321 completed, 82 unknown, 59 recruiting, 26 not yet recruiting. 439 Not applicable, 23 Phase 2, 10 Phase 3, 8 Phase 4, 5 Early Phase 1.
Follow Depressive Symptoms: new trials by email Literature Review of Depressive Symptoms trials Research Report on Depressive Symptoms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy - Borderline Personality Disorder, Borderline Personality Pathology | Phase 1 | Not yet recruiting | University of Minnesota | 18 | 2026-12-01 | 2026-09-22 |
| Electrophysiologic Mechanisms of Ketamine Antidepressant Response Ketamine - Epilepsy, Depressive Symptoms | Phase 2 | Not yet recruiting | Emory University | 37 | 2026-12-01 | 2026-08-17 |
| Parenting-STAIR Modular for Military Fathers and OCONUS Families Parenting-STAIR Modular (PSTAIR-M), Treatment as Usual (TAU) - Depressive Symptoms, Emotional Depression | Not applicable | Not yet recruiting | New York University | 243 | 2026-12-01 | 2026-09-30 |
| Assessment of the Seasonality of Depressive Symptoms in Adolescents Measuring the intensity of the seasonality of depressive symptoms in adolescents - Depressive Symptoms | Not yet recruiting | University Hospital, Rouen | 210 | 2026-12-01 | 2026-10-26 | |
| Improving Student Mental Health Through a Universal Trauma-Informed Intervention RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision - Anxiety Symptoms, Post-traumatic Stress Symptoms | Not applicable | Recruiting | Johns Hopkins Bloomberg School of Public Health | 960 | 2026-10-08 | 2026-10-19 |
| The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study OHDC-DC - Depression, Depressive Disorder | Not applicable | Recruiting | University of Wisconsin, Madison | 8 | 2026-10-01 | 2026-09-29 |
| Task-Shifting Adapted IPT-A for Youth Suicide Prevention Adapted Brief Interpersonal Psychotherapy for Adolescents (IPT-A LAZOS), Usual Community Center Services - Suicidal Ideation, Depressive Symptoms | Not applicable | Not yet recruiting | Boston College | 46 | 2026-10-01 | 2026-07-28 |
| JAK Signaling in Depression and Cognition in Male Football Players Baricitinib - Depressive Symptoms, Cognitive Symptom | Phase 2 | Recruiting | Emory University | 30 | 2026-10-01 | 2026-09-24 |
| Effects of Digital Detox on Mental Health in Young Adults App-based smartphone screen time restriction program - Anxiety Symptoms, Screen Time | Not applicable | Not yet recruiting | University of Bergen | 200 | 2026-09-21 | 2026-09-23 |
| AI Mental Health Tool vs. Psychoeducation Control Ash, Brief Therapist-Delivered Telehealth - Depressive Disorder, Depressive Symptoms | Not applicable | Active not recruiting | Slingshot AI | 500 | 2026-09-11 | 2026-09-25 |
| Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms Irritable Bowel Syndrome (IBS), Functional Dyspepsia | Not yet recruiting | Shandong University | 200 | 2026-09-01 | 2026-10-01 | |
| MindfulCityU-- A Mindfulness Mobile Application for Promoting University Students' Mental Health MindfulCityU, Waitlist control - Depressive Symptoms | Not applicable | Not yet recruiting | City University of Hong Kong | 120 | 2026-09-01 | 2026-04-24 |
| Cognitive Stimulation Program With Virtual Reality for Older Adults With Depressive Symptoms Cognitive stimulation program - Depressive Symptoms | Not applicable | Not yet recruiting | Grupo Lusófona | 60 | 2026-09-01 | 2026-07-17 |
| Nature Photography for Mental Well-Being and Nature Connectedness in Young Adults Nature-Based Mindful Photography, Human-Made Object Photography, Self-Guided Digital Stress Management Handbook - Psychological Distress, Depressive Symptoms | Not applicable | Not yet recruiting | Beijing Normal University | 300 | 2026-09-01 | 2026-09-09 |
