Brain Injuries: Clinical Trials

1400 completed, 516 unknown, 388 recruiting, 181 terminated. 1435 Not applicable, 241 Phase 2, 118 Phase 1, 114 Phase 3, 88 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	1435	Completed 721, Unknown 244, Recruiting 198, Not yet recruiting 87, Terminated 72, Withdrawn 48, Active not recruiting 37, Enrolling by invitation 24, Suspended 4
Phase 2	241	Completed 104, Recruiting 33, Unknown 30, Terminated 28, Withdrawn 21, Not yet recruiting 15, Enrolling by invitation 5, Active not recruiting 3, Suspended 2
Phase 1	118	Completed 60, Unknown 18, Recruiting 17, Withdrawn 8, Not yet recruiting 5, Terminated 5, Active not recruiting 3, Enrolling by invitation 2
Phase 3	114	Completed 47, Terminated 20, Recruiting 17, Unknown 14, Not yet recruiting 10, Withdrawn 4, Active not recruiting 1, Suspended 1
Phase 4	88	Completed 38, Unknown 18, Terminated 13, Recruiting 8, Not yet recruiting 6, Withdrawn 3, Enrolling by invitation 1, Suspended 1
Early Phase 1	34	Unknown 11, Completed 9, Recruiting 5, Withdrawn 4, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1, Suspended 1, Terminated 1

Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury	Phase 2	Not yet recruiting	University of California, Los Angeles	264	2028-01-10	2026-01-16
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury MUSE Stem Cell Therapy - Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients		Not yet recruiting	Healing Hope International	10	2028-01-01	2026-03-10
Behavior Therapy vs Education for Persistent Headache After Mild TBI Headache reprocessing, Headache education - Post-Traumatic Headache	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2027-10-01	2025-12-26
Self-Management Training Among Individuals With TBI Participants will be referred to a community based self-management training program - Traumatic Brain Injury	Not applicable	Not yet recruiting	Boston University Charles River Campus	85	2027-09-01	2026-08-03
Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery Exercise, Return to Activity Progression - Concussion (Diagnosis), Gait Abnormality	Not applicable	Not yet recruiting	Northern Illinois University	30	2027-08-02	2026-10-27
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium		Not yet recruiting	University of Texas Southwestern Medical Center	300	2027-07-01	2026-10-23
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic		Not yet recruiting	University of Texas Southwestern Medical Center	300	2027-07-01	2026-10-23
Correlation and Rapid Analysis of Neurological Injury Using Markers Traumatic Brain Injury (TBI) Patients		Not yet recruiting	Università Vita-Salute San Raffaele	200	2027-06-01	2026-04-29
Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury	Phase 2	Not yet recruiting	Nova Scotia Health Authority	45	2027-06-01	2026-10-09
Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries	Phase 2	Not yet recruiting	VA Office of Research and Development	46	2027-05-24	2026-02-17
Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards Nature Immersion Therapy - Dementia, Acquired Brain Injury Including Stroke	Not applicable	Not yet recruiting	Changi General Hospital	1600	2027-05-01	2026-03-23
Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury	Phase 2 / Phase 3	Not yet recruiting	Northwestern University	432	2027-05-01	2026-08-13
Blood NfL and Functional Outcomes After Moderate-to-Severe TBI neurofilament light chain ECLIA - Traumatic Brain Injury		Not yet recruiting	Rutgers, The State University of New Jersey	175	2027-05-01	2026-10-28
Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study Deep brain stimulation - Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury)	Not applicable	Not yet recruiting	ReEmerge, Inc.	40	2027-02-01	2026-07-28
Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments Locomotion in a virtual reality setting - Traumatic Brain Injury	Not applicable	Recruiting	Pôle Saint Hélier	40	2027-01-04	2026-09-17
hCG Treatment for Rehabilitation From a TBI Ovidrel, Placebo - Traumatic Brain Injury	Early Phase 1	Not yet recruiting	VA Office of Research and Development	50	2027-01-01	2026-10-19
Dynamic, Real-world Learning, Innovative Mobility, and Versatile Exploration (DRIVE): Evaluating a Dose-matched Developmental Powered Mobility Intervention for Young Children With Cerebral Palsy Permobil Explorer Mini, MORE-PT - Cerebral Palsy	Not applicable	Not yet recruiting	University of Washington	48	2027-01-01	2026-10-15
Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II Optimal cerebral perfusion pressure - Traumatic Brain Injury, Severe Traumatic Brain Injury	Not applicable	Not yet recruiting	Maastricht University Medical Center	62	2027-01-01	2026-09-28
Paired VNS For TBI Rehabilitation VNS for TBI group - Traumatic Brain Injury, TBI (Traumatic Brain Injury)	Not applicable	Not yet recruiting	Stony Brook University	20	2027-01-01	2026-08-13
Sleep MAPP in the Polytrauma/TBI System of Care Sleep MAPP Care Pathway - Insomnia Disorder, Mild Traumatic Brain Injury	Not applicable	Not yet recruiting	VA Office of Research and Development	900	2027-01-01	2026-10-21

Showing 20 of 2900. Sign in to see all of them.

