328 completed, 38 unknown, 26 terminated, 12 withdrawn. 199 Phase 2, 92 Phase 1, 69 Not applicable, 25 Phase 3, 16 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| QAIAx (AIhealth4U) - AI Smart Health Cities: Microcity Enclave Program (Quantum AI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360) AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central) - Asperger's Disorder, Asperger Disorder | Not applicable | Not yet recruiting | Veterans Recovery Network Inc. | 1000000 | 2026-09-01 | 2026-09-17 |
| rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder Active H7-coil repetitive transcranial magnetic stimulation (rTMS), Sham H7-coil repetitive transcranial magnetic stimulation (rTMS) - Cocaine Use, Cocaine Dependence | Not applicable | Recruiting | New York State Psychiatric Institute | 30 | 2026-08-14 | 2026-10-22 |
| Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 240 | 2026-02-25 | 2026-10-13 |
| Repurposing Semaglutide for the Treatment of Cocaine Use Disorder Semaglutide, Placebo, cognitive behavioral therapy (CBT). - Cocaine Use Disorder | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 75 | 2026-01-15 | 2026-03-19 |
| Bright Light Therapy During Inpatient Cocaine Detoxification Medical light therapy device, Medical light therapy device sham - Cocaine-Related Disorders | Not applicable | Recruiting | Hôpital le Vinatier | 256 | 2025-09-12 | 2026-06-12 |
| Smartphone Services for Stimulant Use Disorder Smartphone digital therapeutic system - Stimulant Use Disorder | Not applicable | Recruiting | DynamiCare Health | 270 | 2025-06-24 | 2025-07-29 |
| Comparing Efficacy & Safety Of TNX-1300 To Placebo With UC For Treatment Of Acute Cocaine Intoxication In ED Subjects (CATALYST) TNX-1300 (Injection), Placebo (Injection) - Cocaine Use, Cocaine Intoxication | Phase 2 | Terminated | Tonix Pharmaceuticals, Inc. | 3 | 2024-08-16 | 2025-06-24 |
| Dopamine Rhythms in Health and Addiction Brain Dopamine Reactivity, Brain Dopamine Receptor - Cocaine Abuse | Early Phase 1 | Withdrawn | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 2024-04-23 | 2024-04-24 | |
| Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction Ketamine, Placebo, real-time fMRI neurofeedback training - Cocaine Use Disorder, Cocaine Dependence | Phase 2 | Recruiting | Dr. med. Marcus Herdener | 120 | 2024-02-05 | 2024-12-20 |
| Clinical and Atherosclerotic Characteristics of Patients With ACS Associated With Cocaine Use Myocardial Infarction, Acute Coronary Syndrome | Unknown | Hospital El Cruce | 400 | 2023-11-17 | 2024-01-05 | |
| Randomized, Double-blind, Placebo-controlled Cannabis Extract x Placebo for Cocaine Addicts Cannabis Extract Oil SR Capsule - Cocaine Dependence | Phase 4 | Unknown | University of Sao Paulo General Hospital | 60 | 2023-10-23 | 2023-12-13 |
| Clavulanic Acid for the Treatment of Cocaine Use Disorder Clavulanic Acid Only Product, Placebo - Cocaine Dependence | Phase 2 | Active not recruiting | Temple University | 65 | 2023-05-03 | 2024-05-02 |
| Effect of rTMS on Neurotrophines Levels in CUD rTMS - Cocaine Use, Cocaine Dependence | Not applicable | Unknown | ITAB - Institute for Advanced Biomedical Technologies | 60 | 2023-04-30 | 2023-04-21 |
| Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2) Extended-Release Naltrexone, Extended Release Buprenorphine, Placebo (PLB) Injectable matched to XR-NTX - Cocaine Use Disorder | Phase 2 | Completed | University of Texas Southwestern Medical Center | 427 | 2023-04-18 | 2025-10-21 |
| Low-Intensity Focused Ultrasound for Cocaine Use Disorder Low-Intensity Focused Ultrasound, Sham LIFU device - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Completed | University of Virginia | 25 | 2023-03-24 | 2026-05-28 |
| rTMS for Stimulant Use Disorders rTMS, Sham (Placebo) - Cocaine Use Disorder, Methamphetamine Abuse | Not applicable | Completed | Medical University of South Carolina | 129 | 2022-02-04 | 2025-07-03 |
| Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder rTMS - Cocaine Dependence | Not applicable | Recruiting | Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente | 102 | 2022-01-06 | 2024-01-03 |
