3092 completed, 668 unknown, 364 recruiting, 193 terminated. 2527 Not applicable, 455 Phase 2, 398 Phase 4, 273 Phase 3, 214 Phase 1.
Follow Insulin Resistance: new trials by email Literature Review of Insulin Resistance trials Research Report on Insulin Resistance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin Resistance Vigabatrin Pill, Placebo oral tablet - Hyperinsulinism, Insulin Resistance | Phase 2 | Withdrawn | University of Arizona | 2030-04-15 | 2025-07-30 | |
| The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction Caloric Restriction, Hyperglycemic clamp - Type2diabetes | Phase 2 | Not yet recruiting | Adrian Vella | 20 | 2027-12-15 | 2026-10-28 |
| Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus Semaglutide (Wegovy) weekly injection - Gestational Diabetes Mellitus (GDM), Metabolic Syndrome | Phase 2 / Phase 3 | Not yet recruiting | University of Massachusetts, Worcester | 226 | 2027-09-01 | 2026-09-28 |
| cfMSC Therapy for Diabetes cfMSC therapy for diabetes - Type II Diabetes Mellitus | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-11-02 |
| Assessing Trauma-related Links Between Affective and Metabolic Systems prazosin - Posttraumatic Stress Disorder, Metabolic Syndrome | Phase 4 | Not yet recruiting | VA Office of Research and Development | 70 | 2027-03-01 | 2026-10-15 |
| The Simplified Total-body Resistance Exercise for Muscular Hypertrophy for Diabetic Population (D-STORM) D-STORM Resistance Training Programme, usual care - Type 2 Diabetes Mellitus (T2DM), Sarcopenia | Not applicable | Not yet recruiting | Universiti Teknologi Mara | 56 | 2027-01-01 | 2026-06-25 |
| Endoscopic Band Ligation for Type 2 Diabetes Mellitus (ENDOBAND-DM) Endoscopic Band Ligation (ENDOBAND-DM) - Type 2 Diabetes Mellitus (T2DM) | Not applicable | Not yet recruiting | El Katib Hospital | 10 | 2027-01-01 | 2026-09-10 |
| Human Models of Selective Insulin Resistance: Pancreatic Clamp Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Hyperinsulinemia | Phase 1 | Not yet recruiting | Columbia University | 36 | 2027-01-01 | 2026-02-06 |
| Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome Semaglutide + TAU, Placebo + TAU - Schizophrenia Disorder, Metabolic Syndrome | Phase 3 | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | 600 | 2026-12-01 | 2026-08-18 |
| Peripheral Vascular Effects of Insulin in Obesity human insulin - Obesity (BMI>30), Insulin Resistance | Early Phase 1 | Not yet recruiting | University of Missouri-Columbia | 64 | 2026-12-01 | 2026-10-15 |
| VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway Vericiguat 10 MG, Placebo, Insulin Sensitivity Test - Cardiovascular Diseases, Insulin Sensitivity/Resistance | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-12-01 | 2026-01-23 |
| Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity human insulin - Obesity (BMI>30), Insulin Resistance | Early Phase 1 | Not yet recruiting | University of Missouri-Columbia | 64 | 2026-12-01 | 2026-10-15 |
| IGOB131 As A GLP-1 Modulator For Metabolic Disorders In Adults With Obesity IGOB131, Dextrin - Obesity & Overweight | Phase 2 | Not yet recruiting | University of Yaounde 1 | 80 | 2026-12-01 | 2026-10-20 |
| Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial Urolithin A, Placebo - Healthy Volunteer | Not applicable | Recruiting | National Institute on Aging (NIA) | 180 | 2026-11-05 | 2026-11-02 |
| Effects of Meal Macronutrients on Postprandial Lipids High carb then high fat breakfast, High fat then high carb breakfast - Nephrotic Syndrome, Lipodystrophy | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 100 | 2026-11-05 | 2026-11-02 |
| Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity Alpha-lipoic acid, Mirabegron, Placebo - Insulin Resistance, Obesity | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 60 | 2026-11-05 | 2026-11-02 |
| Restoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in Alzheimer's Disease Empagliflozin, Insulin, Insulin Placebo - Alzheimer Disease | Phase 2 | Not yet recruiting | Wake Forest University Health Sciences | 30 | 2026-11-01 | 2026-09-30 |
| Whole-Food Magnesium for Mental and Cardiometabolic Health Low-Dose Whole-Food-Based Magnesium Supplement, Moderate-Dose Whole-Food-Based Magnesium Supplement, Placebo - Elevated Blood Glucose | Not applicable | Not yet recruiting | George Mason University | 45 | 2026-11-01 | 2026-10-08 |
| Metabolic Surgery for Atrial Fibrillation Elimination Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment - Atrial Fibrillation, Obesity and Obesity-related Medical Conditions | Phase 4 | Not yet recruiting | Ali Aminian | 100 | 2026-11-01 | 2026-04-17 |
| Human Cerebrovascular Blood Flow and Sex Differences in Metabolic Syndrome Indomethacin, Placebo, MRI - Metabolic Syndrome | Early Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 72 | 2026-11-01 | 2026-11-02 |
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