14 completed. 14 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 14 |
| Phase 3 | 3 | Completed 3 |
| Phase 1 | 1 | Completed 1 |
Follow Depressive Symptoms: new trials by email Literature Review of Depressive Symptoms trials Research Report on Depressive Symptoms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD) TNX-601 ER, Placebo - Depression, Depressive Disorder | Phase 2 | Completed | Tonix Pharmaceuticals, Inc. | 132 | 2023-03-02 | 2025-02-17 |
| Cannabidiol for Reduction of Brain Neuroinflammation CBD, Placebo - Back Pain, Depressive Symptoms | Phase 2 | Completed | Massachusetts General Hospital | 69 | 2022-01-04 | 2026-10-15 |
| Mindful Self-Compassion (MSC) for Infertility Related Distress Mindful Self-Compassion - Infertility, Female, Distress, Emotional | Phase 1 / Phase 2 | Completed | University of Regina | 50 | 2021-12-01 | 2025-04-08 |
| Esketamine and Perioperative Depressive Symptoms Esketamine, Normal saline - Depressive Symptoms, Esketamine | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 435 | 2021-02-19 | 2025-08-01 |
| eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications - Depression, Major Depressive Disorder | Phase 2 | Completed | Indiana University | 46 | 2020-10-14 | 2023-11-02 |
| Meru Health Ascend Mobile Intervention for Depression in Middle Aged and Older Adults Meru Health Ascend Program - Depression, Depressive Symptoms | Phase 2 / Phase 3 | Completed | Palo Alto Veterans Institute for Research | 70 | 2018-07-12 | 2021-03-10 |
| Stabilizing Behavioral Rhythms to Improve Mental Health Full Package - Depressive Symptoms, Anxiety Symptoms | Phase 2 | Completed | HealthRhythms, Inc. | 128 | 2018-03-01 | 2021-07-01 |
| eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients Beating the Blues (BtB), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications - Depression, Major Depressive Disorder | Phase 2 | Completed | Indiana University | 216 | 2015-07-01 | 2023-10-19 |
| Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED) Pentoxifylline, Placebo, Standard Treatment - Major Depressive Disorder, Depression | Phase 2 | Completed | Indiana University | 36 | 2012-06-01 | 2015-12-03 |
| Beating the Blues for Your Heart Beating the Blues (BtB), Usual Care - Depression, Depressive Symptoms | Phase 2 | Completed | Indiana University | 29 | 2011-07-01 | 2022-12-29 |
| Cognitive Behavioral Therapy for Patients With an Early Psychosis cognitive behavioral therapy - Psychosis, Schizophrenia | Phase 2 | Completed | Oslo University Hospital | 60 | 2011-01-01 | 2014-10-23 |
| Psychopharmacology of Psilocybin in Cancer Patients psilocybin - Depressive Symptoms, Anxiety | Phase 2 | Completed | Johns Hopkins University | 56 | 2007-04-01 | 2018-07-19 |
| Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans sertraline, Placebo, gabapentin - Cocaine Dependence, Depressive Symptoms | Phase 2 | Completed | University of Arkansas | 102 | 2006-01-01 | 2011-04-25 |
| Comparing Paroxetine and Duloxetine on Cardiovascular Measures paroxetine versus duloxetine - Depressive Symptoms | Phase 2 / Phase 3 | Completed | Duke University | 40 | 2005-03-01 | 2014-07-21 |
Depression (14) · Depressive Disorder, Major (4) · Anxiety Disorders (3) · Cardiovascular Diseases (3) · Coronary Artery Disease (3) · Heart Diseases (3) · Dysthymic Disorder (2) · Back Pain (1) · Cocaine-Related Disorders (1) · Depressive Disorder (1) · Diabetes Mellitus, Type 2 (1) · Infertility, Female (1) · Inflammation (1) · Insulin Resistance (1) · Marijuana Abuse (1)
Behavior (14) · Behavioral Symptoms (14) · Mental Disorders (10) · Mood Disorders (4) · Arterial Occlusive Diseases (3) · Arteriosclerosis (3) · Coronary Disease (3) · Depressive Disorder (3) · Myocardial Ischemia (3) · Pathological Conditions, Signs and Symptoms (3) · Vascular Diseases (3) · Chemically-Induced Disorders (2) · Pathologic Processes (2) · Substance-Related Disorders (2) · Brain Diseases (1)
Cognitive Behavioral Therapy (3) · Primary Health Care (2) · Selective Serotonin Reuptake Inhibitors (2) · Therapeutics (2) · Bupropion (1) · Cannabidiol (1) · Esketamine (1) · Gabapentin (1) · Pentoxifylline (1) · Psilocybin (1) · Saline Solution (1) · Serotonin and Noradrenaline Reuptake Inhibitors (1) · Sertraline (1) · tianeptine (1)
Indiana University (4) · Beijing Tiantan Hospital (1) · Duke University (1) · HealthRhythms, Inc. (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Oslo University Hospital (1) · Palo Alto Veterans Institute for Research (1) · Tonix Pharmaceuticals, Inc. (1) · University of Arkansas (1) · University of Regina (1)
United States (11) · Canada (1) · China (1) · Norway (1)
Jesse C Stewart, PhD (2) · Alison Oliveto, PhD (1) · Christine E Gould, PhD (1) · Ellen Frank, PhD (1) · Gregory Sullivan, MD (1) · Jesse C Stewart, Ph.D. (1) · Jesse C. Stewart, Ph.D. (1) · Roland R Griffiths, Ph.D. (1) · Ruquan Han, M.D., Ph D. (1) · Wei Zhang, M.D., Ph.D. (1)
PMID 27909165, PMID 31935529, PMID 35473735, PMID 35917659, PMID 36120713, PMID 36123113, PMID 37209779, PMID 37931480, PMID 39252547, PMID 39639945, PMID 40822596, PMID 40930184, PMID 42119799
P50DA018197 (1), R01HL122245 (1), R21DK123582 (1), R24MH080827 (1), R44MH113520 (1)