265 completed. 265 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 265 | Completed 265 |
Follow Neurocognitive Disorders: new trials by email Literature Review of Neurocognitive Disorders trials Research Report on Neurocognitive Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Health Benefits of Nutraceutical Supplementation in Older Adults. Powder containing whey isolate and herbal extracts (30g sachet) - Age-related Functional Decline, Mild Cognitive Impairment | Phase 4 | Completed | GPLIFE HEALTHCARE PRIVATE LIMITED | 23 | 2025-12-24 | 2026-04-16 |
| Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients Dexmedetomidine, Dexmedetomidine-esketamine combination - Older Patients, Postoperative Care | Phase 4 | Completed | Peking University First Hospital | 100 | 2025-10-21 | 2026-06-30 |
| Mexidol® Efficacy and Safety in Treatment of VCIND in Older Adults Mexidol, Standard Therapy - Vascular Cognitive Impairment no Dementia | Phase 4 | Completed | Pharmasoft | 120 | 2025-09-14 | 2026-07-14 |
| Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery Ciprofol, Propofol - Postoperative Delirium (POD) | Phase 4 | Completed | Wang Tianlong | 225 | 2024-12-23 | 2026-06-30 |
| Satisfaction With Orodispersible vs Conventional Memantine in Moderate to Severe Alzheimer's Disease Memantine, Memantine Oral Tablet - Alzheimer Disease | Phase 4 | Completed | Carnot Laboratories | 105 | 2024-10-04 | 2026-02-18 |
| Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium Dexmedetomidine, Esketamine, Normal saline - Older Patients, Nasal Administration | Phase 4 | Completed | Peking University First Hospital | 340 | 2024-09-02 | 2025-07-31 |
| Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children Dexmedetomidine Hydrochloride, Midazolam, normal Saline - Behavior Problem | Phase 4 | Completed | Fujian Provincial Hospital | 324 | 2024-05-22 | 2026-07-30 |
| Anti-Diabetic Medications to Fight PD and LBD Sitagliptin, Dapagliflozin, Placebo - Lewy Body Dementia, Parkinson Disease | Phase 4 | Completed | Mayo Clinic | 18 | 2024-05-07 | 2026-01-28 |
| Intravenous Magnesium Sulphate Versus Dexmedetomidine for Prevention of Emergence Agitation in Adult Otorhinolaryngologic Surgery Magnesium sulphate, Dexmedetomidine - Adults Undergoing Otorhinolaryngology Surgery | Phase 4 | Completed | Universitas Indonesia | 64 | 2024-05-01 | 2026-04-22 |
| Assess the Effect of Metaxalone 640 mg (M640) Compared to Tizanidine 8 mg on Truck Driving Ability and Cognition metaxalone m640 mg, tizanidine 8mg - Cognitive Impairment | Phase 4 | Completed | Primus Pharmaceuticals | 20 | 2024-04-29 | 2026-09-11 |
| Efficacy of Oral Midazolam for Sedation and Amnesia in Preschool Children Undergoing Dental Procedures Oral midazolam - Dental Anxiety | Phase 4 | Completed | Hanoi Medical University | 80 | 2024-04-01 | 2025-03-25 |
| Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation Propofol, Dexmedetomidine - Emergence Agitation | Phase 4 | Completed | Ain Shams University | 80 | 2024-03-15 | 2025-10-02 |
| Real World Effectiveness and Safety of Deutetrabenazine in Adult Chinese Participants With Huntington's Disease (HD) Chorea in China Deutetrabenazine - Huntington's Disease, Chorea | Phase 4 | Completed | Teva Branded Pharmaceutical Products R&D LLC | 50 | 2024-02-02 | 2026-08-27 |
| Dexmedetomidine and Postoperative Cognitive Dysfunction (POCD) Dexmedetomidine, Sevoflurane - Postoperative Cognitive Dysfunction, Postoperative Pain | Phase 4 | Completed | Udayana University | 112 | 2024-01-07 | 2024-04-19 |
| The Occurrence of Emergence Agitation in Pediatric Strabismus Surgery Bridion 200 MG in 2 ML Injection, Pyridostigmine Bromide 5 MG/ML - Emergence Delirium, Strabismus | Phase 4 | Completed | Konkuk University Medical Center | 76 | 2023-12-01 | 2026-07-15 |
| Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries Remifentanil, dexmedetomidin - Cognitive Dysfunction, Opioid Free Anesthesia | Phase 4 | Completed | Kocaeli University | 48 | 2023-09-01 | 2025-01-27 |
