52 completed, 20 unknown, 14 terminated, 8 recruiting. 31 Phase 2, 24 Phase 3, 23 Phase 4, 19 Not applicable, 7 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release Amitriptyline, Placebo - Microvesicle Particles, Thermal Burn | Phase 1 | Not yet recruiting | Wright State University | 20 | 2027-06-01 | 2026-07-17 |
| Nortriptyline Compared With Amitriptyline for Migraine Prevention at SQUH Nortriptyline, Amitriptyline - Migraine | Phase 4 | Not yet recruiting | Sultan Qaboos University | 90 | 2027-05-01 | 2026-10-02 |
| Pilot Studies Blocking Injury-Induced MVP Release in Skin Using Topical Amitriptyline Amitriptyline, Placebo - Thermal Burn, Amitriptyline | Phase 1 | Not yet recruiting | Wright State University | 50 | 2026-10-01 | 2026-09-30 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM) Galcanezumab, Erenumab 70 mg, Eptinezumab - Migraine Associated Vertigo, Tinnitus | Phase 4 | Not yet recruiting | Stanford University | 120 | 2026-07-01 | 2026-06-17 |
| Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease Amitriptyline, Placebo - Quiescent Crohn's Disease (CD) | Phase 2 | Recruiting | University of Michigan | 100 | 2026-06-03 | 2026-06-05 |
| The Effectiveness of Ultra-Sound Guided Erector Spinae Block With Betamethasone for Management of Truncal Chronic Post Herpetic Neuralgia. Medical management regimen, Erector spinae plane (ESP) block - Postherpetic Neuralgia, Chronic Pain | Not applicable | Recruiting | Cairo University | 40 | 2025-05-01 | 2025-06-05 |
| Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care Topiramate, Flunarizine, Amitriptyline - Migraine | Phase 4 | Not yet recruiting | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | 460 | 2024-10-01 | 2024-07-12 |
| Effect of Ketamine, Amitriptyline and Their Combination on Itch Ketamine 0.5%, Amitriptyline, ketamine + amitriptyline - Itch | Not applicable | Completed | Aalborg University | 30 | 2024-08-20 | 2025-01-30 |
| Comparison of Amitriptyline to Lifestyle Modification as Intervention for Vestibular Migraine Amitriptyline, Lifestyle Modification - Vestibular Migraine | Early Phase 1 | Withdrawn | Vanderbilt University Medical Center | 2024-06-19 | 2026-03-31 | |
| Focal Microvibration and Chronic Lumbosacral Radicular Pain Equistasi®, Sham, Gabapentin; Pregabalin; Duloxetine; Amitriptyline - Pain, Chronic, Lumbosacral Radiculopathy | Not applicable | Unknown | Federico II University | 150 | 2024-04-01 | 2024-03-08 |
| Mesotherapy Treatment of Irritable Bowel Syndrome Mesotherapy with mesocaine, thiocolchicoside, amitriptyline, magnesium pidolate - Inflammatory Bowel Diseases | Phase 2 | Active not recruiting | Polyclinique de l'Europe | 27 | 2024-02-28 | 2025-05-31 |
| Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea Imipramine, Amitriptyline, Vehicle - Rosacea | Phase 2 | Recruiting | Wright State University | 48 | 2024-02-27 | 2026-02-18 |
| Topical Amitriptyline 1% Gel for the Treatment of Burning Mouth Syndrome Topical amitriptyline 1% gel - Burning Mouth Syndrome, Stomatodynia | Completed | Universidad de Murcia | 30 | 2024-01-02 | 2025-10-09 | |
| Treatment of Post-Stroke Central Pain stSCS+Gabapentin or Pregabalin (with optional Duloxetine or Amitriptyline), Gabapentin or Pregabalin (with optional Duloxetine or Amitriptyline) - Central Post-Stroke Pain | Not applicable | Recruiting | Nanchong Central Hospital | 80 | 2024-01-01 | 2026-05-18 |
| Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis Amitriptyline, Flunarizine 5mg - Migraine, Prophylaxis | Not applicable | Unknown | Shalamar Institute of Health Sciences | 84 | 2024-01-01 | 2023-12-29 |
| Amitriptyline for Repetitive Behaviors in Autism Spectrum Disorders amitriptyline - Autism Spectrum Disorder, Repetitive Compulsive Behavior | Phase 3 | Terminated | University of Missouri, Kansas City | 1 | 2023-11-01 | 2025-05-30 |
| Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy Duloxetine alone, Duloxetine augmented with gabapentin, Duloxetine augmented with amitriptyline (as combined therapy) - Neuropathy in Cacer Patien | Phase 2 | Unknown | Beni-Suef University | 160 | 2023-10-10 | 2024-04-16 |
| Responding With Evidence and Access for Childhood Headaches CBT, Amitriptyline - Headache, Headache Disorders | Not applicable | Recruiting | Children's Hospital Medical Center, Cincinnati | 400 | 2023-08-22 | 2026-09-21 |
| EASE (Efficacy of ATX01 Study in Erythromelalgia) Amitriptyline Hydrochloride, Placebo - Erythromelalgia | Phase 2 | Completed | AlgoTherapeutix | 14 | 2023-06-14 | 2024-04-18 |
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Migraine Disorders (13) · Pain (9) · Chronic Pain (8) · Fibromyalgia (7) · Headache (7) · Neuralgia (7) · Depression (6) · Depressive Disorder, Major (5) · Cystitis, Interstitial (3) · Depressive Disorder (3) · Pain, Postoperative (3) · Peripheral Nervous System Diseases (3) · AIDS-Related Complex (2) · Abdominal Pain (2) · Acquired Immunodeficiency Syndrome (2)
Children's Hospital Medical Center, Cincinnati (4) · Mayo Clinic (3) · Wright State University (3) · Boston Medical Center (2) · Danish Headache Center (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Hospital de Clinicas de Porto Alegre (2) · Insel Gruppe AG, University Hospital Bern (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Rambam Health Care Campus (2) · University of Campinas, Brazil (2) · Aalborg University (1) · Alexandria University (1) · AlgoTherapeutix (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1)
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J. Pieter Noordzij, MD (2) · Pascal H Vuilleumier, MD (2) · Scott Powers, PhD (2) · Ulrike Stamer, Professor (2) · Vivek N Iyer, MD (2) · Adrienne D Bonham, MD (1) · Ahmed F El-Yazbi, PhD (1) · Alan G Wade, MBChb (1) · Albert Nadal, MD (1) · Allen A. Lee, MD, MS (1) · Andrew Bishara, MD (1) · Andrew D. Hershey, MD, PhD (1) · Angela L Ofori-Atta, PhD (1) · Ann Davis, Ph.D., MPH, ABPP (1) · Anna P Piovezan, Doctor (1)
PMID 17012991, PMID 17014022, PMID 18053120, PMID 18362604, PMID 18981976, PMID 19358791, PMID 19467572, PMID 19635928, PMID 20059663, PMID 20303115, PMID 20952454, PMID 21593054, PMID 21818576, PMID 21951710, PMID 22282331, PMID 22343090, PMID 22685578, PMID 22991449, PMID 23277262, PMID 23337936, PMID 23497790, PMID 23594025, PMID 23672772, PMID 24067192, PMID 24108148, PMID 24175721, PMID 24368463, PMID 24790277, PMID 24816198, PMID 25052847, PMID 25761431, PMID 25921377, PMID 26474010, PMID 26558538, PMID 26799332, PMID 26947568, PMID 26989894, PMID 26992129, PMID 27045258, PMID 27150263, PMID 27788026, PMID 27916278, PMID 27986927, PMID 28108386, PMID 29199141, PMID 29433613, PMID 29863388, PMID 30259200, PMID 31082018, PMID 31099215
P01HD033988 (2), 2005 (1), 2008 (1), 2023 (1), K23AT009218 (1), R01AR045416 (1), R01AT010171 (1), R01NS050536 (1), R01NS101321 (1), R21HD066629 (1), U01DK065209 (1), U01DK065713 (1), U01NS076788 (1), U54GM104942 (1)