29 completed, 6 terminated, 4 unknown, 1 recruiting. 12 Phase 2, 8 Not applicable, 7 Phase 1, 7 Phase 3, 5 Phase 4.
Follow AIDS Dementia Complex: new trials by email Literature Review of AIDS Dementia Complex trials Research Report on AIDS Dementia Complex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy SV2A PET, TSPO PET - HIV Associated Neurocognitive Disorder, HIV Dementia | Phase 1 / Phase 2 | Recruiting | Yale University | 70 | 2023-05-17 | 2026-10-14 |
| Teleneuropsychological Intervention in Asymptomatic HIV Seropositive Patients: N&C NeuroChange Cognitive stimulation program - Telerehabilitation, Neuropsychology | Not applicable | Withdrawn | Universidad Nacional Autonoma de Mexico | 2022-05-16 | 2024-07-03 | |
| Exploring Racial Disparities in Sleep Health and Neurocognitive Function electroencephalography (EEG) and event related potentials (ERP) - HIV Dementia | Not applicable | Completed | University of Alabama, Tuscaloosa | 30 | 2021-01-01 | 2024-05-10 |
| Rural Dementia Caregiver Project Building Better Caregivers Workshop, Attention Control - Depression, Stress, Psychological | Not applicable | Completed | University of California, San Francisco | 418 | 2020-06-05 | 2025-07-17 |
| HIV-HEART Aging Study HIV Infections, Coronary Disease | Unknown | University Hospital, Essen | 2000 | 2020-05-11 | 2024-07-30 | |
| PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects 18F-FDOPA, 11C-DASB - Depression, HIV Infections | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 46 | 2018-11-20 | 2023-03-21 |
| Effect of Galantamine on Inflammation and Cognition Galantamine, Placebo - HIV Associated Cognitive Motor Complex | Phase 2 | Completed | University of Pennsylvania | 63 | 2017-10-30 | 2024-10-17 |
| Intranasal Insulin for the Treatment of HAND Insulin, intranasal, Placebo, intranasal - HIV Dementia, HIV-Associated Cognitive Motor Complex | Phase 1 / Phase 2 | Terminated | Johns Hopkins University | 21 | 2017-08-01 | 2021-07-07 |
| Individualized Cognitive Training in HIV Individualized Cognitive Training, No-Contact Control - HIV-Associated Cognitive Motor Complex, Aging | Not applicable | Completed | University of Alabama at Birmingham | 109 | 2017-07-27 | 2021-10-19 |
| HIV&HEART Aging Study (12,5 Year Follow up) HIV Infections, Coronary Disease | Completed | University Hospital, Essen | 1809 | 2017-07-03 | 2020-02-05 | |
| SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Nasal Brushing - Encephalopathy, HIV-encephalopathy | Phase 4 | Unknown | University of Turin, Italy | 250 | 2016-03-01 | 2022-05-26 |
| Mental Ability Challenge Study in Adults With and Without HIV Scopolamine Injectable Product, Mecamylamine Pill - HIV-1-infection, Aging, Premature | Completed | Vanderbilt University Medical Center | 22 | 2015-12-01 | 2019-02-25 | |
| Effect of Cobicistat Versus Ritonavir Boosting on the Brain Permeation of Darunavir in HIV-infected Individuals Darunavir, ritonavir, cobicistat - AIDS-related Dementia Complex | Phase 4 | Terminated | University Hospital, Basel, Switzerland | 7 | 2015-07-01 | 2017-02-02 |
| Maraviroc and NeuroAIDS Pathogenesis Maraviroc, Placebo - AIDS Dementia Complex | Phase 2 / Phase 3 | Completed | University of Hawaii | 48 | 2015-06-01 | 2021-08-30 |
| Evaluation of the Role of OCT in the Detection of HIV-associated Neurocognitive Disorder Optical Coherence Tomography - AIDS-Related Dementia Complex | Not applicable | Completed | Centre Hospitalier Universitaire Saint Pierre | 55 | 2015-04-01 | 2022-03-31 |
| Ferumoxytol-enhanced Imaging and Mapping in neuroAIDS Ferumoxytol - AIDS Dementia Complex | Phase 2 | Completed | Beau Nakamoto | 30 | 2015-02-01 | 2017-10-27 |
| A Prospective Observational Trial to Determine Cardiovascular Diseases in HIV-infected Patients Comprehensive non invasive cardiovascular examination - HIV-infection, Coronary Heart Disease | Completed | University Hospital, Essen | 1519 | 2014-10-01 | 2019-10-01 | |
| Effect of Cenicriviroc on HIV Neurocognitive Impairment cenicriviroc - AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex | Phase 2 | Completed | University of Hawaii | 20 | 2014-04-01 | 2020-08-20 |
| Downmodulating Monocyte Activation for HIV-1 Associated Neurocognitive Disorders (HAND) Atorvastatin (generic Lipitor), placebo - HIV Dementia | Phase 4 | Completed | University of Pennsylvania | 11 | 2013-01-01 | 2020-11-23 |
| A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV Long acting methylphenidate, Matched placebo - HIV Dementia | Phase 3 | Unknown | University of California, Los Angeles | 40 | 2012-05-01 | 2012-05-16 |
Showing 20 of 41. Sign in to see all of them.
