1538 completed, 547 recruiting, 381 unknown, 252 not yet recruiting. 2005 Not applicable, 491 Phase 2, 402 Phase 3, 226 Phase 4, 136 Phase 1.
Follow Standard of Care: new trials by email Literature Review of Standard of Care trials Research Report on Standard of Care
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Scaling up the DSMES Learning Collaborative Multicomponent Implementation Strategy (MCIS) Bundle, Standard of Care - Type Two Diabetes Mellitus | Not applicable | Not yet recruiting | Mary Lacy | 96 | 2029-04-01 | 2026-10-22 |
| A Study to Observe the Pattern of Use and Safety of Rivaroxaban in Children Under 2 Years Old With Venous Thromboembolism (VTE) Rivaroxaban (Xarelto, BAY59-7939), Standard of care (SOC) - Venous Thromboembolism, Children Under 2 Years | Not yet recruiting | Bayer | 850 | 2027-09-01 | 2026-10-02 | |
| Family-Focused Study to Support Medication for Opioid Use Disorder FamilyCHESS, Standard of Care - Opioid Use Disorder, Opioid Use Disorder, Moderate | Not applicable | Not yet recruiting | University of Wisconsin, Madison | 338 | 2027-08-31 | 2026-07-07 |
| Grain Moxibustion Treatment on Insomnia: a Randomized Controlled Trial Grain moxibustion, Sham grain moxibustion, Standard care - Sleep Initiation and Maintenance Disorders | Not applicable | Not yet recruiting | Shanghai Institute of Acupuncture, Moxibustion and Meridian | 102 | 2027-07-01 | 2025-05-14 |
| On the Move: Center and Home-Based Exercise to Enhance Mobility in Diabetic Foot Ulcer Recovery 12-week exercise regimen, 12-week standard of care - Diabetic Foot Ulcer | Not applicable | Not yet recruiting | University of Maryland, Baltimore | 60 | 2027-06-01 | 2026-10-07 |
| Appendectomy as an Adjunct Procedure in Endometriosis Surgery Appendectomy, Standard of Care (SOC) - Endometriosis | Not applicable | Not yet recruiting | Mount Sinai Hospital, Canada | 240 | 2027-04-01 | 2026-09-16 |
| Improving TelePrEP Initiation and Retention Outcomes in the US: The MISTR+ Study No Marginal Cost Interventions, Low-Marginal Cost Interventions, Standard of Care - Human Immunodeficiency Virus | Not applicable | Not yet recruiting | Emory University | 223165 | 2027-03-01 | 2026-09-16 |
| BANDICOOT: An Adaptive Platform Trial to Improve Health Outcomes After Paediatric Stem Cell Transplant Standard care - Haematopoietic Stem Cell Transplant, Allogeneic | Not applicable | Not yet recruiting | Murdoch Childrens Research Institute | 10000 | 2027-03-01 | 2026-07-01 |
| PRECISE LBCL: Precision Treatment Readiness Through Comprehensive Genomic Sequencing in 1st Line LBCL Standard of Care (SOC) - LBCL, Comprehensive Genomic | Not yet recruiting | M.D. Anderson Cancer Center | 60 | 2027-02-25 | 2026-09-21 | |
| Impact of Routine Electronic Patient-Reported Outcome (ePRO)Symptom Monitoring During Neoadjuvant Therapy in Patients withPancreatic Adenocarcinoma on Patient Experience and ClinicalOutcomes: A Prospective Pre-Post Implementation Study Standard of Care - ePRO, Symptom Monitoring | Not applicable | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2027-02-21 | 2026-09-21 |
| Home-Based Outpatient Model for BCG Delivery to Reduce Undue Burden on Patients Undergoing Treatment for Non-Muscle Invasive Bladder Carcinoma BCG Solution, Best Practice, Cystoscopy - Non-Muscle Invasive Bladder Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 49 | 2027-01-15 | 2026-10-14 |
| Cannabis Gummy for the Improvement of Sleep and Quality of Life in Patients With Cancer, Pillow Trial Actigraphy, Best Practice, Biospecimen Collection - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Theodore Brasky PhD | 50 | 2027-01-15 | 2026-10-14 |
| Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness Synbiotic, Standard of Care (SOC) - Critical Illness | Phase 1 / Phase 2 | Not yet recruiting | University of Calgary | 64 | 2027-01-01 | 2026-09-10 |
