53 completed, 21 unknown, 8 not yet recruiting, 6 recruiting. 36 Not applicable, 17 Phase 4, 9 Phase 2, 9 Phase 3, 2 Phase 1.
Follow Selective Serotonin Reuptake Inhibitors: new trials by email Literature Review of Selective Serotonin Reuptake Inhibitors trials Research Report on Selective Serotonin Reuptake Inhibitors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition Transdermal estradiol, Standard of care - non hormonal - Menopause, Perimenopause | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2026-11-01 | 2026-07-29 |
| Intradermal Acupuncture as an Adjunct to SSRI Tapering in Major Depressive Disorder Selective Serotonin Reuptake Inhibitors (SSRIs), Sham Intradermal Acupuncture, Intradermal Acupuncture - Major Depressive Disorder | Not applicable | Not yet recruiting | First People's Hospital of Hangzhou | 114 | 2026-10-01 | 2026-09-22 |
| Estimation of Control Before and After Treatment of a Depressive Episode With Serotonin Reuptake Inhibitors Selective Serotonin Reuptake Inhibitors (SSRIs) or serotonergic antidepressants, Experimental tasks - Depression Disorder | Not applicable | Not yet recruiting | Hôpital le Vinatier | 124 | 2026-09-01 | 2026-07-21 |
| Effect of Virtual Reality on Depression in Adolescent Females Virtual reality headset, Selective serotonin reuptake inhibitors(SSRIs) - Depression | Not applicable | Not yet recruiting | Cairo University | 48 | 2026-08-01 | 2026-03-11 |
| Biomarkers and Pharmacogenomics for Precision Depression Therapy Pharmacogenomic Testing, Antidepressant Agents - Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 220 | 2026-07-01 | 2026-07-31 |
| Pattern Separation in Major Depressive Disorder SSRI (escitalopram or sertraline), Extended-Release Memantine, Placebo - Major Depressive Disorder (MDD) | Phase 1 | Recruiting | Jeffrey Miller | 30 | 2026-06-01 | 2026-09-15 |
| Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder Psilocybin, Structured Integrated Reframing Therapy (SIRT), Selective Serotonin Reuptake Inhibitor (SSRI) - Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD) | Phase 3 | Recruiting | Khyber Medical University Peshawar | 60 | 2026-04-01 | 2026-07-14 |
| MAGNESIUM & SSRI VS SSRI ALONE AMONG PATIENTS OF MAJOR DEPRESSIVE DISORDER Use of magnesium with SSRI, SSRI - Major Depressive Diorder | Phase 2 | Active not recruiting | University of Child Health Sciences and Children's Hospital, Lahore | 50 | 2025-12-01 | 2026-03-09 |
| Comparison of the Efficacy and Safety of Dapoxetine, Kegel Exercises, and Acupuncture in the Treatment of Premature Ejaculation: A Randomized, Double-Blind, Placebo-Controlled Trial serotonin reuptake inhibitor (SSRI), Placebo, Acupuncture - Premature Ejaculation | Not applicable | Not yet recruiting | Medipol University | 250 | 2025-10-01 | 2025-07-16 |
| Cohort Study of Honghua Xiaoyao Tablets in the Treatment of Premenstrual Syndrome Based on Target Trial Emulation Framework Honghua Xiaoyao tablets - Premenstrual Syndrome | Not yet recruiting | Lianxin Wang | 266 | 2025-09-30 | 2025-09-15 | |
| A Multicentre Clinical Study SSRIs, fNIRS - the Objective Diagnosis of Depression | Not yet recruiting | Zhongda Hospital | 2250 | 2025-07-30 | 2025-07-14 | |
| Efficacy of Dextromethorphan-Bupropion Versus SSRIs in the Treatment of Major Depressive Disorder Dextromethorphan-Bupropion, SSRIs - Major Depressive Disorder (MDD) | Not applicable | Completed | Asad Ullah Jan | 80 | 2025-05-06 | 2026-05-07 |
| Post-Traumatic Growth Following Eye Movement Desensitization and Reprocessing Therapy Versus SSRIs in Patients With Post-Traumatic Stress Disorder EMDR, SSRIs - PTSD - Post Traumatic Stress Disorder | Not applicable | Completed | Asad Ullah Jan | 130 | 2025-05-06 | 2026-05-07 |
| Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) Therapy Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the Treatment of Post-Traumatic Stress Disorder Eye Movement Desensitization and Reprocessing Therapy, Selective serotonin reuptake inhibitors - PTSD, PTSD - Post Traumatic Stress Disorder | Not applicable | Completed | Asad Ullah Jan | 60 | 2025-05-06 | 2026-05-07 |