HIV Infections (20) · Acquired Immunodeficiency Syndrome (11) · Cognitive Dysfunction (5) · Coronary Disease (3) · Heart Failure (3) · Inflammation (3) · Myocardial Infarction (3) · Neurocognitive Disorders (3) · AIDS-Related Complex (2) · Alzheimer Disease (2) · Dementia (2) · Depression (2) · Aging, Premature (1) · Brain Diseases (1)
Blood-Borne Infections (41) · Communicable Diseases (41) · Genital Diseases (41) · Immune System Diseases (41) · Immunologic Deficiency Syndromes (41) · Infections (41) · Lentivirus Infections (41) · Mental Disorders (41) · Nervous System Diseases (41) · RNA Virus Infections (41) · Retroviridae Infections (41) · Sexually Transmitted Diseases (41) · Sexually Transmitted Diseases, Viral (41) · Urogenital Diseases (41) · Virus Diseases (41)
Zidovudine (6) · (methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine (2) · Atorvastatin (2) · CPI 1189 (2) · Darunavir (2) · Ferrosoferric Oxide (2) · Maraviroc (2) · Ritonavir (2) · Selegiline (2) · abacavir (2) · lopinavir-ritonavir drug combination (2) · 1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one (1) · 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile (1) · Antiretroviral Therapy, Highly Active (1) · Atazanavir Sulfate (1)
National Institute of Allergy and Infectious Diseases (NIAID) (7) · University Hospital, Essen (3) · University of Hawaii (3) · University of Pennsylvania (3) · Centaur Pharmaceuticals (2) · Glaxo Wellcome (2) · Johns Hopkins University (2) · National Institute of Mental Health (NIMH) (2) · Beau Nakamoto (1) · Bristol-Myers Squibb (1) · Cantonal Hospital of St. Gallen (1) · Centre Hospitalier Universitaire Saint Pierre (1) · Holdsworth House Medical Practice (1) · National Institutes of Health Clinical Center (CC) (1) · The HIV Netherlands Australia Thailand Research Collaboration (1)
United States (30) · Germany (3) · Switzerland (2) · Australia (1) · Belgium (1) · Canada (1) · Italy (1) · Mexico (1) · Puerto Rico (1) · Thailand (1) · Uganda (1) · United Kingdom (1)
Bradford Navia (2) · Ronald G Collman, MD (2) · Ardis A Moe, M.D. (1) · B Brew (1) · Beau K Nakamoto, MD, PhD (1) · Beau Nakamoto, MD, PhD (1) · C Hall (1) · Cecilia M. Shikuma, M.D. (1) · Cecilia Shikuma, MD (1) · Clifford DB (1) · David Simpson, M.D. (1) · Dima A Hammoud, M.D. (1) · Edgar R Landa, PhD (1)
PMID 15257881, PMID 17513188, PMID 17666313, PMID 17721095, PMID 18042509, PMID 19890073, PMID 20002869, PMID 20024643, PMID 20400412, PMID 20739268, PMID 20802298, PMID 21181521, PMID 21450595, PMID 21764468, PMID 22027640, PMID 22254197, PMID 23117698, PMID 24352352, PMID 25227930, PMID 28575323, PMID 29764716, PMID 30202890, PMID 30586079, PMID 30586083, PMID 30676359, PMID 30711264, PMID 30865059, PMID 31259847, PMID 31436599, PMID 33449578, PMID 34028959, PMID 34864757, PMID 35363623, PMID 36057375, PMID 36930373, PMID 37675901, PMID 37897201, PMID 41164840
P30AI045008 (1), R01AG057855 (1), R01DA044906 (1), R01MH058076 (1), R01MH125396 (1), R21NR016632 (1), R21NS087951 (1)