402 completed, 146 unknown, 102 recruiting, 41 not yet recruiting. 352 Not applicable, 53 Phase 2, 38 Phase 3, 27 Phase 4, 19 Phase 1.
Follow Consciousness Disorders: new trials by email Literature Review of Consciousness Disorders trials Research Report on Consciousness Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury | Phase 2 | Not yet recruiting | University of California, Los Angeles | 264 | 2028-01-10 | 2026-01-16 |
| An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma Cognitive Processing Therapy - Post-Traumatic Stress Disorder, Chronic, Depressed Mood | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 25 | 2027-01-01 | 2026-10-15 |
| Electroacupuncture at Jing-Well Points for Chronic Disorders of Consciousness: A Randomized Controlled Study With Multimodal Assessment Electrostimulation at the Twelve Hand Jing-Well Points - Disorder of Consciousness | Not applicable | Not yet recruiting | The Third People's Hospital of Huizhou | 66 | 2026-12-23 | 2026-09-02 |
| AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy - Disorders of Consciousness, Vegetative State | Not applicable | Not yet recruiting | Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. | 200 | 2026-12-01 | 2026-10-02 |
| Investigating Near-Threshold Perception During Ultrasonic Deep Brain Stimulation Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Spectroscopy - Consciousness, Level Altered | Not applicable | Not yet recruiting | University of Michigan | 90 | 2026-11-30 | 2026-10-13 |
| Walking With Overground Robotic Exoskeleton Device to Increase Behavioral Responsiveness in Patients With Disorders of Consciousness (WALK DOC) Overground Robotic Exoskeleton (ORE) - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Not yet recruiting | Spaulding Rehabilitation Hospital | 18 | 2026-11-01 | 2026-09-21 | |
| Miniature In-line Respirator Hope inVent - Brain Death, Respiration, Artificial | Not applicable | Not yet recruiting | National Institutes of Health Clinical Center (CC) | 5 | 2026-10-28 | 2026-10-23 |
| Two Sessions of Coach-Delivered Core Transformation for Distress and Well-Being Core Transformation Process - Psychological Distress, Psychological Well-being | Not applicable | Not yet recruiting | Andreas NLP (Legal Entity - Real People Press) | 480 | 2026-10-20 | 2026-10-21 |
| Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall Whole-body point-of-care ultrasound (POCUS) - Accidental Falls, Aged | Recruiting | Kocaeli City Hospital | 105 | 2026-10-12 | 2026-10-21 | |
| Ecological Momentary Intervention (E-Breathing) to Reduce Psychological Distress in Adolescents Slow-paced breathing via ecological momentary intervention, Ecological momentary assessments - Psychological Distress, Depressed Mood | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 100 | 2026-10-01 | 2026-07-21 |
| PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low Mood Prucalopride, Placebo Comparator - Low Mood, Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | University of Oxford | 60 | 2026-10-01 | 2026-10-06 |
| Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in Japan Application of ambulatory cardiac monitor - Atrial Fibrillation (AF), Atrial Flutter | Not applicable | Not yet recruiting | iRhythm Technologies, Inc. | 130 | 2026-09-30 | 2026-10-19 |
| Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP) Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO. - Death, Brain | Not applicable | Not yet recruiting | Centre Hospitalier Régional d'Orléans | 28 | 2026-09-15 | 2026-07-10 |
| Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP) Consciousness Disorders, Persistent Vegetative State | Not yet recruiting | Nicosia General Hospital | 40 | 2026-09-15 | 2026-07-30 | |
| Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study Value of neurofilament light chain (NFL) at different time points - Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 270 | 2026-09-01 | 2026-08-12 | |
| Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage (ICH) | Not yet recruiting | Columbia University | 230 | 2026-09-01 | 2026-08-31 | |
| Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students digital cognitive behavioral therapy for insomnia and digital circadian intervention, digital cognitive behavioral therapy for insomnia, digital health education - Eveningness, Insomnia | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 195 | 2026-09-01 | 2026-09-03 |
| Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence Terminal Illness, End-of-Life Care | Not yet recruiting | Noah Tech, Corp. | 20 | 2026-09-01 | 2026-03-17 | |
| Impact of Lifestyle on Health Maintenance: A Randomized Controlled Trial Intervention of physical activity, Mediterranean Diet Education, Behavioral: Stress-Resilience Training - Metabolic Syndrome, Inactivity/Low Levels of Exercise | Not applicable | Not yet recruiting | University of Zadar | 120 | 2026-09-01 | 2026-09-04 |
| Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC) Italian SWallowing Assessment in Disorders of Consciousness (SWADOC), Italian Brief Evaluation of Receptive Aphasia (BERA) - Consciousness Disorders, Severe Acquired Brain Injury | Not yet recruiting | Alfonso Magliacano | 79 | 2026-09-01 | 2026-07-17 |
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Syncope (196) · Coma (134) · Syncope, Vasovagal (88) · Persistent Vegetative State (87) · Brain Death (71) · Brain Injuries (68) · Brain Injuries, Traumatic (60) · Unconsciousness (54) · Heart Arrest (35) · Arrhythmias, Cardiac (34) · Depression (34) · Stroke (28) · Anxiety Disorders (25) · Atrial Fibrillation (24)
Neurobehavioral Manifestations (776) · Pathological Conditions, Signs and Symptoms (774) · Nervous System Diseases (772) · Neurologic Manifestations (772) · Signs and Symptoms (710) · Unconsciousness (516) · Mental Disorders (301) · Neurocognitive Disorders (289) · Central Nervous System Diseases (285) · Brain Diseases (282) · Pathologic Processes (222) · Cardiovascular Diseases (183) · Heart Diseases (116) · Wounds and Injuries (114)
Transcranial Direct Current Stimulation (22) · Sodium Chloride (12) · Amantadine (8) · Dexmedetomidine (7) · Propofol (7) · Transcranial Magnetic Stimulation (7) · Magnetic Resonance Imaging (6) · Midazolam (5) · Saline Solution (5) · Surveys and Questionnaires (5) · Electrocardiography, Ambulatory (4) · Electroencephalography (4) · Hypothermia, Induced (4) · Ketamine (4) · Midodrine (4)
University of Liege (18) · First Affiliated Hospital of Zhejiang University (17) · Assistance Publique - Hôpitaux de Paris (14) · Hangzhou Normal University (13) · Massachusetts General Hospital (12) · Hospices Civils de Lyon (11) · University of Calgary (10) · University of California, Los Angeles (10) · Abbott Medical Devices (9) · Biotronik SE & Co. KG (9) · Istituto Auxologico Italiano (8) · National Institute of Neurological Disorders and Stroke (NINDS) (7) · Xijing Hospital (7) · Beijing Tiantan Hospital (6) · Xuanwu Hospital, Beijing (6)
United States (189) · France (91) · China (86) · Italy (79) · Canada (50) · United Kingdom (40) · Germany (38) · Belgium (33) · Spain (26) · Brazil (19) · Denmark (19) · Poland (19) · Turkey (Türkiye) (19) · Switzerland (18) · Netherlands (15)
Benyan Luo (6) · Michele Brignole, MD (5) · Haibo Di, Pro. (4) · Anna Estraneo, MD (3) · Haibo Di, Pro (3) · Helen Lavretsky, M.D. (3) · Luca Padua, MD, phD (3) · Melanie Boltzmann, PhD (3) · Nicole Harbert (3) · Sandeep Gulati, PhD (3) · Satish R Raj, MD MSCI (3) · Venkatesh Thiruganasambandamoorthy, CCFP-EM, MSc (3) · Victoria E Claydon, PhD (3) · Anar Murphy, PhD (2)
PMID 15670960, PMID 21712276, PMID 36114133, PMID 22565936, PMID 38036236, PMID 19954851, PMID 24574549, PMID 30354289, PMID 33279955, PMID 19797151, PMID 21156950, PMID 21876461, PMID 22224835, PMID 22275485, PMID 26411271, PMID 27089287, PMID 27402231, PMID 27567470, PMID 27683846, PMID 28901969, PMID 29562304, PMID 30338504, PMID 30941094, PMID 31330187, PMID 31439288, PMID 33504514, PMID 34339231, PMID 34789832, PMID 36467262, PMID 37025684, PMID 37178149, PMID 39198005, PMID 42475649, PMID 10390410, PMID 10634801, PMID 10676584, PMID 10725531, PMID 10798503, PMID 10869046, PMID 10902039, PMID 11146266, PMID 11210997, PMID 11498461, PMID 12076410, PMID 12082237, PMID 12239256, PMID 12243491, PMID 12425407, PMID 12478412, PMID 12625169
2019 (3), 2017 (2), 2018 (2), R61MH138612 (2), 1UG3HL159134-01 (1), 2014 (1), 2016 (1), 2023 (1), DP2HD101400 (1), F32MH123001 (1), K23AG066929 (1), K23HL132052 (1), K23NS136745 (1), K23NS140495 (1), R01AG059613 (1)