101 completed, 35 unknown, 10 not yet recruiting, 9 recruiting. 120 Not applicable, 19 Phase 4, 8 Phase 3, 5 Early Phase 1, 5 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Multiple Nerve Blocks on the Recovery of Patients Undergoing Off Pump CABG Surgeries regional nerve block with local anesthesia, Placebo - Ischemic Heart Disease (IHD), Off-pump Coronary Artery Bypass | Not applicable | Recruiting | Ain Shams University | 30 | 2026-09-10 | 2026-08-31 |
| Microwave Intervention Under Local Anesthesia Local Anesthesia (lidocaine hydrochloride) - Localised Prostate Cancer | Not applicable | Not yet recruiting | Koelis | 20 | 2026-06-15 | 2026-05-19 |
| Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System - Paroxysmal Atrial Fibrillation | Not applicable | Recruiting | China National Center for Cardiovascular Diseases | 390 | 2026-06-01 | 2026-10-16 |
| Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG) - Total Knee Arthroplasty (TKA) | Phase 1 / Phase 2 | Recruiting | University of Chicago | 150 | 2026-03-11 | 2026-06-26 |
| The Effects of Conventional Therapy on Tinnitus, Disability, and Quality of Life in Patients With Tinnitus Neural Therapy of Huneke, Betahistine 24 mg bid (Betaserc) - Tinnitus, Neural Therapy of Huneke | Not applicable | Not yet recruiting | Sisli Hamidiye Etfal Training and Research Hospital | 30 | 2026-03-01 | 2026-03-23 |
| Effect of Adrenaline (1:80,000) Containing Local Anesthesia on Glycemic Level of Diabetic and Healthy Individuals Undergoing Tooth Extraction Local anesthesia with 1:80000 adrenaline - Glycemic Level | Not applicable | Active not recruiting | Dow University of Health Sciences | 90 | 2026-02-21 | 2026-06-08 |
| Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection Botulinium toxin type A injection, Local Anesthesia - Pain Management, Pain | Not applicable | Not yet recruiting | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) | 100 | 2026-02-15 | 2026-02-25 |
| Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible Pulpitis infiltration anesthesia alone, mandibular anesthesia alone, infiltration anesthesia combined with cryotherapy - Irreversible Pulpitis, Cryotherapy | Not applicable | Not yet recruiting | TC Erciyes University | 100 | 2026-01-30 | 2026-02-11 |
| Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesia in Open-Heart Surgery SPSIPB blcok, Parasternal blocks, Local Infiltration - Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Open-heart Surgery | Not applicable | Completed | Bursa City Hospital | 70 | 2026-01-15 | 2026-04-29 |
| M-TAPA Block for Analgesia After Open-Heart Surgery M TAPA block, Parasternal blocks, Local infiltration - Postoperative Pain, Acute Pain | Not applicable | Not yet recruiting | Bursa City Hospital | 80 | 2026-01-15 | 2025-11-19 |
| Intra-Articular PRP Versus Dexamethasone for TMJ Internal Derangement Platelet-Rich Plasma (PRP), Dexamethasone with Local Anaesthetic, Normal Saline (Placebo) - Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement | Not applicable | Completed | University Of Anbar | 30 | 2025-12-10 | 2026-07-09 |
| Oct Angiography Changes After Local Anesthesia in Cataract Surgery Local Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML), Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML), Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML) - OCTA Changes With Local Anesthesia | Not applicable | Not yet recruiting | Sohag University | 100 | 2025-12-01 | 2025-12-23 |
| The Effect of Adding a Local Anesthetic to Transforaminal Epidural Injection in Cervical Disc Herniation. servical transforaminal epidural steroid injection with local anaesthetic, servical transforaminal epidural steroid injection without local anaesthetic - Transforaminal Epidural Injection, Dorsal Root Ganglion Stimulation | Not applicable | Active not recruiting | Aydin Adnan Menderes University | 100 | 2025-11-19 | 2026-02-09 |