| Efficacy of Suvorexant on Post-operative Sleep Disturbance Suvorexant, Placebo - Postoperative Insomnia, Postoperative Delirium | Phase 4 | Completed | Columbia University | 100 | 2023-05-01 | 2026-07-23 |
| Impact of Flumazenil on the Emergence Delirium Flumazenil - Anesthesia, General | Phase 4 | Completed | Korea University Guro Hospital | 68 | 2023-03-05 | 2023-09-06 |
| Feasibility Study on the Use of Redormin®500 on Day-time Cognition Valerian-Hop Extract, Placebo - Sleep Disorders, Circadian Rhythm, Cognitive Dysfunction | Phase 4 | Completed | Max Zeller Soehne AG | 40 | 2023-03-01 | 2026-06-11 |
| Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT) ketamine, fentanyl - Postoperative Pain, Acute, Emergence Delirium | Phase 4 | Completed | Medipol University | 59 | 2023-01-01 | 2024-10-30 |
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Alzheimer Disease (86) · Cognitive Dysfunction (67) · Dementia (47) · Emergence Delirium (37) · Delirium (34) · Cognition Disorders (21) · Depression (13) · Psychomotor Agitation (11) · Postoperative Cognitive Complications (10) · Schizophrenia (10) · Parkinson Disease (9) · Psychotic Disorders (8) · Stroke (8) · Lewy Body Disease (7) · Depressive Disorder, Major (6)
Mental Disorders (262) · Nervous System Diseases (213) · Central Nervous System Diseases (139) · Brain Diseases (138) · Pathological Conditions, Signs and Symptoms (119) · Neurodegenerative Diseases (104) · Signs and Symptoms (102) · Neurologic Manifestations (98) · Neurobehavioral Manifestations (88) · Tauopathies (87) · Dementia (78) · Cognition Disorders (77) · Confusion (65) · Pathologic Processes (59)
Dexmedetomidine (35) · Donepezil (26) · Memantine (26) · Saline Solution (17) · Rivastigmine (16) · Propofol (13) · Sodium Chloride (13) · Sevoflurane (9) · Ketamine (8) · Midazolam (8) · Escitalopram (7) · Haloperidol (7) · Galantamine (6) · Risperidone (6) · Sugars (6)
Novartis (8) · Novartis Pharmaceuticals (7) · Peking University First Hospital (7) · Eisai Inc. (6) · NYU Langone Health (5) · New York State Psychiatric Institute (5) · University of California, Los Angeles (5) · University of Pennsylvania (5) · VA Office of Research and Development (5) · Avid Radiopharmaceuticals (4) · H. Lundbeck A/S (4) · University of Maryland, Baltimore (4) · Ain Shams University (3) · Eisai Korea Inc. (3) · Emory University (3)
United States (106) · China (28) · South Korea (16) · Canada (10) · Egypt (8) · France (7) · Italy (7) · Turkey (Türkiye) (6) · Germany (5) · Japan (5) · Netherlands (5) · Norway (5) · Russia (5) · Spain (5) · Denmark (4)
Dong-Xin Wang, MD, PhD (5) · Davangere Devanand, M.D. (3) · Helen Lavretsky, M.D. (3) · Anita Murthy (2) · John P Handrakis, PT, DPT, EdD (2) · Knut Engedal, Ph D (2) · Malaz Boustani, MD, MPH (2) · Nathan Herrmann, MD (2) · Robert W Buchanan, M.D. (2) · Ronald G Collman, MD (2) · Adam L. Boxer, M.D., Ph.D. (1)
PMID 33189083, PMID 19617584, PMID 35833913, PMID 37142273, PMID 10070549, PMID 10511011, PMID 10588403, PMID 10913502, PMID 11072948, PMID 1130742, PMID 11903027, PMID 12556542, PMID 12640407, PMID 12760985, PMID 14595310, PMID 15114210, PMID 16469995, PMID 16494088, PMID 17060562, PMID 17179249, PMID 17183151, PMID 17986678, PMID 18198262, PMID 18251622, PMID 18372935, PMID 18591575, PMID 18611150, PMID 19210951, PMID 19253247, PMID 19389332, PMID 19812461, PMID 19874395, PMID 19908166, PMID 20040554, PMID 20047899, PMID 20220576, PMID 20429946, PMID 20656516, PMID 20712261, PMID 20729148, PMID 20740210, PMID 2102683, PMID 21062616, PMID 21274364, PMID 21309294, PMID 21390159, PMID 21476613, PMID 21484501, PMID 21561398, PMID 21645184
2005 (2), 2004 (1), 2008 (1), 2014 (1), 2015 (1), 2017 (1), 2019 (1), I01RX003143 (1), K23AA017666 (1), P30AG028747 (1), P30AI045008 (1), P50AG016574 (1), P50NS062684 (1), R01AG015866 (1), R01AG018487 (1)