| AAV8-hCocH for Cocaine Use Disorder AAV8-hCocH - Cocaine Dependence, in Remission | Phase 1 | Active not recruiting | W. Michael Hooten | 10 | 2021-10-08 | 2026-05-26 |
| sTMS for Substance Use-disordered Veterans sTMS, sham sTMS - Cocaine Addiction, Opioid Addiction | Not applicable | Completed | VA Office of Research and Development | 42 | 2021-09-07 | 2024-01-17 |
| Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention Cognitive Behavioral Therapy (CBT), Pioglitazone, Placebo - Cocaine Use Disorder | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 61 | 2021-08-23 | 2026-09-21 |
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Substance-Related Disorders (85) · Opioid-Related Disorders (43) · Behavior, Addictive (30) · Alcoholism (23) · Heroin Dependence (11) · Impulsive Behavior (11) · Attention Deficit Disorder with Hyperactivity (8) · Alcohol-Related Disorders (6) · Marijuana Abuse (6) · Bipolar Disorder (5) · Mental Disorders (5) · Recurrence (5) · Amphetamine-Related Disorders (4) · Depression (4)
Chemically-Induced Disorders (415) · Mental Disorders (411) · Substance-Related Disorders (331) · Behavior (53) · Narcotic-Related Disorders (45) · Compulsive Behavior (30) · Impulsive Behavior (30) · Alcohol-Related Disorders (20) · Pathological Conditions, Signs and Symptoms (11) · Attention Deficit and Disruptive Behavior Disorders (8) · Neurodevelopmental Disorders (8) · Pathologic Processes (7) · Disease Attributes (6) · Mood Disorders (6) · Behavioral Symptoms (5)
Modafinil (22) · Cocaine (21) · Sugars (19) · Cognitive Behavioral Therapy (13) · Dextroamphetamine (12) · Disulfiram (11) · Naltrexone (11) · Methylphenidate (10) · Risperidone (10) · Buprenorphine (9) · Acetylcysteine (8) · Topiramate (8) · Methadone (7) · Transcranial Magnetic Stimulation (7) · Propranolol (6)
National Institute on Drug Abuse (NIDA) (105) · Yale University (41) · New York State Psychiatric Institute (32) · University of Pennsylvania (24) · Medical University of South Carolina (18) · The University of Texas Health Science Center, Houston (16) · Baylor College of Medicine (13) · Johns Hopkins University (9) · University of Texas Southwestern Medical Center (8) · Virginia Commonwealth University (8) · University of Arkansas (6) · University of Sao Paulo General Hospital (5) · Assistance Publique - Hôpitaux de Paris (4) · Temple University (4) · University of Minnesota (4)
United States (365) · Brazil (11) · France (7) · Spain (5) · Switzerland (5) · Canada (3) · Mexico (3) · Argentina (2) · Italy (2) · Netherlands (2) · Australia (1) · Belgium (1) · Chile (1) · Israel (1) · United Kingdom (1)
Walter Ling, M.D. (12) · Herbert Kleber, M.D. (9) · Dorothy Hatsukami, Ph.D. (8) · Eugene Somoza, M.D., Ph.D. (7) · Thomas R Kosten, M.D. (7) · Frances R Levin, M.D. (5) · James Cornish, M.D. (5) · John Grabowski, Ph.D. (5) · Joy M Schmitz, PhD (5) · Kenzie Preston, Ph.D. (5) · Louis Cantilena, M.D. (5) · Richard Foltin, Ph.D. (5) · John Roache, Ph.D. (4) · John Rotrosen, M.D. (4) · Kenneth Silverman, Ph.D. (4)
PMID 25938124, PMID 22775772, PMID 25630964, PMID 38180268, PMID 38551365, PMID 42423707, PMID 10219684, PMID 10517548, PMID 11484693, PMID 15734272, PMID 15827350, PMID 15913920, PMID 16102908, PMID 16107872, PMID 16143741, PMID 16697124, PMID 16730924, PMID 16887281, PMID 16930863, PMID 16953023, PMID 17084789, PMID 17258430, PMID 17272597, PMID 17317350, PMID 17347376, PMID 17512156, PMID 17523584, PMID 17606664, PMID 17613964, PMID 17624688, PMID 17664051, PMID 17705897, PMID 17907858, PMID 17931826, PMID 17970256, PMID 18056026, PMID 18068905, PMID 18079068, PMID 18294021, PMID 18346162, PMID 18349707, PMID 18541617, PMID 18626768, PMID 18681757, PMID 19349312, PMID 19372696, PMID 19414226, PMID 19651710, PMID 19787489, PMID 19805702
P50DA009262 (12), P50DA018197 (10), P50DA009236 (7), P50DA009250 (6), P50DA012756 (5), R01DA012268 (5), P60DA005186 (4), K01DA025073 (3), K20DA000238 (3), R01DA006234 (3), P20DA024157 (2), P50DA009241 (2), P50DA009260 (2), P50DA016556 (2), R01DA012952 (2)