42 completed, 7 terminated, 5 unknown, 4 recruiting. 30 Phase 1, 13 Phase 4, 7 Phase 2, 7 Phase 3, 3 Not applicable.
Follow Cobicistat: new trials by email Literature Review of Cobicistat trials Research Report on Cobicistat
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Compared With Darunavir/Cobicistat Plus Tenofovir Alafenamide/Emtricitabine in Virologically Suppressed People Living With HIV at 24 and 48 Weeks of Follow-up Dual therapy: darunavir/cobicistat + lamivudine, Triple therapy: darunavir/cobicistat plus tenofovir alafenamide/emtricitabine - HIV Infection, Antiretroviral Therapy | Phase 4 | Recruiting | Instituto Mexicano del Seguro Social | 78 | 2025-07-10 | 2026-07-01 |
| Effect of Dolutegravir Compared With Darunavir/Cobicistat on the Severity of Neuropsychiatric Effects al 12 Weeks in Antirretroviral Treatment-Naive Adults. Dolutegravir (DTG), Darunavir/Cobicistat (FDC) - HIV, Insomnia | Phase 4 | Unknown | Instituto Mexicano del Seguro Social | 140 | 2025-06-19 | 2025-06-26 |
| KF2024#1-trial: Esketamine Interaction Study Esketamine Nasal Spray, Esketamine 28 mg, Cobicistat 150 MG - Drug Interactions, Food-drug Interaction | Phase 1 | Completed | Helsinki University Central Hospital | 12 | 2024-12-09 | 2026-03-05 |
| A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments F/TAF (High Dose Tablet), F/TAF (Low Dose Tablet), F/TAF (Lowest Dose Tablet) - HIV-1-infection | Phase 4 | Recruiting | Gilead Sciences | 350 | 2024-08-27 | 2026-10-19 |
| A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Participants. Plixorafenib, Cobicistat - Healthy Participants | Phase 1 | Completed | Fore Biotherapeutics | 28 | 2024-04-24 | 2026-03-27 |
| Improving Osimertinib Exposure and Cost-effectiveness Using Pharmacokinetic Boosting With Cobicistat Cobicistat - Non-small Cell Lung Cancer | Phase 4 | Unknown | Maastricht University Medical Center | 60 | 2024-04-01 | 2024-08-09 |
| A Trial to Assess Cobicistat Boosted Venetoclax in Combination With Azacitidine in Adult Patients With Newly Diagnosed AML azacitidine, Venetoclax, Cobicistat - AML, Adult | Phase 2 | Recruiting | Stichting Hemato-Oncologie voor Volwassenen Nederland | 142 | 2024-01-17 | 2026-09-23 |
| Electrophysiological Effects of Potential QT Prolonging Drugs Clarithromycin, Pimozide, Placebo (Part 1) - Drug-induced QT Prolongation, Pharmacokinetics | Phase 1 | Completed | Food and Drug Administration (FDA) | 44 | 2023-03-21 | 2023-06-22 |
| A Trial of Cobicistat and Gemcitabine and Nab-Paclitaxel in Patients with Advanced Stage or Metastatic Pancreatic Ductal Adenocarcinoma Cobicistat Oral Tablet, Gemcitabin, Nab paclitaxel - CYP3A Inhibitor, Advanced Stage or Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 | Terminated | German Cancer Research Center | 6 | 2022-12-07 | 2025-03-25 |
| A Study of PBI-200 With Ritonavir or Cobicistat in Healthy Volunteers PBI-200 Tablet, Ritonavir Oral Tablet, Cobicistat Oral Tablet - Drug-drug Interaction | Phase 1 | Completed | Pyramid Biosciences | 21 | 2022-09-09 | 2023-01-20 |
| Drug-Drug Interaction Study of Vesatolimod in Adults With HIV-1 Who Have Very Low or Undetectable Virus Levels Vesatolimod, Cobicistat, Voriconazole - Human Immunodeficiency Virus Type 1 (HIV-1) Infection | Phase 1 | Terminated | Gilead Sciences | 18 | 2022-08-19 | 2024-12-03 |
| A Study to Compare the Drug Levels of Atazanavir and Cobicistat Between the Coadministration of Age-Appropriate Mini-Tablet Formulations and the Coadministration of the Individual Reference Products in Healthy Adults Under Fed Conditions Atazanavir, Cobicistat, Atazanavir/Cobicistat Mini-tablet - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 42 | 2022-05-13 | 2022-10-31 |
