609 completed, 189 recruiting, 125 terminated, 94 active not recruiting. 459 Not applicable, 255 Phase 2, 130 Phase 1, 75 Phase 4, 41 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2 Motion Perception Task, Sine Wave Speech Task, Volatility Task - SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder | Not applicable | Not yet recruiting | Washington University School of Medicine | 325 | 2028-04-01 | 2026-10-15 |
| Mobile Health Management of Hypertension mHealth Coaching Intervention, Enhanced Usual Care - Hypertension | Not applicable | Not yet recruiting | University of Chicago | 40 | 2027-09-01 | 2026-08-10 |
| Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial) Nicotinamide, Standard Glaucoma Therapy - Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG) | Phase 2 | Not yet recruiting | University of Chicago | 96 | 2027-06-01 | 2026-10-13 |
| Breakthrough - T1DM and Chronic Kidney Disease Tegoprubart, Islet Cell Transplant - Diabete Type 1, Chronic Kidney Disease | Phase 1 / Phase 2 | Recruiting | University of Chicago | 10 | 2027-04-29 | 2026-08-20 |
| Microbiome Intervention for CAR-T Optimization and Response (MICRO-CART) Live Biotherapeutic Product (LBP), Placebo - Lymphoma, B-Cell, Multiple Myeloma | Phase 1 | Not yet recruiting | University of Chicago | 32 | 2027-02-23 | 2026-10-13 |
| A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck Cemiplimab, Fianlimab, Carboplatin - Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | University of Chicago | 90 | 2027-02-07 | 2026-01-20 |
| Building Rapid Inpatient Delivery of ART to Generate Engagement in HIV Care HIV Treatment | Not yet recruiting | University of Chicago | 40 | 2027-02-01 | 2026-09-29 | |
| Leveraging Pharmacy Technicians to Advance the Reach of Modern Antiretroviral Therapy (PHARM ART) in Community Clinics Pharmacy-technician based model - HIV | Not applicable | Not yet recruiting | University of Chicago | 465 | 2027-01-01 | 2026-04-28 |
| Prospective Study of Induction Medications Used in the Trauma RSI Ketamine, Etomidate, Propofol - Trauma, Rapid Sequence Intubation | Withdrawn | University of Southern California | 2027-01-01 | 2026-05-04 | ||
| Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy Lactulose - Cancer | Phase 1 / Phase 2 | Recruiting | University of Chicago | 55 | 2026-12-15 | 2026-06-16 |
| A Study Evaluating The Combination of Immunotherapy With Radiotherapy in Non-Small Cell Lung Cancer Investigator Choice Immunotherapy (for example: pembrolizumab, cemiplimab, durvalumab, ipilimumab plus nivolumab), Investigator Choice Chemotherapy (for example docetaxel with or without ramucirumab, gemcitabine, or other National Comprehensive Cancer Network (NCCN)-recommended treatments), Ablative Hypofractionated Radiotherapy - Non-Small Cell Lung Cancer, Metastatic Lung Cancer | Phase 2 | Recruiting | University of Chicago | 39 | 2026-12-12 | 2026-06-16 |
| PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients Bravo pH monitoring sessions - GERD | Not applicable | Not yet recruiting | University of Chicago | 80 | 2026-12-01 | 2026-10-13 |
| The NICE-PAD II Trial Nicotinamide Riboside (NR), Placebo - Peripheral Artery Disease (PAD) | Phase 3 | Not yet recruiting | Northwestern University | 250 | 2026-12-01 | 2026-08-24 |
| Collagenase Biobank Study Colorectal (Colon or Rectal) Cancer | Not yet recruiting | University of Chicago | 107 | 2026-12-01 | 2026-10-13 | |
