53 completed, 10 unknown, 8 recruiting, 6 terminated. 30 Not applicable, 16 Phase 2, 12 Phase 3, 9 Phase 1, 8 Phase 4.
Follow Unipolar Depression: new trials by email Literature Review of Unipolar Depression trials Research Report on Unipolar Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) Vortioxetine, Cariprazine (Augmentation Phase) - Unipolar Depression, Bipolar Depression | Phase 4 | Recruiting | Mayo Clinic | 120 | 2026-02-17 | 2026-06-22 |
| Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer Biospecimen Collection, Counseling, Interview - Lung Non-Small Cell Carcinoma, Unipolar Depression | Phase 2 | Recruiting | Alan Davis | 10 | 2026-01-01 | 2026-05-14 |
| Bright Light Therapy for Depressed Geriatric Inpatients Bright light therapy, dim red light - Unipolar Depression | Phase 2 | Enrolling by invitation | Medical University of South Carolina | 20 | 2025-11-14 | 2026-04-16 |
| Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depression Unipolar Depression, Major Depressive Disorder (MDD) | Recruiting | Emobot | 98 | 2025-07-15 | 2025-07-22 | |
| Transcranial Direct Current Stimulation for Depression transcranial direct current stimulation (tDCS) and mindfulness instruction, Sham tDCS and Mindfulness - Unipolar Depression | Not applicable | Recruiting | Soterix Medical | 25 | 2025-07-01 | 2026-10-19 |
| Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST) MRI, MagPro TMS stimulator and coil, Thymatron (R) System IV paired with 4X1 HDECT - Unipolar Depression | Phase 1 | Withdrawn | National Institute of Mental Health (NIMH) | 2025-02-26 | 2025-02-27 | |
| Mood Disorders in Multiple Sclerosis Patients Multiple Sclerosis (MS), Unipolar Depression | Completed | Islamic Azad University, Sanandaj | 85 | 2024-07-01 | 2024-10-22 | |
| Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression Active rTMS over the left DLPFC and over the left DMPFC, Active rTMS over the left DLPFC, Sham rTMS - Unipolar Depression, Bipolar Disorder | Not applicable | Recruiting | Jakub Antczak | 90 | 2024-05-20 | 2024-10-15 |
| Cognitive Enhancement in Unipolar Depression With Yoga Adjuvant yoga intervention - Unipolar Depression | Not applicable | Recruiting | University of Pittsburgh | 32 | 2024-05-17 | 2026-03-27 |
| Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Depression iTBS, cTBS, Sham - Unipolar Depression, Bipolar Disorder | Not applicable | Recruiting | Jakub Antczak | 90 | 2024-05-15 | 2024-10-15 |
| How to Reduce Suicidal Thoughts and Impulsivity in Depression active tDCS stimulating left DLPFC, active tDCS stimulating right OFC, sham tDCS - Unipolar Depression, Impulsive Behavior | Not applicable | Unknown | Centre Hospitalier Universitaire de Besancon | 100 | 2023-09-01 | 2024-05-14 |
| Enoxolone in Major Depression - Biomarker-outcome Relationship Enoxolone - Unipolar Depression | Phase 1 / Phase 2 | Recruiting | Philipps University Marburg | 80 | 2022-09-23 | 2025-12-08 |
| TBS Treatment for Treatment-Resistant Depression Theta Burst Stimulation, Sham Stimulation - Major Depressive Disorder, Unipolar Depression | Not applicable | Completed | University of Sao Paulo | 100 | 2022-06-06 | 2024-04-03 |
| Effect of Tao Calligraphy Meditation and Energized Water on Depression Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love), Drinking Energized water - Unipolar Depression | Not applicable | Active not recruiting | Sha Research Foundation | 50 | 2022-02-10 | 2026-08-06 |
| RTMS Feasibility Study on Adolescent Depression Stimulation Repetitive Transcranial Magnetic Stimulation (rTMS) - Major Depressive Disorder, Unipolar Depression | Not applicable | Completed | Uppsala University | 20 | 2022-01-01 | 2025-02-04 |
| Ketamine As an Adjunctive Therapy for Major Depression (2) Ketamine, Midazolam - Major Depressive Episode, Unipolar Depression | Phase 3 | Completed | University of Dublin, Trinity College | 63 | 2021-09-13 | 2025-02-13 |
| Efficacy of Daylight as Adjunctive Treatment in Patients With Depression Regular exposure to morning daylight - Unipolar Depression | Not applicable | Terminated | University of Aarhus | 12 | 2021-09-01 | 2022-08-10 |
| Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study Double Active: Active portable transcranial stimulation (ptES) and active internet-based behavioral therapy (iBT), ptES-only: Active portable transcranial stimulation (ptES) and sham internet-based behavioral therapy (iBT), Double-sham: Sham portable transcranial stimulation (ptES) and sham internet-based behavioral therapy (iBT) - Major Depressive Disorder, Unipolar Depression | Not applicable | Completed | University of Sao Paulo | 210 | 2021-05-22 | 2022-11-01 |
| Home-administered tDCS for Treatment of Depression Soterix Medical mini-CT tDCS stimulator - Unipolar Depression, Treatment Resistant Depression | Phase 1 | Completed | Soterix Medical | 50 | 2021-02-10 | 2023-01-30 |
| Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression Music - Depressive Disorder, Treatment-Resistant, Depressive Disorder, Major | Not applicable | Completed | Douglas Mental Health University Institute | 32 | 2021-01-11 | 2022-10-04 |
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Depressive Disorder (82) · Depression (31) · Bipolar Disorder (26) · Depressive Disorder, Major (23) · Depressive Disorder, Treatment-Resistant (6) · Mood Disorders (5) · Anxiety Disorders (4) · Cognitive Dysfunction (3) · Adjustment Disorders (2) · Motor Activity (2) · Suicidal Ideation (2) · Anhedonia (1) · Carcinoma, Non-Small-Cell Lung (1) · Consciousness Disorders (1) · Dysthymic Disorder (1)
Mental Disorders (81) · Mood Disorders (77) · Behavior (35) · Behavioral Symptoms (34) · Bipolar and Related Disorders (26) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Nervous System Diseases (5) · Neurologic Manifestations (5) · Neurocognitive Disorders (4) · Cognition Disorders (3) · Neurobehavioral Manifestations (3) · Self-Injurious Behavior (3) · Trauma and Stressor Related Disorders (3) · Suicide (2)
Ketamine (6) · Paroxetine (3) · Transcranial Direct Current Stimulation (3) · Transcranial Magnetic Stimulation (3) · Epoetin Alfa (2) · Erythropoietin (2) · Exercise (2) · Lamotrigine (2) · Midazolam (2) · Sodium Chloride (2) · Ultraviolet Therapy (2) · Venlafaxine Hydrochloride (2) · Amitriptyline (1) · Antidepressive Agents (1) · Betaine (1)
National Institute of Mental Health (NIMH) (7) · Centre Hospitalier Universitaire de Besancon (3) · University of Pittsburgh (3) · Jakub Antczak (2) · Massachusetts General Hospital (2) · Mayo Clinic (2) · Mclean Hospital (2) · Medical University of South Carolina (2) · New York State Psychiatric Institute (2) · Soterix Medical (2) · The University of New South Wales (2) · University of Sao Paulo (2) · Universitätsklinikum Hamburg-Eppendorf (2) · Abbott Medical Devices (1) · Alan Davis (1)
United States (33) · France (7) · Canada (6) · Germany (6) · Denmark (4) · Switzerland (3) · United Kingdom (3) · Australia (2) · Brazil (2) · India (2) · Ireland (2) · Israel (2) · Poland (2) · Spain (2) · Austria (1)
Andre R Brunoni, MD, PhD (2) · Carlos A Zarate, M.D. (2) · Declan M McLoughlin, PhD (2) · Kamilla W. Miskowiak, Prof. (2) · Abhishek Datta, PhD (1) · Alan K Davis, PhD (1) · Allan Young, MD (1) · Amit Anand, MD (1) · Andrea L Dunn, PhD (1) · Atif Rahman, PhD (1) · Aysegul Ozerdem, MD, PhD (1) · Bernard Lerer, MD (1) · Beth L Murphy, MD, PhD (1) · Bogdan Stefanowski, MD (1) · Caroline Masse-Sibille, MD (1)
PMID 26604001, PMID 28231791, PMID 32090783, PMID 10568646, PMID 11556941, PMID 12377293, PMID 14702256, PMID 15365580, PMID 15780843, PMID 1593914, PMID 16540613, PMID 17548749, PMID 18457338, PMID 19414708, PMID 20074703, PMID 20952454, PMID 21367355, PMID 21680918, PMID 23277262, PMID 23364679, PMID 24611024, PMID 25192980, PMID 25220861, PMID 25749590, PMID 26088117, PMID 26578205, PMID 27366831, PMID 27608926, PMID 27881113, PMID 28619114, PMID 28988904, PMID 29111077, PMID 29130400, PMID 29440902, PMID 29673379, PMID 29769159, PMID 30172724, PMID 30184133, PMID 30400939, PMID 30572160, PMID 30686385, PMID 30686386, PMID 30797651, PMID 30819173, PMID 31093302, PMID 31941468, PMID 3204199, PMID 32055965, PMID 32220155, PMID 33128939
2016 (3), U19MH095687 (2), 2019 (1), D43TW009114 (1), R01MH090276 (1), R01MH112815 (1), R25DA020537 (1)