Heart Septal Defects, Atrial: Clinical Trials

72 completed, 38 unknown, 34 recruiting, 16 not yet recruiting. 79 Not applicable, 13 Phase 3, 11 Phase 4, 8 Phase 2, 2 Early Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	79	Completed 28, Recruiting 16, Unknown 16, Not yet recruiting 7, Active not recruiting 4, Terminated 3, Withdrawn 3, Enrolling by invitation 1, Suspended 1
Phase 3	13	Completed 3, Terminated 3, Active not recruiting 2, Recruiting 2, Unknown 2, Withdrawn 1
Phase 4	11	Completed 4, Unknown 3, Not yet recruiting 2, Recruiting 1, Suspended 1
Phase 2	8	Completed 3, Unknown 3, Terminated 1, Withdrawn 1
Early Phase 1	2	Completed 2
Phase 1	2	Completed 2

Follow Heart Septal Defects, Atrial: new trials by email Literature Review of Heart Septal Defects, Atrial trials Research Report on Heart Septal Defects, Atrial

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale	Not applicable	Not yet recruiting	Luciano A. Sposato	2400	2027-03-01	2026-09-18
Dapagliflozin and Right Heart Recovery After ASD Device Closure trans catheter device closure - ASD2(Secundum Atrial Septal Defect)	Not applicable	Not yet recruiting	Assiut University	70	2026-11-01	2026-09-17
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale	Phase 3	Recruiting	Columbia University	32	2026-10-15	2026-10-08
The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema		Not yet recruiting	University of Texas Southwestern Medical Center	50	2026-09-15	2026-08-03
Hummingbird ICE Study ICE Image Guidance - ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Atrial Fibrillation (AF)		Not yet recruiting	Philips Clinical & Medical Affairs Global	1000	2026-09-01	2026-08-19
Comparing Two PFO Closure Devices in Adults With Previous Stroke or TIA PFO Closure procedure - Patent Foramen Ovale, Stroke	Not applicable	Recruiting	Giuseppe Tarantini	1260	2026-07-24	2026-10-05
Safety and Efficacy of the Patent Foramen Ovale Suture System for the Closure of Patent Foramen Ovale Patent Foramen Ovale Suture System, Amplatzer PFO Occluder - Patent Foramen Ovale (PFO)	Not applicable	Not yet recruiting	Shenzhen Bihe Medical Co., Ltd	244	2026-06-30	2026-07-27
Evaluating Percutaneous Repair Of The Atrial Septum With A Novel PFO Occluder: The PROTEA-PFO OUS Study Recross P3 Occluder (P3O) System - PFO, PFO - Patent Foramen Ovale	Not applicable	Recruiting	Recross Cardio, Inc.	15	2026-06-17	2026-07-13
Long-term Outcomes After Percutaneous Patent Foramen Ovale Closure (Severance PFO Registry) Patent Foramen Ovale, Cryptogenic Stroke		Recruiting	Yonsei University	400	2026-06-05	2026-07-23
Safety and Efficacy of the AbsnowTM II Absorbable Atrial Septal Defect Closure System for Atrial Septal Defect Closure Therapy Absnow II Absorbable Atrial Septal Defect Occluder System, Cera Atrial Septal Defect Occluder - Atrial Septal Defect	Not applicable	Not yet recruiting	Lifetech Scientific (Shenzhen) Co., Ltd.	236	2026-04-01	2026-04-14
A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWire Ultrasound-guided intervention with assistance of specialized instruments, fluoroscopy-guided intervention - Atrial Septal Defect (ASD)	Phase 4	Not yet recruiting	Chinese Academy of Medical Sciences, Fuwai Hospital	666	2026-03-14	2026-03-17
Utility of the Perclose ProGlide™ Suture-Mediated Closure Device After Cardiologic Procedures Via the Femoral Vein Approach (Eight-Clover) Perclose ProStyle™ Suture-Mediated Closure System, Conventional Hemostasis (Manual Compression or Figure-of-Eight Suture) - Atrial Fibrillation, Atrial Septal Defect	Not applicable	Enrolling by invitation	Ewha Womans University Mokdong Hospital	200	2026-02-02	2026-09-18
Pulmonary Embolism and Right-to-Left Shunts Pulmonary Embolism (PE), Right-to-Left Shunt		Recruiting	Tufts Medical Center	256	2026-01-30	2026-04-09
Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine Percutaneous Patent Foramen Ovale Closure, No Intervention - Migraine Disorders, Patent Foramen Ovale	Not applicable	Recruiting	First Affiliated Hospital Xi'an Jiaotong University	150	2026-01-14	2026-01-16
Non-Invasive Detection of Right-to-Left Cardiac Shunts Point-of-care ultrasound - Patent Foramen Ovale (PFO)		Recruiting	Scripps Health	75	2026-01-07	2026-02-19
Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device Transcranial Ultrasound Device - Hereditary Haemorrhagic Telangiectasia, PFO - Patent Foramen Ovale	Not applicable	Recruiting	St. Antonius Hospital	40	2026-01-07	2026-02-17
Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder System Active Comparator, Experimental - Cardiovascular Diseases, Cardiovascular Abnormality	Not applicable	Not yet recruiting	Shanghai Lingsi Medical Technology Co., Ltd.	258	2025-12-30	2025-12-23
A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in a Mobile Surgical Unit Mobile Surgical Vehicle Echocardiography-guided ASD closure Group, Conventional Operating Room Echocardiography-guided ASD closure Group - ASD - Atrial Septal Defect	Phase 4	Not yet recruiting	China National Center for Cardiovascular Diseases	300	2025-12-19	2025-12-09
SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs Anticoagulation PFO closure, Medication - Ischemic Stroke, Embolic Stroke of Undetermined Source		Recruiting	Taichung Veterans General Hospital	400	2025-12-16	2026-03-23
Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac Surgery Sugammadex - Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery		Recruiting	Dr. Nguyen Thi Thu Hang	80	2025-12-04	2026-09-01

Showing 20 of 193. Sign in to see all of them.