| A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States Doxycycline, Standard of Care (SOC) - Chlamydia Females, Gonorrhea Female | Phase 4 | Not yet recruiting | Tulane University | 519 | 2027-01-01 | 2026-07-15 |
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Prevention of Oral Mucositis in Adults in With Hematologic Malignancy Aloe Vera Mouthwash, Standard of Care - Acute Leukemia, Acute Myeloid Leukemia | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 206 | 2027-01-01 | 2026-10-22 |
| "Anticipant"-TIPS After a First Portal-hypertension-related Complication in Cirrhosis TIPS, Standard of Care (SOC) - Cirrhosis | Not applicable | Not yet recruiting | University Hospital, Toulouse | 266 | 2027-01-01 | 2026-10-22 |
| Enhancing Cervical Cancer Screening and Treatment in Women Living With HIV in Kenya, the ENHANCE LINKAge Trial Best Practice, Health Promotion and Education, HPV Self-Collection - HIV Infection, Human Papillomavirus-Related Cervical Carcinoma | Not applicable | Not yet recruiting | Emory University | 2280 | 2026-12-31 | 2026-09-17 |
| Sustained Asthma Remission and Reduced Relapse Using a Comprehensive Management Strategy (SARRE-COMS) Comprehensive Biomarker-Guided Management Strategy, Standard of Care - Asthma (Diagnosis) | Not applicable | Not yet recruiting | Hana Serajeddini | 50 | 2026-12-02 | 2026-09-25 |
| Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour Visual Stimulation, standard of care - Hemianopsia, Virtual Reality | Not applicable | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 120 | 2026-12-01 | 2026-09-16 |
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COVID-19 (175) · Diabetic Foot (93) · Breast Neoplasms (82) · Neoplasms (74) · Diabetes Mellitus (64) · Stroke (64) · Diabetes Mellitus, Type 2 (59) · Obesity (59) · Heart Failure (58) · Motor Activity (58) · Anxiety Disorders (55) · Prostatic Neoplasms (51) · Pain (50) · Acquired Immunodeficiency Syndrome (48) · Colorectal Neoplasms (45)
M.D. Anderson Cancer Center (57) · Emory University (56) · Mayo Clinic (41) · Assistance Publique - Hôpitaux de Paris (31) · City of Hope Medical Center (23) · Ohio State University Comprehensive Cancer Center (23) · Johns Hopkins University (21) · Novartis Pharmaceuticals (21) · University of California, San Francisco (21) · VA Office of Research and Development (21) · University of Colorado, Denver (20) · University of Alabama at Birmingham (19) · Wake Forest University Health Sciences (19) · Fred Hutchinson Cancer Center (18) · GlaxoSmithKline (18)
United States (1530) · Canada (229) · France (216) · United Kingdom (202) · Germany (182) · Spain (171) · Italy (167) · China (147) · Belgium (108) · Australia (94) · Netherlands (93) · Denmark (90) · Poland (83) · Turkey (Türkiye) (83) · Sweden (74)
Angelina Ferguson, DNP (5) · Anthony Spirito, PhD (4)
PMID 34473343, PMID 36695483, PMID 34350582, PMID 40243391, PMID 26636489, PMID 34184251, PMID 34658014, PMID 39230271, PMID 11581152, PMID 25773607, PMID 27215559, PMID 28616847, PMID 28932752, PMID 32142651, PMID 32176248, PMID 32871021, PMID 33177145, PMID 33240091, PMID 33687069, PMID 33769555, PMID 34510411, PMID 34531304, PMID 35614292, PMID 35732151, PMID 35816217, PMID 35904046, PMID 37137672, PMID 37439961, PMID 37459086, PMID 37568081, PMID 37682971, PMID 38724182, PMID 38745646, PMID 38775637, PMID 39101506, PMID 39115551, PMID 39208825, PMID 39382077, PMID 40271704, PMID 40569673, PMID 41762058, PMID 10400410, PMID 10516779, PMID 10761958, PMID 10777236, PMID 10805617, PMID 10811152, PMID 11240232, PMID 11413430, PMID 11493907
P30CA033572 (18), 2025 (17), 2023 (15), 2016 (14), 2017 (14), 2018 (13), P30CA138292 (12), 2019 (7), P30CA012197 (5), P30CA016672 (5), UG1CA189974 (5), 2015 (4), P30CA014089 (4), 2005 (3), 2014 (3)