27 completed, 4 recruiting, 2 unknown, 1 active not recruiting. 22 Not applicable, 9 Phase 2, 3 Phase 1, 3 Phase 3, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Betaine vs. Placebo for Serologically Diagnosed Metabolic Dysfunction-associated Steatohepatitis (MASH) Betaine, Placebo - MASH - Metabolic Dysfunction-Associated Steatohepatitis | Phase 2 | Not yet recruiting | Southern California Institute for Research and Education | 70 | 2026-03-31 | 2026-01-08 |
| Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults NMN and TMG (Euexia), Nicotinamide Mononucleotide (NMN), Placebo - Aging, Frailty | Not applicable | Recruiting | Scott Silveira | 40 | 2026-02-21 | 2026-10-07 |
| Effect of Betaine and Choline on Metabolic Health Trimethylglycine, Eggs, Cellulose - Obesity and Obesity-related Medical Conditions | Not applicable | Completed | University of Guelph | 34 | 2025-01-31 | 2026-05-12 |
| Exploratory Study on the Efficacy of Betaine Hydrochloride in Treating Autoimmune Gastritis No intervention (Control Group), Oral betaine hydrochloride (2 capsules, 3 times daily) - Autoimmune Gastritis | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2025-01-03 | 2025-03-30 |
| Betaine Supplementation and Lipid Metabolism in Overweight and Obese Pre-menopausal Women Betaine, Placebo - Overweight and Obesity | Not applicable | Completed | Poznan University of Life Sciences | 54 | 2024-09-01 | 2025-11-24 |
| Betaine, Exercise Performance, and Gut Permeability Betaine, Placebo - Metabolic Disturbance, Permeability; Increased | Not applicable | Completed | Appalachian State University | 23 | 2024-08-13 | 2025-03-11 |
| The Therapeutic Effect of Betaine in Syringomyelia Betaine, Placebo - Syringomyelia | Phase 2 | Recruiting | Xuanwu Hospital, Beijing | 30 | 2024-03-01 | 2024-03-13 |
| Firefighter Thermoregulatory Responses in Active Fire with Betaine Supplementation Betaine, Placebo - Body Temperature Changes, Body Water Dehydration | Not applicable | Completed | Michael J. Ormsbee | 17 | 2023-12-20 | 2024-10-17 |
| Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs. XCM-OM118 Composition comprising olive oil, betaine and xylitol - Oral Mucositis, Quality of Life | Not applicable | Recruiting | Mucosa Innovations, S.L. | 63 | 2022-10-11 | 2026-04-15 |
| Effect on Cytokines IL-1ß, TNF-α, IL-4, and Total Bacterial Load of a Composition Comprising Olive Oil, Trimethylglycine and Xylitol Delivered as a Toothpaste Toothpaste with olive oil, trimethylglycine and xylitol, Toothpaste without olive oil, trimethylglycine nor xylitol - Inflammation, Interleukin-1beta | Not applicable | Completed | Mucosa Innovations, S.L. | 26 | 2022-06-13 | 2025-03-10 |
| Effects of a Composition on the Oral Microbiome, pH, Nitrite/Nitrate Ratio, Elastases and Inflammation in Oral Dysbiosis Test composition Saliactive® (olive product, betaine and xylitol), Placebo, Control - Oral Dysbiosis | Phase 2 / Phase 3 | Completed | Mucosa Innovations, S.L. | 100 | 2021-07-13 | 2024-07-08 |
| Maternal Betaine Supplementation During Breastfeeding Betaine, Placebo - Overweight and Obesity | Phase 1 / Phase 2 | Active not recruiting | Fundació Sant Joan de Déu | 47 | 2021-02-11 | 2026-03-24 |
| Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle Betaine, Placebo - Blood Flow Restriction Training, Betaine Supplementation | Not applicable | Completed | Baylor University | 20 | 2021-02-01 | 2023-03-29 |
| The Effects of Pre-Loaded Betaine Supplementation on Thermoregulation and Exercise Metabolism in the Heat Betaine, BCAA Big 6, Placebo - Healthy | Not applicable | Completed | Florida State University | 14 | 2020-01-21 | 2024-03-13 |
| Effects of Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adults With Hyperhomocysteinemia supplementation of compound nutrients, placebo control - Hyperhomocysteinemia | Not applicable | Unknown | Huilian Zhu | 100 | 2019-05-20 | 2019-05-14 |
| Effect of Betaine and Food on Gastric pH Standardized Meal, Betaine Hydrochloride 1500mg, Betaine Hydrochloride 3000mg - Healthy | Not applicable | Completed | University of California, San Francisco | 9 | 2016-06-01 | 2020-01-23 |
| Betaine METABOLISM OF PATIENTS With Homocystinuria Betaine - Homocystinuria | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 12 | 2015-07-01 | 2023-02-03 |
| Dietary Supplementation to Increase Serum Choline Levels Phosphatidylcholine, Betaine (588 mg qam and 412 mg qpm), Betaine (1000 mg BID) - Healthy | Not applicable | Completed | University of Colorado, Denver | 8 | 2015-04-01 | 2020-09-02 |
| Modulation of Insulin Sensitivity by Betaine Upregulation of FGF21 Betaine, Dextrose - Insulin Sensitivity | Not applicable | Completed | UNC Nutrition Research Institute | 23 | 2014-03-01 | 2014-08-12 |
| Metabolic Effects of Betaine Supplementation Betaine, Placebo - Obesity, Dysglycemia | Phase 2 | Completed | Joslin Diabetes Center | 28 | 2014-01-01 | 2021-04-20 |
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Obesity (4) · Overweight (4) · Cardiovascular Diseases (2) · Hepatitis C, Chronic (2) · Inflammation (2) · Non-alcoholic Fatty Liver Disease (2) · Anemia, Iron-Deficiency (1) · Angelman Syndrome (1) · Ataxia (1) · Body Temperature Changes (1) · Dehydration (1) · Depressive Disorder (1) · Diabetes Mellitus, Type 2 (1) · Dysbiosis (1) · Frailty (1)
University of California, San Francisco (4) · Mucosa Innovations, S.L. (3) · Mayo Clinic (2) · Southern California Institute for Research and Education (2) · University of Nebraska (2) · Wageningen Centre for Food Sciences (2) · Appalachian State University (1) · Assistance Publique - Hôpitaux de Paris (1) · Baylor University (1) · Calvary Hospital, Bronx, NY (1) · Cambridge Health Alliance (1) · Columbia University (1) · Florida State University (1) · Fundació Sant Joan de Déu (1) · Huilian Zhu (1)
United States (19) · Spain (4) · China (3) · Canada (2) · Netherlands (2) · Bangladesh (1) · Brazil (1) · France (1) · Poland (1) · Switzerland (1)
Mark E Mailliard, MD (2) · Petra Verhoef, PhD (2) · Agata Chumrzynska (1) · Ann Olincy, MD (1) · Arthur L. Beaudet, MD (1) · Bruno Gualano, PhD (1) · Camille Hoffman, MD (1) · Carla G Monico, M.D. (1) · Carlos A. Bacino, MD (1) · David C Nieman, DrPH (1) · Francisco Luis Mesa Aguado (1) · Huilian Zhu, professor (1) · Karen Corbin, PhD, RD (1)
PMID 18973181, PMID 21079746, PMID 21109081, PMID 22002941, PMID 23082850, PMID 23980906, PMID 29860335, PMID 31485804, PMID 31640736, PMID 32805463, PMID 36376887, PMID 36424067, PMID 36717385, PMID 37248485, PMID 38014747, PMID 41981946, PMID 42498161, PMID 42841999
R01DK073354 (1), UL1TR001082 (1)