512 completed, 205 unknown, 169 recruiting, 69 not yet recruiting. 372 Not applicable, 133 Phase 2, 103 Phase 3, 68 Phase 1, 54 Phase 4.
Follow Brain Ischemia: new trials by email Literature Review of Brain Ischemia trials Research Report on Brain Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), Aspirin Tablet - Cerebral Infarction | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| Human Umbilical Cord Mesenchymal Stem Cell Therapy (19#iSCLife®-CI) for Cerebral Infarction Patients in Convalescent Period. Allogeneic umbilical cord mesenchymal stem cell, Aspirin Enteric-coated Tablets & Atorvastatin Calcium - Cerebral Infarction | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| Integrating Wearable Monitoring and Clinical Data for Stroke Early Warning Huawei HAY20, AI agent dialogue - Stroke, Ischemic Stroke | Not yet recruiting | Affiliated Hospital of Nantong University | 5000 | 2026-12-01 | 2026-11-04 | |
| Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury Acute Brain Injury, Traumatic Brain Injury | Not yet recruiting | Virginia Commonwealth University | 220 | 2026-11-30 | 2026-08-19 | |
| Upfront Lipid-Lowering Therapy With Statins Combined With Hybutimibe in Patients With Acute Ischemic Stroke or Transient Ischemic Attack. Atorvastatin, Hybutimibe 10mg QD - Ischemia Stroke, TIA (Transient Ischemic Attack) | Phase 3 | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 520 | 2026-11-30 | 2026-11-04 |
| TicAgreLor Versus Placebo to Prevent Cerebral ISCHemia in anEuRysmal Low Grade SAH A Double Blinded Randomised Controlled Study Experimental group: ticagrelor, Control group: placebo - Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia | Phase 3 | Not yet recruiting | University Hospital, Toulouse | 274 | 2026-11-24 | 2026-11-06 |
| PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Multisite) 64Cu-NODAGA-CANF - Carotid Atherosclerosis, Carotid Artery Stenosis Asymptomatic | Not yet recruiting | Washington University School of Medicine | 30 | 2026-11-18 | 2026-11-04 | |
| Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH) Decompressive craniectomy - Aneurysmal Subarachnoid Hemorrhage | Not yet recruiting | University Hospital, Essen | 10000 | 2026-11-01 | 2026-10-14 | |
| Cardiac CT Angiography in Acute Stroke Imaging (SCOPE-CT) Cardiac CT Angiography - Acute Ischemic Stroke and Transient Ischemic Attacks | Not applicable | Not yet recruiting | Ottawa Hospital Research Institute | 50 | 2026-10-26 | 2026-10-27 |
| Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Yongjun Wang | 1440 | 2026-10-16 | 2026-10-22 |
| Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke Zastaprazan, Placebo - Ischemic Stroke, Transient Ischemic Attack | Phase 3 | Not yet recruiting | Asan Medical Center | 984 | 2026-10-15 | 2026-10-09 |
| The PROTECT-HIE Pilot Trial Dobutamine, TnECHO - Hypoxic-ischemic Encephalopathy (HIE) | Phase 2 | Recruiting | University of Alberta | 40 | 2026-10-13 | 2026-11-05 |
| iBCI Optimization for Veterans With Paralysis Mobile neural decoding platform (mobile iBCI) - Spinal Cord Injury, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 2 | 2026-10-02 | 2026-07-27 |
| Cilostazol for Prevention of Recurrent Stroke Trial Cilostazol 100 mg Tablets, Placebo - Stroke Recurrence, Myocardial Infarction | Phase 3 | Not yet recruiting | Stanford University | 2000 | 2026-10-01 | 2026-10-26 |
| Neuro-MoD: Neuroplasticity With Motor Development Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS) - Perinatal Brain Injury | Not applicable | Recruiting | University of Wisconsin, Madison | 8 | 2026-10-01 | 2026-10-19 |
| Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy Sildenafil Citrate (IV) - Hypoxic-Ischemic Encephalopathy | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-10-01 | 2026-03-31 |
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Stroke (439) · Ischemic Attack, Transient (326) · Hypoxia-Ischemia, Brain (244) · Ischemic Stroke (233) · Cerebral Infarction (206) · Brain Infarction (92) · Cerebrovascular Disorders (77) · Brain Diseases (50) · Atrial Fibrillation (46) · Cardiovascular Diseases (42) · Vascular Diseases (41) · Infarction, Middle Cerebral Artery (40) · Nervous System Diseases (40) · Brain Injuries (38)
Central Nervous System Diseases (1055) · Nervous System Diseases (1048) · Vascular Diseases (1047) · Cardiovascular Diseases (1046) · Brain Diseases (1038) · Cerebrovascular Disorders (1011) · Pathological Conditions, Signs and Symptoms (770) · Pathologic Processes (541) · Necrosis (399) · Infarction (392) · Ischemia (379) · Signs and Symptoms (328) · Stroke (292) · Brain Infarction (283)
Aspirin (44) · Clopidogrel (22) · Cilostazol (12) · Saline Solution (11) · Hypothermia, Induced (10) · Magnetic Resonance Imaging (10) · Tissue Plasminogen Activator (9) · Blood Specimen Collection (8) · Exercise (8) · Ticagrelor (8) · Transcranial Direct Current Stimulation (8) · Warfarin (8) · Rivaroxaban (7) · Rosuvastatin Calcium (7) · Standard of Care (7)
Assistance Publique - Hôpitaux de Paris (17) · Beijing Tiantan Hospital (14) · University College, London (12) · Asan Medical Center (9) · Capital Medical University (9) · National Institute of Neurological Disorders and Stroke (NINDS) (9) · University of Alberta (9) · University of Wisconsin, Madison (9) · Xuanwu Hospital, Beijing (9) · University of California, San Francisco (8) · Charite University, Berlin, Germany (7) · Sunnybrook Health Sciences Centre (7) · University of British Columbia (7) · VA Office of Research and Development (7) · Assiut University (6)
United States (250) · China (166) · France (93) · Canada (82) · Germany (69) · United Kingdom (59) · South Korea (46) · Denmark (34) · Spain (33) · Italy (31) · Switzerland (28) · Sweden (27) · Japan (25) · Turkey (Türkiye) (25) · Netherlands (24)
Seetha Shankaran, MD (5) · Abhik Das, PhD (4) · Anup Katheria, MD (3) · Barbara J. Stoll, MD (3) · Brenda B. Poindexter, MD MS (3) · Brian Kalish, MD (3) · Dawn M. Bravata, MD (3) · Kathleen A. Kennedy, MD MPH (3) · Krisa P. Van Meurs, MD (3) · Kurt Schibler, MD (3) · Masayasu Matsumoto, MD, PhD (3) · Michael D Weiss, MD (3)
PMID 24524452, PMID 22163120, PMID 34813082, PMID 35835616, PMID 40391684, PMID 22068990, PMID 23803136, PMID 24957314, PMID 25009491, PMID 25120466, PMID 25964753, PMID 26157378, PMID 27695404, PMID 28455318, PMID 28487349, PMID 29915123, PMID 30355202, PMID 30400876, PMID 30824558, PMID 31378071, PMID 31708447, PMID 32475159, PMID 32792079, PMID 32813884, PMID 33175411, PMID 33428177, PMID 33493046, PMID 35538232, PMID 35703097, PMID 36398903, PMID 36907985, PMID 37652700, PMID 37987871, PMID 39342159, PMID 39901803, PMID 41250198, PMID 41508158, PMID 42559950, PMID 10356105, PMID 10499938, PMID 10648324, PMID 10700504, PMID 10763759, PMID 10811152, PMID 11703564, PMID 11944746, PMID 12165594, PMID 12568169, PMID 14977901, PMID 15035006
U10HD021364 (4), U10HD021373 (4), U10HD021385 (4), U10HD027851 (4), U10HD027853 (4), U10HD027856 (4), U10HD027880 (4), U10HD027904 (4), U10HD034216 (4), U10HD040492 (4), U10HD040689 (4), 2016 (3), 2023 (3), U10HD027871 (3), U10HD036790 (3)