66 completed, 45 unknown, 17 terminated, 15 not yet recruiting. 174 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 174 | Completed 66, Unknown 45, Terminated 17, Not yet recruiting 15, Recruiting 15, Withdrawn 13, Active not recruiting 2, Suspended 1 |
Follow Delirium: new trials by email Literature Review of Delirium trials Research Report on Delirium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-11-01 | 2026-10-29 |
| Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Sphenopalatine Ganglion Block for Functional Endoscopic Sinus Surgery Bupivacaine & normal saline, Dexmedetomidine & Bupivacaine., Dexamethasone & Bupivacaine. - Post Operative Pain, Emergence Agitation | Phase 4 | Not yet recruiting | Sohag University | 60 | 2026-11-01 | 2026-11-10 |
| Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery Quality Opioids - Emergence Delirium, Emergence Agitation | Phase 4 | Not yet recruiting | Konya City Hospital | 88 | 2026-09-05 | 2026-10-06 |
| Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure Low dose ketamine infusion, Dexmedetomidine infusion - Delirium in Intensive Care Unit, Acute Heart Failure (AHF) | Phase 4 | Not yet recruiting | Alexandria University | 150 | 2026-09-01 | 2026-08-24 |
| Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients Lemborexant, Placebo - Sleep Disturbance, Delirium | Phase 4 | Recruiting | Mahidol University | 100 | 2026-09-01 | 2026-10-08 |
| Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children propofol 1mg/kg, Dexmedetomidine - Emergence Delirium, Anesthesia | Phase 4 | Recruiting | Pakistan Institute of Medical Sciences | 114 | 2026-08-28 | 2026-09-02 |
| Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery Remimazolam - Emergence Agitation, General Anesthesia | Phase 4 | Not yet recruiting | Jeju National University School of Medicine | 138 | 2026-07-24 | 2026-07-31 |
| Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging Dexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg - MRI Sedation, Pediatric Sedation | Phase 4 | Recruiting | Boston Children's Hospital | 105 | 2026-06-30 | 2026-09-21 |
| Intranasal Dexmedetomidine or Esketamine for Negative Postoperative Behavioral Changes in Children Dexmedetomidine, Esketamine, Normal Saline - Behavior Problem | Phase 4 | Not yet recruiting | Nanjing Children's Hospital | 342 | 2026-06-01 | 2026-05-06 |
| Dexmedetomidine Nasal Spray on Postoperative Delirium in Elderly Thoracoscopic Lung Resection Patients Dexmedetomidine hydrochloride nasal spray, Placebo - Postoperative Delirium (POD) | Phase 4 | Not yet recruiting | Sichuan Provincial People's Hospital | 264 | 2026-06-01 | 2026-05-12 |
| Dexmedetomidine vs Propofol-lidocaine Mixture in Preventing the Post Operative Emergence Agitation Following Sevoflurane Anasthesia Dexmedetomidine, Propofol, Placebo - Emergence Agitation | Phase 4 | Not yet recruiting | Sohag University | 200 | 2026-05-01 | 2026-05-22 |
| Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery Dexmedetomidine, Standard General Anesthesia - Thyroid Diseases | Phase 4 | Recruiting | Bach Mai Hospital | 100 | 2026-04-13 | 2026-04-15 |
| Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients Esketamine 1, Esketamine 2, Esketamine 3 - Elderly, Noncardiac Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 120 | 2026-04-01 | 2026-04-14 |
| Acetaminophen-Mannitol Injection and Postoperative Delirium Acetaminophen group, Sufentanil group - Postoperative Delirium | Phase 4 | Recruiting | Xiangya Hospital of Central South University | 1092 | 2026-02-02 | 2026-10-29 |
| Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium Dexmedetomidine and Midazolam, Ketamine and Midazolam - Emergence Delirium | Phase 4 | Recruiting | Kasr El Aini Hospital | 50 | 2026-02-01 | 2026-02-27 |
| The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hip Arthroplasty Under Spinal Anesthesia remimazolam sedation reversal with flumazenil, placebo - Postoperative Delirium, Sedation | Phase 4 | Not yet recruiting | Medical University of Gdansk | 150 | 2026-01-01 | 2026-01-06 |
| The Effect of Propofol Versus Lidocaine on Emergence Agitation in Children Undergoing Tonsillectomy. Propofol, Lidocaine %2 ampoule - Emergence Delirium, Anesthesia | Phase 4 | Not yet recruiting | Assiut University | 82 | 2026-01-01 | 2025-12-08 |
| Inhaled Sedation in Critically Ill Patients Isoflurane, Propofol - Sedation, Airway Extubation | Phase 4 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 620 | 2025-12-15 | 2026-06-29 |
| Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery Midazolam, Remimazolam - Delirium, Critical Illness | Phase 4 | Not yet recruiting | Yonsei University | 300 | 2025-12-01 | 2025-12-04 |
Showing 20 of 174. Sign in to see all of them.
