1037 completed, 468 unknown, 280 recruiting, 158 terminated. 602 Not applicable, 295 Phase 2, 232 Phase 3, 155 Phase 4, 90 Phase 1.
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Validation of the iCVS Model in Patients Admitted to the Intensive Care Unit Shock | Not yet recruiting | Meir Medical Center | 1150 | 2028-04-01 | 2026-10-09 | |
| Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU Extended beta-lactam antibiotics, Intermittent Beta-lactam antibiotics - Sepsis, Septic Shock | Not yet recruiting | Assiut University | 90 | 2027-10-01 | 2026-09-01 | |
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent Normal Saline, Centhaquine - Hypovolemic Shock | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 430 | 2027-02-01 | 2026-09-17 |
| Biological Effects of Hemoadsorption in Septic Shock Hemoadsorption cartridge - Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction | Not applicable | Not yet recruiting | Miguel Sanchez Garcia | 16 | 2027-01-07 | 2026-07-20 |
| Remote Ischemic Postconditioning in Septic Shock Remote ischemic conditioning, No intervention - Adult Patients With Septic Shock Admitted in Intensive Care Unit | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 720 | 2027-01-01 | 2026-10-09 |
| SWedish Intensive Care Biobank Any Condition Underlying Critical Illness | Not yet recruiting | Uppsala University | 25000 | 2027-01-01 | 2026-05-13 | |
| Immune Dysregulation During Sepsis: A Natural History Cohort Sepsis, Septic Shock | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 500 | 2027-01-01 | 2026-10-09 | |
| French Observatory on the Management of Cardiogenic Shock 2 Cardiogenic Shock | Not yet recruiting | French Cardiology Society | 1000 | 2027-01-01 | 2026-10-09 | |
| Hong Kong Cardiogenic Shock Initiative Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction | Not yet recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 320 | 2026-12-01 | 2026-09-16 | |
| Capillary Refill Time Variation to Predict Oxygen Comsumption Variation After FLuid Challenge (CARTOFL) Indirect calorimetry measurement - Critically Ill Patients, Circulatory Shock | Not yet recruiting | Hospices Civils de Lyon | 80 | 2026-12-01 | 2026-09-24 | |
| Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis Sepsis, Severe Sepsis | Not yet recruiting | The University of Texas Health Science Center, Houston | 30 | 2026-12-01 | 2025-06-11 | |
| RPM Signals in Outpatient CAR T Therapy Cytokine Release Syndrome, Immune Effector Cell-Associated Neurotoxicity Syndrome | Not yet recruiting | Current Health | 125 | 2026-12-01 | 2026-10-20 | |
| CLL-1/CD70 Dual-Target CAR-T Cell Therapy for Acute Myeloid Leukemia CLL-1-CD70 CAR-T Cell Injection - Acute Myeloid Leukemia (AML), Relapsed/Refractory Acute Myeloid Leukemia | Phase 1 | Not yet recruiting | Liping Dou | 12 | 2026-11-30 | 2026-10-27 |
| FOUR-Based Modification of ICU Severity Scores ICU Mortality (Survival Rate) | Not yet recruiting | Al-Nahrain University | 2000 | 2026-11-01 | 2026-09-22 | |
| Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit 13C6-Glucose - Glucose, Metabolism | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 25 | 2026-11-01 | 2026-09-09 |
| Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic Shock Septic Shock, Sepsis | Not yet recruiting | Assiut University | 54 | 2026-11-01 | 2026-10-13 | |
| Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples InfectID-BSI (Bloodstream Infection) qPCR Assay - Bloodstream Infection, Sepsis | Not yet recruiting | Microbio Co Ltd | 1500 | 2026-11-01 | 2026-10-08 | |
| Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 78 | 2026-11-01 | 2026-09-24 |
| Low Dose Dexamethasone for the Prevention of Cytokine Release Syndrome Associated With Tebentafusp Dexamethasone - Uveal Melanoma, Metastatic | Phase 2 | Not yet recruiting | University of California, San Diego | 34 | 2026-11-01 | 2026-09-03 |
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Shock, Septic (1060) · Sepsis (680) · Shock, Cardiogenic (289) · Systemic Inflammatory Response Syndrome (195) · Multiple Organ Failure (190) · Cytokine Release Syndrome (162) · Critical Illness (151) · Acute Kidney Injury (107) · COVID-19 (103) · Wounds and Injuries (82) · Shock, Hemorrhagic (79) · Respiratory Distress Syndrome (77) · Heart Failure (67) · Inflammation (64)
Pathological Conditions, Signs and Symptoms (2233) · Pathologic Processes (2219) · Inflammation (1403) · Infections (1273) · Systemic Inflammatory Response Syndrome (1260) · Sepsis (519) · Cardiovascular Diseases (497) · Vascular Diseases (434) · Heart Diseases (385) · Myocardial Ischemia (303) · Necrosis (294) · Infarction (293) · Ischemia (293) · Myocardial Infarction (259)
Saline Solution (65) · Norepinephrine (50) · Standard of Care (47) · Sodium Chloride (41) · Hydrocortisone (39) · Blood Specimen Collection (37) · Ascorbic Acid (32) · Vasopressins (24) · Thiamine (21) · Ringer's Lactate (20) · Albumins (19) · Echocardiography (19) · tocilizumab (16) · Dexmedetomidine (15) · esmolol (15)
Assistance Publique - Hôpitaux de Paris (54) · Assiut University (34) · Hospices Civils de Lyon (24) · Southeast University, China (23) · Central Hospital, Nancy, France (21) · Ain Shams University (19) · University Hospital, Strasbourg, France (18) · Cairo University (17) · Centre Hospitalier Universitaire de Nīmes (17) · Centre Hospitalier Universitaire, Amiens (16) · Mahidol University (16) · National Taiwan University Hospital (16) · University Hospital, Montpellier (15) · Beth Israel Deaconess Medical Center (14) · Copenhagen University Hospital, Rigshospitalet (14)
United States (397) · France (366) · China (174) · Germany (140) · Egypt (98) · Italy (97) · Canada (91) · Spain (73) · Netherlands (66) · United Kingdom (54) · Brazil (52) · Denmark (51) · Turkey (Türkiye) (49) · Belgium (46) · Switzerland (43)
Andrea Morelli, MD (7) · Anders Perner, MD, PhD (4) · Holger Thiele, MD (4) · Michael W Donnino, MD (4) · Ahmed Mukhtar, Professor (3) · Alan E Jones, MD (3) · Anand Kumar, MD (3) · Carsten Skurk, MD (3) · Djillali Annane, MD (3) · Djillali Annane, MD, PhD (3) · Eric Bellissant, MD, PhD (3) · Jason Sperry, MD (3)
PMID 26903338, PMID 28101605, PMID 34519356, PMID 36416787, PMID 11794169, PMID 28343448, PMID 34605781, PMID 11445675, PMID 18305265, PMID 19531784, PMID 21516036, PMID 23353941, PMID 23899564, PMID 25392034, PMID 29784057, PMID 32192578, PMID 32520577, PMID 39716214, PMID 10470572, PMID 11395904, PMID 11588440, PMID 12500513, PMID 12519925, PMID 12720570, PMID 12794416, PMID 15276536, PMID 16134766, PMID 16424713, PMID 16497588, PMID 16855261, PMID 17334251, PMID 17638928, PMID 18090355, PMID 18375483, PMID 18434884, PMID 18533029, PMID 18702960, PMID 19926252, PMID 20179283, PMID 20802500, PMID 21615299, PMID 21669950, PMID 21918497, PMID 22073193, PMID 22110166, PMID 22704255, PMID 22751621, PMID 22920912, PMID 23001587, PMID 23067578
2014 (8), 2018 (8), 2017 (6), 2023 (6), 2019 (5), 2005 (3), 2015 (3), 2025 (3), U01HL077863 (3), 2009 (2), 2016 (2), M01RR002558 (2), U54GM062119 (2), 1RC3GM093717-01 (1), 1UG3HL157401-01A1 (1)