Narrower conditions

Brain Injuries, Traumatic (1684)  ·  Brain Concussion (634)  ·  Stroke (255)  ·  Stress Disorders, Post-Traumatic (123)  ·  Craniocerebral Trauma (121)  ·  Post-Concussion Syndrome (95)  ·  Cognitive Dysfunction (92)  ·  Cerebral Palsy (76)  ·  Subarachnoid Hemorrhage (73)  ·  Wounds and Injuries (73)  ·  Consciousness Disorders (72)  ·  Spinal Cord Injuries (71)  ·  Depression (65)  ·  Multiple Sclerosis (54)

Broader conditions

Central Nervous System Diseases (2874)  ·  Nervous System Diseases (2867)  ·  Brain Diseases (2864)  ·  Trauma, Nervous System (2845)  ·  Wounds and Injuries (2797)  ·  Craniocerebral Trauma (2748)  ·  Pathological Conditions, Signs and Symptoms (786)  ·  Wounds, Nonpenetrating (671)  ·  Head Injuries, Closed (643)  ·  Cardiovascular Diseases (500)  ·  Brain Injuries, Traumatic (494)  ·  Signs and Symptoms (493)  ·  Vascular Diseases (483)  ·  Mental Disorders (469)

Interventions

Transcranial Direct Current Stimulation (39)  ·  Exercise (31)  ·  Sodium Chloride (31)  ·  Rehabilitation (25)  ·  Standard of Care (25)  ·  Therapeutics (25)  ·  Blood Specimen Collection (23)  ·  Saline Solution (23)  ·  Hyperbaric Oxygenation (22)  ·  Transcranial Magnetic Stimulation (22)  ·  Magnetic Resonance Imaging (19)  ·  Magnetic Resonance Spectroscopy (17)  ·  Cognitive Behavioral Therapy (16)  ·  Cognitive Training (16)  ·  Dexmedetomidine (15)

Sponsors

VA Office of Research and Development (85)  ·  Kessler Foundation (45)  ·  University of Washington (35)  ·  Children's Hospital Medical Center, Cincinnati (31)  ·  University of Pittsburgh (28)  ·  Copenhagen University Hospital, Rigshospitalet (24)  ·  Assistance Publique - Hôpitaux de Paris (23)  ·  University of Calgary (23)  ·  University of Aarhus (22)  ·  The University of Texas Health Science Center, Houston (21)  ·  University of British Columbia (20)  ·  Massachusetts General Hospital (18)  ·  Assiut University (17)  ·  Icahn School of Medicine at Mount Sinai (17)  ·  Indiana University (17)

Countries

United States (1388)  ·  France (178)  ·  Canada (177)  ·  Italy (117)  ·  China (106)  ·  United Kingdom (83)  ·  Denmark (72)  ·  Spain (72)  ·  Israel (55)  ·  Germany (51)  ·  Switzerland (49)  ·  Egypt (43)  ·  Sweden (37)  ·  Norway (34)  ·  Netherlands (32)

Top investigators

Gregory D Myer, PhD (12)  ·  Ramon Diaz-Arrastia, MD, PhD (10)  ·  Eric M Wassermann, M.D. (9)  ·  Flora Hammond, MD (7)  ·  Jian-Xin Zhou, MD (6)  ·  Leslie Prichep, Ph.D. (6)  ·  Nieto Luis, Master (6)  ·  Noah Silverberg, PhD (6)  ·  Anthony P Kontos, PhD (5)  ·  David R Howell, PhD (5)  ·  Jeanne M Hoffman, PhD (5)  ·  Jeffrey S Kreutzer, PhD (5)  ·  Leighton Chan, M.D. (5)  ·  Lisa A Brenner, PhD (5)  ·  Luca Padua, MD, phD (5)

Results publications

PMID 30413559, PMID 29717652, PMID 31405391, PMID 32228157, PMID 20722504, PMID 20825903, PMID 21515904, PMID 21675055, PMID 21876461, PMID 22224835, PMID 22771222, PMID 23359586, PMID 24040943, PMID 24574549, PMID 25325609, PMID 25727167, PMID 26452709, PMID 26537996, PMID 26866876, PMID 27089287, PMID 27567470, PMID 27654000, PMID 28901969, PMID 29253420, PMID 30098189, PMID 30099354, PMID 30215286, PMID 31271691, PMID 31299040, PMID 31377190, PMID 31394600, PMID 31394602, PMID 31394603, PMID 32278572, PMID 33201041, PMID 34813082, PMID 34873185, PMID 35065038, PMID 35170571, PMID 36585608, PMID 39382077, PMID 40353282, PMID 40440029, PMID 41114449, PMID 10228089, PMID 10424561, PMID 10446825, PMID 10625862, PMID 10668696, PMID 10668904

NIH funding

2018 (7), UL1TR001412 (4), 2017 (3), 2019 (3), 2025 (3), R61MH138612 (3), 2008 (2), 2016 (2), 2023 (2), U01HL077863 (2), 1DP2NS148743-01 (1), 1IK2RD000464-01A2 (1), 1IK2RX001136-01A2 (1), 1IK2RX003073-01A2 (1), 1IK2RX003494-01A2 (1)