100 completed, 27 unknown, 6 recruiting, 5 terminated. 81 Not applicable, 29 Phase 4, 13 Phase 3, 7 Phase 1, 5 Phase 2.
Follow Anesthetics, Local: new trials by email Literature Review of Anesthetics, Local trials Research Report on Anesthetics, Local
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation Platelet-Rich Plasma (PRP) Injections, Local Anesthetic Injection - Neuroma, Phantom Limb Pain After Amputation | Not applicable | Completed | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-09-15 | 2026-10-07 |
| Erector Spinae Plane Block for Acute Low Back Pain Erector Spinae Plane Block with isotonic saline, Erector Spinae Plane Block with local anesthetic - Non-specific Low Back Pain (NSLBP) | Not applicable | Not yet recruiting | University Hospital, Montpellier | 300 | 2026-03-01 | 2026-03-17 |
| Tubeless Strategy for Enhanced Recovery After Sublobar Resection Laryngeal Mask Airway, Thoracic Paravertebral Block with Local Anesthetic, Non-intubated Anesthesia - Pulmonary Nodules, Early Stage Lung Cancer (I and II) | Not applicable | Not yet recruiting | The First Affiliated Hospital of Guangzhou Medical University | 138 | 2026-02-01 | 2026-02-13 |
| The Impact of Saline Temperature and Local Anesthetic Adjuvants on Postoperative Shoulder Pain and Inflammatory Marker Levels Following Laparoscopic Cholecystectomy Room-temperature saline (25-30 ml/kg ) irrigation without local anesthetic., Room-temperature saline (25-30 ml/kg l) with local anesthetic ( 0.25% bupivacaine according to body weight)., Warm saline (37°C, 25-30 ml/kg ) irrigation without local anesthetic. - Shoulder Pain , Laparoscopic Cholecystectomy | Not applicable | Enrolling by invitation | Alexandria University | 216 | 2026-02-01 | 2026-03-17 |
| Stem Cells vs. Steroids for Discogenic Back Pain Autologous stem cells, Corticosteroid, Local anesthetic - Chronic Low Back Pain, Degenerative Disc Disease | Not applicable | Withdrawn | Johns Hopkins University | 2025-09-30 | 2025-10-07 | |
| Cryotherapy as a Topical Anesthetic in Healthy Children Cryotherapy, topical anesthetic, Topical anesthetic gel - Healthy, Topical Anesthesia | Phase 4 | Completed | Ondokuz Mayıs University | 100 | 2025-09-01 | 2026-02-09 |
| Comparison of Injection Techniques in Carpal Tunnel Syndrome 5% Dextrose, Betamethasone and local anesthetic - Carpal Tunnel Syndrome | Phase 4 | Completed | Ankara Etlik City Hospital | 53 | 2025-08-05 | 2026-07-21 |
| Ultrasound-Guided Suprascapular Nerve RFA vs Steroid-Local Anesthetic Injection in Chronic Shoulder Pain Pulsed Radiofrequency (PRF) of the Suprascapular Nerve, Suprascapular Nerve Block with Local Anesthetic and Corticosteroid - Chronic Shoulder Pain, Shoulder Impingement Syndrome | Not applicable | Completed | Nida Koçer Nazlıgül | 104 | 2025-07-27 | 2025-12-24 |
| The Sacral Erector Spinae Plane Block in Total Knee Arthroplasty Local Anesthetic Injection - Total Knee Anthroplasty, Regional Anesthesia | Recruiting | San Giovanni di Dio Hospital | 126 | 2025-07-16 | 2025-08-28 | |
| Rectus Sheath Catheters Following Midline Laparotomy Ropivacaine 0.2%, Saline 0.9% - Acute Abdomen, Ileus | Not applicable | Not yet recruiting | Asklepios Kliniken Hamburg GmbH | 40 | 2025-07-01 | 2025-08-01 |
| Effects of Local Ketamine in Orthognathic Procedures Ketamine, Articaine Hydrochloride + Epinephrine - Dentofacial Deformities, Analgesia | Not applicable | Active not recruiting | Bezmialem Vakif University | 40 | 2025-06-21 | 2026-03-27 |
| Effect of Skin Stretching on Pain Reduction During Local Anesthetic Injections: A Randomized Clinical Study conventional local anesthetic injection, skin stetching technique for local anesthetic injection - Lumbar Spinal Stenosis With Bilateral Lower Extremity Radiculopathy | Not applicable | Completed | Yonsei University | 104 | 2025-05-07 | 2026-10-13 |
| Phenol Neurolysis Versus Local Anesthetic Plus Steroid Genicular Nerve Block in Knee Osteoarthritis Phenol Injection, Bupivacaine + Triamcinolone Acetonide Injection - Knee Osteoarthritis, Genicular Nerve Block | Completed | Salim Sencar | 42 | 2025-05-01 | 2026-08-18 | |
| Evaluation of Response to Pain From Skull Pin Fixation in Craniotomies Scalp nerve block, Opioid Anesthetics, Local Anesthetic Injection - Electroencephalography, Craniotomy Surgery | Completed | Diskapi Teaching and Research Hospital | 120 | 2025-02-28 | 2026-09-25 | |
| Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia for Opioid Consumption in Laparoscopic Hysterectomy General Anesthesia (control group), General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and no fentanyl), General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and 20 mcg fentanyl) - Laparoscopic Hysterectomy, Gynecology | Not applicable | Recruiting | Andrea Saporito | 45 | 2024-11-01 | 2026-09-15 |
| EOIB for Laparoscopic Cholecystectomy ultrasound guided external oblique intercostal plane block, Bupivacaine injection, paracetamol, tramadol, and ondansetron - Cholecystitis, Cholecystitis, Acute | Not applicable | Recruiting | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital | 60 | 2024-10-30 | 2024-11-01 |
| RISS Block for Enhanced Recovery After Video-Assisted Thoracoscopic Surgery Rhomboid Intercostal and Subserratus Plane Block with local anesthetic, Intercostal nerve block - Postoperative Pain, Thoracic Surgery | Not applicable | Completed | Ningbo University | 90 | 2024-09-01 | 2026-03-10 |
| Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery Erector Spinae Block, Local infiltration with local anesthetic - Postoperative Delirium, Pain, Postoperative | Phase 2 | Completed | Rashmi Mueller | 29 | 2024-05-15 | 2026-02-13 |
| Bilateral External Oblique Intercostal Plane Block in Laparoscopic Cholecystectomy local anesthetic injection (bupivacaine), normal saline injection - External Oblique Intercostal Plane Block, Laparoscopic Cholecystectomy | Phase 4 | Completed | Theodor Bilharz Research Institute | 38 | 2024-04-25 | 2024-08-07 |
| Effect of Benzocaine 20% Topical Anesthesia on Pain Levels When Placing Separators in Children Receiving Hall Technique Crowns 20% benzocaine, topical anesthetic, Children's Toothpaste - Effect of Benzocaine on Pain | Early Phase 1 | Completed | Mohammed Bin Rashid University of Medicine and Health Sciences | 32 | 2024-04-14 | 2025-03-19 |
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Pain, Postoperative (32) · Agnosia (19) · Pain (16) · Chronic Pain (11) · Breast Neoplasms (8) · Acute Pain (6) · Hernia, Inguinal (3) · Osteoarthritis, Knee (3) · Shoulder Pain (3) · Bronchiolitis Obliterans Syndrome (2) · Bursitis (2) · Coronary Artery Disease (2) · Hip Fractures (2) · Intervertebral Disc Degeneration (2) · Mouth Diseases (2)
Assiut University (6) · University of Parma (6) · Konya Meram State Hospital (4) · Aretaieion University Hospital (2) · Bezmialem Vakif University (2) · Centro Hospitalar do Porto (2) · Diskapi Teaching and Research Hospital (2) · Fondazione Policlinico Universitario Campus Bio-Medico (2) · Keimyung University Dongsan Medical Center (2) · Northwestern University (2) · Ottawa Hospital Research Institute (2) · Rennes University Hospital (2) · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey (2) · Tanta University (2) · University Hospital Bispebjerg and Frederiksberg (2)
United States (28) · Turkey (Türkiye) (18) · Egypt (15) · Italy (13) · Brazil (8) · Canada (6) · China (6) · France (5) · Denmark (4) · South Korea (4) · Belgium (3) · Greece (3) · Spain (3) · Portugal (2) · Sweden (2)
Guido Fanelli, MD (3) · Andrea Cornini, MD (2) · Giorgio Danelli, MD (2) · Kassiani Theodoraki, PhD, DESA (2) · Marco Baciarello, MD (2) · Vincenzo Bruni, MD (2) · Abhijit Biswas, MD (1) · Adelaide A. Hebert, MD (1) · Ahmed El-Awady, BDS, MS, PhD (1) · Ahmed H Wahba (1)
PMID 35143011, PMID 17920504, PMID 18201346, PMID 21244302, PMID 21869676, PMID 23301559, PMID 24165901, PMID 24289799, PMID 24988555, PMID 25977992, PMID 26010037, PMID 26096484, PMID 26154451, PMID 26512604, PMID 27653293, PMID 28396242, PMID 28494906, PMID 28824857, PMID 28879311, PMID 29078868, PMID 29980989, PMID 30153126, PMID 30204683, PMID 30304509, PMID 30609276, PMID 30999197, PMID 31014382, PMID 31021882, PMID 31094627, PMID 31725158, PMID 31892680, PMID 31925371, PMID 32303377, PMID 32474710, PMID 33277760, PMID 33339924, PMID 33564311, PMID 33585141, PMID 33785209, PMID 34002866, PMID 34117385, PMID 34340839, PMID 34590307, PMID 34733752, PMID 35086112, PMID 35430086, PMID 35852550, PMID 36003715, PMID 36117569, PMID 36369781
2019 (2), R43AR052998 (1), UL1TR001420 (1)