8726 completed, 4640 unknown, 3329 recruiting, 1746 terminated. 7031 Phase 2, 4975 Not applicable, 3711 Phase 1, 1953 Phase 3, 419 Phase 4.
Follow Digestive System Neoplasms: new trials by email Literature Review of Digestive System Neoplasms trials Research Report on Digestive System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Certepetide Phase 1b/2a Continuous Infusion Trial in mPDAC certepetide, nab-paclitaxel, gemcitabine - Pancreas Cancer, Pancreatic Carcinoma | Phase 1 / Phase 2 | Withdrawn | Lisata Therapeutics, Inc. | 2030-01-01 | 2025-06-06 | |
| Adaptive Neoadjuvant Therapy for Esophageal Cancer Neoadjuvant concurrent chemoradiotherapy - Esophageal Carcinoma, Neoadjuvant Therapy | Not applicable | Enrolling by invitation | Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center | 43 | 2028-03-01 | 2025-05-25 |
| Improving Clinic Delivery of HIV-related Anal Health Services PEACHES 2.0 Implementation Strategies - HIV, Gonorrhea | Not applicable | Not yet recruiting | Albert Einstein College of Medicine | 8 | 2028-02-01 | 2026-10-13 |
| The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp Shared Decision Making using a Patient Decision Aid. - Shared Decision Making, Colonic Polyp | Phase 2 | Not yet recruiting | Vejle Hospital | 110 | 2028-02-01 | 2026-04-30 |
| CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Metastatic Colorectal Cancer CA102N, TAS-102, Bevacizumab - Metastatic Colorectal Cancer | Phase 2 | Suspended | Holy Stone Healthcare Co., Ltd | 100 | 2027-12-01 | 2026-09-18 |
| Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer intravoxel incoherent motion magnetic resonance imaging - Rectal Neoplasms, Prognosis | Not yet recruiting | Sichuan Cancer Hospital and Research Institute | 400 | 2027-11-01 | 2025-12-08 | |
| Endoscopic Ultrasound-Guided Pulsed Electric Field Ablation for the Treatment of Pancreatic Neoplasms Clinical Intervention or Procedure, Electronic Health Record Review, Endoscopic Ultrasound-Guided Fine-Needle Aspiration of the Pancreas - Pancreatic Neoplasm, Pancreatic Neuroendocrine Tumor | Not applicable | Enrolling by invitation | Ohio State University Comprehensive Cancer Center | 12 | 2027-10-01 | 2026-10-13 |
| Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome Shuganhuazhuo Formula, Targeted therapy, Immunotherapy - HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine | Phase 2 | Not yet recruiting | Xiang-Qian | 120 | 2027-09-01 | 2026-08-27 |
| Ampligen Combined With SOC Versus SOC Alone Following First-Line Therapy in Subjects With LAPC Rintatolimod - Pancreatic Cancer | Phase 2 | Suspended | AIM ImmunoTech Inc. | 90 | 2027-08-01 | 2026-08-19 |
| Combination of Osemitamab (TST001), Pembrolizumab and Chemotherapy as First-line Therapy in Advanced or Metastatic GC/GEJ Adenocarcinoma Pembrolizumab and either Capcecitabine + Oxaliplatin or Oxaliplatin+Leucovorin + 5-fluorouracil - Gastric Cancer, Gastroesophageal-junction Cancer | Phase 3 | Not yet recruiting | Transcenta Therapeutics (Hangzhou) Co., Ltd. | 820 | 2027-06-30 | 2026-09-29 |
| Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation DN022150+AG( Stage I ）, DN022150+AG（Stage II）, placebo+AG（Stage II） - Pancreatic Cancer, Pancreatic Carcinoma | Phase 2 / Phase 3 | Not yet recruiting | Jiangxi Kvvit Pharmaceutical Co., Ltd. | 465 | 2027-06-06 | 2026-06-18 |
| Multicenter Phase 2 Study of Envafolimab in Biliary Tract Cancers Envafolimab plus Gemcitabine&Cisplatin, Gemcitabine&Cisplatin - Biliary Tract Neoplasms | Phase 2 | Not yet recruiting | 3D Medicines (Sichuan) Co., Ltd. | 126 | 2027-06-01 | 2026-03-25 |
| Immunotherapy Treating GI Cancer engineered immune cells - Cancer | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2027-06-01 | 2026-08-26 |
| Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a (Trastuzumab Deruxtecan), for Advanced Pancreatic Ductal Adenocarcinoma Biospecimen Collection, Diagnostic Imaging Testing, Echocardiography Test - Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 31 | 2027-06-01 | 2026-10-22 |
| SGA-OCRC: Prediction of 90-Day Major Adverse Postoperative Outcomes in Octogenarians With Resectable Colorectal Cancer Octogenarian Patients With Non-metastatic Resectable Colorectal Cancer | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 1000 | 2027-06-01 | 2026-10-29 | |
| Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial Balstilimab, Biopsy Procedure, Biospecimen Collection - Colorectal Adenocarcinoma, Stage II Colorectal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 20 | 2027-05-25 | 2026-09-29 |
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| PET/MRI in Rectal Cancer Total Neo-adjuvant Therapy, 18FDG-PET/MRI scan - Rectal Cancer | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 40 | 2027-05-01 | 2026-10-28 |
| Daraxonrasib in Resectable PDAC Daraxonrasib, Surgical Resection, Adjuvant Chemotherapy - Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer | Phase 1 | Not yet recruiting | Dana-Farber Cancer Institute | 30 | 2027-04-13 | 2026-10-27 |
| Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options Liver transplantation - Colorectal Neoplasms, Liver Neoplasms | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 260 | 2027-04-01 | 2026-09-10 |
Showing 20 of 21768. Sign in to see all of them.