| Pain and Anxiety in Pediatric Dentistry: Computer-Controlled vs. Traditional Anesthesia Digital Anesthesia with SleeperOne 5, Infiltration Anesthesia with a Metal Cartridge Syringe, Mandibular Block Anesthesia with a Metal Cartridge Syringe - Traditional Local Anesthesia, Computer-controlled Electronic Anesthesia | Not applicable | Not yet recruiting | Dicle University | 84 | 2025-10-01 | 2025-09-05 |
| Hysteroscopy Anesthesia for Relief of Pain Local paracervical Anesthesia, Placebo - Pain Management, Outpatient Hysteroscopy | Not applicable | Not yet recruiting | Maimónides Biomedical Research Institute of Córdoba | 70 | 2025-09-06 | 2025-09-17 |
| Photobiomodulation and Tooth Analgesia Photobiomodulation, Topical Benzocaine, Local Anesthesia - Dental Anaesthesia, Dental Pain | Not applicable | Recruiting | University of Maryland, Baltimore | 200 | 2025-07-07 | 2026-08-12 |
| Topical Cryoanesthesia Versus Benzocaine in Pediatric Dentistry Local Anesthesia (lidocaine hydrochloride) - Local Anesthetic Infiltration, Topical Anesthesia | Phase 3 | Completed | Universidad Autonoma de San Luis Potosí | 28 | 2025-06-15 | 2026-01-20 |
| Neural Therapy in Cesareans neural therapy - Visual Analogue Scale | Not yet recruiting | Haseki Training and Research Hospital | 156 | 2025-06-10 | 2025-05-31 | |
| A Study of Changes to Prostate Procedures Prostate Biopsy, Local anesthesia - Prostate Cancer | Phase 3 | Recruiting | Memorial Sloan Kettering Cancer Center | 800 | 2025-05-19 | 2026-09-15 |
| Evaluation of the Feasibility of a Study Comparing Local Anesthesia and General Anesthesia in Conservative Surgery for Breast Cancer conservative surgery for breast cancer with local anesthesia, conservative surgery for breast cancer with general anesthesia - Breast Cancer | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Besancon | 60 | 2025-05-01 | 2025-04-04 |
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Agnosia (23) · Pain, Postoperative (20) · Pain (15) · Hernia, Inguinal (6) · Aortic Valve Stenosis (5) · Breast Neoplasms (5) · Bites and Stings (3) · Carcinoma, Hepatocellular (3) · Carpal Tunnel Syndrome (3) · Fibromyalgia (3) · Patient Satisfaction (3) · Prostatic Neoplasms (3) · Acute Pain (2) · Anxiety Disorders (2) · Arteriovenous Fistula (2)
Ain Shams University (4) · Cairo University (3) · RenJi Hospital (3) · Ageless Regenerative Institute (2) · Assistance Publique - Hôpitaux de Paris (2) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (2) · Baylor College of Medicine (2) · Beijing Tiantan Hospital (2) · Bursa City Hospital (2) · Diskapi Teaching and Research Hospital (2) · Federal University of São Paulo (2) · Mayo Clinic (2) · Medical University of Gdansk (2) · Plovdiv Medical University (2) · Seoul National University Hospital (2)
Turkey (Türkiye) (21) · United States (21) · China (12) · Egypt (12) · France (11) · Canada (10) · United Kingdom (6) · Brazil (5) · Belgium (4) · Denmark (4) · Greece (4) · Pakistan (4) · Poland (4) · Bulgaria (2) · Germany (2)
Sharon McQuillan, MD (2) · Abd-Elazeem A Elbakry, M.D (1) · Ahmad El-Ma'aita, PhD (1) · Ahmed Abdel Rahman Hashem (1) · Aldo Okamura, MD (1) · Anahi Perlas, MD (1) · Andre Chen, Msc (1) · Andrea Scribante, DDS, PhD (1) · Andrew Elimian, MD (1) · Ani Beltcheva (1) · Anil Ranganath, FCAI (1)
PMID 35857365, PMID 40772525, PMID 17368248, PMID 17571915, PMID 17720129, PMID 17724727, PMID 18574578, PMID 19046884, PMID 19126912, PMID 19239413, PMID 19376789, PMID 19871185, PMID 19916251, PMID 19920424, PMID 20020791, PMID 20048117, PMID 20332307, PMID 21238825, PMID 22330261, PMID 22335277, PMID 22726915, PMID 22834681, PMID 23229236, PMID 23549122, PMID 23958289, PMID 24121608, PMID 24165901, PMID 24401769, PMID 25466410, PMID 25509976, PMID 26074287, PMID 26546298, PMID 26885872, PMID 26938989, PMID 27200187, PMID 27492881, PMID 27746552, PMID 28079776, PMID 28436307, PMID 28562733, PMID 28886668, PMID 29199999, PMID 29315129, PMID 29340574, PMID 29643620, PMID 29739917, PMID 29793595, PMID 30143396, PMID 30477773, PMID 30668660
2019 (1), K23AR050607 (1)