111 completed, 24 unknown, 6 recruiting, 6 terminated. 51 Not applicable, 31 Phase 4, 28 Phase 2, 16 Phase 1, 14 Phase 3.
Follow Hyperalgesia: new trials by email Literature Review of Hyperalgesia trials Research Report on Hyperalgesia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Photobiomodulation After Nonsurgical Root Canal Treatment Adjunctive Photobiomodulation, Sham Photobiomodulation - Symptomatic Apical Periodontitis, Postoperative Pain | Not applicable | Not yet recruiting | University of Minnesota | 60 | 2026-10-19 | 2026-10-21 |
| FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy Intercostal Nerve Cryoablation - Pulmonary Dysfunction, Median Sternotomy Recovery | Not applicable | Not yet recruiting | Rutgers, The State University of New Jersey | 100 | 2026-07-15 | 2026-06-09 |
| Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery Perioperative QST and incision pain mapping assessment - Postoperative Pain, Chronic Postsurgical Pain | Not yet recruiting | Tongji Hospital | 46 | 2026-06-08 | 2026-06-17 | |
| Open-Label Safety Study of AXS-14 in Subjects With Fibromyalgia AXS-14 (esreboxetine) - Fibromyalgia | Phase 3 | Enrolling by invitation | Axsome Therapeutics, Inc. | 300 | 2026-04-29 | 2026-10-13 |
| Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design AXS-14 (Esreboxetine), Placebo - Fibromyalgia | Phase 3 | Recruiting | Axsome Therapeutics, Inc. | 620 | 2026-01-14 | 2026-09-04 |
| Music Therapy During Hypothermia in the NICU Live entrained music therapy - Music Therapy, Pain | Not applicable | Not yet recruiting | Fundación Santa Fe de Bogota | 22 | 2025-10-30 | 2025-09-23 |
| Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model Synthetic interstitial fluid (SIF) / SIF neutral pH, Synthetic interstitial fluid (SIF) / SIF acidic pH, Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM - Pain | Early Phase 1 | Completed | Stefan Heber | 42 | 2025-06-17 | 2025-07-29 |
| Internet-delivered Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN) Internet delivered pain coping skills training - CIPN - Chemotherapy-Induced Peripheral Neuropathy | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2025-02-01 | 2025-04-06 | |
| Survey for Parental Perception of Procedural Analgosedation in Pediatric Age. Analgesia, Sensation, Hyperalgesic | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 700 | 2024-12-11 | 2025-01-27 | |
| Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm) - Hyperalgesia, Pain Perception | Not applicable | Completed | University of Guelph | 16 | 2024-05-01 | 2026-06-04 |
| Investigation on the Status Quo of Hyperalgesia in Patients After Thoracoscopic Operation and Study on the Effect of Intraoperative Intervention Flurbiprofen axidate combined with noise-cancelling headphones music, Flurbiprofen axidate combined with noise-cancelling headphones, Flurbiprofen exate on a drip - Thoracoscopic Surgery, Hyperalgesia | Not applicable | Unknown | Fujian Medical University Union Hospital | 90 | 2024-03-17 | 2025-01-24 |
| The Effect of Remimazolam on Opioid Induced Hyperalgesia Remimazolam, Desflurane, Remifentanil - Hyperalgesia, Mechanical | Not applicable | Completed | Wonkwang University Hospital | 108 | 2023-05-19 | 2023-10-06 |
| Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults OLP-injection, Scripted Evidence-based treatment rationale, Experimental model of acute pain - Acute Pain | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 141 | 2023-03-23 | 2025-01-24 |
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis Lacosamide - Chronic Pain, Chronic Pain Syndrome | Phase 1 | Active not recruiting | Indiana University | 21 | 2023-03-17 | 2026-06-03 |
| Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia Remifentanil, Remifentanil+ Placebo, Remifentanil +ultra-low dose naloxone - Hyperalgesia | Phase 2 | Terminated | University of California, Irvine | 8 | 2023-02-25 | 2026-06-04 |
| Childhood Adversity, Inflammatory Reactivity and Persistent Pain Tetravalent Influenza Vaccine, High-frequency electrical stimulation - Chronic Pain, Central Sensitisation | Completed | University of Cape Town | 101 | 2022-06-21 | 2023-11-13 | |