| Pharmacokinetic Boosting of Olaparib to Improve Exposure, Tolerance and Cost-effectiveness Olaparib, Cobicistat - Cancer | Phase 4 | Unknown | Radboud University Medical Center | 160 | 2021-12-15 | 2024-06-12 |
| Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum Bictegravir (BIC), Tenofovir alafenamide (TAF), Long-acting injectable formulation of cabotegravir (CAB LA) - HIV, Tuberculosis | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 205 | 2021-09-01 | 2026-08-26 | |
| A Study of Darunavir in the Presence of Cobicistat When Administered as a Fixed Dose Combination Under Fed Conditions Darunavir, Cobicistat, Darunavir/Cobicistat FDC - Healthy | Phase 1 | Completed | Janssen Research & Development, LLC | 22 | 2021-01-26 | 2025-02-03 |
| A Study in Healthy Participants to Assess the Effect of Darunavir, Emtricitabine, and Tenofovir Alafenamide in the Presence of Cobicistat as Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared With Co-administration of the Separate Agents Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide FDC, Darunavir, Emtricitabine/Tenofovir Alafenamide - Healthy | Phase 1 | Completed | Janssen Research & Development, LLC | 37 | 2021-01-05 | 2025-02-03 |
| Pharmacokinetic Boosting of Osimertinib Cobicistat - Non Small Cell Lung Cancer | Early Phase 1 | Completed | Academisch Ziekenhuis Maastricht | 11 | 2020-11-01 | 2022-09-26 |
| Contribution of Dolutegravir to Obesity and Cardiovascular Disease Dolutegravir 50 MG, Antiretroviral/Anti HIV - HIV-1-infection, Antiviral Drug Adverse Reaction | Phase 4 | Completed | Augusta University | 10 | 2020-09-17 | 2023-07-27 |
| A Study to Examine the Acceptable Taste and to Estimate the Amount of Atazanavir and Cobicistat in the Body When Taken as a Combination Product Versus When Taken as Separate Products at the Same Time Atazanavir/Cobicistat, Reyataz Atazanavir, Cobicistat - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 34 | 2020-02-26 | 2021-11-23 |
| Clinical Trial to Evaluate Pharmacological Interactions Between γ-hydroxybutyrate (GHB) and Cobicistat Cobicistat 150 MG, Placebo, GHB - Pharmacokinetic Interactions, HIV | Phase 1 | Completed | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 12 | 2020-01-30 | 2020-07-22 |
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Acquired Immunodeficiency Syndrome (16) · HIV Infections (12) · Infections (3) · Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Leukemia, Myeloid, Acute (2) · AIDS Dementia Complex (1) · Adenocarcinoma (1) · Anxiety Disorders (1) · Body Weight Changes (1) · Carcinoma (1) · Cardiovascular Abnormalities (1) · Chemsex (1) · Cognition Disorders (1) · Depression (1)
Gilead Sciences (10) · Bristol-Myers Squibb (4) · St Stephens Aids Trust (4) · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (2) · Instituto Mexicano del Seguro Social (2) · Janssen Research & Development, LLC (2) · Janssen Sciences Ireland UC (2) · Janssen Scientific Affairs, LLC (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · National Institutes of Health Clinical Center (CC) (2) · Radboud University Medical Center (2) · ViiV Healthcare (2) · A.O. Ospedale Papa Giovanni XXIII (1) · Academisch Ziekenhuis Maastricht (1) · Augusta University (1)
United States (32) · Netherlands (11) · Puerto Rico (10) · United Kingdom (9) · Belgium (6) · Canada (6) · Germany (6) · Italy (6) · Spain (6) · Thailand (6) · Australia (5) · Brazil (4) · Dominican Republic (4) · France (4) · Mexico (4)
Colleen M Hadigan, M.D. (2) · Mark Mirochnick, MD (2) · Marshall Fordyce, MD (2) · Marta Boffito (2) · Aditya H. Gaur, MD (1) · Angela R Smith, M.D. (1) · Colleen Kelley, MD (1) · David Burger, PharmD, PhD (1) · Geoffrey S Gottlieb, MD PhD (1) · Graeme Moyle, MD, MBBS, Dip GUN (1)
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