10 completed, 6 unknown, 3 not yet recruiting, 2 terminated. 23 Phase 1, 12 Phase 2.
Follow Delirium: new trials by email Literature Review of Delirium trials Research Report on Delirium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Opioid-free Anesthesia and Postoperative Delirium OFA group, OBA group - Postoperative Delirium, Gastrointestinal Tumors | Phase 1 | Not yet recruiting | Qianfoshan Hospital | 174 | 2026-05-01 | 2026-05-22 |
| Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG) - Total Knee Arthroplasty (TKA) | Phase 1 / Phase 2 | Recruiting | University of Chicago | 150 | 2026-03-11 | 2026-06-26 |
| A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of Gastrodin Injection in Healthy Chinese Subjects gastrodin injection；placebo - Delirium | Phase 1 | Not yet recruiting | Kunming Pharmaceuticals, Inc. | 54 | 2026-03-01 | 2026-02-19 |
| Intraoperative Midazolam on Delirium Outcome of Elderly Patients Midazolam, Saline - Delirium, Anxiety | Phase 1 | Completed | Chinese PLA General Hospital | 612 | 2025-09-01 | 2026-09-02 |
| Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries Ketamine, Dexmedetomidine - Emergence Delirium | Phase 1 / Phase 2 | Unknown | Cairo University | 46 | 2024-08-10 | 2024-08-20 |
| Remimazolam for Emergence Delirium Prevention in Children Undergoing Tonsillectomy Remimazolam 20 MG Injection [Byfavo], NaCl (0,9%) - Remimazolam, Tonsillectomy | Phase 1 | Completed | University Hospital of Split | 110 | 2024-04-01 | 2026-07-15 |
| Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care Dexmedetomidine Hydrochloride - Hyperactive Delirium, Delirium of Mixed Origin | Phase 1 / Phase 2 | Unknown | Bruyère Health Research Institute. | 50 | 2024-01-30 | 2025-04-15 |
| Decreasing Emergence Delirium With Personalized Music Personalized Music, No Music - Emergence Delirium | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 394 | 2024-01-26 | 2026-07-23 |
| Dexmedetomidine Versus Ketamine Versus Magnesium Sulfate for the Prevention of Emergence Agitation Following Sevoflurane Induced Anesthesia in Cardiac Catheterization in Pediatrics Dexmedetomidine, Ketamine, Magnesium - Anesthesia Emergence Delirium | Phase 1 / Phase 2 | Unknown | Cairo University | 100 | 2023-09-20 | 2023-10-11 |
| The Effect of Preoperative Duloxetine on the Occurance of Postoperative Delirium in Patients Undergoing Cancer Surgery. Duloxetine 60 MG - Post Operative Delirium | Phase 1 / Phase 2 | Not yet recruiting | Amira Hassan Ahmed Ali | 42 | 2023-08-01 | 2023-07-17 |
| Effect of Different Administration Routes of Dexmedetomidine Combined with Ultrasound-Guided Fascia Iliaca Block on Emergence Agitation After Hip Replacement Surgery Dexmedetomidine Injection, Ropivacaine and Dexmedetomidine, Sodium Chloride Injection - Dexmedetomidine, Fascia Iliaca Block | Phase 1 | Unknown | Qianfoshan Hospital | 207 | 2023-02-05 | 2024-09-26 |
| Comparative Study Between Nebulised Dexmedetomidine and Nebulised Midazolam in Children Undergoing Lower Abdominal Surgeries Nebulised Dexmeditomidine, Nebulised Midazolam - Emergence Delirium, Anxiety Preoperative | Phase 1 | Completed | Ain Shams University | 60 | 2022-11-01 | 2024-05-24 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Effect of Caudal Nalbuphine on Postoperative Emergence Agitation in Pediatrics Undergoing Infra-umbilical Surgeries Nalbuphine, Bupivacain - Agitation, Emergence, Post Operative Pain | Phase 1 | Unknown | Assiut University | 80 | 2022-03-01 | 2022-02-18 |
| Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children Dexamethasone, Ondansetron, Dexmedetomidine - Postoperative Nausea and Vomiting, Post Operative Pain | Phase 1 | Completed | Tanta University | 4 | 2021-10-27 | 2022-04-05 |
| Post Operative Delirium Study Insulin, Saline - Delirium | Phase 1 / Phase 2 | Withdrawn | University of Kansas Medical Center | 2021-02-25 | 2024-08-21 | |
| Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium Rivastigmine Transdermal System [Exelon], Melatonin - Delirium | Phase 1 / Phase 2 | Completed | Ain Shams University | 180 | 2019-11-18 | 2020-07-09 |
| Dexmedetomidine Versus Nalbuphine in Prevention of Emergence Agitation Following Adenotonsillectomy in Pediatrics Dexmedetomidine, Nalbuphine, infusion pump - Emergence Delirium | Phase 1 / Phase 2 | Unknown | Ain Shams University | 120 | 2019-03-05 | 2019-08-20 |
| Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free) Benzodiazepine - limited use strategy, Benzodiazepine - Ad libitum strategy - Post-operative Delirium | Phase 1 | Completed | McMaster University | 480 | 2017-04-01 | 2018-10-16 |
| Melatonin and Sleep in Preventing Delirium in the Hospital Melatonin, Placebo - Delirium | Phase 1 / Phase 2 | Completed | Scripps Health | 94 | 2015-11-01 | 2017-10-04 |
Showing 20 of 23. Sign in to see all of them.
Emergence Delirium (13) · Pain, Postoperative (2) · Respiratory Insufficiency (2) · Anxiety Disorders (1) · Critical Illness (1) · Death (1) · Dementia (1) · Digestive System Neoplasms (1) · Insulin Resistance (1) · Nausea (1) · Postoperative Nausea and Vomiting (1) · Psychomotor Agitation (1) · Shock (1) · Vomiting (1)
Confusion (23) · Mental Disorders (23) · Nervous System Diseases (23) · Neurobehavioral Manifestations (23) · Neurocognitive Disorders (23) · Neurologic Manifestations (23) · Pathological Conditions, Signs and Symptoms (23) · Signs and Symptoms (23) · Pathologic Processes (15) · Postoperative Complications (13) · Pain (2) · Respiration Disorders (2) · Respiratory Tract Diseases (2) · Aberrant Motor Behavior in Dementia (1)
Dexmedetomidine (7) · Sodium Chloride (3) · Ketamine (2) · Lorazepam (2) · Melatonin (2) · Midazolam (2) · Nalbuphine (2) · Propofol (2) · Quetiapine Fumarate (2) · Saline Solution (2) · Alprazolam (1) · Anesthesia, Conduction (1) · Anesthesia, General (1) · Anesthesia, Local (1) · Anesthesia, Spinal (1)
Ain Shams University (3) · Cairo University (2) · Qianfoshan Hospital (2) · Amira Hassan Ahmed Ali (1) · Assiut University (1) · Bruyère Health Research Institute. (1) · Chinese PLA General Hospital (1) · Kunming Pharmaceuticals, Inc. (1) · Mayo Clinic (1) · McMaster University (1) · Queen's University (1) · Scripps Health (1) · Tanta University (1) · University Hospital of Split (1) · University of Chicago (1)
United States (7) · Egypt (6) · Canada (3) · China (3) · Croatia (1) · Saudi Arabia (1)
Amany Saleh, MD (1) · Amira Hassan Ahmed, resident (1) · Chani Traube, MD (1) · Filip Peris (1) · Frank Weinhold, Pharm.D., MS (1) · James Downar, MDCM, MSc (1) · Jonathan Leung, PharmD, RPh (1) · Karim K Fahim (1) · Min Zhang (1) · Paula L Watson, MD (1) · Rania Hussien, MD (1) · Summer Syed, MD (1)
PMID 29671186, PMID 29729237, PMID 32376378, PMID 32416996, PMID 32847776, PMID 33051948, PMID 36419158, PMID 36607634