| Effect of S-ketamine in Cesarean Section Combined Anesthesia S-ketamine - Postoperative Pain | Phase 4 | Completed | The Second Affiliated Hospital of Chongqing Medical University | 120 | 2022-06-14 | 2023-02-24 |
| Electroacupuncture Pain Treatment, Mechanical Hyperalgesia, Quality of Life & Expression of Mu+ B Cells in Fibromyalgia Electroacupuncture, Nutrition, Dietary supplement - Fibromyalgia, Electroacupuncture | Recruiting | University of Crete | 80 | 2022-05-31 | 2022-10-26 | |
| Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation Study Intervention: 25 ms half-sine wave stimulation, Control Intervention: 500 µs rectangular shaped stimulation - Pain Perception, Secondary Hyperalgesia | Not applicable | Completed | University Hospital, Basel, Switzerland | 24 | 2022-05-20 | 2023-11-28 |
| Feasibility Study for Provoked Vestibulodynia Somatosensory Rehabilitation Program, Educational Pain Management Program - Vestibulodynia | Not applicable | Completed | Université de Sherbrooke | 45 | 2022-05-16 | 2023-09-28 |
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Pain (59) · Pain, Postoperative (25) · Chronic Pain (19) · Neuralgia (14) · Agnosia (11) · Acute Pain (7) · Anxiety Disorders (4) · Fibromyalgia (4) · Inflammation (4) · Peripheral Nervous System Diseases (4) · Spinal Cord Injuries (4) · Burns (3) · Complex Regional Pain Syndromes (3) · Depression (3)
Nervous System Diseases (160) · Neurologic Manifestations (160) · Pathological Conditions, Signs and Symptoms (160) · Sensation Disorders (160) · Signs and Symptoms (160) · Somatosensory Disorders (160) · Pain (42) · Pathologic Processes (31) · Neuromuscular Diseases (28) · Postoperative Complications (25) · Peripheral Nervous System Diseases (19) · Neurobehavioral Manifestations (14) · Mental Disorders (13) · Perceptual Disorders (12) · Musculoskeletal Diseases (11)
Remifentanil (16) · Sodium Chloride (10) · Ketamine (9) · Lidocaine (6) · Saline Solution (6) · Gabapentin (5) · Midazolam (4) · Morphine (4) · Capsaicin (3) · Dextromethorphan (3) · Esketamine (3) · Naloxone (3) · Nerve Growth Factor (3) · Pregabalin (3) · Acetaminophen (2)
Copenhagen University Hospital, Rigshospitalet (9) · University Hospital, Clermont-Ferrand (6) · Aalborg University (5) · Medical University of Vienna (5) · University Hospital, Basel, Switzerland (5) · National Institute of Dental and Craniofacial Research (NIDCR) (4) · Seoul National University Hospital (4) · GlaxoSmithKline (3) · Insel Gruppe AG, University Hospital Bern (3) · Leiden University Medical Center (3) · University Hospital, Bordeaux (3) · mads u werner (3) · Assistance Publique - Hôpitaux de Paris (2) · AstraZeneca (2) · Axsome Therapeutics, Inc. (2)
United States (42) · Denmark (17) · France (14) · Switzerland (9) · Canada (8) · United Kingdom (8) · South Korea (7) · Austria (6) · China (6) · Brazil (4) · Netherlands (4) · Belgium (3) · Chile (3) · Germany (3) · Italy (3)
Mads U Werner, MD, DMSc (4) · Burkhard Gustorff, MD (3) · Andrea WM Evers, Prof. Dr. (2) · Bradley K Taylor, M.Sc., Ph.D. (2) · Christine N. Sang, MD, MPH (2) · Mark Wallace, M.D. (2) · Michele Curatolo, M.D., Ph.D. (2) · Tobias Schneider, MD (2) · Victoria J Madden, PhD (2) · Weidong Mi, MD (2) · Alejandro E Delfino, MD (1)
PMID 15983467, PMID 16275600, PMID 16508405, PMID 21300053, PMID 23741350, PMID 24052307, PMID 26305798, PMID 26934941, PMID 10191237, PMID 10691234, PMID 10870744, PMID 10910490, PMID 11165371, PMID 11576045, PMID 11786502, PMID 12826855, PMID 14581110, PMID 14621285, PMID 14678841, PMID 15317861, PMID 15560360, PMID 15647484, PMID 15800228, PMID 16202520, PMID 17123731, PMID 17237664, PMID 17433624, PMID 17635557, PMID 17853395, PMID 18294378, PMID 18299127, PMID 18362258, PMID 18378801, PMID 18419722, PMID 18619874, PMID 18774343, PMID 18806023, PMID 19030010, PMID 19402781, PMID 19409861, PMID 19533519, PMID 19533521, PMID 19789074, PMID 20031953, PMID 20086062, PMID 20562702, PMID 21029787, PMID 21148579, PMID 21249671, PMID 21270403
2008 (2), 2019 (2), R01NS041503 (2), 2005 (1), 2015 (1), 2017 (1), 2023 (1), K24DA023186 (1), K43TW011442 (1), R01DK132709 (1), R21DA050752 (1)