4101 completed, 1516 unknown, 771 recruiting, 429 terminated. 2766 Not applicable, 899 Phase 4, 615 Phase 2, 576 Phase 3, 301 Phase 1.
Follow Arteriosclerosis: new trials by email Literature Review of Arteriosclerosis trials Research Report on Arteriosclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease FGF-1, Placebo - Peripheral Arterial Disease, Stenosis | Phase 1 / Phase 2 | Not yet recruiting | Venturis Therapeutics, Inc. | 24 | 2028-10-15 | 2026-08-19 |
| Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 30 | 2027-12-01 | 2026-03-17 |
| Fibroblast Growth Factor-1 (FGF-1) for the Treatment of Coronary Heart Disease Human Recombinant Fibroblast Growth Factor-1 (FGF 1-141) - low dose, Human Recombinant Fibroblast Growth Factor-1 (FGF1-141) - high dose, Placebo - Coronary Disease, Coronary Heart Disease | Phase 2 | Not yet recruiting | Venturis Therapeutics, Inc. | 150 | 2027-09-01 | 2026-08-19 |
| EDAS Revascularization for Symptomatic Intracranial Atherosclerotic Steno-occlusive Disease Encephaloduroarteriosynangiosis (EDAS), Intensive medical management - Intracranial Atherosclerosis, Intracranial Arterial Stenosis | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 170 | 2027-05-01 | 2026-10-13 |
| Heart tEam Decision-making Assisted by Revaz AI Trial Revaz AI - Coronary Artery Disease | Not applicable | Not yet recruiting | University of Calgary | 712 | 2027-04-01 | 2026-09-24 |
| OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation Oral anticoagulation, Single antiplatelet therapy - Atrial Fibrillation (AF), Coronary Artery Disease | Phase 4 | Not yet recruiting | Ewha Womans University Mokdong Hospital | 2 | 2027-03-01 | 2026-03-27 |
| PCSK9 Inhibitors in Hyperlipidemia and Atherosclerosis Hyperlipidemia, Atherosclerotic Cardiovascular Disease (ASCVD) | Not yet recruiting | Fundación Santa Fe de Bogota | 100 | 2027-02-01 | 2026-10-02 | |
| A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma Evolocumab, Routine Lipid Management, Autoinjector - Coronary Artery Disease, Hypercholesterolemia | Phase 4 | Not yet recruiting | Amgen | 308 | 2027-01-31 | 2026-09-21 |
| Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease RespirAct - Coronary Artery Disease | Not applicable | Not yet recruiting | Indiana University | 30 | 2027-01-10 | 2026-05-26 |
| RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling Intervention 1, Intervention 3, Intervention 2 - Atherosclerosis Cerebral, Carotid Plaque | Phase 4 | Not yet recruiting | Keqiang Zhao | 120 | 2027-01-01 | 2026-09-15 |
| Nursing Intervention for Adaptation After Myocardial Revascularization Nursing Intervention Program, Usual Care - Coronary Artery Disease, Myocardial Revascularization | Not applicable | Not yet recruiting | Universidad de la Sabana | 40 | 2027-01-01 | 2026-05-08 |
| Photobiomodulation in Coronary Artery Bypass Grafting With No-Touch vs Conventional Saphenous Vein Harvesting. Photobiomodulation Therapy, Sham Laser irradiation, Conventional Saphenous Vein Harvesting - Coronary Artery Disease, Coronary Artery Bypass Graft (CABG) | Not applicable | Not yet recruiting | Federal University of São Paulo | 292 | 2027-01-01 | 2026-10-07 |
| Target-Oriented Strategy of Ultra-Low LDL-C (<1.0 vs. 1.0-1.39 mmol/L) in Extreme-High-Risk ASCVD Patients: Clinical Benefit, Safety and Cost-Effectiveness Assessment Lipid-lowering therapy targeting LDL-C <1.0 mmol/L, Lipid-lowering therapy targeting LDL-C 1.0-1.39 mmol/L - Atherosclerotic Cardiovascular Disease (ASCVD) | Not applicable | Not yet recruiting | Beijing Anzhen Hospital | 6000 | 2027-01-01 | 2026-05-29 |
| Intraoperative Ultrasound Assessment of Coronary Artery and Bypass Graft Blood Flow During CABG Intraoperative Ultrasound Blood Flow Measurement - Coronary Artery Disease | Not yet recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 190 | 2027-01-01 | 2026-08-11 | |
| Drug-coated Balloons Versus Drug-eluting Stents for the Treatment of Femoropopliteal In-Stent Restenosis Drug-Coated Balloon-First Strategy, Eluvia Drug-Eluting Stent-First Strategy - Femoropopliteal In-Stent Restenosis (ISR) | Not yet recruiting | Chunshui He | 600 | 2027-01-01 | 2026-09-16 | |
| wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65 Arm 1: wCAR-CARE - Precision Prevention (Arm A), Guideline-directed standard of care - Cardiovascular Diseases (CVD), Coronary Artery Disease | Not applicable | Not yet recruiting | Women's Heart Austria | 800 | 2027-01-01 | 2026-09-30 |
