4162 completed, 1357 unknown, 798 recruiting, 429 terminated. 2652 Not applicable, 984 Phase 2, 661 Phase 3, 550 Phase 4, 445 Phase 1.
Follow Inflammation: new trials by email Literature Review of Inflammation trials Research Report on Inflammation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| OPTIMAL LEAP: Optimizing Dihydroartemisinin-Piperaquine IPTsc Intervals to Advance Learning, Executive Function, Attendance, and Antimalarial Resistance Surveillance in Kenyan Schoolchildren Monthly DP, Quarterly DP - Malaria, Asymptomatic Malaria | Phase 3 | Not yet recruiting | Indiana University | 1500 | 2028-01-01 | 2026-09-01 |
| AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection Ulinastatin and Thymalfasin, Ulinastatin - Aortic Aneurysm and Dissection | Not applicable | Not yet recruiting | Nanjing Medical University | 300 | 2027-12-31 | 2026-02-02 |
| Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU Extended beta-lactam antibiotics, Intermittent Beta-lactam antibiotics - Sepsis, Septic Shock | Not yet recruiting | Assiut University | 90 | 2027-10-01 | 2026-09-01 | |
| Comparing Effects of Fermented and Unfermented Pulses and Gut Microbiota Unfermented chickpea, Fermented chickpea - Fermented Food, Inflammation | Not applicable | Not yet recruiting | Penn State University | 30 | 2027-09-01 | 2026-07-10 |
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| To Evaluate the Safety and Potential Therapeutic Activity of JadiCell™, an Investigational Umbilical Cord-Derived Mesenchymal Stem Cell Therapy, in Patients Diagnosed With Acute Respiratory Distress Syndrome (ARDS). Subjects in the UC-MSC treatment group will receive two intravenous infusions (at day 0 and 3) of 100 million UC-MSC., Controls will receive two infusions of vehicle solution. - Acute Respiratory Distress Syndrome | Phase 3 | Not yet recruiting | Breathe Biologics, Inc. | 128 | 2027-03-01 | 2026-10-01 |
| Comparison of Sepsis Prediction Algorithms Epic Sepsis Model Version - 1, Epic Sepsis Model Version - 2, Emory Sepsis Model - Sepsis | Not yet recruiting | Emory University | 1200 | 2027-03-01 | 2026-10-26 | |
| G-CSF In Neonatal Sepsis With Neutropenia Granulocyte-colony stimulating factor (G-CSF), Standard Sepsis Management - Neonatal Sepsis, Neutropenia | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 52 | 2027-02-15 | 2026-10-22 |
| The Extended Study of Prevalence of Infection in Intensive Care IV Sepsis, Infection | Not yet recruiting | Universidad de la Sabana | 10000 | 2027-02-01 | 2026-06-29 | |
| Biological Effects of Hemoadsorption in Septic Shock Hemoadsorption cartridge - Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction | Not applicable | Not yet recruiting | Miguel Sanchez Garcia | 16 | 2027-01-07 | 2026-07-20 |
| Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure | Not applicable | Not yet recruiting | Duke University | 450 | 2027-01-01 | 2026-07-08 |
| Remote Ischemic Postconditioning in Septic Shock Remote ischemic conditioning, No intervention - Adult Patients With Septic Shock Admitted in Intensive Care Unit | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 720 | 2027-01-01 | 2026-10-09 |
| SWedish Intensive Care Biobank Any Condition Underlying Critical Illness | Not yet recruiting | Uppsala University | 25000 | 2027-01-01 | 2026-05-13 | |
| Immune Dysregulation During Sepsis: A Natural History Cohort Sepsis, Septic Shock | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 500 | 2027-01-01 | 2026-10-09 | |
| The SPARK-PMDD Study Premenstrual Dysphoric Disorder, PMDD | Not yet recruiting | King's College London | 120 | 2027-01-01 | 2026-08-18 | |
| Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis Para-Tyrosine supplementation, Placebo solution - Sepsis | Phase 2 | Suspended | University of Pecs | 296 | 2027-01-01 | 2025-03-30 |
