88 completed, 45 unknown, 13 terminated, 11 recruiting. 69 Phase 2, 40 Phase 3, 35 Not applicable, 22 Phase 4, 16 Phase 1.
Follow Pentoxifylline: new trials by email Literature Review of Pentoxifylline trials Research Report on Pentoxifylline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pentoxifylline Add-On Therapy for Mild-to-Moderate Plaque Psoriasis Pentoxifylline 400 mg Oral Tablet, Placebo - Psoriasis | Not applicable | Not yet recruiting | Wasuchon Chaichan | 140 | 2026-11-01 | 2026-10-06 |
| Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation Pentoxifylline, Placebo, α-Tocopherol - Non-Small Cell Lung Cancer, Radiation Induced Lung Injury (RILI) | Phase 2 | Recruiting | University Health Network, Toronto | 150 | 2026-06-15 | 2026-08-06 |
| Pentoxifylline in Patients With Ulcerative Colitis Mesalamine, Pentoxifylline - Inflammatory Bowel Diseases | Phase 2 | Recruiting | Ihab Elsayed Hassan | 60 | 2026-01-20 | 2026-04-15 |
| Cocaine and Pentoxifylline (BED IN 47) Placebo, Cocaine (IV), Pentoxifylline - Cocaine Use Disorder | Early Phase 1 | Recruiting | William Stoops | 30 | 2025-11-10 | 2026-06-08 |
| Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With Asthenozoospermia Coenzyme Q 10, Pentoxifylline 400 MG Oral Tablet - Asthenozoospermia | Not applicable | Recruiting | Mst.Sumyara Khatun | 56 | 2025-10-01 | 2025-11-26 |
| Clinical Study to Evaluate The Cardioprotective Effect of Pentoxifylline Against Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients Pentoxifylline 400mg plus chemotherapy - Doxorubicin Induced Cardiotoxicity, Breast Cancer | Phase 2 | Completed | Tanta University | 46 | 2025-09-01 | 2026-09-30 |
| Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose) Pravastatin (drug), Pentoxifylline, ketoprofen - Fibrosis Syndrome, Lymphedema | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 250 | 2025-08-08 | 2026-07-24 |
| Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial Pentoxifylline, placebo distilled water - Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy | Not applicable | Not yet recruiting | Alexandria University | 30 | 2025-07-30 | 2025-07-28 |
| Pentoxifylline as Anti-Inflammatory in Patients With Rheumatoid Arthritis Methotrexate, Pentoxifylline - Rheumatoid Arthritis | Phase 2 | Recruiting | Tanta University | 50 | 2025-06-02 | 2026-10-05 |
| Evaluation of Efficacy, Safety and Molecular Mechanism of Pentoxifylline Supplementation in Patients With Hepatic and Obstructive Jaundice Pentoxifylline - Hepatobiliary Disorders | Phase 2 | Completed | Tanta University | 45 | 2025-04-30 | 2026-09-30 |
| Pentoxifylline for Vascular Calcification in Kidney Disease Pentoxifylline 400 MG Oral Tablet, Conventional Medications for Chronic Kidney Disease - Chronic Kidney Disease, Vascular Calcification | Phase 1 / Phase 2 | Not yet recruiting | Mansoura University | 80 | 2025-04-15 | 2025-04-01 |
| Bioequivalence Study of Pentoxifylline 400 Mg in Healthy Subjects Under Fasting and Fed Conditions Pentoxifylline - Healthy, Healthy Donors | Phase 4 | Not yet recruiting | Centro de Atencion e Investigacion Medica | 40 | 2025-04-10 | 2025-02-17 |
| Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE) Pravastatin, Pentoxifylline, Tocopherol - Lymphedema, Fibrosis | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 295 | 2025-02-13 | 2026-09-11 |
| Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible modified PENTOCLO (mPENTOCLO), sham mPENTOCLO - Osteoradionecrosis, Osteoradionecrosis of Jaw | Phase 3 | Recruiting | Sunnybrook Health Sciences Centre | 24 | 2025-01-16 | 2025-09-12 |
