996 completed, 335 unknown, 180 recruiting, 132 terminated. 931 Not applicable, 116 Phase 2, 107 Phase 3, 86 Phase 4, 49 Phase 1.
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acoustic Resonance Therapy for Treating Empty Nose Syndrome Personalized ART, Non-personalized ART - Empty Nose Syndrome, Nasal Obstruction | Not applicable | Not yet recruiting | Stanford University | 40 | 2028-07-01 | 2025-10-10 |
| Adiposity Distribution in Acute Respiratory Failure PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone - Acute Hypoxemic Respiratory Failure, Obesity | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 80 | 2028-01-01 | 2025-06-13 |
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| Quantification of Inspiratory Effort Through Nasal Pressure in Patients Undergoing Weaning From Invasive Mechanical Ventilation and Correlation With Clinical Outcomes Nasal pressure assessment - Respiratory Failure | Not yet recruiting | University of Modena and Reggio Emilia | 175 | 2027-05-01 | 2025-04-25 | |
| TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport Advanced Respiratory Support During Patient Transport - Acute Respiratory Failure, Respiratory Insufficiency | Not yet recruiting | Medipol University | 565 | 2026-12-31 | 2026-09-04 | |
| Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation Oxygen therapy - Weaning From Mechanical Ventilation, Tracheostomy Weaning | Not applicable | Recruiting | Henrik Endeman | 20 | 2026-12-31 | 2026-10-01 |
| ENA-001 for Post Operative Respiratory Depression (PORD) ENA-001 - Respiratory Depression | Phase 2 | Not yet recruiting | Enalare Therapeutics Inc. | 200 | 2026-12-15 | 2026-02-27 |
| Effectiveness and Efficiency of Home Telemonitoring and Non-invasive Ventilation in Patients With COPD and Hypercapnia (EVALECO) Home Non-Invasive Ventilation and Telemonitoring - Pulmonary Disease, Chronic Obstructive (COPD), Hypercapnia | Not yet recruiting | Air Liquide Healthcare Spain | 92 | 2026-12-01 | 2026-10-28 | |
| Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers Quinton Medical Nasal Health Baby® - Nasal Congestion, Common Cold | Not yet recruiting | Laboratoires Quinton International S.L. | 83 | 2026-11-01 | 2026-10-13 | |
| Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea Sleep Inertia Questionnaire (SIQ) - Obstructive Sleep Apnea, Obesity (BMI>30) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 150 | 2026-11-01 | 2026-09-09 |
| Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning - Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy | Not applicable | Not yet recruiting | Rush University Medical Center | 2000 | 2026-11-01 | 2026-09-25 |
| Development and Prospective Validation of the AutoEIT Foundation Model for ARDS AutoEIT Model Training, AutoEIT Blinded Validation - ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure | Not yet recruiting | Ruijin Hospital | 1200 | 2026-11-01 | 2026-10-27 | |
| Diaphragm Ultrasound and Rapid Shallow Breathing Index for Predicting Extubation Success Diaphragm Ultrasonography, Rapid Shallow Breathing Index - Ventilator Weaning, Respiratory Insufficiency | Not yet recruiting | Inonu University | 80 | 2026-11-01 | 2026-10-27 | |
| Impact of Inspiratory Effort and Patient-Ventilator Interaction During the Transition Phase PVA classification software - Mechanically Ventilated Patients, Acute Respiratory Failure (ARF) | Not yet recruiting | Pontificia Universidad Catolica de Chile | 250 | 2026-11-01 | 2026-10-27 | |
| Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) Dopamine administration, Norepinephrine - Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN) | Phase 4 | Recruiting | University of California, Davis | 30 | 2026-10-30 | 2026-08-18 |
| Bedside Spirometry for Acute Lung Injury Hand-held spirometer, NIV - Respiratory Insufficiency | Not applicable | Recruiting | Centre Hospitalier Departemental Vendee | 30 | 2026-10-16 | 2026-10-19 |
| EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS Serial bronchoalveolar lavage and biological-physiological assessment - Acute Hypoxemic Respiratory Failure, Sepsis | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 145 | 2026-10-15 | 2026-08-28 | |
| Observational Study of RHINOSEDAL in Acute Nasal Obstruction RHINOSEDAL - Nasal Obstruction, Common Cold | Not yet recruiting | Laboratoires Elerte | 126 | 2026-10-15 | 2026-06-02 | |
| Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube, Sham Nebulization - Postoperative Sore Throat, Nasal Obstruction | Not applicable | Not yet recruiting | Mansoura University | 105 | 2026-10-15 | 2026-10-15 |
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Nasal Obstruction (170) · Airway Obstruction (143) · Pulmonary Disease, Chronic Obstructive (125) · Respiratory Distress Syndrome (122) · COVID-19 (118) · Hypoventilation (94) · Critical Illness (80) · Hypoxia (78) · Respiratory Aspiration (78) · Obesity Hypoventilation Syndrome (73) · Pneumonia (58) · Sleep Apnea, Obstructive (44) · Dyspnea (42) · Sepsis (39)
Respiratory Tract Diseases (1858) · Respiration Disorders (1845) · Pathological Conditions, Signs and Symptoms (796) · Signs and Symptoms (483) · Lung Diseases (469) · Pathologic Processes (455) · Signs and Symptoms, Respiratory (306) · Nervous System Diseases (297) · Infections (290) · Disease Attributes (233) · Respiratory Tract Infections (225) · Otorhinolaryngologic Diseases (194) · Nose Diseases (173) · Airway Obstruction (169)
Noninvasive Ventilation (67) · Standard of Care (23) · Continuous Positive Airway Pressure (17) · Propofol (16) · Dexmedetomidine (15) · Interactive Ventilatory Support (15) · Prone Position (14) · Saline Solution (14) · Fentanyl (13) · Respiration, Artificial (13) · Dexamethasone (12) · Oxygen (11) · Blood Specimen Collection (9) · Midazolam (8) · Oxymetazoline (8)
Massachusetts General Hospital (25) · Assistance Publique - Hôpitaux de Paris (24) · Assiut University (16) · University of Sao Paulo General Hospital (15) · Unity Health Toronto (14) · University Health Network, Toronto (14) · National Taiwan University Hospital (13) · Laval University (12) · Southeast University, China (12) · Stanford University (12) · Beth Israel Deaconess Medical Center (11) · Aerin Medical (10) · University Hospital, Grenoble (10) · University Hospital, Montpellier (10) · University Medical Center Groningen (10)
United States (483) · France (173) · Italy (123) · Canada (114) · China (105) · Spain (93) · Turkey (Türkiye) (84) · United Kingdom (74) · Germany (69) · Brazil (54) · Egypt (45) · Netherlands (45) · Taiwan (41) · Denmark (34) · Switzerland (33)
Ewan Goligher, MD, PhD (9) · Massimo Antonelli, MD (6) · Seetha Shankaran, MD (6) · Avroy A. Fanaroff, MD (5) · Edward F. Donovan, MD (5) · Laurent Brochard, MD (5) · Lu-Ann Papile, MD (5) · Richard A. Ehrenkranz, MD (5) · Sheldon B. Korones, MD (5) · Barbara J. Stoll, MD (4) · Charles R. Bauer, MD (4) · David K. Stevenson, MD (4) · Davide Chiumello, MD (4) · Lorenzo Berra, MD (4)
PMID 25003980, PMID 25980660, PMID 25981908, PMID 27997805, PMID 28466461, PMID 3230208, PMID 34473343, PMID 10793162, PMID 16331304, PMID 22382596, PMID 22797452, PMID 23460154, PMID 24199628, PMID 25496504, PMID 25529351, PMID 25915102, PMID 26810133, PMID 26923627, PMID 27255952, PMID 27406165, PMID 27620287, PMID 27677861, PMID 27941477, PMID 28346762, PMID 28528348, PMID 28851800, PMID 28860265, PMID 28930478, PMID 29146865, PMID 29756407, PMID 29936327, PMID 30935737, PMID 31209698, PMID 31368798, PMID 31915621, PMID 32071135, PMID 32171076, PMID 32925318, PMID 33820434, PMID 33853139, PMID 34115638, PMID 34322364, PMID 35244208, PMID 35639525, PMID 36656551, PMID 38865147, PMID 38990335, PMID 40920961, PMID 10080847, PMID 10400143
U10HD021385 (7), U10HD027880 (7), U10HD027904 (6), U10HD034216 (6), 2019 (5), 2025 (5), M01RR000070 (5), M01RR000750 (5), M01RR000997 (5), M01RR006022 (5), M01RR008084 (5), U10HD021364 (5), U10HD021397 (5), U10HD021415 (5), U10HD027853 (5)