846 completed, 192 recruiting, 150 terminated, 59 withdrawn. 743 Not applicable, 153 Phase 2, 95 Phase 4, 74 Phase 1, 57 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Role of Environmental Temperatures in Respiratory Control Thermoneutral temperature environment, Cold temperature environment, Hot temperature environment - Work of Breathing | Not applicable | Not yet recruiting | Indiana University | 15 | 2028-10-01 | 2026-03-13 |
| OPTIMAL LEAP: Optimizing Dihydroartemisinin-Piperaquine IPTsc Intervals to Advance Learning, Executive Function, Attendance, and Antimalarial Resistance Surveillance in Kenyan Schoolchildren Monthly DP, Quarterly DP - Malaria, Asymptomatic Malaria | Phase 3 | Not yet recruiting | Indiana University | 1500 | 2028-01-01 | 2026-09-01 |
| Pilot of an AI-Enabled Autism Caregiver Support Tool in Indiana and Kenya AI-Enabled Autism Caregiver Support Tool - Autism Spectrum Disorder | Not applicable | Not yet recruiting | Indiana University | 60 | 2028-01-01 | 2026-09-16 |
| ImmuNe ParameTERs to Predict Immunotherapy REsponse and Toxicity (INTERPRET) Cancer | Not yet recruiting | Indiana University | 100 | 2028-01-01 | 2026-07-15 | |
| Pepea Pamoja: Cluster-Randomized Trial for Caregivers of Children With Autism in Kenya Professionally-facilitated groups, Peer-facilitated groups - Autism Spectrum Disorder, Autism | Not applicable | Not yet recruiting | Indiana University | 240 | 2027-07-01 | 2026-08-31 |
| The Role of Breathing Perception in Respiratory Control Ambient Noise, Increased Auditory Feedback, Noise Distraction - Work of Breathing | Not applicable | Not yet recruiting | Indiana University | 15 | 2027-06-01 | 2026-03-13 |
| Reciprocal Innovation to Optimize Low-Tech Augmentative and Alternative Communication (AAC) for Individuals Automated AAC Assessment and Low-Tech AAC Implementation Support, Standard AAC Support - Autism, Neurodevelopment | Not applicable | Not yet recruiting | Indiana University | 500 | 2027-06-01 | 2026-05-12 |
| The Bone and hEArt Health Consequences of Ovarian agiNg (BEACON) Study Ovarian Aging, Adverse Pregnancy Outcomes | Not yet recruiting | Indiana University | 655 | 2027-04-01 | 2026-06-02 | |
| Virtual Communication in the Hospital: Impact on Patients and Surrogates VCHIPS - Communication, Anxiety | Not applicable | Withdrawn | Indiana University | 2027-03-31 | 2026-04-22 | |
| AIM 3 Focused Adaptation of a Mobile Caregiver Intervention for Dementia Caregivers Brain CareNotes Latino, Dementia Care app - Caregiver Burden of People With Dementia | Not applicable | Not yet recruiting | Indiana University | 60 | 2027-03-01 | 2026-08-28 |
| Effect Of Percutaneous Electrical Nerve Field Stimulation on Symptom Control/Nervous System Activity in Patients w/Diabetes Types 1/2 PERCUTANEOUS ELECTRICAL FIELD NERVE STIMULATION, Sham percutaneous electrical nerve field stimulation - Diabetes, Gastroparesis | Not applicable | Not yet recruiting | Indiana University | 60 | 2027-02-10 | 2026-10-01 |
| Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease RespirAct - Coronary Artery Disease | Not applicable | Not yet recruiting | Indiana University | 30 | 2027-01-10 | 2026-05-26 |
| Improving Mental Healthcare Outcomes for Minoritized Veterans Through a Peer-led, Patient Navigation Program (PARTNER-MH 2.0) PARTNER-MH, Educational Brochure - Diagnoses of Depression, Anxiety | Not applicable | Not yet recruiting | VA Office of Research and Development | 268 | 2027-01-04 | 2026-06-16 |
| Eye Tracking and Autism in Former Preterm Infants Eye-tracking device - Autism, Prematurity | Not applicable | Not yet recruiting | Indiana University | 40 | 2027-01-04 | 2026-08-14 |
| Efficacy and Safety of Slow Release Dehydroepiandrosterone (DHEA ) Slow Release DHEA, Placebo - Asthma | Phase 2 | Not yet recruiting | Indiana University | 30 | 2027-01-01 | 2026-02-27 |