Narrower conditions

Foramen Ovale, Patent (135)  ·  Stroke (40)  ·  Ischemic Stroke (31)  ·  Migraine Disorders (26)  ·  Atrial Fibrillation (16)  ·  Heart Defects, Congenital (12)  ·  Ischemic Attack, Transient (11)  ·  Heart Septal Defects, Ventricular (10)  ·  Ductus Arteriosus, Patent (7)  ·  Cardiovascular Diseases (6)  ·  Heart Diseases (6)  ·  Epilepsy (5)  ·  Heart Septal Defects (5)  ·  Heart Valve Diseases (5)

Broader conditions

Congenital Abnormalities (192)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (192)  ·  Cardiovascular Abnormalities (191)  ·  Heart Septal Defects (188)  ·  Cardiovascular Diseases (187)  ·  Heart Diseases (187)  ·  Heart Defects, Congenital (181)  ·  Nervous System Diseases (88)  ·  Brain Diseases (82)  ·  Central Nervous System Diseases (82)  ·  Vascular Diseases (68)  ·  Cerebrovascular Disorders (60)  ·  Pathological Conditions, Signs and Symptoms (28)  ·  Headache Disorders (27)

Interventions

Aspirin (8)  ·  Clopidogrel (7)  ·  Septal Occluder Device (5)  ·  Dexmedetomidine (3)  ·  Echocardiography (3)  ·  Aspirin, Dipyridamole Drug Combination (2)  ·  Dipyridamole (2)  ·  Drug Delivery Systems (2)  ·  Prasugrel Hydrochloride (2)  ·  Rivaroxaban (2)  ·  Sodium Chloride (2)  ·  apixaban (2)  ·  Anesthesia, Conduction (1)  ·  Anesthesia, General (1)  ·  Anesthesia, Local (1)

Sponsors

Abbott Medical Devices (12)  ·  Lifetech Scientific (Shenzhen) Co., Ltd. (11)  ·  W.L.Gore & Associates (7)  ·  Chinese Academy of Medical Sciences, Fuwai Hospital (6)  ·  China National Center for Cardiovascular Diseases (4)  ·  Assistance Publique - Hôpitaux de Paris (3)  ·  Carag AG (3)  ·  Cierra (3)  ·  National Heart, Lung, and Blood Institute (NHLBI) (3)  ·  University Health Network, Toronto (3)  ·  University of Oregon (3)  ·  Yonsei University (3)  ·  Asan Medical Center (2)  ·  Assiut University (2)  ·  Cardiox Corporation (2)

Countries

United States (49)  ·  China (26)  ·  Germany (25)  ·  France (19)  ·  Canada (17)  ·  Italy (11)  ·  South Korea (11)  ·  Switzerland (9)  ·  United Kingdom (7)  ·  Belgium (5)  ·  Denmark (5)  ·  Egypt (5)  ·  Poland (5)  ·  Ireland (4)  ·  Netherlands (4)

Top investigators

Eric Horlick, MD (3)  ·  Lusine Abrahamyan, MD, PhD (3)  ·  Robert Sommer, MD (3)  ·  Andrew Lovering, PhD (2)  ·  Daniela Trabattoni, MD (2)  ·  David Dodick, MD (2)  ·  Horst Sievert, MD (2)  ·  Horst Sievert, Prof. Dr. (2)  ·  Mark Reisman, MD (2)  ·  Ronald Lauer (2)  ·  Werner Budts, MD, PhD (2)  ·  Xiangbin Pan, Doctor (2)  ·  Aditya K Kaza (1)  ·  Akiva Tamir, M.D (1)  ·  Alan M. Haltiner, Ph.D. (1)

Results publications

PMID 32381162, PMID 34032839, PMID 36891906, PMID 12045168, PMID 13678932, PMID 15232117, PMID 19380621, PMID 19808512, PMID 21051670, PMID 21356042, PMID 22417252, PMID 22958084, PMID 23514285, PMID 24630875, PMID 24762035, PMID 25147037, PMID 25313847, PMID 25967578, PMID 26470854, PMID 26551304, PMID 26908949, PMID 27056964, PMID 27649347, PMID 27966652, PMID 28633478, PMID 28801537, PMID 28874164, PMID 28902580, PMID 28902593, PMID 29090661, PMID 29191325, PMID 29368313, PMID 29544871, PMID 29910193, PMID 31060047, PMID 31133575, PMID 31140194, PMID 31211145, PMID 31612072, PMID 32083653, PMID 32208831, PMID 32797064, PMID 32847382, PMID 32965476, PMID 33303305, PMID 33789756, PMID 34006504, PMID 34015096, PMID 34259012, PMID 34455822

NIH funding

2019 (2), P50HL042266 (1), P50HL062178 (1), R01HL039052 (1), R01NS032525 (1), R01NS067139 (1), R56HL128813 (1)