509 completed, 206 unknown, 164 recruiting, 67 not yet recruiting. 369 Not applicable, 133 Phase 2, 101 Phase 3, 68 Phase 1, 54 Phase 4.
Follow Brain Ischemia: new trials by email Literature Review of Brain Ischemia trials Research Report on Brain Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), Aspirin Tablet - Cerebral Infarction | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| Human Umbilical Cord Mesenchymal Stem Cell Therapy (19#iSCLife®-CI) for Cerebral Infarction Patients in Convalescent Period. Allogeneic umbilical cord mesenchymal stem cell, Aspirin Enteric-coated Tablets & Atorvastatin Calcium - Cerebral Infarction | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury Acute Brain Injury, Traumatic Brain Injury | Not yet recruiting | Virginia Commonwealth University | 220 | 2026-11-30 | 2026-08-19 | |
| Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH) Decompressive craniectomy - Aneurysmal Subarachnoid Hemorrhage | Not yet recruiting | University Hospital, Essen | 10000 | 2026-11-01 | 2026-10-14 | |
| Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke Zastaprazan, Placebo - Ischemic Stroke, Transient Ischemic Attack | Phase 3 | Not yet recruiting | Asan Medical Center | 984 | 2026-10-15 | 2026-10-09 |
| The PROTECT-HIE Pilot Trial Dobutamine, TnECHO - Hypoxic-ischemic Encephalopathy (HIE) | Phase 2 | Recruiting | University of Alberta | 40 | 2026-10-13 | 2026-10-20 |
| iBCI Optimization for Veterans With Paralysis Mobile neural decoding platform (mobile iBCI) - Spinal Cord Injury, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 2 | 2026-10-02 | 2026-07-27 |
| Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy Sildenafil Citrate (IV) - Hypoxic-Ischemic Encephalopathy | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-10-01 | 2026-03-31 |
| Cilostazol for Prevention of Recurrent Stroke Trial Cilostazol 100 mg Tablets, Placebo - Stroke Recurrence, Myocardial Infarction | Phase 3 | Not yet recruiting | Stanford University | 2000 | 2026-10-01 | 2026-10-15 |
| Safely Quenching Complement in Stroke Survivors Pegcetacoplan Injection [Empaveli] - Acute Ischemic Stroke, Cerebral Infarction | Phase 1 | Not yet recruiting | Columbia University | 20 | 2026-10-01 | 2026-04-29 |
| Clinical Significance of Internal Carotid Artery Dolichoarteriopathy Internal Carotid Artery Dolichoarteriopathy, Carotid Artery Tortuosity | Not yet recruiting | Kuban State Medical University | 560 | 2026-10-01 | 2026-10-20 | |
| Neuro-MoD: Neuroplasticity With Motor Development Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS) - Perinatal Brain Injury | Not applicable | Recruiting | University of Wisconsin, Madison | 8 | 2026-10-01 | 2026-10-19 |
| Epidiolex Trial for Presymptomatic Treatment of Sturge-Weber Syndrome Epidiolex 100 mg/mL Oral Solution - Sturge - Weber Syndrome (SWS) | Phase 2 | Recruiting | Johns Hopkins University | 10 | 2026-09-17 | 2026-10-02 |
| EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 310 | 2026-09-16 | 2026-08-13 | |
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study TAU + Group Therapy (EAET), Treatment as Usual (TAU) - Aquired Brain Injury, Stroke | Not applicable | Recruiting | Uppsala University | 110 | 2026-09-15 | 2026-10-01 |
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Stroke (435) · Ischemic Attack, Transient (321) · Hypoxia-Ischemia, Brain (243) · Ischemic Stroke (229) · Cerebral Infarction (206) · Brain Infarction (92) · Cerebrovascular Disorders (76) · Brain Diseases (50) · Atrial Fibrillation (45) · Cardiovascular Diseases (41) · Vascular Diseases (41) · Nervous System Diseases (40) · Brain Injuries (38) · Infarction, Middle Cerebral Artery (38)
Central Nervous System Diseases (1047) · Nervous System Diseases (1040) · Cardiovascular Diseases (1039) · Vascular Diseases (1039) · Brain Diseases (1030) · Cerebrovascular Disorders (1004) · Pathological Conditions, Signs and Symptoms (765) · Pathologic Processes (536) · Necrosis (397) · Infarction (390) · Ischemia (377) · Signs and Symptoms (327) · Stroke (289) · Brain Infarction (281)
Aspirin (44) · Clopidogrel (22) · Cilostazol (12) · Saline Solution (11) · Hypothermia, Induced (10) · Magnetic Resonance Imaging (10) · Tissue Plasminogen Activator (9) · Blood Specimen Collection (8) · Exercise (8) · Ticagrelor (8) · Transcranial Direct Current Stimulation (8) · Warfarin (8) · Rivaroxaban (7) · Rosuvastatin Calcium (7) · Dabigatran (6)
Assistance Publique - Hôpitaux de Paris (17) · Beijing Tiantan Hospital (14) · University College, London (12) · Asan Medical Center (9) · Capital Medical University (9) · National Institute of Neurological Disorders and Stroke (NINDS) (9) · University of Alberta (9) · University of Wisconsin, Madison (9) · Xuanwu Hospital, Beijing (9) · University of California, San Francisco (8) · Charite University, Berlin, Germany (7) · Sunnybrook Health Sciences Centre (7) · University of British Columbia (7) · VA Office of Research and Development (7) · Assiut University (6)
United States (249) · China (164) · France (93) · Canada (81) · Germany (68) · United Kingdom (59) · South Korea (46) · Denmark (34) · Spain (32) · Italy (30) · Sweden (27) · Switzerland (27) · Japan (25) · Turkey (Türkiye) (25) · Netherlands (23)
Seetha Shankaran, MD (5) · Abhik Das, PhD (4) · Anup Katheria, MD (3) · Barbara J. Stoll, MD (3) · Brenda B. Poindexter, MD MS (3) · Brian Kalish, MD (3) · Dawn M. Bravata, MD (3) · Kathleen A. Kennedy, MD MPH (3) · Krisa P. Van Meurs, MD (3) · Kurt Schibler, MD (3) · Masayasu Matsumoto, MD, PhD (3) · Michael D Weiss, MD (3)
PMID 24524452, PMID 22163120, PMID 34813082, PMID 35835616, PMID 40391684, PMID 22068990, PMID 23803136, PMID 24957314, PMID 25009491, PMID 25120466, PMID 25964753, PMID 26157378, PMID 27695404, PMID 28455318, PMID 28487349, PMID 29915123, PMID 30355202, PMID 30400876, PMID 30824558, PMID 31378071, PMID 31708447, PMID 32475159, PMID 32792079, PMID 32813884, PMID 33175411, PMID 33428177, PMID 33493046, PMID 35538232, PMID 35703097, PMID 36398903, PMID 36907985, PMID 37652700, PMID 37987871, PMID 39342159, PMID 39901803, PMID 41250198, PMID 41508158, PMID 42559950, PMID 10356105, PMID 10499938, PMID 10648324, PMID 10700504, PMID 10763759, PMID 10811152, PMID 11703564, PMID 11944746, PMID 12165594, PMID 12568169, PMID 14977901, PMID 15035006
U10HD021364 (4), U10HD021373 (4), U10HD021385 (4), U10HD027851 (4), U10HD027853 (4), U10HD027856 (4), U10HD027880 (4), U10HD027904 (4), U10HD034216 (4), U10HD040492 (4), U10HD040689 (4), 2016 (3), 2023 (3), U10HD027871 (3), U10HD036790 (3)