535 completed, 166 unknown, 103 recruiting, 56 terminated. 597 Not applicable, 97 Phase 3, 68 Phase 2, 59 Phase 4, 35 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults Multi-nutrient supplement, Exercise - Sarcopenia | Not applicable | Withdrawn | McMaster University | 2030-01-20 | 2024-01-30 | |
| Transition Coaching in Rheumatology transition coaching - Rheumatic Conditions | Not applicable | Not yet recruiting | McMaster University | 86 | 2027-03-01 | 2026-09-24 |
| Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial Pain Science Education, Biomedical Education - Knee Arthritis Osteoarthritis | Not applicable | Not yet recruiting | McMaster University | 82 | 2027-02-01 | 2026-09-16 |
| Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee Standard care, Multicomponent opioid reduction and pain management pathway - Knee Arthroplasty, Total, Partial Knee Arthroplasty | Not applicable | Not yet recruiting | McMaster University | 170 | 2027-02-01 | 2026-10-30 |
| Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode. Arthroscopic stabilization, Rehabilitation including a period of immobilization followed by physical therapy - Shoulder Dislocation | Not applicable | Not yet recruiting | McMaster University | 30 | 2027-01-01 | 2026-10-07 |
| The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study Usual Medical Care, Usual Medical Care + Chiropractic Care - Back Pain | Not applicable | Not yet recruiting | McMaster University | 24 | 2026-12-01 | 2026-10-14 |
| Functional Mobility and Resistance Exercise for Postmenopausal Females With Type 1 Diabetes Resistance exercise - Type 1 Diabetes (T1D), Menopause | Not applicable | Not yet recruiting | Institut de Recherches Cliniques de Montreal | 63 | 2026-12-01 | 2026-10-01 |
| Conservative Care Versus Decompression Trial for Degenerative Cervical Myelopathy Pilot Decompression Surgery, Conservative Care - Degenerative Cervical Myelopathy | Not applicable | Not yet recruiting | McMaster University | 56 | 2026-12-01 | 2026-10-07 |
| AI-Adaptive AR Training for Balance and Falls Prevention in Older Adults AI-Enhanced Augmented Reality Balance and Mobility Training - Older Adults, Older Adults, Balance | Not applicable | Not yet recruiting | McMaster University | 30 | 2026-11-30 | 2026-08-25 |
| Fatigue in Long COVID Lightning Process, Activity Pacing - Long COVID | Not applicable | Not yet recruiting | McMaster University | 100 | 2026-11-01 | 2026-07-13 |
| Mechanisms of Weight Loss: Tirzepatide vs Semaglutide Tirzepatide, Semaglutide - Obesity (Disorder) | Phase 4 | Recruiting | McMaster University | 80 | 2026-10-31 | 2026-10-28 |
| SAFE (Self-Administration of Flumist to ImprovE Uptake: A Household-Based Cluster Randomized Trial) LAIV FLUMIST - Influenza (Healthy Volunteers) | Phase 4 | Not yet recruiting | McMaster University | 966 | 2026-10-15 | 2026-07-31 |
| ACSS Approach on Dysphagia Anterior Cervical Spine Surgery | Recruiting | Hamilton Health Sciences Corporation | 100 | 2026-10-01 | 2026-09-30 | |
| Personalized Probiotic Treatments for Irritable Bowel Syndrome Probiotic containing B longum, Probiotic Lactobacillus, Placebo - Irritable Bowel Syndrome (IBS) | Not applicable | Enrolling by invitation | McMaster University | 30 | 2026-10-01 | 2026-10-13 |
| Antireflux Surgery Without Preoperative Esophageal Manometry Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry - GERD, Hiatal Hernia | Not applicable | Not yet recruiting | McMaster University | 96 | 2026-10-01 | 2026-08-10 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| Evaluating in Person Curriculum for Educating Obstetrical Residents on Better Caring for 2 Spirit Metis Patients Using and AI Assisted OSCE. 2S Métis Cultural Safety Academic Half Day &AI-OSCE, Standard Institutional Cultural Safety Training&AI-OSCE - Cultural Safety, Medical Education | Not applicable | Not yet recruiting | University of Manitoba | 90 | 2026-09-23 | 2026-08-12 |
| Group CBT for Paternal Perinatal Depression Cognitive Behavioral Therapy for Paternal Perinatal Depression - Perinatal Depression, Fathers | Not applicable | Not yet recruiting | McMaster University | 112 | 2026-09-15 | 2026-08-13 |
| Rhythm Psychophysics With Parkinson's Patients Withholding Levodopa - Parkinson Disease(PD) | Not applicable | Not yet recruiting | McMaster University | 34 | 2026-09-01 | 2026-06-15 |
| Trauma Informed Goal Management Training With a "Support Person" Module for Individuals Impacted by Post-Traumatic Stress Trauma-Informed Goal Management Training (TIGMT), Trauma Informed Goal Management Training - Assist (TIGMT-Assist) - Post Traumatic Stress | Not applicable | Not yet recruiting | McMaster University | 64 | 2026-09-01 | 2026-09-01 |
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Motor Activity (44) · Stroke (27) · Asthma (26) · COVID-19 (22) · Depression (22) · Breast Neoplasms (21) · Obesity (21) · Anxiety Disorders (20) · Cardiovascular Diseases (20) · Pain, Postoperative (19) · Diabetes Mellitus (17) · Diabetes Mellitus, Type 2 (17) · Osteoarthritis, Knee (17) · Depression, Postpartum (16) · Venous Thromboembolism (16)
Exercise (22) · Cognitive Behavioral Therapy (15) · Saline Solution (10) · Standard of Care (10) · Fecal Microbiota Transplantation (6) · Pregabalin (6) · Sodium Chloride (6) · Surveys and Questionnaires (6) · Transcranial Magnetic Stimulation (6) · Bupivacaine (5) · Diet Therapy (5) · Escitalopram (5) · High-Intensity Interval Training (5) · Resistance Training (5) · Dalteparin (4)
Canada (896) · United States (72) · Australia (18) · United Kingdom (17) · Spain (14) · India (13) · Brazil (11) · Netherlands (11) · Saudi Arabia (10) · Italy (9) · Argentina (8) · China (8) · Belgium (7) · Austria (6) · Colombia (6)
Stuart M Phillips, PhD (14) · Gail Gauvreau, PhD (12) · Julie Richardson, PhD (9) · Michael Van Ameringen, MD, FRCPC (9) · Stuart Phillips, PhD (9) · Alexandra Papaioannou, MD, MSc (8) · Parameswaran Nair, MD, PhD (8) · Sheila Sprague, PhD (8) · Premysl Bercik, MD (7) · Stuart Phillips, Ph.D. (7) · Ryan Van Lieshout, MD, PhD (6) · Ada Tang, PhD (5) · Gerard Slobogean, MD (5) · Margaret McKinnon, PhD (5) · Maureen J MacDonald, PhD (5)
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R01AA027381 (2), 2009 (1), P30CA008748 (1), R01AG077481 (1), R01AI165327 (1), R01AR055130 (1), R01DC011020 (1), R01HL098045 (1), U01HL088476 (1), UM1AR063386 (1)