Colorectal Neoplasms (6118) · Pancreatic Neoplasms (3675) · Carcinoma, Hepatocellular (3375) · Stomach Neoplasms (3175) · Colonic Neoplasms (2382) · Rectal Neoplasms (2239) · Esophageal Neoplasms (1844) · Liver Neoplasms (1288) · Neoplasms (1193) · Breast Neoplasms (1106) · Neoplasm Metastasis (898) · Carcinoma, Non-Small-Cell Lung (821) · Lung Neoplasms (773) · Ovarian Neoplasms (709) · Gastrointestinal Neoplasms (694)
Digestive System Diseases (21682) · Neoplasms by Site (21448) · Neoplasms (20575) · Gastrointestinal Diseases (14393) · Gastrointestinal Neoplasms (13754) · Intestinal Diseases (9452) · Intestinal Neoplasms (9344) · Rectal Diseases (7912) · Colonic Diseases (7851) · Neoplasms by Histologic Type (6335) · Neoplasms, Glandular and Epithelial (5683) · Carcinoma (5073) · Endocrine System Diseases (4435) · Endocrine Gland Neoplasms (4379)
Oxaliplatin (1279) · Fluorouracil (1218) · Capecitabine (994) · Gemcitabine (916) · Leucovorin (869) · Bevacizumab (811) · Irinotecan (751) · Cisplatin (616) · Radiotherapy (519) · Cetuximab (457) · pembrolizumab (418) · Paclitaxel (365) · Nivolumab (318) · Drug Therapy (315) · Sorafenib (289)
National Cancer Institute (NCI) (482) · Sun Yat-sen University (389) · Fudan University (362) · M.D. Anderson Cancer Center (288) · Memorial Sloan Kettering Cancer Center (229) · Hoffmann-La Roche (153) · National Taiwan University Hospital (152) · Shanghai Zhongshan Hospital (147) · Seoul National University Hospital (145) · Tianjin Medical University Cancer Institute and Hospital (144) · Yonsei University (131) · Assistance Publique - Hôpitaux de Paris (112) · Samsung Medical Center (112) · City of Hope Medical Center (109) · Mayo Clinic (105)
United States (6792) · China (5258) · France (1599) · South Korea (1448) · Italy (1198) · Spain (1119) · United Kingdom (1024) · Germany (996) · Canada (958) · Taiwan (816) · Japan (665) · Netherlands (656) · Belgium (624) · Australia (548) · Denmark (428)
Tim F Greten, M.D. (22) · Ajay Goel, PhD (21) · Ming Shi, MD (21) · Norman Wolmark, MD (21)
PMID 33538338, PMID 35623069, PMID 39863139, PMID 26808342, PMID 30207593, PMID 36306483, PMID 12049862, PMID 40341124, PMID 15496622, PMID 35588252, PMID 37162250, PMID 11981766, PMID 19192962, PMID 12540794, PMID 18650514, PMID 29433850, PMID 31268130, PMID 33356421, PMID 40340830, PMID 15273542, PMID 19095497, PMID 20375404, PMID 20728210, PMID 21561347, PMID 22646630, PMID 26049686, PMID 26187751, PMID 28712102, PMID 29628281, PMID 30679026, PMID 31378656, PMID 31401903, PMID 32402160, PMID 32816630, PMID 34143971, PMID 36852452, PMID 36990609, PMID 37598000, PMID 37934000, PMID 12091661, PMID 18316791, PMID 19097774, PMID 19269519, PMID 19339720, PMID 21374666, PMID 21596621, PMID 21997132, PMID 22070868, PMID 23433878, PMID 24131140
2023 (111), 2025 (79), 2019 (73), 2017 (68), 2015 (62), 2018 (62), 2016 (59), P30CA033572 (50), 2014 (48), 2009 (46), P30CA015083 (42), P30CA016672 (42), 2008 (37), P30CA014089 (34), U10CA032102 (32)