| Modified Jailed Balloon Technique vs Jailed Wire Technique in Coronary Bifurcation Intervention jailed wire technique, Modified jailed balloon technique - Coronary Artery Disease | Not applicable | Not yet recruiting | Assiut University | 140 | 2027-01-01 | 2026-10-14 |
| Rapid Inflation/Deflation Compared With Prolonged High-Pressure Balloon Inflation Prolonged inflation, Rapid inflation - Coronary Artery Disease, Coronary Stent Occlusion | Not applicable | Not yet recruiting | Central Arkansas Veterans Healthcare System | 40 | 2027-01-01 | 2026-10-21 |
| Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma Statins (atorvastatin, rosuvastatin, simvastatin, or pravastatin), +/- ezetimibe, +/- PCSK9 inhibitor (alirocumab, evolocumab, inclisiran) - Melanoma | Not applicable | Recruiting | University of Colorado, Denver | 40 | 2026-12-31 | 2026-08-07 |
| FRAME, External Support for Lower Limb Autologous Grafts FRAME - Peripheral Arterial Disease, Peripheral Artery Disease | Not applicable | Suspended | Vascular Graft Solutions Ltd. | 30 | 2026-12-31 | 2025-02-04 |
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Coronary Artery Disease (4728) · Atherosclerosis (1482) · Peripheral Arterial Disease (1356) · Cardiovascular Diseases (672) · Myocardial Ischemia (407) · Coronary Disease (403) · Myocardial Infarction (373) · Chronic Limb-Threatening Ischemia (353) · Diabetes Mellitus (338) · Heart Diseases (328) · Acute Coronary Syndrome (260) · Intermittent Claudication (222) · Peripheral Vascular Diseases (215) · Stroke (209) · Angina Pectoris (206)
Arterial Occlusive Diseases (7579) · Vascular Diseases (7537) · Cardiovascular Diseases (7036) · Heart Diseases (4722) · Myocardial Ischemia (4540) · Coronary Disease (4431) · Pathological Conditions, Signs and Symptoms (2196) · Pathologic Processes (1512) · Atherosclerosis (1474) · Peripheral Vascular Diseases (1399) · Nutritional and Metabolic Diseases (915) · Signs and Symptoms (880) · Metabolic Diseases (857) · Ischemia (793)
Clopidogrel (216) · Aspirin (185) · Percutaneous Coronary Intervention (160) · Ticagrelor (115) · Atorvastatin (102) · Exercise (87) · Rosuvastatin Calcium (77) · Prasugrel Hydrochloride (60) · Ezetimibe (59) · Drug-Eluting Stents (54) · Stents (51) · Angioplasty (49) · Coronary Artery Bypass (49) · Simvastatin (42) · Standard of Care (41)
National Heart, Lung, and Blood Institute (NHLBI) (126) · Abbott Medical Devices (97) · Yonsei University (75) · Boston Scientific Corporation (61) · China National Center for Cardiovascular Diseases (59) · Seung-Jung Park (58) · Cordis US Corp. (48) · University of Florida (47) · Seoul National University Hospital (46) · Ottawa Heart Institute Research Corporation (41) · Assiut University (40) · AstraZeneca (40) · Massachusetts General Hospital (38) · Insel Gruppe AG, University Hospital Bern (36) · Mayo Clinic (36)
United States (2042) · China (771) · Germany (609) · Italy (456) · South Korea (454) · United Kingdom (446) · France (409) · Netherlands (408) · Canada (396) · Spain (308) · Belgium (299) · Denmark (250) · Switzerland (234) · Brazil (219) · Austria (209)
Seung-Jung Park, MD, PhD (31) · Bon-Kwon Koo, MD, PhD (18) · Marc Bosiers, MD (13) · Koen Deloose, MD (12) · Dominick J Angiolillo, MD, PhD (11) · Gregg W Stone, MD (11) · Ron Waksman, MD (11) · David Kandzari, MD (10) · Mary McDermott, MD (10) · Shao-Liang Chen, MD (10) · Shigeru Saito, MD (10)
PMID 42573020, PMID 35224730, PMID 40875095, PMID 42035974, PMID 25940520, PMID 31567024, PMID 24746650, PMID 19463432, PMID 20142198, PMID 23468513, PMID 23523454, PMID 23636237, PMID 30690141, PMID 31543165, PMID 33025243, PMID 35802393, PMID 36588397, PMID 37565307, PMID 17296825, PMID 23232250, PMID 24510638, PMID 26354543, PMID 26825231, PMID 29089314, PMID 30165437, PMID 31561250, PMID 32227755, PMID 32609313, PMID 32890442, PMID 33939604, PMID 34056911, PMID 35641327, PMID 35916348, PMID 36137674, PMID 37256598, PMID 37619976, PMID 37745109, PMID 39329200, PMID 40590244, PMID 41913985, PMID 17145250, PMID 17223489, PMID 17982182, PMID 18765162, PMID 19228612, PMID 19717846, PMID 20129555, PMID 21232717, PMID 21670242, PMID 22017936
2025 (15), 2017 (11), 2023 (10), 2009 (8), 2016 (8), 2015 (6), 2018 (6), 2014 (5), 2019 (5), U01HL088942 (4), 2005 (3), R01AG031750 (3), R01HL092954 (3), 2004 (2), 2008 (2)