| Effects of Exercise Intervention on Sleep Quality and Emotional Problems in College Students With Depressive Symptoms Archery Exercise, Non-exercise Control - Depressive Symptoms, Sleep Disturbance | Not applicable | Not yet recruiting | Capital University of Physical Education and Sports, China | 80 | 2026-08-01 | 2026-07-31 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral Reconstruction Combined dexmedetomidine-esketamine administration, Placebo administration - Ureteral Stricture, Dexmedetomidine | Phase 4 | Not yet recruiting | Peking University First Hospital | 658 | 2026-08-01 | 2026-08-14 |
| Examining the Health Effects of NPOWER365 Among Black Same Gender Loving Men NPOWER365 HIV care intervention - Sexual and Gender Minorities, Social Stigma | Not applicable | Not yet recruiting | Rutgers, The State University of New Jersey | 350 | 2026-08-01 | 2026-06-10 |
| Using a School-Based Depression Literacy Psychoeducation Program With AI Chatbot to Improve Depression Literacy and Help-Seeking Among High School Students school-based depression literacy program - Depressive Symptoms, Mental Health (Depression) | Not applicable | Not yet recruiting | Chang Hsiu-Ju | 720 | 2026-08-01 | 2026-08-27 |
| Sleep More, Stress Less: 90-Day Trial of Neuralli Mood Neuralli Mood - Psychological Stress, Sleep Disturbance | Not applicable | Recruiting | Efforia, Inc | 100 | 2026-06-30 | 2026-07-21 |
| Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation Metformin, Antidepressant Therapy - Depression, Depressive Disorder | Not applicable | Recruiting | Riphah International University | 200 | 2026-06-17 | 2026-08-07 |
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Depression (528) · Anxiety Disorders (190) · Psychological Well-Being (47) · Depressive Disorder (29) · Depressive Disorder, Major (27) · Stress Disorders, Post-Traumatic (26) · Stress, Psychological (19) · Emotional Regulation (18) · Motor Activity (18) · Sleep Initiation and Maintenance Disorders (17) · Mood Disorders (16) · Pain (13) · Neoplasms (12) · Cardiovascular Diseases (11) · Cognitive Dysfunction (11)
Behavioral Symptoms (526) · Behavior (525) · Mental Disorders (284) · Pathological Conditions, Signs and Symptoms (83) · Nervous System Diseases (75) · Signs and Symptoms (56) · Mood Disorders (46) · Personal Satisfaction (46) · Neurologic Manifestations (40) · Pathologic Processes (38) · Social Behavior (38) · Brain Diseases (37) · Central Nervous System Diseases (37) · Trauma and Stressor Related Disorders (33) · Stress Disorders, Traumatic (32)
Cognitive Behavioral Therapy (23) · Therapeutics (20) · Exercise (13) · Ketamine (6) · Mindfulness-Based Cognitive Therapy (6) · Mindfulness (4) · Saline Solution (4) · Sertraline (4) · Transcranial Magnetic Stimulation (4) · Acceptance and Commitment Therapy (3) · Bupropion (3) · Cardiac Rehabilitation (3) · Cholecalciferol (3) · Cognitive Training (3) · Control Groups (3)
The University of Hong Kong (19) · Johns Hopkins University (8) · University of Pennsylvania (8) · Universitätsklinikum Hamburg-Eppendorf (7) · Johns Hopkins Bloomberg School of Public Health (6) · Linkoeping University (6) · The Hong Kong Polytechnic University (6) · Wroclaw University of Health and Sport Sciences (6) · Columbia University (5) · Indiana University (5) · Koç University (5) · University of Michigan (5) · Duke University (4) · McMaster University (4) · Medical University of South Carolina (4)
United States (205) · Hong Kong (32) · Canada (27) · Spain (24) · Germany (21) · China (15) · Sweden (15) · Turkey (Türkiye) (14) · Brazil (12) · Italy (9) · Denmark (8) · Netherlands (8) · Poland (8) · Taiwan (8) · Norway (7)
Gerhard Andersson, PhD (4) · Janiece L Taylor, PhD (3) · Jennifer Dahne, PhD (3) · Terry Lum, PhD (3) · Aarthi Padmanabhan, PhD (2) · Akash Wasil (2) · Bernhard Kulzer, PhD (2) · Courtney Millar, PhD (2) · David L Brody, MD, PhD (2) · Elan C Hope, PhD (2) · Gloria Wong, PhD (2) · Guiyun Xu, MD (2) · Guy W Fincham, MSc (2)
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2023 (2), P30AG022845 (2), R01MD017610 (2), 2009 (1), 2015 (1), 2016 (1), 2018 (1), 3UG1CA189824-04S1 (1), 5RC1MD004563-02 (1), D43TW011302 (1), F31MH108280 (1), IK2CX002629 (1), K01AA027564 (1), K01HL141676 (1), K01MD013910 (1)