189 completed, 26 unknown, 15 terminated, 10 active not recruiting. 82 Phase 4, 65 Phase 2, 45 Phase 3, 31 Phase 1, 28 Not applicable.
Follow Emtricitabine: new trials by email Literature Review of Emtricitabine trials Research Report on Emtricitabine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Repurposing a Combination Antiretroviral Drug Therapy to Target Retrotransposons and Treat Early Alzheimer's Disease Emtricitabine and tenofovir disoproxil fumarate combination, Placebo - Alzheimer's Disease | Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 20 | 2026-12-01 | 2026-08-31 |
| An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in Africa Dolutegravir (DTG), Abacavir (ABC), Lamivudine (3TC) - HIV Infection | Phase 3 | Not yet recruiting | University College, London | 800 | 2026-11-01 | 2026-08-28 |
| Dolutegravir/Lamivudine in Treatment-Naïve Pregnant Women Dolutegravir/Lamivudine 50 MG-300 MG Oral Tablet [DOVATO], TDF/XTC or TAF/FTC plus Dolutegravir (XTC stand for lamivudine OR emtricitabine) - HIV-1-infection | Phase 4 | Recruiting | Fundación Huésped | 210 | 2026-09-10 | 2026-09-18 |
| Bioequivalence Study of ADC118 Tablets in Healthy Chinese Volunteers Under Fasting Conditions ACC118-Test, Reference - Human Immunodeficiency Virus (HIV) Infection | Phase 1 | Completed | Jiangsu Aidea Pharmaceutical Group Co., Ltd. | 48 | 2026-04-10 | 2026-08-10 |
| Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention Lenacapavir Injection, Emtricitabine/tenofovir disoproxil fumarate (F/TDF), Emtricitabine/tenofovir alafenamide (F/TAF) - HIV Infections | Recruiting | Gilead Sciences | 3000 | 2026-03-17 | 2026-10-21 | |
| A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) VH4524184, Emtricitabine (FTC) and tenofovir alafenamide (TAF) Fixed Dose Combination (FDC) tablets, Dolutegravir / Lamivudine (DTG/3TC) - HIV Infections | Phase 2 | Recruiting | ViiV Healthcare | 186 | 2026-02-11 | 2026-07-23 |
| Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers tenofovir alafenamide [TAF] 50 mg/emtricitabine [FTC] 400mg - Healthy Volunteer, HIV Prevention | Phase 1 | Recruiting | Johns Hopkins University | 24 | 2026-01-06 | 2026-02-13 |
| Reverse Transcriptase Inhibitors in Aicardi Goutières Syndrome Tenofovir (TDF) and Emtricitabine (FTC), Placebo - Aicardi Goutières Syndrome | Phase 1 / Phase 2 | Withdrawn | Children's Hospital of Philadelphia | 2025-12-01 | 2025-05-01 | |
| A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010) MK-8527, Emtricitabine/tenofovir disoproxil (FTC/TDF), Placebo matched to MK-8527 - Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis | Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 4580 | 2025-11-10 | 2026-10-20 |
| Improving Access to PrEP (HIV Prevention Medication) for People in Underserved Areas of Rio de Janeiro Oral Pre-Exposure Prophylaxis (PrEP) (Tenofovir Disoproxil Fumarate/Emtricitabine), Community-Based PrEP Delivery Model, Telehealth and mHealth Support - HIV Infections | Not applicable | Recruiting | Oswaldo Cruz Foundation | 400 | 2025-09-01 | 2026-05-13 |
| Research on the Psychological Status of Patients With HIV-1 Infection All kinds of INSTI medications, All kinds of conventional medications - HIV-1-infection, Anxiety Depression | Not yet recruiting | Shanxi Bethune Hospital | 500 | 2025-08-01 | 2025-07-23 | |
| Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study Emtricitabine (FTC), Descovy® (TAF/FTC), Placebo to Match Emtricitabine 200mg/Tenofovir Alafenamide 25 mg. - Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD) | Phase 1 | Active not recruiting | National University Hospital, Singapore | 48 | 2025-06-30 | 2026-08-10 |
| DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infection Doravirine + tenofovir DF + lamivudine, Dolutegravir + tenofovir DF + lamivudine or emtricitabine - HIV-1-infection | Phase 3 | Recruiting | ANRS, Emerging Infectious Diseases | 610 | 2025-01-27 | 2026-07-27 |
| UNIVERSAL 1: Pharmacokinetic Study of a Novel DTG/FTC/TAF Dose Ratio for Children dolutegravir (DTG)/emtricitabine (FTC)/tenofovir alafenamide (TAF) regimen, Dolutegravir (DTG)/ Emtricitabine (FTC)/tenofovir alafenamide (TAF) - HIV Infection | Phase 2 | Completed | PENTA Foundation | 53 | 2024-12-11 | 2026-03-04 |
| Study of Lenacapavir Taken Twice a Year for HIV Pre-Exposure Prophylaxis (PrEP) Lenacapavir Injection, Lenacapavir Tablet, Emtricitabine/tenofovir disoproxil fumarate (F/TDF) - Pre-Exposure Prophylaxis of HIV Infection | Phase 2 | Active not recruiting | Gilead Sciences | 268 | 2024-10-07 | 2026-06-15 |
| Antiviral Clinical Trial for Long Covid-19 tenofovir disoproxil/emtricitabine, Selzentry, Placebo - Long Covid | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 90 | 2024-10-01 | 2026-03-13 |
| Accelerated ART Initiation for PWHIV Who Are Out of Care The Accelerate model of care, bictegravir/emtricitabine/tenofovir alafenamide 50/200/25 mg - HIV Infections, ART | Phase 4 | Active not recruiting | University of Missouri-Columbia | 120 | 2024-04-29 | 2026-08-05 |
| Impact of Long-acting Injectable Cabotegravir for HIV PrEP in MSM in France. Cabotegravir Tablets, for oral use., Cabotegravir Extended-Release Injectable Suspension, for intramuscular use., Tenofovir disoproxil/Emtricitabine 300mg/200mg fixed-dose combination tablets, for oral use - Prevention | Phase 3 | Not yet recruiting | ANRS, Emerging Infectious Diseases | 322 | 2024-04-01 | 2024-02-23 |
| Implementing Oral (Event-driven and Daily) and Long-acting Pre-Exposure Prophylaxis in Mobile Men in Sub-Saharan Africa Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC), cabotegravir (CAB-LA), Cabotegravir (CAB-LA), Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC) - HIV | Phase 3 | Not yet recruiting | MRC/UVRI and LSHTM Uganda Research Unit | 400 | 2024-04-01 | 2023-11-15 |
| Doravirine Versus Integrase Inhibitors on Backbone of Emtricitabine and Tenofovir Alafenamide in HIV Doravirine 100 Mg - HIV I Infection, Cardiovascular Risk Factor | Early Phase 1 | Completed | University of Texas Southwestern Medical Center | 26 | 2024-03-01 | 2026-01-30 |
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HIV Infections (115) · Acquired Immunodeficiency Syndrome (44) · Hepatitis B (9) · Hepatitis B, Chronic (8) · Infections (6) · COVID-19 (4) · Homosexuality (4) · Sexually Transmitted Diseases (4) · Alzheimer Disease (3) · Cognitive Dysfunction (3) · HIV Seropositivity (3) · Hepatitis C (3) · Medication Adherence (3) · Cardiovascular Diseases (2) · Coitus (2)
National Institute of Allergy and Infectious Diseases (NIAID) (18) · Gilead Sciences (15) · ANRS, Emerging Infectious Diseases (10) · University of North Carolina, Chapel Hill (8) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (7) · ViiV Healthcare (7) · French National Agency for Research on AIDS and Viral Hepatitis (6) · Johns Hopkins University (6) · Kirby Institute (6) · Asian-Pacific Alliance of Liver Disease, Beijing (5) · Bristol-Myers Squibb (5) · University of California, San Diego (5) · Emory University (4) · Merck Sharp & Dohme LLC (4) · St Stephens Aids Trust (4)
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