| Neurobiological and Genomic Predictors of Relapse in Depression Antidepressant Medications - Healthy, Major Depressive Disorder (MDD) | Recruiting | Mehmet Kemal Arikan | 204 | 2025-01-01 | 2026-01-09 | |
| Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders Sertraline, Placebo - Neurodevelopmental Disorders, Autism | Phase 2 | Recruiting | Holland Bloorview Kids Rehabilitation Hospital | 130 | 2024-09-16 | 2026-07-27 |
| Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms Seltorexant, Placebo, Selective Serotonin Reuptake Inhibitor (SSRI)/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) - Depressive Disorder, Major | Phase 3 | Recruiting | Janssen Research & Development, LLC | 752 | 2024-07-25 | 2026-09-25 |
| Effectiveness of Dry Needling Adjuvant to Selective Serotonin Reputake Inhibitors vs TP Injection for Pain Management Dry Needling, Trigger points injections, serotonin reuptake inhibitor (SSRI) - Pain, Fibromyalgia | Not applicable | Unknown | Superior University | 35 | 2023-11-01 | 2024-06-13 |
| Prospective Clinical Cohort Study of Depression selective serotonin reuptake inhibitors, TMS - Major Depressive Disorder | Unknown | Sir Run Run Shaw Hospital | 300 | 2023-06-15 | 2023-10-27 | |
| Assessment of the Improvement in Cognitive Levels of Postmenopausal Depression Patients by Estrogen Fematon (estradiol/estradiol-norethindrone acetate combination tablet package)+SSRIs, SSRIs - Postmenopausal Depression, Estrogen | Not applicable | Unknown | Xiao Wang | 40 | 2023-05-12 | 2024-04-10 |
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Depressive Disorder, Major (44) · Depression (24) · Anxiety Disorders (8) · Depressive Disorder (6) · Obsessive-Compulsive Disorder (6) · Stress Disorders, Post-Traumatic (5) · Stroke (4) · Generalized Anxiety Disorder (3) · Bipolar Disorder (2) · Combat Disorders (2) · Depressive Disorder, Treatment-Resistant (2) · Dysthymic Disorder (2) · Fibromyalgia (2) · Neoplasms (2) · Pain (2)
Eli Lilly and Company (7) · Shanghai Mental Health Center (5) · Asad Ullah Jan (3) · Xiaomei Shao (3) · Adams Clinical (2) · All India Institute of Medical Sciences, Bhubaneswar (2) · Cairo University (2) · GlaxoSmithKline (2) · Indiana University (2) · Janssen Research & Development, LLC (2) · National Institute of Mental Health (NIMH) (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · The Third Affiliated hospital of Zhejiang Chinese Medical University (2) · University of Sao Paulo (2) · University of Texas Southwestern Medical Center (2)
United States (28) · China (18) · Pakistan (6) · Brazil (5) · Mexico (5) · Spain (5) · Turkey (Türkiye) (4) · Belgium (3) · Canada (3) · France (3) · Germany (3) · India (3) · Japan (3) · Slovakia (3) · South Korea (3)
Xiaomei Shao, Ph.D (4) · Abdul Khalid (1) · Albert Pinhasov, PhD (1) · Amit Anand, MD (1) · Anatoly Kreinin, MD, PhD (1) · Asad Ullah Jan, MBBS,FCPS (1) · Atif Najum, MBBS, FCPS (1) · Boadie W Dunlop, MD/MS (1) · Boris Modrau, M.D. (1) · Carlos A Zarate, M.D. (1)
PMID 27035159, PMID 27685842, PMID 12813115, PMID 15939837, PMID 17389902, PMID 18974308, PMID 19212970, PMID 19376453, PMID 19574030, PMID 19578654, PMID 19829198, PMID 20146834, PMID 20483968, PMID 20975857, PMID 21059176, PMID 21256670, PMID 21311704, PMID 21367351, PMID 21464362, PMID 21536692, PMID 21658349, PMID 21762829, PMID 21907540, PMID 22075098, PMID 22121927, PMID 22129562, PMID 22152230, PMID 22230827, PMID 22304968, PMID 22401488, PMID 22404963, PMID 22687487, PMID 22841131, PMID 23171815, PMID 23184657, PMID 23225338, PMID 23290323, PMID 23332608, PMID 23370069, PMID 23377641, PMID 23407203, PMID 23562005, PMID 23580378, PMID 23608160, PMID 23729989, PMID 23750465, PMID 23801589, PMID 23886736, PMID 23948637, PMID 24163386
2016 (1), 2023 (1), N01MH090003 (1), P30MH066386 (1), R01HL122245 (1), R01MH067692 (1), R01MH073719 (1), R01MH113748 (1), R18HL092862 (1), R21DK123582 (1), U01MH057858 (1)