | Phase 4 | Terminated | University of California, Los Angeles | 108 | 2012-11-01 | 2016-10-21 |
| Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia. Transdermal Methylphenidate - Dementia, Accidental Falls | Phase 4 | Terminated | St. Louis University | 14 | 2012-11-01 | 2018-07-24 |
| Nuedexta in the Treatment of Pseudobulbar Affect in Patients With Alzheimer's Disease Nuedexta (20/10) - Alzheimer's Disease, Pseudobulbar Affect (PBA) | Phase 4 | Terminated | St. Joseph's Hospital and Medical Center, Phoenix | 34 | 2012-08-28 | 2019-10-29 |
| Optimisation of Antipsychotic Drug Use in Older People Patients- dose titration - Alzheimer's Disease, Schizophrenia | Phase 4 | Terminated | Institute of Psychiatry, London | 64 | 2012-05-01 | 2017-04-19 |
Showing 20 of 39. Sign in to see all of them.
Delirium (13) · Cognitive Dysfunction (9) · Alzheimer Disease (8) · Emergence Delirium (6) · Dementia (3) · Postoperative Cognitive Complications (3) · AIDS Dementia Complex (2) · Agnosia (2) · Depression (2) · Pain (2) · Acquired Immunodeficiency Syndrome (1) · Arthritis (1) · Bipolar Disorder (1) · Brain Injuries (1)
Mental Disorders (39) · Nervous System Diseases (31) · Pathological Conditions, Signs and Symptoms (24) · Signs and Symptoms (22) · Neurologic Manifestations (21) · Neurobehavioral Manifestations (19) · Confusion (16) · Brain Diseases (12) · Central Nervous System Diseases (12) · Cognition Disorders (12) · Pathologic Processes (9) · Dementia (8) · Neurodegenerative Diseases (8) · Postoperative Complications (8)
Dexmedetomidine (4) · Galantamine (3) · Acetaminophen (2) · Cobicistat (2) · Darunavir (2) · Dexamethasone (2) · Donepezil (2) · Memantine (2) · Propofol (2) · Saline Solution (2) · Adderall (1) · Antiretroviral Therapy, Highly Active (1) · Clonidine (1) · Control Groups (1) · Emtricitabine (1)
Peking University First Hospital (3) · University Hospital, Basel, Switzerland (3) · Cady, Roger, M.D. (1) · Cantonal Hospital of St. Gallen (1) · Changhua Christian Hospital (1) · Duke University (1) · Eisai Korea Inc. (1) · Emory University (1) · Endeavor Health (1) · Eva Szigethy (1) · Giovanni Di Perri (1) · GlaxoSmithKline (1) · Henry Ford Health System (1) · Hvidovre University Hospital (1) · Icahn School of Medicine at Mount Sinai (1)
United States (19) · Switzerland (5) · China (3) · Germany (3) · South Korea (2) · Denmark (1) · Italy (1) · Netherlands (1) · Singapore (1) · Spain (1) · Taiwan (1) · United Kingdom (1)
Dong-Xin Wang, MD, PhD (2) · Ahmed A Baig, M.D. (1) · Alexa Hollinger, MD (1) · Amit Anand, MD (1) · Arjen JC Slooter, MD. PhD. (1) · Bret R Rutherford, MD (1) · Cheng-Chen Chang, M.D. (1) · Christopher Heard, MD (1) · Dong-xin Wang, Wang (1) · Eva Szigethy, MD, PhD (1) · George T Grossberg, M.D. (1) · Glenn S. Murphy, MD (1) · Heezoo Kim, MD, PhD (1) · James R Burke, PhD (1)
PMID 17667565, PMID 18813051, PMID 20802298, PMID 21056464, PMID 21889262, PMID 28575323, PMID 28710219, PMID 33189083, PMID 37906406
2009 (1), I21RX002180 (1), R01MH123660 (1)