| Effect of Pentadecanoic Acid Supplementation on Red Blood Cell Health and Biological Aging in Healthy Older Adults Pentadecanoic Acid, Placebo - Red Blood Cell Health, Biological Aging | Phase 2 | Not yet recruiting | ReCellience15, Inc | 93 | 2027-01-01 | 2026-10-05 |
| Prediction and Prevention of Bloodstream Infections After Kidney Transplantation Pivmecillinam, Placebo - Kidney Transplant Infection, Bloodstream Infection | Phase 3 | Not yet recruiting | Susanne Dam Nielsen, MD, DMSc | 180 | 2027-01-01 | 2026-10-16 |
| Impact of Restrictive Diets on Inflammation and Quality of Life in Autoimmune Thyroiditis Gluten-free, casein-free, low-glycemic-index diet - Thyroid Autoimmune Disease, Hashimoto's Thyroiditis | Not applicable | Not yet recruiting | University of Barcelona | 60 | 2027-01-01 | 2026-10-19 |
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Sepsis (2294) · Shock, Septic (1060) · Obesity (308) · Infections (286) · Bacteremia (260) · Critical Illness (206) · Systemic Inflammatory Response Syndrome (195) · Cardiovascular Diseases (188) · Neonatal Sepsis (188) · Insulin Resistance (187) · Neuroinflammatory Diseases (179) · COVID-19 (170) · Cytokine Release Syndrome (162) · Cellulitis (157)
Pathological Conditions, Signs and Symptoms (7590) · Pathologic Processes (7565) · Infections (3767) · Systemic Inflammatory Response Syndrome (3395) · Shock (1362) · Sepsis (1040) · Signs and Symptoms (999) · Nutritional and Metabolic Diseases (899) · Respiratory Tract Diseases (816) · Cardiovascular Diseases (805) · Nervous System Diseases (716) · Urogenital Diseases (677) · Vascular Diseases (677) · Disease Attributes (629)
Blood Specimen Collection (156) · Saline Solution (102) · Sodium Chloride (92) · Standard of Care (73) · Exercise (72) · Ascorbic Acid (58) · Vancomycin (50) · Hydrocortisone (46) · Norepinephrine (44) · Meropenem (40) · Colchicine (35) · Daptomycin (35) · Dexmedetomidine (34) · Control Groups (33) · Interleukin 1 Receptor Antagonist Protein (33)
Assistance Publique - Hôpitaux de Paris (85) · Ain Shams University (63) · Assiut University (56) · Radboud University Medical Center (50) · National Institute of Allergy and Infectious Diseases (NIAID) (47) · University of Florida (43) · Emory University (39) · National Taiwan University Hospital (37) · Copenhagen University Hospital, Rigshospitalet (33) · Massachusetts General Hospital (32) · Southeast University, China (31) · Hospices Civils de Lyon (30) · University of Aarhus (30) · University of British Columbia (30) · Cairo University (28)
United States (2087) · France (554) · China (478) · Canada (353) · Italy (341) · United Kingdom (335) · Germany (326) · Spain (298) · Turkey (Türkiye) (239) · Netherlands (238) · Brazil (228) · Egypt (217) · Denmark (203) · Belgium (152) · Sweden (149)
Robert B Innis, M.D. (12) · Peter Pickkers, MD, PhD (10) · David C Nieman, DrPH (8) · Andrea Morelli, MD (7) · David C. Nieman, DrPH (6) · Bernd Jilma, MD (5) · Claudia Spies, MD, Prof. (5)
PMID 26903338, PMID 37916745, PMID 11445675, PMID 28459966, PMID 28597967, PMID 33891293, PMID 28101605, PMID 29749279, PMID 31280481, PMID 34605781, PMID 21516036, PMID 25749867, PMID 26903335, PMID 28343448, PMID 34519356, PMID 34905144, PMID 36416787, PMID 37316690, PMID 11794169, PMID 16424713, PMID 18158437, PMID 19531784, PMID 20179283, PMID 23353941, PMID 23899564, PMID 24171518, PMID 24794878, PMID 25392034, PMID 26903336, PMID 27940189, PMID 28871441, PMID 29084247, PMID 29784057, PMID 30018799, PMID 30597021, PMID 30716446, PMID 31077258, PMID 31909868, PMID 32192578, PMID 32520577, PMID 32865380, PMID 33620405, PMID 34536218, PMID 34741280, PMID 34922058, PMID 39428602, PMID 39716214, PMID 40622772, PMID 41314665, PMID 10470572
2023 (19), 2019 (16), 2014 (15), 2025 (15), 2015 (12), 2017 (12), 2008 (11), 2016 (11), 2018 (9), 2009 (8), 2005 (5), P30AG028740 (5), U10HD021373 (5), U10HD021385 (5), M01RR000070 (4)