9 completed, 3 terminated, 2 recruiting, 1 enrolling by invitation. 16 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 9, Terminated 3, Recruiting 2, Enrolling by invitation 1, Unknown 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Unipolar Depression: new trials by email Literature Review of Unipolar Depression trials Research Report on Unipolar Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer Biospecimen Collection, Counseling, Interview - Lung Non-Small Cell Carcinoma, Unipolar Depression | Phase 2 | Recruiting | Alan Davis | 10 | 2026-01-01 | 2026-05-14 |
| Bright Light Therapy for Depressed Geriatric Inpatients Bright light therapy, dim red light - Unipolar Depression | Phase 2 | Enrolling by invitation | Medical University of South Carolina | 20 | 2025-11-14 | 2026-04-16 |
| Enoxolone in Major Depression - Biomarker-outcome Relationship Enoxolone - Unipolar Depression | Phase 1 / Phase 2 | Recruiting | Philipps University Marburg | 80 | 2022-09-23 | 2025-12-08 |
| Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders Erythropoietin, Saline - Bipolar Disorder, Cognitive Impairment | Phase 2 | Completed | Lars Vedel Kessing | 103 | 2017-07-05 | 2023-03-16 |
| Effects of Erythropoietin for Cognitive Side-effects of ECT Erythropoietin, Saline - ECT, Cognitive Impairment | Phase 2 | Completed | Martin Balslev Jørgensen | 60 | 2017-06-26 | 2023-09-21 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) electroconvulsive therapy (ECT), Ketamine - Treatment Resistant Depression, Electroconvulsive Therapy | Phase 2 / Phase 3 | Completed | Bo Hu | 403 | 2017-04-07 | 2023-09-28 |
| Improve: Integrating Emotion Focused Components Into Psychological Therapy Psychological therapy (PT) as TAU with integrated emotion focused components (TAU - EFT), Psychological therapy (PT) as TAU with focus on self-regulation (TAU - SR) - Unipolar Depression, Anxiety Disorder | Phase 2 | Completed | University of Bern | 104 | 2015-04-01 | 2019-09-10 |
| tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients transcranial Direct Current Stimulation (tDCS) (Eldith DC NeuroConn Stimulator) - Resistant Depression, Moods Disorders | Phase 2 | Completed | Centre Hospitalier Universitaire de Besancon | 87 | 2012-07-19 | 2023-06-06 |
| Investigating tDCS as a Treatment for Unipolar and Bipolar Depression Sham tDCS device, Soterix tDCS device - Unipolar Depression, Bipolar Depression | Phase 2 / Phase 3 | Completed | The University of New South Wales | 120 | 2012-06-01 | 2015-12-02 |
| EScitalopram PIndolol ONset of Action escitalopram, pindolol, escitalopram - Unipolar Depression | Phase 2 / Phase 3 | Terminated | Markus KOSEL | 18 | 2010-10-01 | 2015-05-27 |
| Randomized Clinical Trial of an Exposure-based Cognitive Therapy for Depression Cognitive-Behavioral Therapy for Depression, Exposure-Based Cognitive Therapy for Depression - Unipolar Depression | Phase 2 | Unknown | University of Zurich | 142 | 2010-01-01 | 2012-10-31 |
| The Antidepressant Efficacy of the Anticholinergic Scopolamine Scopolamine - Unipolar Depression, Bipolar Depression | Phase 2 | Terminated | National Institute of Mental Health (NIMH) | 17 | 2006-08-01 | 2016-11-10 |
| Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies Scopolamine Nasal Spray - Mood Disorders, Healthy | Phase 2 | Terminated | National Institute of Mental Health (NIMH) | 197 | 2003-02-27 | 2021-03-22 |
| RCT of Psychoeducational Program of Depression Control with depression course (CWD) - Unipolar Depression | Phase 2 | Completed | Norwegian Institute of Public Health | 155 | 2001-03-01 | 2022-04-06 |
| Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group fluoxetine or desipramine - Major Depressive Disorder, Major Depression | Phase 2 | Completed | National Institute of General Medical Sciences (NIGMS) | 700 | 1999-11-01 | 2008-10-10 |
| Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders Magstim Super Rapid Magnetic Stimulator, Cadwell MES-10 - Bipolar Disorder, Mood Disorder | Phase 2 | Completed | National Institute of Mental Health (NIMH) | 91 | 1996-05-01 | 2006-07-13 |
Depressive Disorder (16) · Depression (8) · Bipolar Disorder (7) · Depressive Disorder, Major (4) · Mood Disorders (3) · Cognitive Dysfunction (2) · Adjustment Disorders (1) · Anxiety Disorders (1) · Carcinoma, Non-Small-Cell Lung (1) · Depressive Disorder, Treatment-Resistant (1) · Mania (1) · Mental Disorders (1) · Stress Disorders, Traumatic (1)
Mental Disorders (15) · Mood Disorders (13) · Behavior (8) · Behavioral Symptoms (8) · Bipolar and Related Disorders (7) · Cognition Disorders (2) · Neurocognitive Disorders (2) · Trauma and Stressor Related Disorders (2) · Bronchial Neoplasms (1) · Carcinoma, Bronchogenic (1) · Lung Diseases (1) · Lung Neoplasms (1) · Neoplasms (1) · Neoplasms by Site (1) · Nervous System Diseases (1)
Epoetin Alfa (2) · Erythropoietin (2) · Sodium Chloride (2) · Cognitive Behavioral Therapy (1) · Counseling (1) · Desipramine (1) · Dexetimide (1) · Electroconvulsive Therapy (1) · Escitalopram (1) · Fluoxetine (1) · Glycyrrhetinic Acid (1) · Interviews as Topic (1) · Ketamine (1) · Phototherapy (1) · Pindolol (1)
National Institute of Mental Health (NIMH) (3) · Alan Davis (1) · Bo Hu (1) · Centre Hospitalier Universitaire de Besancon (1) · Lars Vedel Kessing (1) · Markus KOSEL (1) · Martin Balslev Jørgensen (1) · Medical University of South Carolina (1) · National Institute of General Medical Sciences (NIGMS) (1) · Norwegian Institute of Public Health (1) · Philipps University Marburg (1) · The University of New South Wales (1) · University of Bern (1) · University of Zurich (1)
United States (8) · Switzerland (3) · Denmark (2) · Australia (1) · France (1) · Germany (1) · Norway (1)
Kamilla W. Miskowiak, Prof. (2) · Alan K Davis, PhD (1) · Amit Anand, MD (1) · Carlos A Zarate, M.D. (1) · Franz Caspar, Prof. PhD (1) · Harald Murck, MD PhD (1) · Julio Licinio, MD (1) · Lars V. Kessing, Prof. (1) · Markus Kosel, MD-PhD (1) · Martin Grosse Holtforth, Professor MD (1) · Maura L Furey, Ph.D. (1) · Odd Steffen Dalgard, M.D., Ph.D. (1) · Rindy Fernandes, DO (1)
PMID 15365580, PMID 19414708, PMID 20074703, PMID 23364679, PMID 25220861, PMID 26578205, PMID 27366831, PMID 27881113, PMID 29111077, PMID 29130400, PMID 29673379, PMID 30172724, PMID 30184133, PMID 30400939, PMID 30572160, PMID 33128939, PMID 37224232, PMID 38010758, PMID 38128460, PMID 38519416, PMID 40900112
2016 (2), R25DA020537 (1)