| Home-Based Lower-Extremity Heat Therapy for Walking Function in Peripheral Artery Disease Lower-Extremity Heat Therapy, Sham Lower-Extremity Heat Therapy - PAD, PAD - Peripheral Arterial Disease | Not applicable | Not yet recruiting | Aquilo Sports, LLC | 40 | 2027-01-01 | 2026-06-17 |
| Supplementation of Gut-brain Axis (GLP-1)-Activating Carbohydrates for Increasing Satiety in Adolescents With Obesity gut-brain axis (GLP-1)-activating food carbohydrate, starch-based placebo control (commercial maltodextrin) - Obesity & Overweight | Phase 2 | Not yet recruiting | Indiana University | 62 | 2027-01-01 | 2026-10-21 |
| Safety and Efficacy of OTL78 0.06 mg/kg ZOPOCIANINE given 1-7 days prior to surgery - Prostate Cancer Surgery, Prostate Cancer Metastatic Disease | Phase 2 / Phase 3 | Recruiting | Clinton Bahler | 45 | 2026-12-01 | 2026-10-22 |
| Supporting Families in the ICU Spiritual Care Assessment and Intervention (SCAI) Framework, ICU Guide - Anxiety, Well-Being | Not applicable | Not yet recruiting | Indiana University | 64 | 2026-11-01 | 2026-08-27 |
| Cognitive and Behavioral Approaches to Reduce Binge Eating and Excess Weight in Adolescents (Online) Cognitive-Behavioral Therapy for Adolescent Binge Eating, Lifestyle Behavioral Obesity Intervention, Active Control - Binge Eating, Overweight and Obesity | Not applicable | Not yet recruiting | Indiana University | 159 | 2026-11-01 | 2026-10-05 |
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Breast Neoplasms (47) · Depression (46) · Anxiety Disorders (36) · Alzheimer Disease (35) · Cognitive Dysfunction (29) · Diabetes Mellitus (27) · Neoplasms (27) · Dementia (26) · Substance-Related Disorders (23) · Hypertension (22) · Obesity (22) · Asthma (21) · Colorectal Neoplasms (21) · Cardiovascular Diseases (20) · Heart Failure (20)
Educational Status (10) · Standard of Care (10) · Bupivacaine (9) · Cognitive Behavioral Therapy (9) · Blood Specimen Collection (8) · Ethanol (7) · Exercise (7) · Methods (7) · Radiosurgery (7) · Sodium Chloride (7) · Therapeutics (7) · Acceptance and Commitment Therapy (6) · Bevacizumab (6) · Capecitabine (6) · Cyclophosphamide (6)
United States (1250) · Kenya (38) · Canada (20) · Uganda (11) · India (7) · China (5) · Mali (5) · United Kingdom (5) · Germany (4) · Italy (4) · Nigeria (4) · Switzerland (4) · Guatemala (3) · Mexico (3) · Netherlands (3)
Thomas V Nowak, MD (11) · Malaz Boustani, MD, MPH (10) · Amit Anand, MD (9) · Douglas K Rex, MD (9) · Gregory D Zimet, PhD (8) · Aaron E Carroll, MD, MS (7) · Flora Hammond, MD (7) · James E Tisdale, PharmD (7) · Julia LeBlanc, MD, MPH (7) · Yar Yeap, MD (7) · Kathy Miller, MD (6) · Kieren J Mather, MD (6) · Louis B Cantor, MD (6) · Sashwati Roy, PhD (6) · Sherif Farag, MD, PhD (6)
PMID 37811711, PMID 34813082, PMID 19398687, PMID 21494337, PMID 22494121, PMID 25981554, PMID 26896702, PMID 27650271, PMID 28351364, PMID 31780277, PMID 33583058, PMID 35288147, PMID 38215876, PMID 41436014, PMID 10727592, PMID 10828502, PMID 10870744, PMID 10870982, PMID 10899243, PMID 11001602, PMID 11068116, PMID 11165371, PMID 11171742, PMID 11690728, PMID 11723370, PMID 11737514, PMID 11786502, PMID 11991872, PMID 12030525, PMID 12640853, PMID 12646602, PMID 12798184, PMID 12835199, PMID 14510658, PMID 14582032, PMID 14621285, PMID 14652237, PMID 14760317, PMID 15133328, PMID 15550799, PMID 15632378, PMID 15647484, PMID 15685451, PMID 15800228, PMID 15840177, PMID 16168100, PMID 16246975, PMID 16320034, PMID 16508405, PMID 16936159
U01HG010225 (5), 1OT2OD028183-01 (4), KL2TR002530 (4), P60AA007611 (4), R01NS112367 (4), UL1TR002529 (4), P60AR020582 (3), R01HL095149 (3), R21MH140210 (3), U01DK061737 (3), U24DK122927 (3), 1OT2OD023847-01 (2), K22LM009160 (2), K23DK122015 (2), P01DK043881 (2)