Emergence Delirium (94) · Cognitive Dysfunction (11) · Postoperative Cognitive Complications (10) · Pain, Postoperative (9) · Postoperative Complications (8) · Critical Illness (5) · Mental Disorders (5) · Pain (5) · Psychomotor Agitation (5) · Sleep Initiation and Maintenance Disorders (5) · Anxiety Disorders (4) · Depression (4) · Neurocognitive Disorders (4) · Agnosia (3)
Pathological Conditions, Signs and Symptoms (174) · Nervous System Diseases (173) · Neurobehavioral Manifestations (173) · Neurologic Manifestations (173) · Signs and Symptoms (173) · Confusion (171) · Neurocognitive Disorders (170) · Mental Disorders (169) · Pathologic Processes (109) · Postoperative Complications (94) · Cognition Disorders (19) · Behavior (9) · Behavioral Symptoms (9) · Cognitive Dysfunction (9)
Dexmedetomidine (58) · Propofol (32) · Saline Solution (30) · Sodium Chloride (19) · Sevoflurane (17) · Ketamine (13) · Midazolam (13) · Haloperidol (8) · Fentanyl (6) · Desflurane (5) · Esketamine (5) · Isoflurane (5) · Remifentanil (5) · ramelteon (5) · remimazolam (5)
Peking University First Hospital (12) · Chinese PLA General Hospital (4) · Ain Shams University (3) · Assiut University (3) · Beijing Chao Yang Hospital (3) · Chung-Ang University Hospital (3) · Second Affiliated Hospital of Wenzhou Medical University (3) · Alexandria University (2) · Beth Israel Deaconess Medical Center (2) · Cairo University (2) · Capital Medical University (2) · Fujian Provincial Hospital (2) · Hvidovre University Hospital (2) · Icahn School of Medicine at Mount Sinai (2) · Korea University Guro Hospital (2)
China (47) · United States (39) · Egypt (14) · South Korea (13) · Canada (6) · Turkey (Türkiye) (6) · Netherlands (5) · Denmark (4) · Germany (3) · Indonesia (3) · Austria (2) · Belgium (2) · Italy (2) · Norway (2) · Russia (2)
Dong-Xin Wang, MD, PhD (8) · Alexa Hollinger, MD (2) · Jeff Silverstein, MD (2) · Jian-Xin Zhou, MD (2) · Malaz Boustani, MD, MPH (2) · Stephen Choi, MD,MSc,FRCPC (2) · Weidong Mi, MD (2) · Xiaochun Zheng, MD (2) · Ahmed Elhaddad, Ass.prof. (1) · Alex Bekker, MD, PhD (1) · Alexander V. Mironenko, MD, PhD (1) · Anders Perner, MD,PhD (1) · Andi Ade W Ramlan (1) · Arjen JC Slooter, MD. PhD. (1)
PMID 12760985, PMID 15114210, PMID 12075033, PMID 1394752, PMID 15082703, PMID 15817019, PMID 1593914, PMID 16677266, PMID 17179249, PMID 18372935, PMID 19347026, PMID 19422355, PMID 19687169, PMID 19865006, PMID 20047899, PMID 20740210, PMID 21056464, PMID 21309294, PMID 21390159, PMID 21926597, PMID 22065690, PMID 22235871, PMID 22301509, PMID 22553919, PMID 22826531, PMID 22886871, PMID 2301747, PMID 23110746, PMID 23182527, PMID 23506796, PMID 24261644, PMID 25168927, PMID 25348864, PMID 25535538, PMID 26077062, PMID 26118922, PMID 26601849, PMID 27787936, PMID 28182690, PMID 28593326, PMID 28710219, PMID 28754225, PMID 28904966, PMID 29466591, PMID 29482596, PMID 29498534, PMID 29628826, PMID 29881956, PMID 29929533, PMID 30169416
2014 (1), 2017 (1), 2019 (1), R01AG029656 (1), R15AG034915 (1)