| Promoting ColorBRAVE Conversations in Families ColorBRAVE - Child Development, Parents | Not applicable | Not yet recruiting | Tulane University | 1200 | 2026-12-01 | 2026-10-13 |
| The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults Apple Cider Vinegar - Kidney Stones, Urine Specimen Collection | Not applicable | Not yet recruiting | University of Chicago | 30 | 2026-12-01 | 2026-07-07 |
| Hospital Based Continuous Patient Monitoring System Consumer Wearable Device Vital Sign Measurement - Trauma, Appendectomy | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 250 | 2026-11-01 | 2026-10-08 |
| Pharmacokinetic Study of Therapeutic Plasma Exchange Spectra Optia Apheresis System - Immune-related Adverse Event | Withdrawn | University of Chicago | 2026-11-01 | 2026-09-24 | ||
| Evaluating Treatment Outcomes Using Darolutamide and Androgen Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer. Darolutamide, Physician choice Androgen Deprivation (Hormone) Therapy - Prostate Cancer | Phase 4 | Not yet recruiting | University of Chicago | 80 | 2026-11-01 | 2026-01-08 |
| Trastuzumab Deruxtecan to Treat HER2 + Newly Diagnosed Metastatic GI Cancers Trastuzumab Deruxtecan - HER2 Positive Newly Diagnosed Metastatic Esophageal, Gastric, GEJ Cancer Patients With an ECOG Performance Status of 2 | Phase 2 | Not yet recruiting | University of Chicago | 43 | 2026-11-01 | 2026-01-08 |
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Breast Neoplasms (38) · Prostatic Neoplasms (33) · Substance-Related Disorders (30) · Neoplasms (28) · Head and Neck Neoplasms (27) · Diabetes Mellitus (23) · Opioid-Related Disorders (22) · Obesity (19) · Depression (18) · Diabetes Mellitus, Type 2 (18) · Multiple Myeloma (18) · Asthma (17) · Lung Neoplasms (16) · Squamous Cell Carcinoma of Head and Neck (16) · COVID-19 (15)
Paclitaxel (23) · Carboplatin (22) · Dexamethasone (20) · Fluorouracil (20) · pembrolizumab (20) · Cisplatin (18) · Nitrous Oxide (12) · Irinotecan (11) · Leucovorin (11) · Nivolumab (11) · Radiotherapy (11) · Sirolimus (11) · Sugars (11) · Bevacizumab (10) · Cyclophosphamide (10)
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James Zacny, Ph.D. (17) · Robert M Naclerio, MD (13) · Jon E Grant, MD, JD, MPH (11) · Eve Van Cauter, PhD (10) · John P Kress, MD (9) · Esra Tasali, MD (8) · Harriet de Wit (8) · Hedy L. Kindler, MD (8) · Jon E Grant, JD, MD, MPH (8) · Everett Vokes, MD (7) · Melissa Gilliam, MD, MPH (7) · Walter M. Stadler, MD, FACP (7) · Ezra Cohen, MD (6) · Fuad M Baroody, MD (6) · Harriet de Wit, PhD (6)
PMID 34582562, PMID 36909590, PMID 17241734, PMID 21123449, PMID 21334602, PMID 21958447, PMID 22061038, PMID 22710617, PMID 23251869, PMID 23522057, PMID 23817024, PMID 24458353, PMID 24800110, PMID 25273286, PMID 25979608, PMID 26160288, PMID 26200928, PMID 26494483, PMID 27271308, PMID 28406662, PMID 28740827, PMID 30260448, PMID 30704863, PMID 30953588, PMID 31811557, PMID 32799938, PMID 33861952, PMID 33878489, PMID 33914891, PMID 34599167, PMID 35128308, PMID 36130734, PMID 36173600, PMID 36375174, PMID 36418846, PMID 36711165, PMID 36931706, PMID 37864258, PMID 38616053, PMID 39117276, PMID 40063391, PMID 40232856, PMID 42035974, PMID 42184934, PMID 10333907, PMID 10395122, PMID 10409601, PMID 10487591, PMID 10522604, PMID 10707230
P30CA014599 (18), R01DA008391 (17), P50MD017349 (8), R01DA002812 (8), P30DK092949 (5), R01AG055425 (4), R01HL089637 (4), R01DK071696 (3), U24HD069031 (3), UG1HD041267 (3), UG1HD054214 (3), UG1HD054241 (3), UG1HD069010 (3), UG1HD069013 (3), UG1HD110057 (3)