7 completed, 1 recruiting. 8 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 8 | Completed 7, Recruiting 1 |
Follow Unipolar Depression: new trials by email Literature Review of Unipolar Depression trials Research Report on Unipolar Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) Vortioxetine, Cariprazine (Augmentation Phase) - Unipolar Depression, Bipolar Depression | Phase 4 | Recruiting | Mayo Clinic | 120 | 2026-02-17 | 2026-06-22 |
| The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. Ketamine Hydrochloride - Major Depression, Bipolar I Disorder | Phase 4 | Completed | Mayo Clinic | 75 | 2017-06-01 | 2022-03-15 |
| A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise Venlafaxine XR, Aerobic Exercise, Lorazepam - Depression, Depressive Disorder, Major | Phase 4 | Completed | Kirk Erickson, PhD | 31 | 2015-03-01 | 2018-05-23 |
| Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression Ketamine, Methohexital - Unipolar Depression, Bipolar Depression | Phase 4 | Completed | Northwell Health | 31 | 2010-06-01 | 2023-03-09 |
| Effects of Electroconvulsive Therapy (ECT) on Serotonin-1A Receptor Binding ECT - Unipolar Depression | Phase 4 | Completed | Medical University of Vienna | 12 | 2009-06-01 | 2011-11-16 |
| Natural Supplements for Unipolar Depression Supplements of L-methionine, betaine and folate - Unipolar Depression | Phase 4 | Completed | Cambridge Health Alliance | 20 | 2004-12-01 | 2017-04-18 |
| Paroxetine and Interpersonal Psychotherapy for Maintaining Health and Well-being in Elderly Individuals With Depression Interpersonal Psychotherapy, paroxetine - Unipolar Depression | Phase 4 | Completed | University of Pittsburgh | 225 | 1999-03-01 | 2013-08-02 |
| The Effects of Sleep Deprivation on Antidepressant Response total sleep deprivation, PET imaging - Unipolar Depression | Phase 4 | Completed | University of Pittsburgh | 80 | 1999-02-01 | 2013-08-02 |
Depressive Disorder (8) · Depression (4) · Bipolar Disorder (3) · Depressive Disorder, Major (2) · Motor Activity (1) · Sleep Deprivation (1)
Mental Disorders (8) · Mood Disorders (8) · Behavior (4) · Behavioral Symptoms (4) · Bipolar and Related Disorders (3) · Dyssomnias (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1) · Sleep Wake Disorders (1)
Ketamine (2) · Betaine (1) · Exercise (1) · Folic Acid (1) · Interpersonal Psychotherapy (1) · Lorazepam (1) · Magnetic Resonance Spectroscopy (1) · Methohexital (1) · Paroxetine (1) · Venlafaxine Hydrochloride (1) · Vortioxetine (1) · cariprazine (1)
Mayo Clinic (2) · University of Pittsburgh (2) · Cambridge Health Alliance (1) · Kirk Erickson, PhD (1) · Medical University of Vienna (1) · Northwell Health (1)
United States (7) · Austria (1)
Aysegul Ozerdem, MD, PhD (1) · Deniz Ceylan, MD, PhD (1) · Georgios Petrides, M.D. (1) · Kirk Erickson, PhD (1) · Mark A Frye, MD (1) · Richard Frey, MD (1) · Robert T Dunn, MD, PhD (1)
PMID 16540613, PMID 18457338, PMID 30797651, PMID 34623633, PMID 38142892, PMID 38479192, PMID 42702010