226 completed, 24 unknown, 22 terminated, 14 recruiting. 88 Phase 4, 70 Phase 1, 69 Phase 2, 51 Phase 3, 39 Not applicable.
Follow Bupropion: new trials by email Literature Review of Bupropion trials Research Report on Bupropion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder | Phase 4 | Not yet recruiting | Bausch Health Americas, Inc. | 246 | 2027-07-01 | 2026-09-29 |
| Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 120 | 2027-03-01 | 2026-07-20 |
| Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis Bupropion Hydrochloride 150 MG - End Stage Renal Disease, Fatigue | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 16 | 2027-02-01 | 2026-11-02 |
| Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic Risk Bupropion 150 mg, Lyophilized powder from edible mushrooms, Lifestyle Management - Cardiometabolic Syndrome, Obesity and Cardiovascular Risk | Phase 3 | Not yet recruiting | Uppsala University | 250 | 2026-10-30 | 2026-09-08 |
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression. Aripiprazole Augmentation, Bupropion Augmentation - Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder | Phase 2 | Not yet recruiting | Washington University School of Medicine | 300 | 2026-10-01 | 2026-10-16 |
| BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder Aromatase Inhibitors, Bupropion, GnRH agonist - Early-stage Breast Cancer, Hypoactive Sexual Desire Disorder | Phase 1 / Phase 2 | Not yet recruiting | University of Illinois at Chicago | 100 | 2026-09-01 | 2026-08-24 |
| Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT) AXS-05 (dextromethorphan-bupropion), Bupropion, Placebo - Smoking Cessation | Phase 3 | Recruiting | Axsome Therapeutics, Inc. | 705 | 2026-08-27 | 2026-11-06 |
| Biomarkers and Pharmacogenomics for Precision Depression Therapy Pharmacogenomic Testing, Antidepressant Agents - Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 220 | 2026-07-01 | 2026-07-31 |
| Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation Metformin, Antidepressant Therapy - Depression, Depressive Disorder | Not applicable | Recruiting | Riphah International University | 200 | 2026-06-17 | 2026-08-07 |
| A Phase 1, First-in-human Study of VX-433 VX-433, Placebo, Midazolam - Narcolepsy Type 1 (NT1) | Phase 1 | Recruiting | Vertex Pharmaceuticals Incorporated | 118 | 2026-05-21 | 2026-06-08 |
| Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol BICX104 naltrexone implantable pellet, Bupropion 150 mg XL, Naltrexone (depot) - Healthy Adult Male and Female Volunteers | Phase 1 | Recruiting | BioCorRx Pharmaceuticals Inc | 30 | 2026-03-16 | 2026-05-13 |
| Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants Repotrectinib, Metformin, Digoxin - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 30 | 2025-12-31 | 2026-03-27 |
| Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis Standard Varenicline Dosing (1 mg BID), Bupropion 150 mg twice daily, Increased Varenicline Dosing (1mg TID) - Pancreatitis, Chronic, Pancreatitis, Acute | Phase 2 | Withdrawn | Mayo Clinic | 2025-11-06 | 2026-07-07 | |
| Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants Vorasidenib, Bupropion, Flurbiprofen - Healthy Adult Participants | Phase 1 | Completed | Institut de Recherches Internationales Servier (I.R.I.S.) | 28 | 2025-10-07 | 2026-02-17 |
| Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet Naltrexone/Bupropion, Placebo - Obesity; Drug, Obesity, Morbid | Phase 4 | Recruiting | Laval University | 108 | 2025-06-04 | 2025-08-08 |
| A Study to Investigate How Multiple Oral Doses of AZD2389 Affect the Pharmacokinetics of Midazolam, Caffeine, and Bupropion in Healthy Participants AZD2389, Midazolam, Caffeine - Advanced Chronic Liver Disease, Healthy Participants | Phase 1 | Completed | AstraZeneca | 16 | 2025-05-08 | 2025-07-24 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure Clozapine, Esketamine Nasal Product, Escitalopram - Schizophrenia and Related Disorders, Major Depressive Disorder | Phase 3 | Terminated | Dr. Inge Winter | 1 | 2025-04-27 | 2026-11-05 |
| Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study) early time restricted Mediterranean diet, Mysimba - Diabetes Mellitus, Type 2, Liver Fibrosis | Phase 4 | Enrolling by invitation | Carmen Dietvorst | 70 | 2025-04-14 | 2026-04-21 |
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Smoking Cessation (68) · Tobacco Use Disorder (54) · Depressive Disorder, Major (50) · Depression (47) · Smoking (34) · Obesity (15) · Cigarette Smoking (14) · Schizophrenia (13) · Bipolar Disorder (9) · Tobacco Use Cessation (9) · Depressive Disorder (8) · Substance-Related Disorders (8) · Behavior, Addictive (7) · Depressive Disorder, Treatment-Resistant (7) · Dysthymic Disorder (7)
National Institute on Drug Abuse (NIDA) (19) · Duke University (14) · New York State Psychiatric Institute (13) · Yale University (10) · Axsome Therapeutics, Inc. (6) · Actavis Inc. (5) · Indiana University (5) · M.D. Anderson Cancer Center (5) · Pfizer (5) · VA Office of Research and Development (5) · Centre for Addiction and Mental Health (4) · GlaxoSmithKline (4) · Mayo Clinic (4) · US Department of Veterans Affairs (4) · University of California, Los Angeles (4)
United States (215) · Canada (24) · South Korea (9) · China (8) · Germany (8) · Spain (8) · Belgium (7) · United Kingdom (6) · Australia (5) · Brazil (5) · Finland (4) · Israel (4) · Mexico (4) · Netherlands (4) · South Africa (4)
Antonio R. Pizarro,, M.D. (5) · Jed E Rose, Ph.D. (4) · A Eden Evins, MD, MPH (3) · Aviv M Weinstein, Ph.D (2) · E. Jennifer Edelman, MD, MHS (2) · Eric A Dedert, PhD (2) · Jean C Beckham, Ph.D. (2) · Jean C Beckham, PhD (2) · Jean C. Beckham, Ph.D. (2) · Jennifer W. Tidey (2) · Jonathan W. Stewart, M.D. (2)
PMID 37230961, PMID 37142273, PMID 34611902, PMID 36999619, PMID 37335995, PMID 41401709, PMID 11765093, PMID 12095672, PMID 12439223, PMID 14982685, PMID 15005752, PMID 15110730, PMID 15138759, PMID 15203809, PMID 15330403, PMID 15349007, PMID 15465989, PMID 15541061, PMID 15569893, PMID 15631608, PMID 15677618, PMID 15723025, PMID 15898966, PMID 15950022, PMID 15960566, PMID 16023735, PMID 16036283, PMID 16102908, PMID 16123753, PMID 16157462, PMID 16168792, PMID 16176440, PMID 16197928, PMID 16203030, PMID 16240558, PMID 16338761, PMID 16339615, PMID 16339616, PMID 16426088, PMID 16448626, PMID 16449473, PMID 16449474, PMID 16552982, PMID 16566627, PMID 16595351, PMID 16635643, PMID 16675760, PMID 16677228, PMID 16801293, PMID 16816280
2023 (3), P50DA027840 (3), 2018 (2), 2019 (2), K01DA019446 (2), K23MH076049 (2), P50AA015632 (2), P50DA018185 (2), P50DA019706 (2), 1RC1HL099668 (1), 1UG3MH137353-01 (1), 2009 (1), 2015 (1), 2016 (1), 2017 (1)