| Efficacy, Satisfaction, and Safety of the Mesolipo® Protocol for the Treatment of Localized Adiposity Mesolipo®, Pentoxifylline - Localized Adiposity | Not applicable | Completed | Antony de Paula Barbosa | 12 | 2025-01-01 | 2026-08-04 |
| To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery Pentoxifylline (also known as oxpentifylline), Plasmalyte - Liver Regeneration | Not applicable | Recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-01-01 | 2025-07-25 |
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Pentoxifylline for Prevention of Contrast Induced Nephropathy in Chronic Kidney Diseased Patients in Intensive Care Unit Pentoxifylline, Normal saline - Pentoxifylline, Contrast Induced Nephropathy | Not applicable | Completed | Tanta University | 70 | 2024-07-01 | 2026-05-01 |
| Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke Pentoxifylline - Cognitive Impairment | Phase 1 / Phase 2 | Unknown | The First Hospital of Hebei Medical University | 200 | 2024-04-10 | 2024-04-03 |
| Renoprotective Effects of Dapagliflozin Versus Pentoxiphylline in Chronic Kidney Disease Patients Dapagliflozin 10mg Tab, Pentoxifylline 400 MG - Chronic Kidney Diseases | Phase 3 | Unknown | Ain Shams University | 210 | 2024-03-01 | 2024-05-20 |
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Fibrosis (11) · Renal Insufficiency, Chronic (10) · Breast Neoplasms (8) · Hepatitis, Alcoholic (7) · Inflammation (7) · Kidney Failure, Chronic (5) · Non-alcoholic Fatty Liver Disease (5) · Diabetic Nephropathies (4) · HIV Infections (4) · Cardiovascular Diseases (3) · Colorectal Neoplasms (3) · Depressive Disorder, Major (3) · Diabetes Mellitus, Type 2 (3) · Head and Neck Neoplasms (3) · Hepatopulmonary Syndrome (3)
Tanta University (14) · Ain Shams University (8) · National Taiwan University Hospital (6) · University Health Network, Toronto (5) · Institute of Liver and Biliary Sciences, India (4) · Mansoura University (4) · Alexandria University (3) · Beni-Suef University (3) · Indiana University (3) · M.D. Anderson Cancer Center (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Al-Azhar University (2) · Arak University of Medical Sciences (2) · Assistance Publique - Hôpitaux de Paris (2) · Cooperative International Neuromuscular Research Group (2)
Egypt (43) · United States (41) · Mexico (8) · Canada (7) · Taiwan (7) · Brazil (6) · India (5) · Iran (5) · France (4) · Israel (4) · Spain (4) · United Kingdom (4) · Turkey (Türkiye) (3) · China (2) · Germany (2)
Cathy Hammerman, MD (2) · Diana Escolar, MD (2) · Samir K. Gupta, MD, MS (2) · Talar A Merzamohammad, Pharm. D (2) · Wilfred Levin, MD (2) · Yung-Ming Chen, M.D. (2) · Abd Elazeez AT Shabaan, PhD (1) · Adel Gaber Bakr, PhD (1) · Ahmed ElGhandour, MD (1) · Alexandra Taylor (1) · Alfonso M. M Cueto-Manzano, MD, MSc, PhD (1) · Alireza Esteghamati, MD (1) · Amar R Deshpande, MD (1) · Amin Banihashemi (1)
PMID 37916745, PMID 25970116, PMID 10488881, PMID 10924859, PMID 11675328, PMID 11943418, PMID 14605526, PMID 14647046, PMID 15122768, PMID 1531090, PMID 15542159, PMID 16026887, PMID 16155013, PMID 16322159, PMID 16537374, PMID 16953900, PMID 17366834, PMID 17438178, PMID 17518367, PMID 18358930, PMID 18487215, PMID 18668653, PMID 18993042, PMID 19216016, PMID 19445945, PMID 19553649, PMID 20102716, PMID 21037437, PMID 21220611, PMID 21677329, PMID 21748765, PMID 21752095, PMID 21846410, PMID 21943236, PMID 22037714, PMID 22074157, PMID 22086414, PMID 22265847, PMID 22323480, PMID 22742890, PMID 22816029, PMID 23140366, PMID 23244073, PMID 23593327, PMID 24026598, PMID 24515621, PMID 25393877, PMID 25945012, PMID 26112745, PMID 26300986
R01HL095149 (2), 2008 (1), 2016 (1), R01DA063069 (1), R03DK065958 (1), R21DK078012 (1), R21DK101889 (1), R24MH080827 (1), U01AA021893 (1)